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Picomolar-sensitiveβ-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulatedπ-elongated dioxaborine-dyes

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Bioactive Materials 2022年第7期7卷 239-248页

作者： Jusung An Peter Verwilst Hira Aziz Jinwoo Shin Sungsu Lim Ilwha kim Yun Kyung kim Jong seung kim Department of Chemistry Korea UniversitySeoul02841South Korea KU Leuven Rega Institute for Medical ResearchMedicinal Chemistry3000LeuvenBelgium Convergence Research Center for Diagnosis Treatment and Care System of DementiaBrain Science InstituteKorea Institute of Science and Technology(KIST)Seoul02792South Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792South Korea

The pathological origin of Alzheimer’s disease(AD)is still shrouded in mystery,despite intensive worldwide research *** selective visualization ofβ-amyloid(Aβ),the most abundant proteinaceous deposit in AD,is pivotal to reveal AD *** date,several small-molecule fluorophores for Aβspecies have been developed,with increasing binding *** the current work,two organic small-molecule dioxaborine-derived fluorophores were rationally designed through tailoring the hydrophobicity with the aim to enhance the binding affinity for Aβ_(1-42) fibrils-while concurrently preventing poor aqueous solubility-via biannulate donor motifs in D-π-A *** unprecedented sub-nanomolar affinity was found(K_(d)=0.62±0.33 nM)and applied to super-sensitive and red-emissive fluorescent staining of amyloid plaques in cortical brain tissue ex *** fluorophores expand the dioxaborine-curcumin-based family of Aβ-sensitive fluorophores with a promising new imaging agent.

关键词： β-Amyloid Small-molecular fluorescent probe Dioxaborine-dye Hydrophobicity tailoring Alzheimer’s disease

Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing

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International Journal of Oral Science 2023年第3期15卷 513-526页

作者： Pa Reum Lee Jihoon kim Heather Lynn Rossi Sena Chung seung Yub Han Junhyong kim Seog Bae Oh Department of Neurobiology and Physiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoulRepublic of Korea Genomics and Computational Biology Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathobiology University of PennsylvaniaPhiladelphiaPAUSA Department of Biology University of PennsylvaniaPhiladelphiaPAUSA Brain Science Institute Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea

Dental primary afferent(DPA)neurons and proprioceptive mesencephalic trigeminal nucleus(MTN)neurons,located in the trigeminal ganglion and the brainstem,respectively,are essential for controlling masticatory *** extensive transcriptomic studies on various somatosensory neurons,there is still a lack of knowledge about the molecular identities of these populations due to technical challenges in their circuit-validated ***,we employed high-depth single-cell RNA sequencing(scRNA-seq)in combination with retrograde tracing in mice to identify intrinsic transcriptional features of DPA and MTN *** transcriptome analysis revealed five major types of DPA neurons with cell type-specific gene enrichment,some of which exhibit unique mechano-nociceptive properties capable of transmitting nociception in response to innocuous mechanical stimuli in the ***,we discovered cellular heterogeneity within MTN neurons that potentially contribute to their responsiveness to mechanical stretch in the masseter muscle ***,DPA and MTN neurons represented sensory compartments with distinct molecular profiles characterized by various ion channels,receptors,neuropeptides,and ***,our study provides new biological insights regarding the highly specialized mechanosensory functions of DPA and MTN neurons in pain and proprioception.

关键词： trigeminal specialized Together

Regulating the microenvironment with nanomaterials:Potential strategies to ameliorate COVID-19

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药学学报:英文版 2023年第9期13卷 3638-3658页

作者： Zhicheng Liu Zhuolei Han Xin Jin Jusung An Jaewon kim Wenting Chen Jong seung kim Ji Zheng Jun Deng Department of Urology Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Department of Urology Urological Surgery Research InstituteSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing 400038China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Chemistry Korea UniversitySeoul 02841South Korea Department of Rheumatology and Clinical Immunology Army Medical CenterThird Military Medical University(Army Medical University)Chongqing 400042China

COVID-19,caused by SARS-CoV-2,has resulted in serious economic and health *** treatments remain inadequate to extinguish the epidemic,and efficient therapeutic approaches for COVID-19 are urgently being ***,accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in *** addition,recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection,providing new insight into COVID-19 *** literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 *** fill this gap,this review systematically discusses alterations of homeostasis in COVID-19 patients and potential ***,advances in nanotechnology-based strategies for promoting homeostasis restoration are ***,we discuss the challenges and prospects of using nanomaterials for COVID-19 *** review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

关键词： Coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Therapeutic approaches Nanotechnology Nanomaterial technologies Microenvironment Microenvironmental disorder Altered homeostasis

Industry cluster,organizational diversity,and innovation

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International Journal of Innovation Studies 2023年第3期7卷 205-213页

作者： Haewon kim seung-June Hwang Woojin Yoon Department of Strategic Management Hanyang University Graduate SchoolSeoul04763South Korea College of Business and Economics Hanyang University ERICA CampusAnsan-siGyeonggi-do15588South Korea

This study explains the factors that enhance the innovation performance of a cluster by focusing on its knowledge *** on the literature on industry clusters,organizational diversity,and innovation,we suggest testable ***,this study suggests that two types of organizational diversity(diversity of nationality and organization type)positively impact the innovation performance of the *** addition,the cluster network size and embeddedness have a positive moderating effect on the relationship between organizational diversity and innovation *** study aims to determine whether the innovation performance of industry clusters varies depending on the degree of diversity of organizations in the cluster and whether their network characteristics may strengthen the positive effect of organizational *** study contributes to the research stream related to industry clusters and organizational diversity and provides practical implications to practitioners participating in creating and growing such clusters.

关键词： Industry cluster Innovation Organizational diversity Network size Embeddedness

Neotectonic transpressional intraplate deformation in eastern Eurasia: Insights from active fault systems in the southeastern Korean Peninsula

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Geoscience Frontiers 2023年第4期14卷 123-136页

作者： Namgwon kim seung-Ik Park Chang Soo Cho Youngbeom Cheon Alexander L.Peace Department of Geology Kyungpook National UniversityDaegu 41566Republic of Korea Earthquake Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea Active Tectonics Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea School of Earth Environment and SocietyMcMaster UniversityHamiltonON L8S 4K1Canada

Transpression occurs in response to oblique convergence across a deformation zone in intraplate regions and plate *** Korean Peninsula is located at an intraplate region of the eastern Eurasian Plate and has been deformed under the ENE–WSW maximum horizontal compression since the late *** this study,we analyzed short-term instrumental seismic(focal mechanism)and long-term paleoseis-mic(Quaternary fault outcrop)data to decipher the neotectonic crustal deformation pattern in the south-eastern Korean ***(paleo-)seismic data acquired from an NNE–SSW trending deformation zone between the Yangsan and Ulleung fault zones indicate spatial partitioning of crustal deformation by NNW–SSE to NNE–SSW striking reverse faults and NNE–SSW striking strike-slip faults,supporting a strike-slip partitioned transpression *** instantaneous and finite neotectonic strains,estimated from the focal mechanism and Quaternary outcrop data,respectively,show discrepan-cies in their axes,which can be attributed to the switching between extensional and intermediate axes of finite strain during the accumulation of wrench-dominated ***,some major faults,including the Yangsan and Ulsan fault zones,are relatively misoriented to slip under the current stress condition but,paradoxically,have more(paleo-)seismic records indicating their role in accommodating the neotectonic transpressional *** propose that fluids,heat flow,and lithospheric structure are potential factors affecting the reactivation of the relatively misoriented major *** findings provide insights into the accommodation pattern of strain associated with the neotectonic crustal extrusion in an intraplate region of the eastern Eurasian Plate in response to the collision of the Indian Plate and the sub-duction of the Pacific/Philippine Sea Plates.

关键词： Transpression Strike-slip partition Intraplate strain accommodation Fault-slip analysis Slip tendency analysis

Organic functional dyes

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Green Chemical Engineering 2023年第4期4卷 377-378页

作者： Zhi-Qian Guo Wei-Hong Zhu Jiangli Fan Jong seung kim Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian116024China Research Institute of Dalian University of Technology in Shenzhen Shenzhen518057China Department of Chemistry Korea UniversitySeoul02841South Korea

Functional dyes go beyond traditional color applications and offer distinctive properties and functionalities,making them suitable for a wide range of industrial applications such as healthcare,agriculture,textiles,and *** dyes can serve as fluorescent probes in medical research,photosensitizers in cancer therapy,pesticide markers in agriculture,antimicrobial agents on textiles,and charge transport materials in *** ongoing research into new functional dyes reflects the interest of industries in identifying novel applications for these materials.

关键词： materials. functional dyes

Plant-derived nanovesicles: Current understanding and applications for cancer therapy

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Bioactive Materials 2023年第4期22卷 365-383页

作者： Ngoc Phung Ly Hwa seung Han Myungsuk kim Jae Hyung Park Ki Young Choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea School of Chemical Engineering College of EngineeringSungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Sciences and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Biomedical Institute for Convergence at SKKU Sungkyunkwan UniversitySuwon16419Republic of Korea

Plant-derived vesicles(PDVs)are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological *** the last decade,PDVs have gained much attention for their involvement in different biological processes,including intercellular communication and defense response,and recent scientific evidence has opened a new avenue for their applications in cancer ***,much remains unknown about these vesicles,and current research remains *** review aims to provide a comprehensive introduction to PDVs,from their biological characteristics to purification methods,and to summarize the status of their potential development for cancer therapy.

关键词： Plant-derived vesicles Extracellular vesicles Cancer therapy Anti-cancer Drug delivery

Regression of gastric endoscopic submucosal dissection induced polypoid nodular scar after Helicobacter pylori eradication:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12793-12798页

作者： Byung Chul Jin Ae Ri Ahn Seong-Hun kim seung Young Seo Department of Internal Medicine Jeonbuk National University Medical SchoolResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea Department of Pathology Jeonbuk National University Medical SchoolResearch Institute of Clinical Medicine of Jeonbuk National UniversityBiomedical Research Institute of Jeonbuk National University Hospitaland Research Institute for Endocrine SciencesJeonju 56445South Korea

BACKGROUND Endoscopic submucosal dissection(ESD)is the treatment of choice for early gastric cancer and premalignant gastric *** some cases,ESD induced ulcer heals as a polypoid nodular scar(PNS).These scars may make the physicians raise several clinical implications such as post-ESD neoplastic *** SUMMARY We described a case of gastric ESD induced PNS which is regressed after Helicobacter pylori(***)eradication.A 58-year-old male patient was referred to the outpatient clinic for evaluation and treatment of gastric low-grade dysplasia(LGD).ESD was performed.A PNS was developed at the ESD *** endoscopic biopsy was done and there was no histological evidence of remnant tumor or recurrence but a hyperplastic mucosal *** PNS showed increase in size in follow-up endoscopy,and the biopsy specimen demonstrated *** *** eradication was done and the PNS was *** *** eradication is considerable for the regression of PNS if *** infesta tion is confirmed.

关键词： Polypoid nodular scar Helicobacter pylori Endoscopic submucosal dissection Case report

Evaluation of Pre-Emergence and Post-Emergence Herbicides for Weed Management in Miscanthus sacchariflorus and Miscanthus sinensis

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1439-1467页

作者： Bimal Kumar Ghimire Chang Yeon Yu seung Hyun kim Ill Min Chung Department of Crop Science College of Sanghuh Life ScienceKonkuk UniversitySeoul05029Korea Bioherb Research Institute Kangwon National UniversityChuncheon24341Kore

Miscanthus,is a promising bioenergy crop,considered superior to other bioenergy crops because of its higher water and nutrient use efficiency,cold tolerance,and higher production of *** weeds and grass weeds,cause major problems in the Miscanthus field.A field experiment was conducted in 2018 and 2019,to assess the effects of pre-emergence(alachlor and napropamide)and post-emergence herbicides(nicosulfuron,dicamba,bentazon,and glufosinate ammonium)on broadleaf and grass weeds in *** and *** *** weed control efficiency and phytotoxicity of pre-and post-emergence herbicides were evaluated at 30 days after treatment(DAT)and compared to those of the control *** results showed wide variations in the susceptibility of the weed species to the treated *** with nicosulfuron 40 ***^(-1) provided the most effective overall weed control(with 10%visual injury),without affecting the height and biomass of neither Miscanthus species in the ***-emergence herbicides such as glufosinate ammonium 400 ***^(-1) and dicamba 482 ***^(-1) were effective and inhibited the growth and density of the majority of weeds to a 100%;however,they showed significant phytotoxicity(toxicity scale of 1-10)to both species of *** application of glufosinate ammonium caused severe injuries to the foliar region(90%visual injury)of both Miscanthus ***,*** showed a slightly higher tolerance to the herbicides nicosulfuron,bentazon and napropamide with 10%visual injury at the recommended dose than *** present study clearly showed that infestation of broadleaf and grass weeds in Miscanthus fields can cause significant damage to the growth and biomass of Miscanthus and applying pre-emergence and post-emergence herbicides effectively controls the high infestation of these weeds.

关键词： miscanthus herbicides weeds biomass chlorophyll visual injury