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Isolation and Structural Analysis of an Acidic Polysaccharide from Astragalus membranaceus （Fisch.） Bunge

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Journal of Integrative Plant Biology 2006年第11期48卷 1379-1384页

作者： shun-Chun wang Jun-Jie Shan Zheng-Tao wang Zhi-Bi Hu Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

A new water-soluble hetero-polysaccharlde, APSID3, was obtained from a hot-water extract of the roots of Astragalus membranaceus （Flsch.） Bunge by DEAE-Sepharose Fast Flow and Sephacryl S-300 chromatography. The molecular weight of APSID3 was estimated to be 5.79 × 10^5 Da. Based on a sugar composlUon analysis, methylatlon analysis, partial hydrolysis and 13C nuclear magnetic resonance experimentation, It was concluded that the minimal repeat unit of APSID3 was composed of one terminal arablnose, one 1,5-1Inked arabinose, one 1,3-1Inked rhamnose, one 1,3,4-1Inked rhamnose, five 1,4-1Inked methyl galacturonates and six 1,4-1inked methyl glucuronates.

关键词： Astragalus membranaceus hetero-polysaccharide isolation and purification structural analysis.

Analysis of High-Cr Cast Iron/Low Carbon Steel Wear-resistant Laminated Composite Plate Prepared by Hot-rolled Symmetrical Billet

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 109-123页

作者： Yanwei Li Yugui Li Peisheng Han shun wang Zhengyi Jiang Xiaogang wang Shanxi Provincial Key Laboratory of Metallurgical Device Design Theory and Technology(State Key Laboratory Cultivation Base of Province-Ministry Co-Construct) Taiyuan University of Science and TechnologyTaiyuanChina School of Mechanical Materials and Mechatronic EngineeringUniversity of WollongongWollongong NSW2522Australia

This study developed a new technology for preparing high-chromium cast iron(HCCI)/low-carbon steel(LCS)wear-resistant composite plates by hot rolling at a 1050°C and a rolling speed of 0.2 m/*** effects of different rolling reductions(30%,45%,and 60%)on the microstructure(interface and HCCI layer)and mechanical properties(bonding strength,hardness,and wear resistance)of the composite plate were *** images showed that when the reduction was increased,no impurities and interlayers were found between the microscopic interfaces after hot rolling,and the bonding interface exhibited a wave-like *** analysis showed that the Cr element diffusion between two metals after hot rolling was promoted when the reduction was increased,thereby improving the bonding quality under the same rolling temperature and rolling *** showed that due to the stress release effect of the LCS of the cladded layer,the macro-slab shape after hot rolling performed well,and the brittle HCCI layer underwent thermoplastic deformation without ***,the increase of rolling reduction improved the bonding *** the rolling reduction was increased,the volume fraction of Cr-carbides in the HCCI layer also increased,resulting in an increase of hardness and wear-resistance.

关键词： High chromium cast iron symmetrical billet hot rolled laminated composite plate

The Largest Spatial Frame Quotient on Prequantale

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Chinese Quarterly Journal of Mathematics 2006年第3期21卷 402-405页

作者： wang Xue-qiang wang shun- qin Department of Mathematics Nanyang Normal University Nanyang 473061 China College of Mathematics and Information Science Shaanxi Normal University Xi＇an 710062 China

Prequantale quotient is defined in terms of prequantic nucleus, some equivalent propositions of which is obtained. Also, prequantale quotient is proved to coincide with the quotient object in PQuant up to isomorphism.... 详细信息

关键词： prequantale nucleus prequantale quotient

盐酸伐地那非片在中国健康受试者中的生物等效性研究

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中国临床药理学杂志 2024年第16期40卷 2373-2377页

作者：徐媛媛王小妮谢晶张峰张文赵胜龙周焕黄顺旺蚌埠医科大学第一附属医院临床试验研究中心安徽蚌埠233000 创新药物药学研究与临床评价安徽省联合共建学科重点实验室安徽蚌埠233000 合肥创新医药技术有限公司安徽合肥230088

目的评价在空腹及餐后条件下中国健康受试者服用受试制剂与参比制剂盐酸伐地那非片后2种制剂的生物等效性。方法本研究用随机、开放、单剂量、两制剂、两序列、两周期、双交叉设计,空腹试验入组40例男性健康受试者,餐后试验入组66例男... 详细信息

目的评价在空腹及餐后条件下中国健康受试者服用受试制剂与参比制剂盐酸伐地那非片后2种制剂的生物等效性。方法本研究用随机、开放、单剂量、两制剂、两序列、两周期、双交叉设计,空腹试验入组40例男性健康受试者,餐后试验入组66例男性健康受试者。试验分两周期进行,每周期服用受试制剂或参比制剂盐酸伐地那非片20 mg。用液相色谱串联质谱(LC/MS-MS)法测定血浆中伐地那非的药物浓度。用非房室模型计算药代动力学参数,用SAS 9.4或以上版本程序数据统计软件对安全性评价指标进行统计分析。结果空腹试验盐酸伐地那非片受试制剂与参比制剂的主要药代动力学参数:C_(max)分别为(34.94±18.33)和(36.69±19.45)ng·mL^(-1);AUC_(0-t)分别为(74.38±34.11)和(74.25±33.37)ng·mL^(-1)·h;AUC_(0-∞)分别为(76.70±34.36)和(76.46±33.84)ng·mL^(-1)·h。餐后试验盐酸伐地那非片受试制剂与参比制剂的主要药代动力学参数:C_(max)分别为(22.84±12.48)和(21.68±11.12)ng·mL^(-1);AUC_(0-t)分别为(70.82±35.88)和(72.71±34.63)ng·mL^(-1)·h;AUC_(0-∞)分别为(73.48±36.44)和(75.29±35.12)ng·mL^(-1)·h。空腹及餐后条件下受试者口服盐酸伐地那非片受试制剂和参比制剂20 mg后血浆中原型药物伐地那非的主要药代动力学参数例如C_(max)、AUC_(0-t)及AUC_(0-∞)的几何均值比的90%置信区间均落在80.00%~125.00%等效区间内。结论盐酸伐地那非片受试制剂与参比制剂在空腹和餐后条件下在中国健康受试者体内具有生物等效性。

关键词：盐酸伐地那非片药代动力学生物等效性液相色谱串联质谱法

红曲色素的抗氧化活性及对HepG2氧化损伤的保护作用研究

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食品安全质量检测学报 2024年第8期15卷 58-65页

作者：陈琴王顺周坚贾喜午沈汪洋陈轩武汉轻工大学食品科学与工程学院武汉430023 农产品加工与转化湖北省重点实验室武汉430023 大宗粮油精深加工教育部重点实验室武汉430023

目的研究纯化后的红曲色素(monascus pigments,MPs)抗氧化活性及对HepG2细胞氧化损伤的修复作用。方法以红曲米粉为原料,对其含有的MPs进行提取、纯化和鉴定。通过测定MPs的总抗氧化能力、1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picry... 详细信息

目的研究纯化后的红曲色素(monascus pigments,MPs)抗氧化活性及对HepG2细胞氧化损伤的修复作用。方法以红曲米粉为原料,对其含有的MPs进行提取、纯化和鉴定。通过测定MPs的总抗氧化能力、1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基和2,2’-联氮-二(3-乙基-苯并噻唑啉-6-磺酸)二铵盐[2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)ammonium salt,ABTS]阳离子自由基清除率评估了其抗氧化活性。同时,选用0.20 mmol/L的H2O2建立氧化应激模型,探索不同浓度MPs对细胞氧化损伤的保护机制。结果纯化后的MPs含有4种MPs单体,分别为安卡红曲黄素、红曲玉红素、红曲素和潘红胺。MPs的总抗氧化能力(total antioxidant capacity,T-AOC)、DPPH自由基和ABTS阳离子自由基清除率与其浓度呈正相关。用不同浓度的MPs预处理后,与MC组相比,较低浓度(10μg/mL)的MPs能显著提高细胞的存活率,但较高浓度的MPs(20μg/mL)显著降低了细胞的存活率,这可能是H2O2与MPs协同作用导致的。随着MPs浓度增加,细胞中活性氧累积量逐渐减少。当MPs质量浓度为20μg/mL时,过氧化氢酶和超氧化物歧化酶活性分别从14.75 U/mL±0.04 U/mL、3.87 U/mL±0.09 U/mL提升至15.25 U/mL±0.05 U/mL、8.29 U/mL±0.68 U/mL。结论MPs有较强的自由基清除能力,对H2O2诱导的氧化损伤有保护作用,这可能是与MPs提高了抗氧化酶活性,降低了细胞内ROS累积量有关。

关键词：红曲色素自由基清除 HepG2细胞抗氧化

Solvent polarity-induced photoluminescence enhancement (SPIPE): A method enables several-fold increase in quantum yield of silicon nanoparticles

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Nano Research 2019年第2期12卷 315-322页

作者： Xiao-Bin Shen Bin Song Bei Fang Xiao Yuan You-Yong Li shun-Yi wang shun-Jun Ji Yao He Laboratory of Nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC) Soochow University Suzhou 215123 China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

Fluorescent silicon nanoparticles (SiNPs) bring exciting opportunities for long-awaited silicon-based optical application, while intrinsic indirect band gap of silicon severely limits photoluminescent quantum yield (PLQY) of SiNPs. To address this critical issue, we herein demonstrate a facile and general method, Le., solvent polarity-induced photoluminescence enhancement (SPIPE)1 yielding several-fold increase in quantum yield (QY) of SiNPs. Typically, different kinds of 4-substituented-1,8-naphthalic anhydride molecules, Le., 4-Br-1,8-naphthalic anhydride (BNA)1 4-triphenylamino-1,8-naphthalic anhydride (TPNA)1 and 4-dimethylamino-1,8-naphthalic anhydride (DMNA)1 are rationally designed and synthesized, which serve as surface ligands for the production of BNA-, TPNA-, and DMNA-capped small-sized (diameter:- 3.8-5.8 nm) SiNPs with QY of^8%,~15%,~16%, respectively. Of particular significance, QY of the resultant SiNPs could be greatly enhanced from^10% to^50% through the SPlPE strategy. Taken together with the theoretical calculation and the results of time-correlated single photon counting, we reveal that actived excited-state charge transfer interactions between surface-covered ligand and silicon oxide coating would be responsible for the observed QY enhancement. Moreover, other five kinds of solvents (i.e., methanol, isopropanol, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile) are further employed for the SiNPs treatment, and similar improvement of QY values are observed, convincingly demonstrating the universal evidence of SPIPE of the SiNPs.

关键词： silicon nanoparticles quantum yield fluorescent surface ligand solvent polarity

Impacts of inorganic salts ions on the polar components desorption efficiency from tight sandstone:A molecular dynamics simulation and QCM-D study

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Petroleum Science 2022年第2期19卷 900-915页

作者： shun wang Jing wang Hui-Qing Liu Hong-Quan Zhang Fang-Na Liu Ronald Omara Erik State Key Laboratory of Petroleum Resources and Prospecting in China University of Petroleum Beijing102249China MOE Key Laboratory of Petroleum Engineering in China University of Petroleum Beijing102249China Research Institute of Shanxi Yanchang Petroleum(Group)Co. Ltd.XianShanxi710075China

Ions in brine significantly affect ***,the mechanism of EOR with different brine is still *** Combining Molecular Dynamics(MD)method and Quartz Crystal Microbalance with Dissipation(QCM-D)technology to analyze ions distribution and the mechanisms in detaching acidic components on the sandstone,an effective method to determine the detaching capacity was *** results show that detaching capacity is related to ions distribution and hydration *** the oil/brine/rock system,ions far from the rock are favorable for detaching,while ions near the rock are unfavorable for detaching due to ion bridging *** hydrogen bond between water and naphthenic acid is key to *** strengthen the detaching by forming hydrated ions with water,and the detaching capacity is negatively correlated with hydrated ions radius and positively correlated with the water coordination *** detaching determination coefficient was established by considering the ions distribution,ions types,and hydration strength,then verified by *** brine detaching capacity with different Ca^(2+)/Mg^(2+)ratios was predicted based on MD and detaching determination coefficient,and verified by *** optimal Ca^(2+)/Mg^(2+)ratio gave 7:*** study provides theoretical guidance for targeted regulation of brine composition to improve the recovery of tight sandstone reservoir.

关键词： Tight sandstone reservoir Smart water Molecular simulation Quartz crystal microbalance with dissipation

基于OBE理念的“食品微生物学”课程思政教学模式的探索

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食品工业 2024年第5期45卷 292-295页

作者：李宗泽王顺郝子娜锦州医科大学基础医学院锦州121001 锦州医科大学食品与健康学院锦州121001

把课程思政融入教学工作中是高校开展立德树人的根本任务。“食品微生物学”是食品科学与工程类专业学生的专业必修课程,其课程特色使得教材知识点中可以挖掘出大量思政元素,因此在“食品微生物学”的授课过程中开展课程思政具有得天独... 详细信息

把课程思政融入教学工作中是高校开展立德树人的根本任务。“食品微生物学”是食品科学与工程类专业学生的专业必修课程,其课程特色使得教材知识点中可以挖掘出大量思政元素,因此在“食品微生物学”的授课过程中开展课程思政具有得天独厚的优势。研究通过聚焦学习效果、重构教材内容、制定教学策略、反向课程设计、多元化评价五个维度对“食品微生物学”开展基于OBE教学理念的课程思政改革,取得了课程目标长效改革方案的制定、动静态相结合的课程思政案例库的建设、针对不同学生的个性化教学策略的制定等成效,以期为培养具有文化自信、民族自豪感、爱国主义情怀、严谨的科学精神的新时代大学生提供借鉴。

关键词：课程思政 OBE教学理念食品微生物学

Nonlinear optical properties of novel H-shaped chromophores

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Chinese Chemical Letters 2009年第5期20卷 620-622页

作者： Chao Zhi Zhang Guo Yuan Lu Chang shun wang Department of Chemistry Southeast University Nanjing 210096 China Department of Chemistry Nanfing University Nanjing 210009 China Department of Physics Shanghai Jiaotong University Shanghai 200240 China

Novel and effective H-shaped chromophores were doped into polymethyl methacrylate （PMMA） to form guest-host polymer thin films. The measurement results of Maker fringe method show that the polymer thin films containing the H-shaped chromophores as a guest exhibit high second harmonic coefficients （d33） compared with other two-dimensional chromophores.

关键词： Nonlinear optical property H-shaped chromophore Guest-host polymer thin film Second harmonic coefficient