Role of Notch signaling in regulating innate immunity and inflammation in health and disease

作     者：Yingli Shang Sinead Smith Xiaoyu Hu 

作者机构：School of Medicine and Institute for Immunology Tsinghua University Beijing 100084 China Department of Clinical Medicine Trinity College Dublin Dublin 2 Ireland 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2016年第7卷第3期

页      面：159-174页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 0906[农学-兽医学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the National Basic Research Program (973 Program) National Natural Science Foundation of China Young Investigator Award funds from Peking-Tsinghua Center of Life Sciences 

主　　题：inflammation innate immunity macrophages Notch signaling RBP-J 

摘      要：The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of acute and chronic inflammation. In this review article, we will describe the evidence accumulated during the recent years to support a key regulatory role of the Notch pathway in innate immune and inflammatory responses and discuss the potential implications of such regulation for pathogenesis and therapy of inflammatory disorders.