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Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment

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Cellular & Molecular Immunology 2009年第2期6卷 143-147页

作者： kang Soo Lee Ji hyung Chung Kyung Hye Lee Min-Jeong shin Byoung Hoon Oh Soo hyung Lee Chang hyung Hong Department of Psychiatry Yonsei University College of Medicine Institution of Behavioral Science in Medicine Yonsei University College of Medicine Yonsei University Research Institute of Science for Aging Yonsei University Department of Food and Nutrition College of Health Science Korea University Department of Family Medicine Seoul Medical Center Department of Psychiatry Ajou University School of Medicine Memory Impairment Center Ajou University Hospital Ajou University School of Medicine

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment （MCI）. In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 （MCP-3）, and beta-nerve growth factor （β-NGF） in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

关键词： mild cognitive impairment cytokine plasma inflammation biomarker

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

Dissipation-free approach for realizing non-Hermitian dynamics in a superconducting circuit

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Yi-Hao kang Yang Xiao Yu Wang Qi-Ping Su Chui-Ping Yang School of Physics Hangzhou Normal University Fujian Key Laboratory of Quantum Information and Quantum Optics Fuzhou University Department of Physics Fuzhou University

Non-Hermitian dynamics exhibits a wealth of surprising and potentially useful phenomena. However, it is typically realized by coupling a system with thermal reservoirs, which makes the system suffer from thermal fluctuations associated with the dissipation. Here, we propose a dissipation-free approach to realize non-Hermitian dynamics using a superconducting circuit composed of two resonators and a superconducting qutrit. The non-Hermiticity arises in the dynamical matrix for the evolution of the two resonators in the Heisenberg picture, via a photon-number non-conserved dynamics. The energy spectrum of the non-Hermitian dynamical matrix can be retrieved by measuring the state of the two resonators, and a phase transition of the energy spectrum can be observed by varying the control parameters. In the realization of the non-Hermitian dynamics, the dissipation of the system and the post-selection are not required. Thus, the approach is implemented in a deterministic way, and the reservoir-induced noise is suppressed. Numerical simulations indicate that the energy spectrum of the non-Hermitian dynamical matrix obtained via the measurement of the resonators is in accordance with the theoretical prediction. Moreover, we demonstrate the parity discrimination for the state of two four-level qudits as an application, exhibiting the potential of the non-Hermitian dynamics in the field of quantum measurement. This work opens a new avenue for the realization of non-Hermitian dynamics and may have a significant implication in exploring the non-Hermitian phenomena.

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Compensating the impurities on the Cu surface by MOFs for enhanced hydrocarbon production in the electrochemical reduction of carbon dioxide

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Journal of Energy Chemistry 2022年第3期31卷 68-73,I0003页

作者： shin Joon kang Jong Ho Won Hansaem Choi Woohyeong Sim Mun Kyoung Kim Siraj Sultan Youngkook Kwon hyung Mo Jeong School of Mechanical Engineering and Department of Smart Fab.Technology Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea Department of Chemistry Kookmin University77 Jeongneung-roSeongbuk-guSeoul 02707Republic of Korea School of Energy and Chemical Engineering Emergent Hydrogen Technology R&D CenterUlsan National Institute of Science and Technology50 UNIST-gilUlsan 44919Republic of Korea

Copper(Cu)provides a cost-effective means of producing value-added fuels through the electrochemical reduction of carbon dioxide(CO_(2)RR).However,we observed the production of hydrocarbons via CO_(2)RR on commercial Cu films is less efficient because of the surface impurities,i.e.,*** monoxide(CO),a reaction intermediate of CO_(2)RR to hydrocarbons,binds strongly to the Fe sites and interrupts the production of hydrocarbons,resulting in an active hydrogen evolution reaction(HER).Herein,we report a method of blocking the effect of Fe impurities on the Cu surface through the preferential growth of nano-sized metal-organic frameworks(MOFs)on Fe *** zirconium(Zr)-based MOFs(UiO-66)forms a compensating layer on Cu film via the terephthalic acid(TPA)-Fe coordination bond,the Ui O-66 coated Cu film(UiO-66@Cu)presents significantly improved hydrocarbon Faradaic efficiency(FE)of 37.59%compared to 14.68%FE on commercial Cu film(99.9%purity)by suppressing *** to X-ray photoelectron spectroscopy(XPS)analysis,the UiO-66 ligand binds to entire metallic Fe site on the Cu surface,while metallic Cu is ***,UiO-66@Cu provides active sites of Cu for CO_(2)RR and leads to highly efficient and selective production of hydrocarbons.

关键词： Impurity on Cu film Zr-based MOFs Electrocatalysts CO_(2)reduction Hydrocarbon

Optimal design considering structural efficiency of compressed natural gas fuel storage vessels for automobiles

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 199-204页

作者： Myung-Chang kang hyung Woo LEE Chul KIM National Core Research Center for Hybrid Materials Solution Pusan National University Research Institute of Mechanical Technology Pusan National University

The shape and thickness of the dome were investigated with the aim of optimizing the type II CNG storage vessels by using a finite element analysis technique. The thickness of the liners and reinforcing materials was optimized based on the requirement of the cylinder and dome parts. In addition, the shape of the dome, which is most suitable for type lI CNG storage vessels, was proposed by a process of review and analysis of various existing shapes, and the minimum thickness was established in this sequence： metal liners, composite materials and dome parts. Therefore, the new proposed shape products give a mass reduction of 4.8 kg（5.1%）

关键词： CNG fuel storage vessel mechanical property dome part bursting structural analysis

Microstructure comparison of ZK60 alloy under casting,twin roll casting and hot compression

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Transactions of Nonferrous Metals Society of China 2010年第5期20卷 763-768页

作者：王守仁王敏 kang Suk-bong CHO Jae-hyung School of Mechanical Engineering University of Ji'nan School of Materials Science and Engineering Shandong University Korea Institute of Materials Science 66 Sangnam-dongChangwon 641010Korea

The microstructures of ZK60 alloy under conventional direct as-casting (DC),twin roll casting (TRC) and twin roll casting followed by hot compression (TRC-HC) were analyzed by optical morphology (OM),electron backscatter diffraction (EBSD) and X-ray diffraction (XRD).The deformation condition of hot compression is 350 ℃,0.1 s?*** microstructural evolution under TRC-HC deformation followed by annealing at different temperatures and time was *** results show that TRC provides more modified microstructure compared with *** are found in TRC processing;dynamic recrystallization (DRX),shear bands and twins are found in TRC-HC.A short annealing time has little effect on hardness,while during a long time annealing,it is found that low annealing temperatures increase the micro-hardness and high temperature decreases it.

关键词： microstructural evolution anneal dynamic recrystallization static recrystallization twin-roll casting hot compression magnesium alloy ZK60

Laparoscopic surgery for gastric cancer:Current status and future direction

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Chinese Journal of Cancer Research 2021年第2期33卷 133-141页

作者： So Hyun kang hyung-Ho Kim Department of Surgery Seoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Surgery Seoul National University College of MedicineSeoul 03080Republic of Korea

Gastric cancer is still a major cause of death *** laparoscopic gastrectomy(LG)has gained evidence as a standard treatment for early gastric cancer in the distal stomach,there are still concerns regarding its application for gastric cancer in the upper stomach and advanced gastric ***,LG has shown to have faster recovery,shorter hospital stay,less pain,and less blood loss in many retrospective and prospective *** application of LG has now extended from conventional radical gastrectomy to novel approaches such as function-preserving gastrectomy and sentinel-node navigated *** on the use of laparoscopy in treatment for stage IV gastric cancer are rare,but show that there may be some roles of LG in selected *** the development of new laparoscopic tools that augment human ability,the future of LG should move on from proving non-inferiority to demonstrating superiority compared to the traditional open gastrectomy.

关键词： Laparoscopy stomach neoplasm minimally invasive surgical procedures

Measured Performance and Analysis of the Residual Settlement of a PVD-Improved Marine Soft Ground

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Journal of Ocean University of China 2021年第5期20卷 1055-1066页

作者： kang Gichun KIM Tae-hyung YUN Seong-Kyu Department of Civil Engineering College of EngineeringGyeongsang National UniversityJinju 52828Republic of Korea Department of Civil Engineering Korea Maritime and Ocean UniversityBusan 606-791Republic of Korea Engineering Research Institute Gyeongsang National UniversityJinju 52828Republic of Korea

Prefabricated vertical drains(PVDs)are commonly used to shorten the drainage path for consolidation as part of the improvement of marine soft *** studies that focus on the primary consolidation settlement of PVD-improved soft ground have been conducted;however,residual settlement has been scarcely *** settlement is the net effect of secondary compression and the remaining primary consolidation and generally occurs while the facilities are *** this study,residual settlement was investigated using the measured field settlement data obtained from the surface settlement plate and multilayer settlement *** study determined that PVD still has some effect on residual settlement and can reduce the settlement *** settlement is only related to the PVD-improved soil layer and only occurs significantly in the middle zone of that layer over a few *** middle zone may be related to the time delay of excess pore water pressure *** study concluded that the remaining primary consolidation in the PVD-improved soil layer is the primary cause of residual settlement,whereas secondary compression in the PVD-improved soil layer is only a minor cause.

关键词： residual settlement prefabricated vertical drain(PVD) operating facilities primary consolidation secondary compres-sion marine soft ground