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Neural Regeneration Research 2012年第22期7卷 1715-1721页

作者： Sung Eun Kim ll Gyu Ko Mal soon Shin Chang ju Kim Young Gwan Ko Hanjin Cho Department of Physiology College of Medicine Kyung Hee University Department of Emergency Medicine College of Medicine Kyung Hee University Department of Emergency Medicine Korea University Ansan Hospital

Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyI-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.

关键词： wintracerebral hemorrhage organotypic hippocampal slice culture bovine colostrum apoptotic celldeath N-methyI-D-aspartic acid caspase-3 hippocampus memory

Fruits extracts of Hovenia dulcis *** lipopolysaccharide—stimulated inflammatory responses through nuclear factor—kappaB pathway in Raw 264.7 cells

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 349-355页

作者： ju-Yeon park Jin-Young Moon Sun-Dong park Won-Hwan park Hyuck Kim Jai-Eun Kim Department of Acupoint College of Korean Medicine.Dongguk University Department of Prescription College of Korean MedicineDongguk University Department of Diagnostics College of Korean Medicine.Dongguk University Department of Pathology College of Korean Medicine.Dongguk University

Objective:To investigate the anti-inflammatory effects and the action mechanism of the fruits of Horenia dulcis(***) in lipopolysaccharide(LPS)-induced mouse macrophage Raw ***:The extract of *** fruits(EHDF) were extracted with 70%*** macrophages were treated with different concentrations of EHDF in the presence and absence of LPS(1 μg/mL).To demonstrate the inflammatory mediators including nitric oxide,inducible nitric oxide synthase and cyclooxygenase(COX)-2 expression levels were analyzed by usingin vitro assay ***-derived pro-inflammatory cytokines including interleukin-1 β.tumor necrosis factor- α and prostaglandin F_2 were determined using ELISA *** viability,heme oxygenase-1 expression,nuclear factor-kappaB and nuclear factor F.2-related factors 2 translocation were also ***:EHDF potently inhibited the LPS-stimulated nitric oxide,inducible nitric oxide ***-2,interleukin-1 β and tumor necrosis factor- α expression in a dose-dependent *** suppressed the phosphorylation of inhibited kappaB-alpha and p65 nuclear *** of macrophage cells with EHDF alone induced the heme oxygenase-1 and nuclear translocation of nuclear factor E2-reIated factor ***:These results suggest that the ethanol extract of *** fruit exerts its anti-inflammatory effects by inhibiting inhibited kappaBalpha phorylation and nuclear translocation of nuclear factor-kappaB.

关键词： Fruits of Hovenia dulcis Inflammation Macrophage Nuclear factor-kappaB Heme oxygenase-1

High-dose hepatitis B immunoglobulin therapy in hepatocellular carcinoma with hepatitis B virus-DNA/hepatitis B e antigen-positive patients after living donor liver transplantation

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World Journal of Gastroenterology 2016年第14期22卷 3803-3812页

作者： Eung Chang Lee Seong Hoon Kim Seung Duk Lee Hyeongmin park soon-Ae Lee Sang-Jae park Center for Liver Cancer National Cancer Center

AIM: To investigate the impact of high-dose hepatitis B immunoglobulin(HBIG) on hepatocellular carcinoma(HCC) and hepatitis B virus(HBV) recurrence and overall survival after living donor liver transplantation(LDLT).METHODS: We investigated 168 patients who underwent LDLT due to HCC, and who were HBV-DNA/hepatitis B e antigen(HBe Ag)-positive, from January 2008 to December 2013. After assessing whether the patients met the Milan criteria, they were assigned to the low-dose HBIG group and high-dose HBIG group. Using the propensity score 1:1 matching method, 38 and 18 pairs were defined as adhering to and not adhering to the Milan criteria. For each pair, HCC recurrence, HBV recurrence and overall survival were analyzed by the Kaplan-Meier method and the log rank test according to the HBIG dose. RESULTS: Among those who met the Milan criteria, the 6-mo, 1-year, and 3-year HCC recurrence-free survival rates were 88.9%, 83.2%, and 83.2% in the low-dose HBIG group and 97.2%, 97.2%, and 97.2% in the high-dose HBIG group, respectively(P = 0.042).In contrast, among those who did not meet the Milan criteria, HCC recurrence did not differ according to the HBIG dose(P = 0.937). Moreover, HBV recurrence and overall survival did not differ according to the HBIG dose among those who met(P = 0.317 and 0.190, respectively) and did not meet(P = 0.350 and 0.987, respectively) the Milan criteria. CONCLUSION: High-dose HBIG therapy can reduce HCC recurrence in HBV-DNA/HBe Ag-positive patients after LDLT.

关键词： Hepatitis B immune globulin Hepatocellular carcinoma Hepatitis B virus-DNA Liver transplantation Hepatitis B e antigen

Synchronization criteria for coupled Hopfield neural networks with time-varying delays

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Chinese Physics B 2011年第11期20卷 140-150页

作者： M.J.park O.M.Kwon ju H.park S.M.Lee E.J.Cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of MedicineChungbuk National University

This paper proposes new delay-dependent synchronization criteria for coupled Hopfield neural networks with time-varying delays. By construction of a suitable Lyapunov Krasovskii＇s functional and use of Finsler＇s lemma, novel synchronization criteria for the networks are established in terms of linear matrix inequalities （LMIs） which can be easily solved by various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： Hopfield neural networks coupling delay synchronization Lyapunov method

Leader-following consensus criteria for multi-agent systems with time-varying delays and switching interconnection topologies

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Chinese Physics B 2012年第11期21卷 144-153页

We consider multi-agent systems with time-varying delays and switching interconnection topologies. By con- structing a suitable Lyapunov-Krasovskii functional and using the reciprocally convex approach, new delay-dependent consensus criteria for the systems are established in terms of linear matrix inequalities （LMIs）, which can be easily solved by using various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： consensus multi-agent systems time delay Lyapunov method

Enhancement of Au–Ag–Te contents in tellurium-bearing ore minerals via bioleaching

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International Journal of Minerals,Metallurgy and Materials 2018年第3期25卷 262-270页

作者： Nag-Choul Choi Kang Hee Cho Bong ju Kim soonjae Lee Cheon Young park Department of Rural Systems Engineering Seoul National University Department of Earth and Environmental Sciences Korea University Department of Energy and Resource Engineering Chosun University

The purpose of this study was to enhance the content of valuable metals, such as Au, Ag, and Te, in tellurium-bearing minerals via bioleaching. The ore samples composed of invisible Au and Au paragenesis minerals(such as pyrite, chalcopyrite, sphalerite and galena) in combination with tellurium-bearing minerals(hessite, sylvanite and Tellurobismuthite) were studied. Indigenous microbes from mine drainage were isolated and identified as Acidithiobacillus ferrooxidans, which were used in bioleaching after adaption to copper. The effect of the microbial adaption on the bioleaching performance was then compared with the results produced by the non-adaptive process. The microbial adaption enhanced the Au–Ag–Te contents in biological leaching of tellurium-bearing ore minerals. This suggests that bioleaching with adapted microbes can be used both as a pretreatment and in the main recovery processes of valuable metals.

关键词： tellurium-bearing mineral bioleaching adaptation Au–Ag–Te Acidithiobacillus ferrooxidans

State estimation for neural neutral-type networks with mixed time-varying delays and Markovian jumping parameters

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Chinese Physics B 2012年第10期21卷 29-37页

作者： S.Lakshmanan ju H.park H.Y.jung P.Balasubramaniam Department of Information and Communication Engineering/Electrical Engineering Yeungnam University214-1 Dae-DongKyongsan 712-749Republic of Korea Department of Mathematics Gandhigram Rural Institute-Deemed UniversityGandhigram - 624 302TamilnaduIndia

This paper is concerned with a delay-dependent state estimator for neutral-type neural networks with mixed timevarying delays and Markovian jumping *** addressed neural networks have a finite number of modes,and the modes may jump from one to another according to a Markov *** construction of a suitable Lyapunov-Krasovskii functional,a delay-dependent condition is developed to estimate the neuron states through available output measurements such that the estimation error system is globally asymptotically stable in a mean *** criterion is formulated in terms of a set of linear matrix inequalities（LMIs）,which can be checked efficiently by use of some standard numerical packages.

关键词： neural networks state estimation neutral delay Markovian jumping parameters

Design and evaluation of nicorandil extended-release tablet

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 108-113页

作者： ju-Young Kim Chun-Woong park Beom-Jin Lee Eun-Seok park Yun-Seok Rhee College of Pharmacy Woosuk UniversityWanju-gun 565-701Republic of Korea College of Pharmacy Chungbuk National UniversityCheongju 361-763Republic of Korea College of Pharmacy Ajou UniversitySuwon 443-749Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 440-746Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Gyeongsang National UniversityJinju 660-701Republic of Korea

The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in *** was employed to estimate optimum dissolution and absorption rate of *** dissolution test was employed using pH 1.2,4.0,6.8 buffer solution,or water,to measure the in vitro release behaviors of nicorandil formulations.A single dose(15 mg)of each formulation was orally administered to four beagle dogs under fasted conditions,and the pharmacokinetic parameters were *** in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle *** was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release *** nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release *** release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extendedrelease *** results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

关键词： Nicorandil In vitro In vivo Pharmacokinetic Extended-release

Rapid determination of lithium-ion battery degradation: High C-rate LAM and calculated limiting LLI

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Journal of Energy Chemistry 2022年第4期31卷 663-671页

作者： Gyuwon Seo Jaeyun Ha Moonsu Kim Jihyeon park Jaewon Lee Eunoak park Sungyool Bong Kiyoung Lee soon Jong Kwon Seung-pil Moon Jinsub Choi Jaeyoung Lee Electrochemical Reaction and Technology Laboratory School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Gwangju 61005South Korea Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212South Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005South Korea Korea Electric Power Corporation Research Institute Daejeon 34056South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes(ifRC-CHESS) GISTGwangju 61005South Korea

Herein,incremental capacity-differential voltage (IC-DV) at a high C-rate (HC) is used as a non-invasive diagnostic tool in lithium-ion batteries,which inevitably exhibit capacity fading caused by multiple mechanisms during charge/discharge *** battery degradation modes are complex,the simple output of capacity fading does not yield any useful data in that *** IC and DV curves obtained under restricted conditions (<0.1C,25℃) were applied in non-invasive analysis for accurate observation of degradation symptoms,a facile,rapid diagnostic approach without intricate,complex calculations is critical in on-board ***,Li Ni_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC532)/graphite pouch cells were cycled at 4 and 6C and the degradation characteristics,i.e.,loss of active materials (LAM) and loss of lithium inventory (LLI),were parameterized using the IC-DV *** the incremental current cycling,the initial steep LAM and LLI slopes underwent gradual transitions to gentle states and revealed the gap between low-and high-current measurements.A quantitative comparison of LAM at high and low C-rate showed that a IC;revealed the relative amount of available reaction region limited by cell ***,this did not provide a direct relationship for estimating the LAM at a low ***,the limiting LLI,which is calculated at a C-rate approaching 0,was obtained by extrapolating the LLI through more than two points measured at high C-rate,and therefore,the LLI at 0.1C was accurately determined using rapid cycling.

关键词： Battery degradation Rapid degradation diagnosis Loss of active materials(LAM) Loss of lithium inventory(LLI) Incremental capacity(IC) Differential voltage(DV)

Traumatic neuroma of remnant cystic duct mimicking duodenal subepithelial tumor:A case report

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World Journal of Clinical Cases 2020年第17期8卷 3821-3827页

作者： Dong-Hwan Kim Ji-Ho park Jin-Kyu Cho jung-Wook Yang Tae-Han Kim Sang-Ho Jeong Young-Hye Kim Young-Joon Lee soon-Chan Hong Eun-jung jung Young-Tae ju Chi-Young Jeong ju-Yeon Kim Department of Surgery Gyeongsang National University College of MedicineGyeongsang National University HospitalJinju 52727South Korea Department of Pathology Gyeongsang National University College of MedicineGyeongsang National University HospitalJinju 52727South Korea

BACKGROUND Gastrointestinal subepithelial tumors(GSTs),incidentally detected during upper gastrointestinal(GI)endoscopy,may be lesions derived from the GI wall or may be caused by compression from external *** general,traumatic neuroma is a benign nerve tumor that results from postoperative nerve injury,occurring in the bile duct as one of the complications after *** is the first case report demonstrating that neuroma of the cystic duct can be incorrectly perceived as a duodenal subepithelial tumor by compressing the duodenal *** SUMMARY We report the case of a 72-year-old man with traumatic neuroma of the cystic duct after *** tumor was mistaken for a duodenal subepithelial tumor on preoperative upper GI endoscopy and endoscopic ultrasonography due to external compression of the GI *** patient had no symptoms,and his laboratory test results were ***,in a series of follow-up endoscopies,the tumor was found to have grown in size,so it was surgically *** lesion was completely removed by laparoscopic endoscopic cooperative *** patient was discharged on postoperative day 7 without *** Traumatic neuroma of the cystic duct can be mistaken for GSTs in GI endoscopy.

关键词： Case report Neuroma Tumor Endoscopy Laparoscopy Cholecystectomy