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Ocular surface changes in moderate-to-severe acne vulgaris

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1049-1057页

作者： Ci-Yi Pan Dong-Jie Sun Han-Ling Li Li Ma Min Zhang song-Yuan Tang Hui Zhang Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Stomatology the First People’s Hospital of Yunnan ProvinceKunming 650100Yunnan ProvinceChina Institute of Health Studies School of Public HealthKunming Medical UniversityKunming 650500Yunnan ProvinceChina

AIM:To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry ***:This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy *** participants completed the Ocular Surface Disease Index(OSDI)*** following ocular surface-related parameters were measured:tear meniscus height(TMH),noninvasive tear breakup time(NIBUT),Schirmer I test(SIT),lipid layer thickness(LLT)score of the tear film,meibum score,meibomian gland orifice obstruction score,the ratio of meibomian gland loss,conjunctival hyperemia score,and corneal fluorescein staining(CFS)***:The stability of the tear film decreased in acne vulgaris *** the acne group,the TMH and NIBUT were lower,whereas the OSDI,meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss,and conjunctival hyperemia score were higher compared with controls(P0.05).In two dry eye groups,the TMH,NIBUT,and LLT score were lower in the acne with dry eye(acne-DE)group,and the meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher(P0.05).CONCLUSION:Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne *** tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye.

关键词： acne vulgaris meibomian gland dysfunction dry eye tear film

Drug-eluting bead transarterial chemoembolization as neoadjuvant therapy pre-liver transplantation for advanced-stage hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2476-2486页

作者： Zhao-Dan Ye Li Zhuang Meng-Chen song Zhe Yang Wu Zhang Jing-Feng Zhang Guo-Hong Cao Department of Radiology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Diagnostic and Therapeutic Center for Difficult Diseases Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina

BACKGROUND The objectives of this study were to assess the safety and efficacy of drug-eluting bead transarterial chemoembolization(DEB-TACE)as neoadjuvant therapy before liver transplantation(LT)for advanced-stage hepatocellular carcinoma(HCC)and to analyze the prognostic *** To determine whether DEB-TACE before LT is superior to LT for advanced-stage *** A total of 99 individuals diagnosed with advanced HCC were studied *** participants were categorized into the following two groups based on whether they had received DEB-TACE before LT:DEB-TACE group(n=45)and control group(n=54).The participants were further divided into two subgroups based on the presence or absence of segmental portal vein tumor thrombus(PVTT).The DEB-TACE group consisted of two subgroups:Group A(n=31)without PVTT and group B(n=14)with *** control group also had two subgroups:Group C(n=37)without PVTT and group D(n=17)with *** on patient demographics,disease characteristics,therapy response,and adverse events(AEs)were *** overall survival(OS)and recurrence-free survival(RFS)rates were assessed using Kaplan-Meier *** and multivariate Cox regression analyses were conducted to determine the parameters that were independently related to OS and *** The DEB-TACE group exhibited an overall response rate of 86.6%.Following therapy,there was a significant decrease in the median alpha-fetoprotein(AFP)level(275.1 ng/mL vs 41.7 ng/mL,P<0.001).The main AE was post-embolization *** 2-year rates of RFS and OS were significantly higher in the DEB-TACE group than in the control group(68.9%vs 38.9%,P=0.003;86.7%vs 63.0%,P=0.008).Within the subgroups,group A had higher 2-year rates of RFS and OS compared to group C(71.0%vs 45.9%,P=0.038;83.8%vs 62.2%,P=0.047).The 2-year RFS rate of group B was markedly superior to that of group D(64.3%vs 23.5%,P=0.002).Results from multivariate analyses showed that pre-LT DEB-TACE[hazard ratio(HR)=

关键词： Hepatocellular carcinoma Liver transplantation Portal vein tumor thrombus Drug-eluting bead transarterial chemoembolization Neoadjuvant treatment

Comparative Assessment of Impacts of Future Climate Change on Runoff in Upper Daqinghe Basin,China

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Chinese Geographical Science 2024年第3期34卷 564-578页

作者： INGABIRE Romaine CHANG Yuru liu Xia CAO Bo UMUGWANEZA Adeline SHEN Yanjun Key Laboratory of Agricultural Water Resources Hebei-Key Laboratory of Water Saving AgricultureCenter for Agricultural Re-sources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China Uni-versity of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Desert and Oasis Ecology Xinjiang Insti-tute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

Assessing runoff changes is of great importance especially its responses to the projected future climate change on local scale basins because such analyses are generally done on global and regional scales which may lead to generalized conclusions rather than specific *** change affected the runoff variation in the past in the upper Daqinghe Basin,however,the climate was mainly considered uncertain and still needs further studies,especially its future impacts on runoff for better water resources management and *** with a set of climate simulations,a daily conceptual hydrological model(MIKE11-NAM)was applied to assess the impact of climate change on runoff conditions in the Daomaguan,Fuping and Zijingguan basins in the upper Daqinghe *** hydrological data(2008–2017)were used to evaluate the applicability of the MIKE11-NAM *** bias correction,future projected climate change and its impacts on runoff(2025–2054)were analysed and compared to the baseline period(1985–2014)under three shared social economic pathways(SSP1-2.6,SSP2-4.5,and SSP5-8.5)scenarios from Coupled Model Intercomparison Project Phase 6(CMIP6)*** MIKE-11 NAM model was applicable in all three Basins,with both R^(2)and Nash-Sutcliffe Efficiency coefficients greater than 0.6 at daily scale for both calibration(2009–2011)and validation(2012–2017)periods,*** uncertainties remain,temperature and precipitation are projected to increase compared to the baseline where higher increases in precipitation and temperature are projected to occur under SSP2-4.5 and SSP5-8.5 scenarios,respectively in all the *** changes will range between 12%–19%whereas temperature change will be 2.0℃–2.5℃ under the SSP2-4.5 and SSP5-8.5 scenarios,*** addition,higher warming is projected to occur in colder months than in warmer ***,the runoff of these three basins is projected to respond to projected climate changes differe

关键词： runoff climate change MIKE11-NAM model Coupled Model Intercomparison Project Phase 6(CMIP6) upper Daqinghe Basin,China

Bionic soft robotic gripper with feedback control for adaptive grasping and capturing applications

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Frontiers of Mechanical Engineering 2024年第1期19卷 129-148页

作者： Tingke WU Zhuyong liu Ziqi MA Boyang WANG Daolin MA Hexi YU Department of Engineering Mechanics School of Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China MOE Key Laboratory of Hydrodynamics Shanghai Jiao Tong UniversityShanghai 200240China

Robots are playing an increasingly important role in engineering *** robots have promising applications in several fields due to their inherent advantages of compliance,low density,and soft interactions.A soft gripper based on bio-inspiration is proposed in this *** analyze the cushioning and energy absorption mechanism of human fingertips in detail and provide insights for designing a soft gripper with a variable stiffness *** investigate the grasping modes through a large deformation modeling approach,which is verified through *** characteristics of the three grasping modes are quantified through testing and can provide guidance for robotics ***,the adaptability of the soft gripper is verified by grasping multi-scale and extremely soft ***,a cushioning model of the soft gripper is proposed,and the effectiveness of cushioning is verified by grasping extremely sharp objects and living ***,we validate the advantages of the variable stiffness of the soft gripper,and the results show that the soft robot can robustly complete assemblies with a gap of only 0.1 *** to the unstructured nature of the engineering environment,the soft gripper can be applied in complex environments based on the abovementioned experimental ***,we design the soft robotics system with feedback capture based on the inspiration of human catching *** feasibility of engineering applications is initially verified through fast capture experiments on moving *** design concept of this robot can provide new insights for bionic machinery.

关键词： soft bionic gripper variable stiffness structure large deformation modeling feedback control soft robotic system

评估超声脂肪分数对代谢相关脂肪性肝病的诊断价值

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中国超声医学杂志 2024年第7期40卷 771-774页

作者：张杰何年安中国科学技术大学附属第一医院(安徽省立医院)超声医学科

目的探讨超声脂肪分数(UDFF)技术在代谢相关脂肪性肝病中的诊断价值。方法收集诊断为脂肪肝的61例患者，均行超声脂肪分数、磁共振质子密度脂肪分数(MRI-PDFF)及相关实验室检查。所有病例均在肝脏V段进行5次UDFF测量及3次PDFF测量，... 详细信息

目的探讨超声脂肪分数(UDFF)技术在代谢相关脂肪性肝病中的诊断价值。方法收集诊断为脂肪肝的61例患者，均行超声脂肪分数、磁共振质子密度脂肪分数(MRI-PDFF)及相关实验室检查。所有病例均在肝脏V段进行5次UDFF测量及3次PDFF测量，取中位数值用于分析。采用Pearson相关性分析比较UDFF和MRI-PDFF的相关性。组内相关系数(ICC)及Bland-Altman差值图分析UDFF与MRI-PDFF一致性，并分析UDFF测值的可重复性。利用方差分析统计UDFF及其他指标在不同程度脂肪肝中的差异性。结果 ICC(r=0.900,P<0.001)与Bland-Altman差值图(P=0.145, CI=-5.0～7.5)显示UDFF与MRI-PDFF检查结果具有较好的一致性。UDFF测值重复性很高(r=0.942,P<0.001)。Pearson相关性分析显示两者呈正相关(r=0.912,P<0.001)。UDFF测值在不同分级脂肪肝中差异有统计学意义。结论 UDFF能可靠地定量肝脏脂肪含量，提高超声对不同程度脂肪肝的诊断价值。

关键词：代谢相关脂肪性肝病超声脂肪分数质子密度脂肪分数

State of the art in movement around a remote point:a review of remote center of motion in robotics

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Frontiers of Mechanical Engineering 2024年第2期19卷 1-28页

作者： Wuxiang ZHANG Zhi WANG Ke MA Fei liu Pengzhi CHENG Xilun DING School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Ningbo Institute of Technology Beihang UniversityNingbo 315832China Intelligent Aerospace Manufacturing Engineering Technology Co. Ltd.Beijing 100191China

The concept of remote center of motion(RCM)is pivotal in a myriad of robotic applications,encompa-ssing areas such as medical robotics,orientation devices,and exoskeletal *** efficacy of RCM technology is a determining factor in the success of these robotic *** paper offers an exhaustive review of RCM technologies,elaborating on their various methodologies and practical *** delves into the unique characteristics of RCM across different degrees of freedom(DOFs),aiming to distill their fundamental *** addition,this paper categorizes RCM approaches into two primary classifications:design based and control *** are further organized according to their respective DOFs,providing a concise summary of their core *** upon the understanding of RCM’s versatile capabilities,this paper then transitions to an in-depth exploration of its applications across diverse robotic *** this review,we critically analyze the existing research challenges and issues that are inherently present in both RCM methodologies and their *** discussion is intended to serve as a guiding framework for future research endeavors and practical deployments in related areas.

关键词： remote center of motion mechanism robotics medical robot orientation device exoskeleton

Reinforcement Learning-Based Energy Management for Hybrid Power Systems:State-of-the-Art Survey,Review,and Perspectives

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 1-25页

作者： Xiaolin Tang Jiaxin Chen Yechen Qin Teng liu Kai Yang Amir Khajepour Shen Li College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooON N2L 3G1Canada School of Civil Engineering Tsinghua UniversityBeijing 100084China

The new energy vehicle plays a crucial role in green transportation,and the energy management strategy of hybrid power systems is essential for ensuring energy-efficient *** paper presents a state-of-the-art survey and review of reinforcement learning-based energy management strategies for hybrid power ***,it envisions the outlook for autonomous intelligent hybrid electric vehicles,with reinforcement learning as the foundational *** of all,to provide a macro view of historical development,the brief history of deep learning,reinforcement learning,and deep reinforcement learning is presented in the form of a ***,the comprehensive survey and review are conducted by collecting papers from mainstream academic *** most of the contributions based on three main directions—algorithm innovation,powertrain innovation,and environment innovation—provides an objective review of the research ***,to advance the application of reinforcement learning in autonomous intelligent hybrid electric vehicles,future research plans positioned as“Alpha HEV”are envisioned,integrating Autopilot and energy-saving control.

关键词： New energy vehicle Hybrid power system Reinforcement learning Energy management strategy

技术创新对黄河流域地区和长江经济带碳生产率影响路径比较——基于数字金融的中介效应

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资源科学 2024年第3期46卷 450-461页

作者：宋成镇刘庆芳马伟杨定宋金平李柄泓北京师范大学地理科学学部北京100875

[目的]本文旨在探讨技术创新对碳生产率的影响路径,充分发挥技术创新的减碳增效能力,为推动区域高质量发展和双碳目标实现提供参考。[方法]本文以黄河流域地区和长江经济带为研究区域,运用STIRPAT模型探讨技术创新对碳生产率的影响路径... 详细信息

[目的]本文旨在探讨技术创新对碳生产率的影响路径,充分发挥技术创新的减碳增效能力,为推动区域高质量发展和双碳目标实现提供参考。[方法]本文以黄河流域地区和长江经济带为研究区域,运用STIRPAT模型探讨技术创新对碳生产率的影响路径,并构建中介效应模型检验数字金融的中介作用。[结果]①技术创新能够促进碳生产率水平提升,且影响效果存在区域异质性。技术创新对碳生产率的提升效果表现为长江经济带强于黄河流域地区。②数字金融在技术创新与碳生产率之间存在部分中介效应,技术创新能够通过促进数字金融发展提升区域碳生产率水平。数字金融的中介效果也表现为长江经济带强于黄河流域地区。③提高城镇化率和经济发展水平能够提升黄河流域地区碳生产率水平。提高城镇化率和经济发展水平,加快产业结构升级,能够提升长江经济带碳生产率水平。[结论]本文建议提升城市技术创新能力,推动数字金融与传统产业深度融合,强化区域产业技术交流与合作,促进黄河流域地区和长江经济带产业绿色化转型,进而实现区域低碳可持续发展。

关键词：技术创新数字金融碳生产率 STIRPAT模型中介效应黄河流域地区长江经济带

Selective leaching of calcium from mechanically activated mixed rare earth concentrate

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Journal of Rare Earths 2024年第6期42卷 1149-1156,I0006页

作者： Jiang liu Bingxue Chen Yuanqi Feng Yijun Cao Yukun Huang Yuan Shi Meng Li Zhongyuan Critical Metals Laboratory School of Chemical EngineeringZhengzhou UniversityZhengzhou450001China State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050China

The loss of rare earths(REs)takes place during the pre-decalcification process of mixed rare earth *** an effort to reduce such RE loss,a novel idea to improve the leaching selectivity of Ca to REs by applying selective mechanical activation was ***,regarding the key minerals affecting the leaching selectivity of Ca to REs,the differences in the mechanical activation behaviors of CaF_(2) and REFCO_(3) were studied,and we find that the lattice strain of CaF_(2) increases from 0.21%to 0.42%,whereas that of REFCO_(3) increases from 0.31%to 0.40%.Notably,CaF_(2) demonstrates a larger lattice strain than REFCO_(3),indicating greater mechanical activation energy storage and higher leaching ***,the HCl leaching process was studied.A significant leaching selectivity of Ca to REs,from 21.6 to 35.1,is achieved through mechanical *** Ca leaching rate reaches 80.7%when the RE loss is 2.3%in the activated *** study provides an novel approach for achieving selective extraction of specific components via mechanical activation pretreatment.

关键词： Mixed rare earth concentrate Pre-decalcification Selective mechanical activation Selective leaching