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NνDEx-100 conceptual design report

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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang Jun Liu Chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-Yun Xiao Jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-Liang Zhang Jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)seF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of seF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)seF_(6) China Jinping Underground Laboratory

比较0.01%阿托品滴眼液和重复低强度红光照射对近视前期儿童眼部生物学参数的影响

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中华眼外伤职业眼病杂志 2024年第3期46卷 161-171页

作者：常铭航符爱存尚丽丽孙广莉郑州大学第一附属医院眼科河南省眼科医院郑州450052

目的比较应用0.01%阿托品滴眼液和重复低强度红光(RLRL)照射对近视前期儿童眼部生物学参数的影响。方法前瞻性随机对照研究。纳入2021年5月至2021年11月就诊于郑州大学第一附属医院的近视前期[双眼等效球镜度(se)为-0.75~+0.50 D]儿童6... 详细信息

目的比较应用0.01%阿托品滴眼液和重复低强度红光(RLRL)照射对近视前期儿童眼部生物学参数的影响。方法前瞻性随机对照研究。纳入2021年5月至2021年11月就诊于郑州大学第一附属医院的近视前期[双眼等效球镜度(se)为-0.75~+0.50 D]儿童62例。按随机数字表法分为两组,阿托品组(30例)双眼每晚睡前滴0.01%阿托品滴眼液,红光组(32例)双眼行RLRL照射,每天2次,至少间隔4 h,每次3 min,每周使用5 d。两组儿童均干预6个月后停用1个月。历史对照组为2020年7月至2020年10月观察的与本研究受试者基线资料相匹配、双眼se为-0.75~+0.50 D的近视前期儿童25例。随访7个月,观察阿托品组与红光组的se、眼轴长度(AL)、黄斑中心凹下脉络膜厚度(SFCT)、黄斑中心凹下脉络膜血管指数(SFCVI)、调节幅度、瞳孔直径、散光度、角膜曲率、前房深度和眼压的变化,并分别与历史对照组进行比较。结果随访6个月,阿托品组se、AL、SFChT和SFCVI分别为(-0.37±0.54)D、(23.75±0.77)mm、(337.16±61.11)μm和0.37±0.10,其中se和AL较基线[(-0.22±0.51)D和(23.59±0.74)mm]增加,差异有统计学意义(t=3.13、7.06,P=0.003、Pse、AL、SFCT和SFCVI分别为(-0.28±0.43)D、(23.70±0.76)mm、(351.67±63.74)μm和0.41±0.11,其中AL、SFCT和SFCVI相较基线[(23.62±0.77)mm、(335.20±58.90)μm和0.37±0.12]增加,差异有统计学意义(t=3.68、3.39、3.23,P=0.001、0.001、0.002),而se与基线时[(-0.24±0.32)D]相比差异无统计学意义(t=0.80,P=0.428)。经多因素线性回归分析,阿托品组se和AL的变化量[0.00(-0.36,0.00)D、(0.16±0.14)mm]均大于红光组[0.00(-0.19,0.00)D、(0.08±0.09)mm],而SFCT和SFCVI的变化量[5.48(-8.90,21.79)μm、0.01(-0.05,0.05)]均小于红光组[23.23(2.67,49.10)μm、0.06(0.00,0.10)],差异有统计学意义(β=0.120、-0.072、16.610、0.048,P=0.048、0.029、0.012、0.013)。阿托品组调节幅度为(12.52±1.97)D,较基线时减少(t=3.51,P0.05)。历史对照组的se和AL变化量分别为-0.31(-0.50,-0.25)D和(0.28±0.14)mm,红光组和阿托品组的se进展和AL增长与历史对照组相比,差异均有统计学意义(均Pse变化量为(-0.06±0.07)D和(-0.05±0.05)D,AL变化量为(0.04±0.05)mm和(0.02±0.06)mm。两组各参数与基线时相比差异均无统计学意义(均P>0.05)。结论0.01%阿托品滴眼液和RLRL照射均能有效控制近视前期儿童se进展和AL增长,且RLRL照射效果更好。RLRL照射对SFCT和SFCVI以及0.01%阿托品滴眼液对调节幅度和瞳孔直径的影响均具有可逆性。

关键词：近视儿童阿托品重复低强度红光预防生物学参数

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学龄期儿童黄斑区视网膜血流密度和厚度分析

中华眼底病杂志 2024年第1期40卷 44-51页

作者：高莎莎尚丽丽符爱存常铭航贺音王铭金学民雷博张凤妍郑州大学第一附属医院眼科郑州450000 河南省眼科研究所河南省立眼科医院郑州450003

目的观察并分析学龄期儿童黄斑区视网膜毛细血管血流密度和视网膜厚度与屈光度的相关性。方法横断面研究。2022年5~12月于郑州大学第一附属医院眼科就诊的学龄期儿童182名纳入研究。其中,男性95名,女性87名;年龄6~12岁;等效球镜度(se)+0... 详细信息

目的观察并分析学龄期儿童黄斑区视网膜毛细血管血流密度和视网膜厚度与屈光度的相关性。方法横断面研究。2022年5~12月于郑州大学第一附属医院眼科就诊的学龄期儿童182名纳入研究。其中,男性95名,女性87名;年龄6~12岁;等效球镜度(se)+0.50~-6.00 D。根据右眼se将受检者分为正视眼组(+0.50≤sesese≤-6.00 D),分别为54、71、57例。采用扫频源光相干断层扫描血管成像仪对右眼黄斑区6 mm×6 mm范围进行扫描。软件自动将黄斑中心凹6 mm范围内视网膜划分为以黄斑中心凹为中心的3个同心圆,分别为直径1 mm的中心凹区、1~3 mm的内环区、3~6 mm的外环区。测量黄斑区6 mm范围内不同分区视网膜浅层毛细血管丛(SVP)、深层毛细血管丛(DVP)血流密度和视网膜厚度。单因素线性回归、多重线性回归、平滑曲线拟合、阈值效应分析黄斑不同分区SVP、DVP、视网膜厚度与屈光度的相关性。结果正视眼组、低度近视眼组、中度近视眼组受检眼中心凹区、内环区、外环区SVP(F=6.64、26.06、22.69)、DVP(F=7.97、25.01、5.09)血流密度比较,差异有统计学意义(Pse呈正相关(Pse呈线性正相关(β=-0.91、-1.40,Pse为存在拐点(sese呈正相关(Pse>-3.00 D时,除内环区DVP血流密度外,其余均与se呈负相关(P0.05)。单因素线性回归、多重线性回归分析结果显示,内环区、外环区视网膜厚度与se呈负相关(β=1.99、3.05,Pse无相关性(β=-1.65,P>0.05)。结论屈光度+0.50~-6.00 D的学龄期儿童,随屈光度增加,黄斑中心凹区视网膜毛细血管血流密度逐渐升高,内环区、外环区先升高后降低;内环区、外环区视网膜厚度逐渐降低,中心凹区视网膜厚度未发生显著变化。

关键词：扫频源光相干断层扫描血管成像儿童黄斑区血管密度视网膜厚度

Growth of uniformly doped black phosphorus films through versatile atomic substitution

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Science China(Information Sciences) 2023年第6期66卷 78-86页

作者： Cheng CHEN Yang LU chang LI Xingang HOU Yongjie WANG Junrong ZHANG Junyong WANG Kai ZHANG School of Nano-Tech and Nano-Bionics University of Science and Technology of China CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences Nano Science and Technology Institute University of Science and Technology of China

For the emerging excellent two-dimensional semiconductor black phosphorus(BP), doping has been proven as an effective way to tune its intrinsic properties. For the further development and expansion of BP-based research and application, the direct growth of doped BP films is highly desirable but still remains a challenge. In this work, the direct growth of uniformly doped-BP films on silicon substrates is achieved by a simple one-step vapor growth. The proposed decoupled feeding strategy significantly improves the effectiveness of doping and enables uniform dopant distribution in the grown films. The substitutional doping nature and high crystal quality of the grown doped films are confirmed by microscopy and crystal structural determination. Electrical transport measurement results reveal that se and Te dopants perform mild electron doping effect and enable improve the electron mobility relative to pristine BP, while As dopant performs mild hole doping effect. It is believed that the direct growth of doped BP films in this work will facilitate the research development of BP in electronics and optoelectronics.

关键词： black phosphorus dope vapor growth thin film two-dimensional materials

Comparative effects of artemisia vulgaris and charcoal moxa stimulating Zhongwan(CV 12) on body temperature in healthy participants:a cross-over single-blind randomized study

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Journal of Traditional Chinese Medicine 2015年第5期35卷 551-557页

作者： Ho-yeon Go Ju Ah Lee Sunyoung Park Sunju Park Jeong-Su Park Chunhoo Cheon seong-Gyu Ko Kyung-Hwan Kong Chan-yong Jun Jong-hyeong Park Mi-Ran Shin se-Hoon Lee Department of Internal Medicine College of Korean MedicineSemyung University Department of Public Health The Catholic University of Korea Medical Research Division Korea Institute of Oriental Medicine Department of Physiology College of Korean MedicineSemyung University Department of Preventive Medicine College of Korean MedicineDaejeon University Center for Clin ical Research and Genomics College of Oriental Medicine and Institu te of Oriental MedicineKyung Hee University Department of Internal Medicine College of Korean MedicineGachon University Department of Sasang Constitutional Medicine College of Korean MedicineSemyung University

OBJECTIVE:To evaluate the efficacy,safety,satisfaction,discomfort and patient preference of moxa cones of artemisia vulgaris and charcoal ***:This comparative study of moxibustion treatment with Artemisia vulgaris and charcoal moxa cone stimulating Zhongwan(CV 12) is a cross-over single-blinded,randomized clinical trial.A total of 40 healthy subjects(24 males and 16females) participated in this *** subjects dropped out of the ***-eight subjects were treated with Artemisia vulgaris and charcoal moxa cones for 30 min in a cross-over *** treatment,the patients underwent a 30 minute waiting period,and then the temperatures at Tanzhong(CV 17),Zhongwan(CV 12) and Guanyuan(CV 4) were measured using digital infrared thermal ***:After the use of Artemisia vulgaris moxa,the patients' body temperatures were slightly lowered at Tanzhong(CV 17),Zhongwan(CV 12)and Guanyuan(CV 4),but the changes were not statistically *** the use of charcoal moxa,the patients' body temperatures were somewhat increased at Zhongwan(CV 12) and Guanyuan(CV 4),but the changes were not statistically *** Artemisia vulgaris moxa use,the body temperature difference between Zhongwan(CV 12) and Guanyuan(CV 4)was significantly *** charcoal moxa use,the body temperature difference between Tanzhong(CV 17) and Zhongwan(CV 12) was significantly decreased in males and in the whole *** change was caused by the difference in the moxibustion type and by gender ***:This pilot study found that moxibustion did not raise the body temperature,but temperature differences between acupoints were *** large-scale randomized controlled trials are needed for the effect of moxibustion on body temperature.

关键词：随机对照试验温度差木炭艾草健康体内临床试验交叉设计

Hybrid Friction Stir Welding of High-carbon Steel

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Journal of Materials Science & Technology 2011年第2期27卷 127-130页

作者： Don-Hyun Choi chang-Yong Lee Byung-Wook Ahn Jung-Hyun Choi Yun-Mo yeon Keun Song seung-Gab Hong Won-Bae Lee Ki-Bong Kang seung-Boo Jung School of Advanced Materials Science and Engineering Sungkyunkwan University 300 Cheoncheon-dongJangan-guSuwonGyeonggi-do 440-746South Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology 335 GwahangnoYuseong-guDaejeon 305-701South Korea Department of Advanced Materials Application Suwon Science College 9-10Botong-liJeongnam-myeonHwasungGyeonggi-do 445-742South Korea Technical Research Lab POSCO Corp.Goedong-dongNam-guPohangGyeongbuk790-785South Korea

A high-carbon steel joint,SK5（0.84 wt% C）,was successfully welded by friction stir welding（FSW）,both without and with a gas torch,in order to control the cooling rate during *** welding,the weld zone comprised gray and black regions,corresponding to microstructural variation：a martensite structure and a duplex structure of ferrite and cementite,*** volume fraction of the martensite structure and the Vickers hardness in the welds were decreased with the using of the gas torch,which was related with the lower cooling rate.

关键词： Friction stir welding High-carbon steel Transformation Martensite

Effect of the herbal medicine Danggui Sini plus Wuzhuyu Shengjiang Tang on erythrocyte deformability in normal subjects: a cross-over trial

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Journal of Traditional Chinese Medicine 2018年第5期38卷 769-772页

作者： JiEun Lee seung-yeon Cho seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park chang-Nam Ko Ki-Ho Cho seungwon Kwon Department of Cardiology and Neurology College of Korean Medicine Kyung Hee University

OBJECTIVE: To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang(DSWST) has any transient effect on erythrocyte deformability in normal ***: A total of 25 subjects [mean age(27.8± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte ***: The elongation index increased significantly after 2 h(P = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant differenceobserved. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration,DSWST improved erythrocyte deformability significantly compared to water(P < 0.001).CONCLUSION: DSWST has a transient effect on erythrocyte deformability in normal subjects.

关键词： Erythrocyte deformability Peptide elongation factors Raynaud disease Coldness of hands and feet Cross-over studies Danggui Sini plus Wuzhuyu Shengjiang Tang

Therapeutic efficacy and stent patency of transhepatic portal vein stenting after surgery

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World Journal of Gastroenterology 2016年第44期22卷 9822-9828页

作者： Ung Bae Jeon chang Won Kim Tae Un Kim Ki seok Choo Joo yeon Jang Kyung Jin Nam Chong Woo Chu Je Ho Ryu Department of Radiology Pusan National University Yangsan Hospital Department of Radiology Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Hospital Department of Surgery Pusan National University Yangsan Hospital

AIM To evaluate portal vein(PV) stenosis and stent patency after hepatobiliary and pancreatic surgery, using abdominal computed tomography(CT).METHODS Percutaneous portal venous stenting was attempted in 22 patients with significant PV stenosis(> 50%)-after hepatobiliary or pancreatic surgery- diagnosed by abdominal CT. Stents were placed in various stenotic lesions after percutaneous transhepatic portography. Pressure gradient across the stenotic segment was measured in 14 patients. Stents were placed when the pressure gradient across the stenotic segment was > 5 mm Hg or PV stenosis was > 50%, as observed on transhepatic portography. Patients underwent followup abdominal CT and technical and clinical success, complications, and stent patency were *** Stent placement was successful in 21 patients(technical success rate: 95.5%). Stents were positioned through the main PV and superior mesenteric vein(n = 13), main PV(n = 2), right and main PV(n = 1), left and main PV(n = 4), or main PV and splenic vein(n = 1). Patients showed no complications after stent placement. The time between procedure and final follow-up CT was 41-761 d(mean: 374.5 d). Twenty stents remained patent during the entire follow-up. Stent obstruction-caused by invasion of the PV stent by a recurrent tumor- was observed in 1 patient in a follow-up CT performed after 155 d after the procedure. The cumulative stent patency rate was 95.7%. Small in-stent low-density areas were found in 11(55%) patients; however, during successive follow-up CT, the extent of these areas had *** Percutaneous transhepatic stent placement can be safe and effective in cases of PV stenosis after hepatobiliary and pancreatic surgery. Stents show excellent patency in follow-up abdominal CT, despite development of small in-stent low-density areas.

关键词： Liver Vein Stent Computed tomography Surveillance Efficace

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复合材料机身结构多学科优化设计

飞行器强度研究 2024年第1期 55-60页

作者：卢杰聂小华王海燕杰常亮朱家文中国飞机强度研究所强度与结构完整性全国重点实验室西安710065

在翼身融合飞机机身结构优化设计阶段,为了充分考虑各学科之间的耦合与影响,针对多学科响应分析协调、多学科约束统一等问题,提出了一种兼顾结构、气动、噪声等多个学科的结构优化设计方案,建立了以结构重量为目标函数,以结构尺寸为设... 详细信息

在翼身融合飞机机身结构优化设计阶段,为了充分考虑各学科之间的耦合与影响,针对多学科响应分析协调、多学科约束统一等问题,提出了一种兼顾结构、气动、噪声等多个学科的结构优化设计方案,建立了以结构重量为目标函数,以结构尺寸为设计变量,考虑多个学科设计约束的优化模型,确定了以序列无约束极小化方法为求解优化问题的数学算法。将整套优化方案运用于翼身融合复合材料机身结构的优化设计,经过优化设计,各个学科的约束函数均得到满足,机身的半结构重量减少了6.9%,为翼身融合构型民机轻量化设计提供技术储备。

关键词：翼身融合民机多学科优化设计复合材料多约束