Shared changes in angiogenic factors across gastrointestinal vascular conditions:A pilot study

作     者：Atiyekeogbebe R Douglas Grainne Holleran Sinead M Smith Deirdre McNamara 

作者机构：TAGG Research CentreSchool of MedicineTrinity College DublinDublin D24Ireland 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2020年第11卷第3期

页      面：40-47页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：We thank all the volunteers and medical staff who agreed to participate in this study 

主　　题：Gastric antral vascular ectasia Portal hypertensive gastropathy Angiodysplasia Angiopoietins Angiogenic factors Recurrent bleeding 

摘      要：BACKGROUND Neovascularisation is common to a variety of gastrointestinal(GI)disorders with differing aetiologies and presentations;usually affecting adults above 60 *** angiogenic factors modulated by disease specific elements could be a common denominator and represent novel diagnostic and therapeutic *** yet,assessment of angiogenic factors across several GI vascular disorders associated with recurrent bleeding and anaemia has not been *** To assess serum levels of angiogenic factors in several intestinal vascular *** A case control study was performed in Tallaght University Hospital in patients with endoscopically proven small bowel angiodysplasia(SBA),portal hypertensive gastropathy(PHG),gastric antral vascular ectasia(GAVE)and nonbleeding,non-anaemic *** enzyme-linked immunosorbent assay,concentrations of Angiopoietin 1(Ang-1),Ang-2 and vascular endothelial growth factor(VEGF)were measured from 2 serum tubes of blood following informed *** relative expression of Ang-1 and Ang-2 and Ang-1/2 ratio was calculated and compared between *** analysis was applied using a t-test,and a P value of0.05 was considered *** To date 44 samples were tested:10 SBA,11 PHG,8 GAVE and 15 *** age 60(range 20-85)years and 20(45%)were *** were significantly younger(49 years vs 66 years,P=0.0005).There was no difference in VEGF levels between the groups(P=0.6).SBA,PHG and GAVE Ang-1 levels were similar and were significantly lower than controls,(P=0.0002,95%CI:241 to 701).Ang-2 levels were statistically higher in PHG and GAVE groups compared to controls(P= 0.01, 95%CI: 77.8 to 668) and as a result, also had a lower Ang-1/2 ratioscompared to controls. While SBA Ang-2 levels were higher than controls, this didnot reach statistical significance. Neither age nor haemoglobin level, which wassimilar between disease groups, could explain the difference. In addition, themedian Ang-1/A