Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment

作     者：Kang Soo Lee Ji Hyung Chung Kyung Hye Lee Min-Jeong Shin Byoung Hoon Oh Soo Hyung Lee Chang Hyung Hong 

作者机构：Department of Psychiatry Yonsei University College of Medicine Institution of Behavioral Science in Medicine Yonsei University College of Medicine Yonsei University Research Institute of Science for AgingYonsei University Department of Food and Nutrition College of Health Science Korea University Department of Family Medicine Seoul Medical Center Department of Psychiatry Ajou University School of Medicine Memory Impairment Center Ajou University Hospital Ajou University School of Medicine 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2009年第6卷第2期

页      面：143-147页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by a grant from the Korea Health 21 R&D Project of the Ministry of Health & Welfare  Republic of Korea (A050079) 

主　　题：mild cognitive impairment cytokine plasma inflammation biomarker 

摘      要：A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment （MCI）. In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 （MCP-3）, and beta-nerve growth factor （β-NGF） in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.