5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（FEPMTX）:A Wide-Spectrum Regimen of Salvage Chemotherapyfor High- Grade Advanced Gastric Cancer
作者单位：Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery ⅡSchool of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Korea University Hospital M.D. Ulsan University Hospital M.D. Korean Cancer Center Hospital M.D. Korean Cancer Center Hospital M.D. Chungbuk National University Hospital M.D. Chonbuk National University Hospital M.D. Hanyang University Hospital Korea M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D.
会议名称：《2000全国肿瘤学术大会》
会议日期：2000年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：正Twenty-one patients with primary high-grade advanced gastric cancer in whom the presence of stage ? was con- firmed by preoperative diagnostic imaging,were treated with a wide-spectrum regimen,designated as FEPMTX therapy to establish an effective salvage *** therapy consisted of 5-fluorouracil（5-FU）and the triple biochemical modulators;methotrexate（MTX）,calcium leucovorin（LV）,cisplatin（CDDP）,and in addition of epiru- bicin（EPI）.The schedule comprised 3 days continuous administration of 5-FU（350 mg/m2/day）and MTX（35 mg/ m2）on day 1,LV（30 mg/m2）on the day 2,LV（30 mg/m2）and CDDP（30 mg/m2）and EPI（20 mg/m2）on day *** treatment was performed two or more courses with 2 weeks interval in *** partial responses（PR）, five no changes（NC）and five progressive diseases（PD）were obtained,and the response rate was 52%.Ten patients （PR 7,NC 2,PD 1）were received gastrectomy（resectability rate 48%）.The survival in all cases resulted in median survival of 184 days and one-year survival rate of 23%.While there is no significant difference insurvival between the cases with or without the resection of the primary lesion,the survival of responders was significantly longer than that of non-responders（median survival time;responder 356days,non-responder 152days）.Adverse effects such as myelo- suppression and anorexia and fatigue sometimes occurred,but were mild and all the patients well *** therapy is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxic for patients with stage?gastric cancer.