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Vlodulation of ABA Signaling by Altering VxGФl Vlotif of PP2cs in Oryza sativa

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Molecular Plant 2017年第9期10卷 1190-1205页

作者： Seungsu Han

The abscisic acid （ABA） signaling pathway is regulated by clade A type 2c protein phosphatases （PP2cAs） in plants. In the presence of ABA, PP2cs release stress/ABA-activated protein kinases by binding to ABA-bound receptors （PYl/RcARs） for activation. Although the wedging tryptophan in PP2cs is critical in the interaction with PYl/RcARs in Arabidopsis and rice, it remains elusive as to how other interface regions are involved in the interaction. Here, we report the identification of a conserved region on PP2cs, termed the VxG4Фl motif, which modulates the interaction with PYl/RcARs through its second and fourth residues. The effects of the second and fourth residues on the interaction of OsPP2cS0 with several OsPYIJRcAR proteins were investigated by systematic mutagenesis. One OsPP2c50 mutant, VFGMl （＂FM＂） mutant, lowered the affinity to OsPYl/RcAR3 by Ф15-fold in comparison with the wUd-type. compar- ison of the crystal structures of wild-type OsPP2c50：ABA：OsPYI./RcAR3 with those composed of FM mutant revealed local conformational changes near the VxGФl motif, further supported by hydrogen-deute- rium exchange mass spectrometry. In rice protoplasts, ABA signaling was altered by mutations in the VxGФl motif. Transgenic Arabidopsis plants overexpressing OsPP2c50 and OsPP2c5OFM showed altered ABA sensitivity. Taken together, the VxGФl motif of PP2cs appears to modulate the affinity of PP2cs with PYl/RcARs and thus likely to alter the ABA signaling, leading to the differential sensitivity to ABA in planta.

关键词： ABA receptor type 2c protein phosphatase VxGФl motif Oryza sativa

Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats

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World Journal of Gastroenterology 2015年第25期21卷 7754-7763页

作者： Eugene chang lisa Kim Se Eun Park Eun-Jung Rhee Won-Young lee Ki-Won Oh Sung-woo Park cheol-Young Park Department of Nutritional Science and Food Management Ewha Womans University Diabetes Research Institute Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Division of Endocrinology and Metabolism Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

AIM: To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes. METHODS: Male age-matched lean control lETO and obese and diabetic OlETF rats were administered either PBS or ezetimibe(10 mg/kg per day) via stomach gavage for 20 wk. changes in weight gain and energy intake were regularly monitored. Blood and liver tissue were harvested after overnight fasting at the end of study. Histological assessment was performed in liver tissue. The concentrations of glucose, insulin, triglycerides(TG), free fatty acids(FFA), and total cholesterol(Tc) in blood and TG, FFA, and TG in livertissue were measured. m RNA and protein abundance involved in autophagy was analyzed in the liver. To investigate the effect of ezetimibe on autophagy and reduction in hepatic fat accumulation, human Huh7 hepatocytes were incubated with ezetimibe(10 μmol/l) together with or without palmitic acid(PA, 0.5 mmol/l, 24 h). Transmission electron microscopy(TEM) was employed to demonstrate effect of ezetimibe on autophagy formation. Autophagic flux was measured with bafilomycin A1, an inhibitor of autophagy and following immunoblotting for autophagy-related protein ***: In the OlETF rats that received ezetimibe(10 mg/kg per day), liver weight were significantly decreased by 20% compared to OlETF control rats without changes in food intake and body weight(P lipid parameters including TG, FFA, and Tc in liver tissue of ezetimibe-administrated OlETF rats were dramatically decreased at least by 30% compared to OlETF controls(P lucose, insulin, HOMA-IR, and lipid profiles were also improved by ezetimibe(P lated m RNA expression including ATG5, ATG6, and ATG7 and the protein level of microtubule-associated protein light chain 3(lc3) were significantly increased in the liver in rats that received ezetimibe(P likewise, for hepatocytes cultured in vitro,

关键词： Autophagy Ezetimibe Hepatic steatosis Nonalcoholic fatty liver disease

Efficacy and safety of vildagliptin/pioglitazone combination therapy in Korean patients with diabetes

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World Journal of Diabetes 2010年第5期1卷 153-160页

作者： Sun-woo Kim Sei Hyun Baik Kun Ho Yoon Hyoung woo lee claudia Filozof Kangbuk Samsung Hospital Korea University Guro Hospital catholic University Medical center Kangnam St.Mary's Hospital YeungNam University Medical center Novartis Pharma AG PostfachBaselCH-4002 Switzerland

AIM:To assess the efficacy and safety of vildagliptin/pioglitazone combination therapy in Korean patients with type 2 diabetes mellitus(T2DM).METHODS:This was a post hoc analysis in Korean patients,from a 24-wk,randomized,active-controlled,double-blind,parallel-group,multicenter *** patients were aged between 18 and 80 years,drug naive,and had been diagnosed with T2DM [hemoglobin A1c(HbA1c):7.5-11.0 and fasting plasma glucose(FPG):< 270 mg/dl(< 15 mmol/l)].Patients were randomized(1:1:1:1) to receive the vildagliptin/pioglitazone comb ination at 100/30 mg q.d.(high-dose) or 50/15 mg q.d.(low-dose),vildagliptin 100 mg q.d.,or pioglitazone 30 mg *** primary outcome measure was change in HbA1c from baseline to ***:The distribution of baseline demographic and clinical parameters was well balanced between treatment *** overall mean age,body mass index,HbA1c,FPG,and duration of disease were 50.8 years,24.6 kg/m2,8.6,10.1 mmol/l,and 2.2 years,*** mean changes(± standard error) in HbA1c from baseline(~8.7) to week 24 endpoint were-2.03 ± 0.16(high-dose,N = 34),-1.88 ± 0.15(low-dose,N = 34),-1.31 ± 0.21(vildagliptin,N = 36),and-1.52 ± 0.16(pioglitazone,N = 36).The high-dose combination therapy demonstrated greater efficacy than monotherapies [vildagliptin(P = 0.029) and pioglitazone(P = 0.027)].Percentage of patients achieving HbA1c < 7 and ≤ 6.5 was the highest in the high-dose group(76 and 68) followed by low-dose(58 and 47),vildagliptin(59 and 37),and pioglitazone(53 and 28) *** overall incidence of adverse events was ***:In Korean patients,first-line treatment with high-dose combination therapy improved glycemic control compared to pioglitazone and vildagliptin monotherapies,consistent with results published for the overall study population.

关键词： Type 2 diabetes mellitus Vildagliptin Pioglitazone

Pathologic Analysis of Glioblastoma Via Stereotactic Biopsies combined with Enhanced MR Images and ~11c-methionine PET

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Pathologic Analysis of Glioblastoma Via Stereotactic Biopsie...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Tae-Young Jung Shin Jung In-Young Kim Kyung-Sub Moon woo-Youl Jang Seung-Jin Park Young-Hee Kim Hyung-Seok Kim Jung-Joon Min Jahae Kim Departments of Neurosurgery Chonnam National University Research Institute of Medical Sciences chonnam National University Hwasun Hospital & Medical School GwangjuSouth Korea Departments of Brain Tumor Research laboratory Chonnam National University Research Institute of Medical Sciences Departments of Biomedical Engineering Chonnam National University Research Institute of Medical Sciences Departments of Pathology Chonnam National University Research Institute of Medical Sciences Departments of Nuclear Medicine Chonnam National University Research Institute of Medical Sciences

Objective:To obtain more representative biopsy specimens in glioblastoma,we combined MR stereotactic planning with 11c-methionine PET and analyzed the pathologic ***:From December 2009 to October 2010,we performed stereotactic biopsies in 12 patients with radiologically heterogeneous,ring-enhanced *** biopsied the MR enhanced lesions having higher 11c-methionine uptake and the MR non-enhanced lesions having lower uptake and analyzed differences in pathologic diagnoses between *** pathologic findings,including cell density,Ki-67 lI,microvessel density,and number of endothelial proliferations,were analyzed as correlating factors of the degree of 11c-methionine uptake（T/N ratio）.We performed immunohistochemical staining for l-amino acid transporter 1（lAT1） to demonstrate the correlation with T/N ratio and the pattern of ***:The final diagnosis of each specimen was *** T/N ratio correlated statistically with enhancement（p = 0.000）.The diagnostic failure rate was 33.3%（4/12 patients） when we selected only one MR enhanced,high 11c-methionine uptake lesion,and 40%（4/10 patients） when we selected one MR non-enhanced,low 11c-methionine uptake *** T/N ratio showed a statistical correlation with cell density depending on the degree of necrosis,lAT1 immunopositivity,microvessel density,number of endothelial proliferations,and Ki-67 lI（p = 0.002,0.032,0.057,0.24 and 0.741,respectively）.lAT1 was localized in the tumor cells,vascular endothelium,and the vicinity of endothelial ***:Multiple stereotactic biopsies combined with enhanced MR images and 11cmethionine PET could provide the diagnostic yield in glioblastoma,which mostly differing cell densities depending on the degree of necrosis.

关键词： biopsy 11c-methionine PET enhanced MRI glioblastoma lAT1 stereotaxic

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东加勒比群岛的概率地震危险性评估

世界地震译丛 2012年第3期43卷 29-58页

作者： F.Bozzoni M.corigliano c.G.lai W.Salazar l.Scandella E.Zuccolo J.latchman l.lynch R.Robertson 杨国栋(译) 袁道阳(译) 不详甘肃省地震局

完成了北边包括背风群岛(从安圭拉到多米尼加)和南边包括向风群岛(从马提尼克到格林纳达)、巴巴多斯、特立尼达和多巴哥的东加勒比地区(10°N～19°N,59°W～64°W)的地震危险性概率分析,计算了概率地震危险性图。该分析是用能够系统考... 详细信息

完成了北边包括背风群岛(从安圭拉到多米尼加)和南边包括向风群岛(从马提尼克到格林纳达)、巴巴多斯、特立尼达和多巴哥的东加勒比地区(10°N～19°N,59°W～64°W)的地震危险性概率分析,计算了概率地震危险性图。该分析是用能够系统考虑基于模型(即,认识的)不确定性及其对计算地震动参数影响的标准逻辑树方法进行的。我们使用0.025°空间分辨率的场点网格对研究岛屿的区域完成了地震危险性计算。采用了两种不同的计算方法:基于适当潜在发震区(SZ)定义的标准cornell-McGuire方法(cornell,1968;McGuire,1976)和由woo(1996)提出的克服了与震源定义有关的模糊的区域自由方法。我们认真仔细地研究了加勒比地区的浅地壳、板内和界面俯冲地震活动之间的相互作用和复杂性。通过合并所有可用的数据库,为这个地区编辑了一个更新综合目录。而且为确定在分析中使用最适宜的地震动预测方程也进行了认真仔细的调查研究。计算了4个重现期(RP)(95年、475年、975年和2475年)的地震动水平分量的统一危险谱和结构周期从0s到3s的22个谱加速度(SA)值。计算出2475年重现期0.2s和1.0s的谱加速度值后可以根据国际建筑规范确定研究区域的地震危险性(IBc,International code council[Icc],2009)。

关键词：地震危险性评估概率分析群岛加勒比地区地震危险性图空间分辨率地震动多米尼加

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超声弹性成像显示1786个不可触及的乳腺肿物:在决定活检方面的诊断价值

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国际医学放射学杂志 2012年第4期 395-395页

作者： Y. Ann c. Nariya M.c. Jung R.K. Hye l.Y. Bo K.M. woo 秦乃姗 Department of Radiology Seoul National University College of Medicine Seoul National University Hospital101 Daehangno Jongno-guSeoul110-744RepublicofKorea

摘要目的通过超声弹性成像与组织病理学的相关性,比较其与常规超声在决定活检方面的诊断价值。方法经组织病理学证实的1538名妇女共1786个不可触及的乳腺肿物(良性1523个,恶性263个)均进行常规超声成像及超声弹性成像,并进行BI-RADS分... 详细信息

摘要目的通过超声弹性成像与组织病理学的相关性,比较其与常规超声在决定活检方面的诊断价值。方法经组织病理学证实的1538名妇女共1786个不可触及的乳腺肿物(良性1523个,恶性263个)均进行常规超声成像及超声弹性成像,并进行BI-RADS分级及弹性评分。以决定活检为标准比较两种

关键词：乳腺肿瘤 B型超声超声弹性成像活检

Fungal diversity notes 603–708: taxonomic and phylogenetic notes on genera and species

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Fungal Diversity 2017年第6期87卷 1-235页

作者： Kevin D.Hyde chada Norphanphoun Vanessa P.Abreu Anna Bazzicalupo K.W.Thilini chethana Marco clericuzio Monika c.Dayarathne Asha J.Dissanayake Anusha H.Ekanayaka Mao-Qiang He Sinang Hongsanan Shi-Ke Huang Subashini c.Jayasiri Ruvishika S.Jayawardena Anuruddha Karunarathna Sirinapa Konta Ivana Kusan Hyun lee Junfu li chuan-Gen lin Ning-Guo liu Yong-Zhong lu Zong-long luo Ishara S.Manawasinghe Ausana Mapook Rekhani H.Perera Rungtiwa Phookamsak chayanard Phukhamsakda Igor Siedlecki Adriene Mayra Soares Danushka S.Tennakoon Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yuan-Pin Xiao Jing Yang Xiang-Yu Zeng Faten A.Abdel-Aziz Wen-Jing li Indunil c.Senanayake Qiu-Ju Shang Dinushani A.Daranagama Nimali Ide Silva Kasun M.Thambugala Mohamed A.Abdel-Wahab Ali H.Bahkali Mary l.Berbee Saranyaphat Boonmee D.Jayarama Bhat Timur S.Bulgakov Bart Buyck Erio camporesi Rafael F.castaneda-Ruiz Putarak chomnunti Minkwan Doilom Francesco Dovana Tatiana B.Gibertoni Margita Jadan Rajesh Jeewon E.B.Gareth Jones Ji-chuan Kang Samantha c.Karunarathna Young woon lim Jian-Kui liu Zuo-Yi liu Helio longoni Plautz Jr Saisamorn lumyong Sajeewa S.N.Maharachchikumbura Neven Matocec Eric H.c.McKenzie Armin Mesic Daniel Miller Julia Pawłowska Olinto l.Pereira Itthayakorn Promputtha Andrea I.Romero leif Ryvarden Hong-Yan Su Satinee Suetrong Zdenko Tkalcec Alfredo Vizzini Ting-chi Wen Komsit Wisitrassameewong Marta Wrzosek Jian-chu Xu Qi Zhao Rui-lin Zhao Peter E.Mortimer Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18Forlı`Italy centre of Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China college of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China college of life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Botany University of British ColumbiaVancouverCanada Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Department of crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityP.O.Box 34123 Al-KhodOman Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Department of Molecular Phylogenetics and Evolution Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsaw_Zwirki i Wigury 10102-089 WarsawPoland Departamento de Micologia Centro de BiocienciasUniversidade Federal de PernambucoAv.da Engenharia s/nRecifePernambuco 50760-600Brazil Dipartimento

This is the sixth in a series of papers where we bring collaborating mycologists together to produce a set of notes of several taxa of *** this study we introduce a new family Fuscostagonosporaceae in *** also introduce the new ascomycete genera Acericola,castellaniomyces,Dictyosporina and longitudinalis and new species Acericola italica,Alternariaster trigonosporus,Amarenomyces dactylidis,Angustimassarina coryli,Astrocystis bambusicola,castellaniomyces rosae,chaetothyrina artocarpi,chlamydotubeufia krabiensis,colletotrichum lauri,collodiscula chiangraiensis,curvularia palmicola,cytospora mali-sylvestris,Dictyocheirospora cheirospora,Dictyosporina ferruginea,Dothiora coronillae,Dothiora spartii,Dyfrolomyces phetchaburiensis,Epicoccum cedri,Epicoccum pruni,Fasciatispora calami,Fuscostagonospora cytisi,Grandibotrys hyalinus,Hermatomyces nabanheensis,Hongkongmyces thailandica,Hysterium rhizophorae,Jahnula guttulaspora,Kirschsteiniothelia rostrata,Koorchalomella salmonispora,longitudinalis nabanheensis,lophium zalerioides,Magnibotryascoma mali,Meliola clerodendri-infortunati,Microthyrium chinense,Neodidymelliopsis moricola,Neophaeocryptopus spartii,Nigrograna thymi,Ophiocordyceps cossidarum,Ophiocordyceps issidarum,Ophiosimulans plantaginis,Otidea pruinosa,Otidea stipitata,Paucispora kunmingense,Phaeoisaria microspora,Pleurothecium floriforme,Poaceascoma halophila,Periconia aquatica,Periconia submersa,Phaeosphaeria acaciae,Phaeopoacea muriformis,Pseudopithomyces kunmingnensis,Ramgea ozimecii,Sardiniella celtidis,Seimatosporium italicum,Setoseptoria scirpi,Torula gaodangensis and Vamsapriya *** also provide an amended account of Rhytidhysteron to include apothecial ascomata and a J?*** type species of Ascotrichella hawksworthii(Xylariales genera incertae sedis),Biciliopsis leptogiicola(Sordariomycetes genera incertae sedis),Brooksia tropicalis(Micropeltidaceae),Bryochiton monascus(Teratosphaeriaceae),Bryomyces scapaniae(Pseud

关键词： Ascomycota Basidiomycota Mucoromycota Phylogeny Taxonomy

An Earth-mass planet in a time of cOVID-19:KMT-2020-BlG-0414lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang cheongho Han Iona Kondo Jennifer c.Yee chung-Uk lee Andrew Gould Shude Mao leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok cha Dong-Jin Kim Hyoun-woo Kim Seung-lee Kim Dong-Joo lee Yongseok lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man cheung Alex li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BlG-0414 lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance Dl~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by cOVID-19(two KMT sites and OGlE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

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应用cAIPIRINHA-VIBE序列的团注DcE-MRI诊断胰腺恶性肿瘤的可行性

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国际医学放射学杂志 2017年第1期 103-103页

作者： J.Huh Y.choi D.c.woo N.Seo B.Kim c.K.lee 谢双双 Department of Radiology and Research Institute of radiology Asan Medical Center University of Ulsan College of Medicine

摘要目的评估应用cAIPIRINHA-VIBE序列的团注动态对比增强(DcE)MRI诊断胰腺恶性肿瘤的可行性。材料与方法 32例病人注射2 m l钆对比剂后应用cAIPIRINHA-VIBE

关键词： cAIPIRINHA-VIBE MRI DcE-MRI 团注恶性肿瘤胰腺序列