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Purinergic signaling systems across comparative models of spinal cord injury

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Neural Regeneration Research 2022年第3期17卷 2391-2398页

作者： eva e.Stefanova Angela L.scott Department of Pathology and Molecular Medicine McMaster UniversityHamiltonONCanada

Within the last several decades,the scientific community has made substantial progress in elucidating the complex pathophysiology underlying spinal cord ***,despite the many advances using conventional mammalian models,both cellular and axonal regeneration following spinal cord injury have remained out of *** this sense,turning to non-mammalian,regenerative species presents a unique opportunity to identify pro-regenerative cues and chara cterize a spinal cord microenvironment permissive to *** the signaling pathways hypothesized to be dysregulated during spinal cord injury is the purinergic signaling *** addition to its well-known role as energy currency in cells,ATP and its metabolites are small molecule neurotransmitte rs that mediate many diverse cellular processes within the central nervous *** our unde rstanding of the roles of the purinergic system following spinal cord injury is limited,this signaling pathway has been implicated in all injury-induced secondary processes,including cellular death,inflammation,reactive gliosis,and neural *** that the purinergic system is also evolutionarily conserved between mammalian and non-mammalian species,comparisons of these roles may provide important insights into conditions responsible for recovery ***,we compare the secondary processes between key model species and the influence of purinergic signaling in each *** our understanding of this signaling system and pro-regenerative conditions continues to evolve,so does the potential for the development of novel therapeutic interventions for spinal cord injury.

关键词： cell death differenriation glia inflammation neurogenesis proliferation purinergic signaling reactive gliosis regeneration spinal cord injury teleost

A modified intron of VRT2 drives glume and grain elongation in wheat

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Molecular Plant 2021年第9期14卷 1421-1423页

作者： Laura e.Dixon scott A.Boden Faculty of Biological Sciences University of LeedsLeeds LS29JTUK School of Agriculture Food and WineWaite Research InstituteUniversity of AdelaideGlen OsmondSA 5064Australia

Yield is a complex trait that is determined predominantly by the number,size,and weight of grain produced by a plant,which are all in fluenced by multiple genes and environ mental *** cereals,grain size is in flue need by envir on mental signals including nutrient availability and temperature,and by variation for genes that control the dimensions of a grain or the size of floral organs(e.g.,Heang and Sassa,2012;Brinton et al.,2017;Adamski et al.,2021;Liu et al.,2021;Xiao et al.,2021).Three recent studies have investigated subspecies of tetrapioid and hexapioid wheat that produce Ion ger grains,which form in florets that contain elongated floral structures(Adamski et al.,2021;Liu et al.,2021;Xiao et al.,2021);their findings provide new understanding of the genes controlling floret architecture,which could be used by breeders to enhance grain size and yield.

关键词： grain organs wheat

Forge AHeAD with stricter criteria in future trials of embolic stroke of undetermined source

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Neural Regeneration Research 2022年第5期17卷 1009-1010页

作者： David Z.Rose scott e.Kasner Department of Neurology Morsani College of MedicineUniversity of South FloridaTampaFLUSA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

What lurks within the crypt?With more than 200 known causes of is chemic stroke(Saver,2016),what should be the minimum work up?Many centers offer high-resolution brain imaging and vessel studies,telemetry monitoring f... 详细信息

关键词： strict thoracic centers

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2024年全球经济压力点

商业周刊（中文版） 2024年第2期 4-5页

作者： Malcolm scott enda Curran 易语(译) 不详

全球经济2023年经受了以往罕有的考验:通胀和几十年来最激进的货币紧缩行动,欧洲和中东的战火以及中美之间日益加深的摩擦,所有这一切都迫使企业对供应链和安全进行重新考量。

关键词：供应链货币紧缩通胀全球经济

Hybrid Predictive ensembles:Synergies Between Human and Computational Forecasts

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Journal of Social Computing 2021年第2期2卷 89-102页

作者： Lu Hong PJ Lamberson scott e Page Department of Finance Loyola University ChicagoChicagoIL 606002USA Department of Communication University of California at Los Angeles(UCLA)Los AngelesCA 90095USA School University of MichiganAnn ArborMI 48104USA

An increasing proportion of decisions,design choices,and predictions are being made by hybrid groups consisting of humans and artificial intelligence(AI).In this paper,we provide analytic foundations that explain the potential benefits of hybrid groups on predictive tasks,the primary use of *** analysis relies on interpretive and generative signal frameworks as well as a distinction between the big data used by AI and the thick,often narrative data used by *** derive several conditions on accuracy and correlation necessary for humans to remain in the *** conclude that human adaptability along with the potential for atypical cases that mislead AI will likely mean that humans always add value on predictive tasks.

关键词： collective intelligence predictive models hybrid groups big data thick data

A Comparative Study of the L2 Pragmatic Competence of University Students in Hong Kong and the Chinese Mainland:The Contributions of Sociocultural Context and Linguistic Proficiency

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Chinese Journal of Applied Linguistics 2024年第3期47卷 371-392,524页

作者： scott AUBReY Rod eLLIS Faculty of education Chinese University of Hong Kong School of education Curtin UniversityAustralia

This study investigates the differences in pragmatic competence between Hong Kong and Chinese mainland university *** included 19 native speakers of english,115 Chinese mainland students,divided into those who had spent time abroad in an english-speaking country(CM A)and those who had not(CM NA),and 97 Hong Kong students,divided into those from an english-medium secondary school(Hong Kong eMI)and those from a Chinese-medium school(Hong Kong CMI).Linguistic proficiency was measured by a C-test,and pragmatic competence by a Metapragmatic Knowledge Test,an Irony Test and a Monologic Role *** scores were compared using ANCOVAs to control for differences in *** results point to a continuum of pragmatic competence—eMI>CMI>CM A>CM NA—reflecting the groups’access to english in real-life *** differences between the Hong Kong groups and the Chinese mainland groups were clearest in those tests measuring processing capacity(i.e.,Irony Response Time and the Monologic Role Play).CM A,but not CM NA,performed as well as the Hong Kong groups on measures of metapragmatic *** results are discussed in terms of Bialystok’s(1993)distinction between analyzed representation and control of processing.

关键词： pragmatic competence social context Hong Kong the Chinese mainland metapragmatic knowledge processing capacity

“建构它们的生存空间”:作为地理媒介实践的“助猫”研究

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热带地理 2024年第8期44卷 1487-1499页

作者：胡康斯科特·麦夸尔李昕恬北京外国语大学国际新闻与传播学院北京100087 墨尔本大学文化与传播学院墨尔本3010澳大利亚

流浪猫作为边缘动物活跃于人类的生存空间之中,数智技术的发展使人类围绕流浪猫所展开的混合性空间交互具有特殊的文化生产与人际互动意义。文章运用技术漫游、深度访谈等方法,结合媒介地理学中的地理媒介理论,对深度媒介化社会中的“... 详细信息

流浪猫作为边缘动物活跃于人类的生存空间之中,数智技术的发展使人类围绕流浪猫所展开的混合性空间交互具有特殊的文化生产与人际互动意义。文章运用技术漫游、深度访谈等方法,结合媒介地理学中的地理媒介理论,对深度媒介化社会中的“助猫实践”展开研究,主要考察助猫者如何建构媒介化助猫空间、以何种方式与流浪猫产生空间性交互、助猫空间中存在何种媒介化期待与解释、产生了哪些人际交往或矛盾,又会如何影响地点的形塑与认知。研究发现,人与媒介在动态交互中建构出突破虚实维度的助猫空间,人的“数字化漫游”、流浪猫的“超可见性”在其中上演;基于所建构的助猫空间,猫与猫屋的流动(转移、搬迁、拆除)伴随着人与空间的对话、协商与斗争,具有丰富的空间生产意义;助猫者凭借数字媒介在具有混合性质的助猫空间中与不同行动方相遇,同一或对立的关系在此过程中生成,编谱着地方性的记忆情结,折射出存在于社会的现实问题,乃至不同物种之间的共生问题。在此基础上,从理论层面对过往媒介地理学研究进行反思,细分出“技术型地理媒介”与“生命型地理媒介”,以拓展地理媒介的研究版图,并勾勒出人与流浪猫共生空间建构的机制。

关键词：地理媒介边缘动物流浪猫 “助猫” 生存空间生存意义

Region-specific microRNA signatures in the human epididymis

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Asian Journal of Andrology 2018年第6期20卷 539-544页

作者： James A Browne Shih-Hsing Leir scott e eggener Ann Harris Department of Genetics and Genome Sciences Case Western Reserve UniversityClevelandOH 44106USA Human Molecular Genetics Program Lurie Children＇s Research CenterChicagoIL 60614USA Department of Pediatrics Northwestern University Feinberg School of MedicineChicagoIL 60611USA Section of Urology University of Chicago Medical CenterChicagoIL 60611USA.

The epithelium of the human epididymis maintains an appropriate luminal environment for sperm maturation that is essential for male fertility. Regional expression of small noncoding RNAs such as microRNAs contributes to segment-specific gene expression and differentiated functions. MicroRNA profiles were reported in human epididymal tissues but not specifically in the epithelial cells derived from those regions. Here, we reveal miRNA signatures of primary cultures of caput, corpus, and cauda epididymis epithelial cells and of the tissues from which they were derived. We identify 324 epithelial cell-derived microRNAs and 259 tissue-derived microRNAs in the epididymis, some of which displayed regionalized expression patterns in cells and/or tissues. Caput cell-enriched miRNAs included miR-573 and miR-155. Cauda cell-enriched miRNAs included miR-1204 and miR-770. Next, we determined the gene ontology pathways associated with in silico predicted target genes of the differentially expressed miRNAs. The effect of androgen receptor stimulation on miRNA expression was also investigated. These data show novel epithelial cell-derived miRNAs that may regulate the expression of important gene networks that are responsible for the regionalized gene expression and function of the epididymis.

关键词： caput cauda corpus human epididymis microRNA

Numerical modeling of the effects of roughness on flow and eddy formation in fractures

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Journal of Rock Mechanics and Geotechnical engineering 2017年第1期9卷 105-115页

作者： scott Briggs Bryan W. Karney Brent e. Sleep University of Toronto Toronto M5S 1A4 Canada

The effect of roughness on flow in fractures was investigated using lattice Boltzmann method(LBM).Simulations were conducted for both statistically generated hypothetical fractures and a natural dolomite fracture. The effect of increasing roughness on effective hydraulic aperture, Izbash and Forchheimer parameters with increasing Reynolds number(Re) ranging from 0.01 to 500 was examined. The growth of complex flow features, such as eddies arising near the fracture surface, was directly associated with changes in surface roughness. Rapid eddy growth above Re values of 1, followed by less rapid growth at higher Re values, suggested a three-zone nonlinear model for flow in rough fractures. This three-zone model, relating effective hydraulic conductivity to Re, was also found to be appropriate for the simulation of water flow in the natural dolomite fracture. Increasing fracture roughness led to greater eddy volumes and lower effective hydraulic conductivities for the same Re values.

关键词： Hydrogeology Fracture flow Fracture roughness Computational fluid dynamics Lattice Boltzmann method(LBM)