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5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（FEPMTX）:A Wide-Spectrum Regimen of Salvage Chemotherapyfor High- Grade Advanced Gastric Cancer

5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（...

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2000全国肿瘤学术大会

作者： Kazuo Kinoshita Yutaka Yonemura Toshiharu Sawa Tatsukazu Miyata Hiroshi Sakuma Nobuo Matsuki Sigehiro Tanaka Sachio Fushida Takashi Fujimura Young Jae Mok Byung Sik kim Jong In Lee Dong Wook Choi Young Jin Song Doo hyun Yang Sung Joon Kwon Itsuo Miyazaki Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Korea University Hospital M.D. Ulsan University Hospital M.D. Korean Cancer Center Hospital M.D. Korean Cancer Center Hospital M.D. Chungbuk National University Hospital M.D. Chonbuk National University Hospital M.D. Hanyang University Hospital Korea M.D. Department of Surgery Ⅱ School of medicine Kanazawa University13-1 Takara-machiKanazawaJapan M.D.

＜正＞Twenty-one patients with primary high-grade advanced gastric cancer in whom the presence of stage ? was con- firmed by preoperative diagnostic imaging,were treated with a wide-spectrum regimen,designated as FEPMTX therapy to establish an effective salvage *** therapy consisted of 5-fluorouracil（5-FU）and the triple biochemical modulators;methotrexate（MTX）,calcium leucovorin（LV）,cisplatin（CDDP）,and in addition of epiru- bicin（EPI）.The schedule comprised 3 days continuous administration of 5-FU（350 mg/m2/day）and MTX（35 mg/ m2）on day 1,LV（30 mg/m2）on the day 2,LV（30 mg/m2）and CDDP（30 mg/m2）and EPI（20 mg/m2）on day *** treatment was performed two or more courses with 2 weeks interval in *** partial responses（PR）, five no changes（NC）and five progressive diseases（PD）were obtained,and the response rate was 52%.Ten patients （PR 7,NC 2,PD 1）were received gastrectomy（resectability rate 48%）.The survival in all cases resulted in median survival of 184 days and one-year survival rate of 23%.While there is no significant difference insurvival between the cases with or without the resection of the primary lesion,the survival of responders was significantly longer than that of non-responders（median survival time;responder 356days,non-responder 152days）.Adverse effects such as myelo- suppression and anorexia and fatigue sometimes occurred,but were mild and all the patients well *** therapy is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxic for patients with stage?gastric cancer.

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Reactivation of tuberculosis in hepatocellular carcinoma treated with transcatheter arterial chemoembolization: A report of 3 cases

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World Journal of Radiology 2012年第5期4卷 236-240页

作者： Yun Jeung kim Pyung Gohn Goh Hee Seok Moon Eaum Seok Lee Seok hyun kim Byung Seok Lee Heon Young Lee Division of Hepatology Department of Internal Medicine Chung-Nam National University Hospital 640 Daesa-Dong Jung-Gu Daejeon 301-721 South Korea

Pulmonary tuberculosis is an opportunistic infection that can be reactivated in immunocompromised conditions, for example, in malignancy or after liver transplantation. Hepatocellular carcinoma (HCC) has a high mortality rate because it is frequently diagnosed at an advanced stage. Although surgical resection is the established curative measure for HCC, it is only feasible for earlystage HCC. Transcatheter arterial chemoembolization (TACE) is the most common treatment modality for patients with unresectable HCC. However, repeated TACE sessions and, occasionally, the tumor itself can further impair the reserve hepatic function and immunity. We report 3 recent cases of HCC with reactivation of pulmonary tuberculosis after TACE.

关键词： Hepatocellular carcinoma Reactivation Transcatheter arterial chemoembolization Tuberculosis

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全新高效Kappa 1.6L GDI发动机的开发

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汽车与新动力 2017年第4期 23-32页

作者： K.Hwang I.Hwang H.Lee H.Park H.Choi K.Lee W.kim H.kim B.Han J.Lee B.Shin D.hyun 陈荣俊

现代起亚汽车公司推出适用于混合动力车型的全新Kappa 1.6L汽油缸内直喷(GDI)发动机,并于2016年初在韩国市场投产。该机型达到了汽油机力图实现40%的最高热效率;并且能够输出充沛的动力,满足车辆的动态行驶性能。开发全新Kappa 1.6LGDI... 详细信息

现代起亚汽车公司推出适用于混合动力车型的全新Kappa 1.6L汽油缸内直喷(GDI)发动机,并于2016年初在韩国市场投产。该机型达到了汽油机力图实现40%的最高热效率;并且能够输出充沛的动力,满足车辆的动态行驶性能。开发全新Kappa 1.6LGDI发动机旨在提高燃油效率。为了获得最高燃油效率,设计了行程缸径比为1.35的紧凑型燃烧室。采用的关键技术还包括:高压缩比阿特金森循环,带有高能点火线圈的冷却废气再循环(EGR)系统,以及强滚流进气道。在大幅抑制爆燃后,燃油效率得以改善。具体做法是采用分离型冷却系统,并配有2套节温器和嵌块,机油喷射活塞冷却技术,以及中空充钠排气门。基于两级式压力控制机油泵和低流速机油,以及运动部件采用的低摩擦涂层等技术,Kappa 1.6LGDI发动机的摩擦损失也被控制在最小值。与此同时,集成了压力控制阀(OCV)的连续可变气门正时(CVVT)系统具有迅捷的响应速度,克服了CVVT系统用在阿特金森循环上相位角变大的问题。为了符合超低排放车辆(SULEV)排放法规,喷油器经激光钻孔成型,其燃油喷束形式为强滚流和平顶活塞而作了改进,系统喷油压力达到了20 MPa。

关键词：缸内直喷汽油机废气再循环喷油压力低摩擦涂层

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别有洞天——首尔PANAM旗舰店

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现代装饰 2022年第6期 24-29页

作者： Sung chul Park Areum Han Soo Jeong Lim Sung Young Heo Min Ju Lee Sang Hee Park Jae Sung LEE(摄影) Tak hyun kim(摄影) 范嘉苑(编译) 不详

位于首尔的圣水洞(seongsu-dong)绝对是韩国近年最火的热门地区之一。从前,圣水洞到处都是制造商店,包括印刷店、手工鞋店及皮革行业。如今,却吸引了很多MZ世代的年轻人前去,因为圣水洞与其他地方不同,它将过去与现在和谐结合,形成了独... 详细信息

位于首尔的圣水洞(seongsu-dong)绝对是韩国近年最火的热门地区之一。从前,圣水洞到处都是制造商店,包括印刷店、手工鞋店及皮革行业。如今,却吸引了很多MZ世代的年轻人前去,因为圣水洞与其他地方不同,它将过去与现在和谐结合,形成了独树一帜的文化。这里汇集了各种各样的商业空间,既有由旧工厂和仓库改造的商店,又有融合该地区特色的新生空间,使之拥有了与众不同的独特氛围,许多国际知名品牌也在此开设旗舰店,无疑成为拥有众多时尚品牌的热门区域。

关键词：皮革行业商业空间国际知名品牌仓库改造时尚品牌旗舰店首尔过去与现在

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糙叶五加正丁醇萃取部位抗炎活性成分研究

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天然产物研究与开发 2021年第4期33卷 598-606页

作者：唐思琪罗姣黄浩吴贤哲金伦喆刘向前李小军赣南医学院药学院国家中药现代化工程技术研究中心客家中医药资源研究分中心赣州341000 湖南中医药大学药学院长沙410208 圆光大学药学院韩国益山54538

本文对糙叶五加果实正丁醇萃取物的抗炎活性成分进行研究。采用硅胶柱色谱、C_(18)柱色谱、LH-20型羟丙基葡聚糖凝胶(Sephadex LH-20)柱色谱、半制备液相及重结晶等方法进行分离纯化,利用波谱分析结合理化性质鉴定化合物的结构。从糙叶... 详细信息

本文对糙叶五加果实正丁醇萃取物的抗炎活性成分进行研究。采用硅胶柱色谱、C_(18)柱色谱、LH-20型羟丙基葡聚糖凝胶(Sephadex LH-20)柱色谱、半制备液相及重结晶等方法进行分离纯化,利用波谱分析结合理化性质鉴定化合物的结构。从糙叶五加果实正丁醇萃取部位中分离鉴定出17个化合物,分别为槲皮素-3-O-β-D-吡喃葡萄糖苷(1)、槲皮素-3-O-β-D-吡喃半乳糖苷(2)、芦丁(3)、1,3-双咖啡酰奎宁酸(4)、1,4-双咖啡酰奎宁酸(5)、1,5-双咖啡酰奎宁酸(6)、3,4-双咖啡酰奎宁酸(7)、3,5-双咖啡酰奎宁酸(8)、4,5-双咖啡酰奎宁酸(9)、绿原酸甲酯(10)、(2E,6S)-1-羟基-2,6-二甲基-2,7-辛二烯-6-β-D-吡喃葡萄糖苷(11)、(2Z,6R)-6-羟基-2,6-二甲基-2,7-辛二烯-1-β-D-吡喃葡萄糖苷(12)、(2Z,6R)-1-羟基-2,6-二甲基-2,7-辛二烯-6-β-D-吡喃葡萄糖苷(13)、(2E,6R)-6-羟基-2,6-二甲基-2,7-辛二烯-1-β-D-吡喃葡萄糖苷(14)、(2E,6R)-1-羟基-2,6-二甲基-2,7-辛二烯-6-β-D-吡喃葡萄糖苷(15)、(-)-(3S,4S,6R)-3,6-二羟基-1-薄荷烯6-O-β-D-吡喃葡萄糖苷(16)、(-)-(3S,4S,6R)-3,6-二羟基-1-薄荷烯3-O-β-D-吡喃葡萄糖苷(17)。化合物11、16、17为首次从五加科植物中分离得到;化合物13~15为首次从五加属植物中分离得到;除化合物1~9之外,其他化合物均为首次从该种植物中分离得到。其中,在0~80μM的浓度范围内,被测试化合物均无明显的细胞毒性,化合物10和16具有较好的NO抑制活性且呈剂量相关;化合物6和17表现出了适度的NO抑制活性;其它被测试化合物具有微弱的或者无NO抑制效果。

关键词：糙叶五加黄酮苷咖啡酰奎宁酸单萜苷化学成分抗炎活性

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基于SEM的在韩中国留学生免税商品购买意愿影响因素研究

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当代韩国 2018年第3期 55-65页

作者：王佳桐朱甜甜〔韩〕金显喆韩国国立群山大学韩国国立群山大学融合技术创业系

本文以在韩中国留学生为研究对象,主要研究影响其购买韩国免税商品的动机和意愿的因素,并了解在韩中国留学生购买免税品种类以及消费取向。本文采用问卷调查的方式获取数据,应用SPSS20. 0对数据进行描述性分析和探索性分析,并应用AMOS22... 详细信息

本文以在韩中国留学生为研究对象,主要研究影响其购买韩国免税商品的动机和意愿的因素,并了解在韩中国留学生购买免税品种类以及消费取向。本文采用问卷调查的方式获取数据,应用SPSS20. 0对数据进行描述性分析和探索性分析,并应用AMOS22. 0对数据进行验证性因子分析和建立SEM结构方程模型,最终得出价格感知度、当地免税政策知晓度、群体影响对购买动机有显著性影响,购买动机对购买意愿有显著影响,而品牌认知度对购买动机没有显著影响的结论。

关键词：在韩中国留学生免税商品消费调查

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Multidetector computed tomography features of pancreatic metastases from leiomyosarcoma: Experience at a tertiary cancer center

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World Journal of Radiology 2016年第3期8卷 316-321页

作者： Chong hyun Suh Abhishek Keraliya Atul B Shinagare Kyung Won kim Nikhil H Ramaiya Sree Harsha Tirumani Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine Asan Medical Center Department of Radiology Namwon Medical Center Department of Imaging Dana Farber Cancer Institute Harvard Medical School Department of Radiology Brigham and Women’s Hospital Harvard Medical School

AIM: To describe the multidetector computed tomography features of pancreatic metastasis from leiomyosarcoma(LMS).METHODS: Between January 1995 and December 2012, 13 consecutive patients(11 women, 2 men; mean age of 57 years; range, 38-78 years) with pancreatic metastases from LMS were included in our study. Imaging features including location, number, largest dimension, tumor attenuation and enhancement characteristics, presence of necrosis, pancreatic ductal dilatation, common bile duct(CBD) dilatation, presence of pancreatitis, and atrophy were ***: The most common site of origin of the pancreatic metastases from LMS was uterus(38.5%), followed by retroperitoneum(30.8%) and extremity(23.1%). None of the patients in our study had pancreas as the first site of metastasis. All patients developed pancreatic metastases at a median interval of 24 mo. Pancreatic metastases from LMS were solitary in 8/13 patients and multiple in 5/13 patients, had no predilection for any part of the pancreas, were hypovascular on arterial phase in 10/13 patients and associated with pancreatic duct dilatation in 3/13 patients. None had CBD dilatation. None of the pancreatic metastases in LMS cohort caused pancreatitis, and atrophy. Median duration of follow-up was 19 mo for LMS cohort during which two patients underwent resection of metastasis(median survival 45 mo) while the remaining underwent systemic therapy(median survival 13 mo).CONCLUSION: Pancreatic metastases from LMS are often solitary and hypovascular masses and less commonly associated with pancreatic ductal dilatation, CBD dilatation, pancreatitis or pancreatic atrophy. Surgical resection of solitary LMS pancreatic metastasis can be considered due to the long survival of these patients.

关键词： Pancreatic metastasis Hypovascular Renal cell carcinoma Leiomyosarcoma Multidetector computed tomography

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用Al或Mo /Al /Mo低阻材料改善4-Mask工艺中Al腐蚀的方法(英文)

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液晶与显示 2006年第5期21卷 501-505页

作者：劉聖烈崔螢石金奉柱柳在一李禹奉李貞烈京东方科技集团股份有限公司中央研究院

为了减少制造工艺的过程,改进的4-Mask工艺中采用Al基的数据线已得到进一步的完善。但这个工艺仍存在很多问题,主要是为减少工艺过程,而引入干法刻蚀对Al有腐蚀作用。本文应用CF4/O2等离子体处理,很好地阻止了对Al的腐蚀,得到很好的效果... 详细信息

为了减少制造工艺的过程,改进的4-Mask工艺中采用Al基的数据线已得到进一步的完善。但这个工艺仍存在很多问题,主要是为减少工艺过程,而引入干法刻蚀对Al有腐蚀作用。本文应用CF4/O2等离子体处理,很好地阻止了对Al的腐蚀,得到很好的效果,对改进后4-Mask工艺的进一步应用具有非常重要的意义。

关键词：液晶显示器腐蚀 Al,Mo/Al/Mo 等离子体处理

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Chinese Prescription Kangen-karyu as Potential Anti-Alzheimer’s Disease Therapeutic:Analyses of BACE1 and GSK-3βInhibitory Activities

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Journal of Integrative Medicine（双语） 2021年第2期10卷 37-42页

作者： Chan Hum Park Min Jo kim hyun Ah Jung Jae Sue Choi Jin Pyeong Jeon Takako Yokozawa Institute of New Frontier Research Team Hallym Clinical and Translational Science InstituteHallym UniversityChuncheon24252Republic of Korea Department of Medicinal Crop Research National Institute of Horticultural and Herbal ScienceRural Development AdministrationEumseong369-873Republic of Korea Department of Food Science and Human Nutrition Chonbuk National UniversityJeonju561-756Republic of Korea Department of Food and Life Science Pukyong National UniversityBusan 608-737Republic of Korea Institute of New Frontier Stroke Research Team College of MedicineHallym UniversityChuncheon24252Republic of Korea Department of Neurosurgery College of MedicineHallym UniversityChuncheon24252Republic of Korea Graduate School of Science and Engineering for Research University of ToyamaToyama930-8555Japan

Inhibition ofβ-site amyloid precursor protein-cleaving enzyme 1(BACE1)or glycogen synthase kinase-3β(GSK-3β)is estimated to be the central therapeutic approach for Alzheimer’s disease(AD).In this study,water extract of Kangenkaryu,its crude drug and chemical composition used in oriental medicine were evaluated regarding their BACE1 and GSK-3βinhibitory *** resonance energy transfer was used to characterize the BACE1 inhibitory effect of Kangen-karyu,its crude drug and chemical ***-3βactivity was determined using the Kinase-Glo Luminescent Kinase Assay *** water extract of Kangen-karyu inhibited BACE1 and GSK-3βin concentration-dependent manners when compared with reference drugs,quercetin and *** six components of Kangen-karyu,the water extracts of Salviae Miltiorrhizae Radix or Cyperi Rhizoma exhibited significant inhibitory effects on BACE1 and GSK-3β.Among the constituents of Salviae Miltiorrhizae Radix extract,salvianolic acid C,salvianolic acid A,rosmarinic acid,and magnesium lithospermate B significantly inhibited *** addition,they inhibited GSK-3βwith an IC50 value range of 6.97 to 135.35μ*** these results,one of the effectiveness and its mechanisms of action of Kangen-karyu against AD may be the inhibition of BACE1 and GSK-3β,and one of the active ingredients of Kangen-karyu is Salviae Miltiorrhizae Radix and its constituents.

关键词： Alzheimer’s disease β-Site amyloid precursor protein-cleaving enzyme 1 Glycogen synthase kinase-3β Kangen-karyu Salviae Miltiorrhizae Radix Salvianolic acid C Salvianolic acid B

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ACUPUNCTURE STIMULATION IMPROVES MEMORY IMPAIRMENT INDUCED BY SCOPOLAMINE IN RATS

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Journal of Integrative Medicine 2014年第3期 255-255页

作者： Bombi Lee Bongjun Sur Jinhee Park Sung-Hun kim Mijung Yeom Insop Shim Hyejung Lee Dae-hyun Hahm Kyung Hee University

Objective: The purpose of this study was to examine whether acupuncture stimulation at the Baihui(GV20) improves memory defects caused by administration of scopolamine(SCO) to the *** effects of acupuncture stimulation at the GV20 on the cholinergic system as well as the expression of brain-derived neurotrophic factor(BDNF) and cAMP-response element-binding protein(CREB) in the hippocampus were also ***: Male rats were administered with SCO(2 mg/kg, i.p.) once daily for 14 *** stimulation at GV20 was performed for 5 min before SCO ***: Acupuncture stimulation at GV20 improved memory impairment as measured by the passive avoidance test(PAT) and reduced the escape latency for finding the platform in the Morris water maze(MWM) *** stimulation at the GV20 significantly alleviated memory-associated decreases in the expression levels of choline acetyltransferase(ChAT), BDNF and CREB proteins in the ***, acupuncture stimulation at the GV20 significantly restored the expression of choline transporter 1(CHT1), vesicular acetylcholine transporter(VAChT), BDNF and CREB mRNAs in the ***: These results demonstrated that acupuncture stimulation at the GV20 has significant neuroprotective effects against neuronal impairment and memory dysfunction caused by SCO in ***, these findings suggested that acupuncture stimulation at the GV20 might be a useful therapy in various neurodegenerative diseases for the improvement of cognitive functioning via stimulating cholinergic enzyme activities and regulating BDNF and CREB expression in the brain.

关键词： CREB BDNF SCO ACUPUNCTURE STIMULATION IMPROVES MEMORY IMPAIRMENT INDUCED BY SCOPOLAMINE IN RATS

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