检索结果-南通市图书馆

Trypanosoma cruzi invasion in non-phagocytic cells:an ultrastructural study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2018年第3期42卷 105-108页

作者： Juan Agustín CUETO Emile SANTOS BARRIAS Wanderley de SOUZA Patricia silvia romano IHEM Universidad Nacional de CuyoCONICETLaboratorio de Biología de Tripanosoma cruzi y de la célula hospedadoraMendozaArgentina Universidad Nacional de Cuyo.Facultad de Ciencias Médicas.Área de Biología Celular y Molecular.Mendoza.Argentina Universidad Nacional de Cuyo.Facultad de Ciencias Médicas.Instituto de Fisiología.Mendoza.Argentina Laboratório de Ultraestrutura Celular Hertha Meyer Instituto de Biofísica Carlos Chagas FilhoCentro de Ciência da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens e Centro Nacional de Bioimagens-CENABIO Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Metrologia Qualidade e Tecnologia-InmetroRio de JaneiroBrazil

Trypanosoma cruzi is the causative agent of Chagas *** parasite requires the intracellular niche in order to proliferate and disseminate the *** invasion,*** resides temporarily in an acidic vacuole which is lysed by a not well-understood *** electron microscopy was used to describe the process of *** escape from the parasitophorous vacuole over the *** HeLa(non-professional phagocytic cells)as host cell,we observed that recently internalized parasites reside in a membrane-bounded vacuole.A few hours later,the first sign of vacuole disruption appeared as membrane *** observation was followed by a progressive vacuole swelling as evidenced by an electron-lucent halo between the parasite and the vacuole ***,the vacuole membrane remnants reorganized as small vesicles that eventually disappeared from the vicinity of the ***,parasites reach the host cell cytosol where replication takes *** thorough ultrastructural description of this process set the base for a comprehensive understanding of the parasite-host cell interaction and,thus open the possibility of new therapeutic intervention strategies.

关键词： Parasitophorous vacuole Pathogen Parasites Chagas disease Infectious diseases

Atypical antipsychotics and oxidative cardiotoxicity:review of literature and future perspectives to prevent sudden cardiac death

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第8期18卷 663-685页

作者： Stefano D’Errico Raffaele La Russa Aniello Maiese Alessandro Santurro Matteo Scopetti silvia romano Martina Zanon Paola Frati Vittorio Fineschi Department of Medical Surgical and Health SciencesUniversity of TriesteTriesteItaly Department of Clinical and Experimental Medicine University of FoggiaFoggiaItaly IRCSS Neuromed Mediterranean Neurological Institute PozzilliItaly Department of Surgical Pathology MedicalMolecular and Critical AreaUniversity of PisaPisaItaly Department of Anatomical HistologicalForensic and Orthopaedic SciencesSapienza University of RomeRomeItaly

Oxidative stress is considered the principal mediator of myocardial injury under pathological *** is well known that reactive oxygen(ROS)or nitrogen species(RNS)are involved in myocardial injury and repair at the same time and that cellular damage is generally due to an unbalance between generation and elimination of the free radicals due to an inad-equate mechanism of antioxidant defense or to an increase in ROS and *** adverse cardiovascular events are often asso-ciated with drugs with associated findings such as fibrosis or inflammation of the *** efforts in the preclinical phase of the development of drugs,cardiotoxicity still remains a great *** toxicity due to second-generation anti-psychotics(clozapine,olanzapine,quetiapine)has been observed in preclinical studies and described in patients affected with mental disorders.A role of oxidative stress has been hypothesized but more evidence is needed to confirm a causal relationship.A better knowledge of cardiotoxicity mechanisms should address in the future to establish the right dose and length of treatment without impacting the physical health of the patients.

关键词： drugs inflammation oxidative

Trypanosoma rangeli:growth in mammalian cells in vitro and action of a repositioned drug(17-AAG)and a natural extract(Artemisia *** oil)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2019年第1期43卷 13-19页

作者： Ana Laura CIMADOR Emeli Luciana GALANTE Lucila Ibel MUNOZ Patricia silvia romano Antonella Denisse LOSINNO Maria Cristina VANRELL Facultad de Farmacia y Bioquimica Universidad Juan Agustin Maza.MendozaArgentina Facultad de Ciencias Medicas Universidad Nacional de Cuyo.MendozaArgentina Laboratorio de Biologia de Trypanosoma cruzi y la celula hospedadora-Instituto de Histologia y Embriologia“Dr.Mario H.Burgos”IHEM-CONICET-Universidad Nacional de Cuyo.Mendoza Argentina

Trypanosoma rangeli and *** are both parasitic unicellular species that infect *** ***,the causative agent of Chagas disease,*** is an infective and non-pathogenic parasite for humans,but pathogenic for vectors from the Rhodnius *** both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of *** in mammalian cells,we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on *** found that *** exhibits a cycle of infection in Vero cells similar to that for *** and that the repurposed drug,17-AAG,and the natural extract Artemisia *** oil produce a toxic effect on epimastigotes showing a trypanocidal action from the fifth day of *** treatments also affected the infection of trypomastigotes and reduced the capacity of replication of amastigotes of *** ***/*** coinfection cases have been reported,the finding of drugs with potential activity against both species could be significant in the ***,studies of susceptibility of both species to drugs could also help to know the different mechanisms of pathogenicity in humans displayed by *** that are absent in ***.

关键词： Life-cycle Treatment Trypanosoma rangeli

Label-free sensing of ultralow-weight molecules with all-dielectric metasurfaces supporting bound states in the continuum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2018年第7期6卷 726-733页

作者： silvia romano GIANLUIGI ZITO STEFANIA TORINO GIUSEPPE CALAFIORE ERIKA PENZO GIUSEPPE COPPOLA STEFANO CABRINI IVO RENDINA VITO MOCELLA Institute for Microelectronics and Microsystems Unit of Naples National Council of Research Institute of Protein Biochemistry National Council of Research Lawrence Berkeley National Laboratory Molecular Foundry Division

The realization of an efficient optical sensor based on a photonic crystal metasurface supporting bound states in the continuum is reported. Liquids with different refractive indices, ranging from 1.4000 to 1.4480, are infiltrated in a microfluidic chamber bonded to the sensing dielectric metasurface. A bulk liquid sensitivity of 178 nm/RIU is achieved, while a Q-factor of about 2000 gives a sensor figure of merit up to 445 in air at both visible and infrared excitations. Furthermore, the detection of ultralow-molecular-weight(186 Da) molecules is demonstrated with a record resonance shift of 6 nm per less than a 1 nm thick single molecular layer. The system exploits a normal-to-the-surface optical launching scheme, with excellent interrogation stability and demonstrates alignment-free performances, overcoming the limits of standard photonic crystals and plasmonic resonant configurations.

关键词：高效光学传感器折射率理论研究通讯技术

Inflammatory bowel diseases and human reproduction:A comprehensive evidence-based review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第23期20卷 7123-7136页

作者： Stefano Palomba Giuliana Sereni Angela Falbo Marina Beltrami silvia Lombardini Maria Chiara Boni Giovanni Fornaciari romano Sassatelli Giovanni Battista La Sala Obstetrics and Gynecology Unit Department of ObstetricsGynecology and PediatricsAzienda Ospedaliera ASMNIstituto di Ricovero e Cura a Carattere Scientifico42123 Reggio EmiliaItaly Gastroenterology and Digestive Endoscopy Unit Department of Oncology and Advanced TechnologiesAzienda Ospedaliera ASMNIstituto di Ricovero e Cura a Carattere Scientifico42123 Reggio EmiliaItaly Medicine and Gastroenterology Unit Azienda Ospedaliera ASMNIstituto di Ricovero e Cura a Carattere Scientifico42123 Reggio EmiliaItaly Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto University of Modena and Reggio Emilia41124 ModenaItaly

To evaluate the effects of inflammatory bowel diseases(IBDs)on human reproduction,we reviewed the current literature using a systematic search for published studies(articles and/or abstracts)without limits for English *** searched on Medline(through PubMed),the Institute for Scientific Information,the Web of Science and the websites for the registration of controlled trials(http://***/).Bibliographies of retrieved articles,books,expert opinion review articles and reviewed bibliographies from subject experts were manually *** and abstracts were screened initially,and potential relevant articles were identified and *** possible,data were analyzed by comparing IBD patients vs healthy controls,and patients with active IBDs vs those with disease in *** effects of IBDs on female fertility,fertility in infertile couples,pregnancy and male infertility were examined *** with IBDs in remission have normal *** the moment,there is no established guideline for the preservation of fertility in women with IBD undergoing *** data are needed regarding guidelines for the management of these *** regarding IBDs and infertility are currently completely *** the prevalence of intestinal pathology in young adults of childbearing age,this field is of great scientific and clinical interest,opening up important future *** important and as yet unexplored point is the response to treatments for infertility in patients with *** particular,the question is whether the reproductive outcomes(clinical and biological)can be influenced by the IBD of one of the *** goals for successful reproductive outcomes in IBD population are correct counseling and disease *** significantly affect several reproductive aspects of human(female,male,couple)*** data are needed to develop guidelines for the clinical management of subjects of

关键词： Inflammatory bowel diseases Fertility Infertility Pregnancy

Structural and Vibrational Study of 2-（Quinolin-8-yloxy）-Acetic Acid based on FT-IR-Raman Spectroscopy and DFT Calculations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Chemistry and Chemical Engineering 2011年第8期5卷 747-758页

作者： Gerardo R. Arganaraz Elida romano Juan Zinczuk silvia A. Brandan Catedra de Quimica General. Instituto de Quimica Inorganiea. Faeultad de Bioquimica Quimica y Farmacia. Universidad Nacional de Tucuman. Ayacucho 471. 4000. San Miguel de Tucuman. Tucumcin. R. Argentina Instituto de Qulmica Rosario （CONICET-UNR） Facultad de Ciencias Bioquimicas y Farmacduticas Suipacha 531 2000 Rosario Santa Fe. R. Argentina

We have prepared the 2-（quinolin-8-yloxy）-acetic acid and characterized it by infrared and Raman spectroscopies in the solid phase. The Density Functional Theory （DFT） method, together with the 6-31G^＊ and 6-311＋＋ G^＊＊ basis sets, show that three stable molecules, for the anhydrous and monohydrated compounds were theoretically determined in the gas phase, and that probably the two more stable conformations are present in the solid phase of the monohydrated compound. The harmonic vibrational wavenumbers for the optimized geometries were calculated at B3LYP/6-31G^＊and B3LYP/6-311＋＋G^＊＊ levels. For a complete assignment of all the observed bands in the vibrational spectra the DFT calculations were combined with Pulay＇s scaled quantum mechanical force field （SQMFF） methodology in order to fit the theoretical Wavenumber values to the experimental ones. The characteristics of the electronic delocalization of all structures of both forms were performed by using natural bond orbital （NBO）, while the corresponding topological properties of electronic charge density are analysed by employing Bader＇s atoms in molecules theory （AIM）.

关键词： 2-(Quinolin-8-yloxy)-acetic acid vibrational spectra molecular structure force field DFT calculations

Synthesis, Structural Study and Spectroscopic Characterization of a Quinolin-8-Yloxy Derivative with Potential Biological Properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Synthesis Theory and Applications 2013年第1期2卷 8-32页

作者： Elida romano María V. Castillo Jorgelina L. Pergomet Juan Zinczuk silvia A. Brandán Chemistry Rosario Institute (CONICET-UNR) Faculty of Biochemistry and Pharmacists Sciences Rosario R. Argentina Faculty of Biochemistry Chemistry and Pharmacy of the National University of Tucumán Tucumán R. Argentina

We have prepared the (5-chloro-quinolin-8-yloxy) acetic acid and characterized it by using infrared, Raman and multi-dimensional nuclear magnetic resonance spectroscopies. The density functional theory (DFT) together with the 6-31G* and 6-311++G** basis sets were used to study its structure and vibrational properties. Three stable conformations of the compound were theoretically determined in gas phase and probably these conformations are present in the solid phase. The harmonic vibrational wavenumbers for the optimized geometries were calculated at the same theory levels. For a complete assignment of the observed bands in the vibrational spectra, the DFT calculations were combined with Pulay’s scaled quantum mechanical force field (SQMFF) methodology in order to fit the theoretical wavenumber values to the experimental ones. Besides, the force constants of the three conformers of (5-chloro-quinolin-8-yloxy) acetic acid were calculated and compared with those obtained by us for the 2-(quinolin-8-yloxy) acetic acid. In addition, the characteristics of the electronic delocalization of those structures were performed by using natural bond orbital (NBO), while the corresponding topological properties of electronic charge density are analysed by employing Bader’s atoms in molecules theory (AIM).

关键词： (5-Chloro-Quinolin-8-Yloxy) Acetic Acid Vibrational Spectra Molecular Structure Force Field DFT Calculations

Observatory science with eXTP

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves