检索结果-南通市图书馆

Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

引用

World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'Donnell Anthony O'Connor sinead smith Deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

引用

Protein & Cell 2016年第3期7卷 159-174页

作者： Yingli Shang sinead smith Xiaoyu Hu School of Medicine and Institute for Immunology Tsinghua University Beijing 100084 China Department of Clinical Medicine Trinity College Dublin Dublin 2 Ireland

The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of acute and chronic inflammation. In this review article, we will describe the evidence accumulated during the recent years to support a key regulatory role of the Notch pathway in innate immune and inflammatory responses and discuss the potential implications of such regulation for pathogenesis and therapy of inflammatory disorders.

关键词： inflammation innate immunity macrophages Notch signaling RBP-J

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia

引用

World Journal of Gastrointestinal Pathophysiology 2017年第3期8卷 127-132页

作者： Grainne Holleran Mary Hussey sinead smith Deirdre McNamara Department of Clinical Medicine Trinity Centre for Health SciencesTallaght Hospital24 DublinIreland

To assess the use of serum levels of angiopoietin-1 (Ang1), Ang2 and tumor necrosis factor-α (TNFα) as predictive factors for small bowel angiodysplasia (SBA). METHODSSerum samples were collected from patients undergoing capsule endoscopy for any cause of obscure gastrointestinal bleeding (OGIB) or anaemia. Based on small bowel findings patients were divided into 3 groups: (1) SBA; (2) other bleeding causes; and (3) normal, according to diagnosis. Using ELISA technique we measured serum levels of Ang1, Ang2 and TNFα and compared mean and median levels between the groups based on small bowel diagnosis. Using receiver operator curve analysis we determined whether any of the factors were predictive of SBA. RESULTSSerum samples were collected from a total of 120 patients undergoing capsule endoscopy for OGIB or anaemia: 40 with SBA, 40 with other causes of small bowel bleeding, and 40 with normal small bowel findings. Mean and median serum levels were measured and compared between groups; patients with SBA had significantly higher median serum levels of Ang2 (3759 pg/mL) compared to both other groups, with no significant differences in levels of Ang1 or TNFα based on diagnosis. There were no differences in Ang2 levels between the other bleeding causes (2261 pg/mL) and normal (2620 pg/mL) groups. Using Receiver Operator Curve analysis, an Ang2 level of > 2600 pg/mL was found to be predictive of SBA, with an area under the curve of 0.7. Neither Ang1 or TNFα were useful as predictive markers. CONCLUSIONElevations in serum Ang2 are specific for SBA and not driven by other causes of bleeding and anaemia. Further work will determine whether Ang2 is useful as a diagnostic or prognostic marker for SBA.

关键词： Angiodysplasia Small intestinal bleeding Capsule endoscopy Angiogenic factors Angiopoietin-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Shared changes in angiogenic factors across gastrointestinal vascular conditions:A pilot study

引用

World Journal of Gastrointestinal Pharmacology and Therapeutics 2020年第3期11卷 40-47页

作者： Atiyekeogbebe R Douglas Grainne Holleran sinead M smith Deirdre McNamara TAGG Research Centre School of MedicineTrinity College DublinDublin D24Ireland

BACKGROUND Neovascularisation is common to a variety of gastrointestinal(GI)disorders with differing aetiologies and presentations;usually affecting adults above 60 *** angiogenic factors modulated by disease specific elements could be a common denominator and represent novel diagnostic and therapeutic *** yet,assessment of angiogenic factors across several GI vascular disorders associated with recurrent bleeding and anaemia has not been *** To assess serum levels of angiogenic factors in several intestinal vascular *** A case control study was performed in Tallaght University Hospital in patients with endoscopically proven small bowel angiodysplasia(SBA),portal hypertensive gastropathy(PHG),gastric antral vascular ectasia(GAVE)and nonbleeding,non-anaemic *** enzyme-linked immunosorbent assay,concentrations of Angiopoietin 1(Ang-1),Ang-2 and vascular endothelial growth factor(VEGF)were measured from 2 serum tubes of blood following informed *** relative expression of Ang-1 and Ang-2 and Ang-1/2 ratio was calculated and compared between *** analysis was applied using a t-test,and a P value of<0.05 was considered *** To date 44 samples were tested:10 SBA,11 PHG,8 GAVE and 15 *** age 60(range 20-85)years and 20(45%)were *** were significantly younger(49 years vs 66 years,P=0.0005).There was no difference in VEGF levels between the groups(P=0.6).SBA,PHG and GAVE Ang-1 levels were similar and were significantly lower than controls,(P=0.0002,95%CI:241 to 701).Ang-2 levels were statistically higher in PHG and GAVE groups compared to controls(P= 0.01, 95%CI: 77.8 to 668) and as a result, also had a lower Ang-1/2 ratioscompared to controls. While SBA Ang-2 levels were higher than controls, this didnot reach statistical significance. Neither age nor haemoglobin level, which wassimilar between disease groups, could explain the difference. In addition, themedian Ang-1/A

关键词： Gastric antral vascular ectasia Portal hypertensive gastropathy Angiodysplasia Angiopoietins Angiogenic factors Recurrent bleeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combined antrum and corpus biopsy protocol improves Helicobacter pylori culture success

引用

World Journal of Gastrointestinal Pathophysiology 2022年第1期13卷 34-40页

作者： Denise E Brennan Colm O'Morain Deirdre McNamara sinead M smith Department of Clinical Medicine Trinity College DublinTrinity CentreTallaght University HospitalDublin D24Ireland

BACKGROUND Helicobacter pylori(***)causes chronic gastritis,peptic ulcer disease,gastric adenocarcinoma and mucosa-associated lymphoid tissue *** rates have fallen,mainly due to antimicrobial *** guidelines recommend that first-line treatment is based on the local prevalence of antimicrobial resistance and that rescue therapies are guided by antimicrobial susceptibility testing(AST).However,*** culture is challenging and culture-based AST is not routinely performed in the majority of *** of *** culture from clinical specimens will enable more widespread AST to determine the most appropriate antimicrobials for *** *** To determine whether dual antrum and corpus biopsy sampling is superior to single antrum biopsy sampling for *** *** The study received ethical approval from the joint research ethics committee of Tallaght University Hospital and ***’s *** referred for upper gastrointestinal endoscopy were invited to *** were collected in tubes containing Dent’s transport medium and patient demographics were *** were used to inoculate Colombia blood agar *** were incubated under microaerobic conditions and evaluated for the presence of *** analyses were performed using Graphpad *** variables were compared using the two-tailed independent *** variables were compared using the two-tailed Fisher exact *** all cases,a P value less than 0.05 was considered *** In all,samples from 219 ***-infected patients were analysed in the *** mean age of recruited patients was 48±14.9 years and 50.7%(n=111)were *** most common endoscopic finding was gastritis(58.9%;n=129).Gastric ulcer was diagnosed in 4.6%(n=10)of patients,while duodenal ulcer was diagnosed in 2.7%(n=6).Single antrum biopsies were collected from 73 patients,whereas combined antrum

关键词： Helicobacter pylori Culture Antimicrobial susceptibility testing Antimicrobial Antrum Corpus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：