Atypical antipsychotics and oxidative cardiotoxicity:review of literature and future perspectives to prevent sudden cardiac death

作     者：Stefano D’Errico Raffaele La Russa Aniello Maiese Alessandro Santurro Matteo Scopetti Silvia Romano Martina Zanon Paola Frati Vittorio Fineschi Stefano D'Errico;Raffaele La Russa;Aniello Maiese;Alessandro Santurro;Matteo Scopetti;Silvia Romano;Martina Zanon;Paola Frati;Vittorio Fineschi

作者机构：Department of MedicalSurgical and Health SciencesUniversity of TriesteTriesteItaly Department of Clinical and Experimental MedicineUniversity of FoggiaFoggiaItaly IRCSS Neuromed Mediterranean Neurological InstitutePozzilliItaly Department of Surgical PathologyMedicalMolecular and Critical AreaUniversity of PisaPisaItaly Department of AnatomicalHistologicalForensic and Orthopaedic SciencesSapienza University of RomeRomeItaly 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2021年第18卷第8期

页      面：663-685页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

主　　题：drugs inflammation oxidative 

摘      要：Oxidative stress is considered the principal mediator of myocardial injury under pathological *** is well known that reactive oxygen(ROS)or nitrogen species(RNS)are involved in myocardial injury and repair at the same time and that cellular damage is generally due to an unbalance between generation and elimination of the free radicals due to an inad-equate mechanism of antioxidant defense or to an increase in ROS and *** adverse cardiovascular events are often asso-ciated with drugs with associated findings such as fibrosis or inflammation of the *** efforts in the preclinical phase of the development of drugs,cardiotoxicity still remains a great *** toxicity due to second-generation anti-psychotics(clozapine,olanzapine,quetiapine)has been observed in preclinical studies and described in patients affected with mental disorders.A role of oxidative stress has been hypothesized but more evidence is needed to confirm a causal relationship.A better knowledge of cardiotoxicity mechanisms should address in the future to establish the right dose and length of treatment without impacting the physical health of the patients.