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Nonalcoholic Fatty Liver Disease(NAFLD)Name Change:Requiem or Reveille?

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 931-938页

作者： Shivaram P.Singh Prajna Anirvan Reshu khandelwal sanjaya k.satapathy Department of Gastroenterology Sriram Chandra Bhanj Medical CollegeCuttackOdishaIndia Division of Hepatology Sandra Atlas Bass Center for Liver Diseases and TransplantationDonald and Barbara Zucker School of Medicine at Hofstra/Northwell HealthManhassetNYUSA

Nonalcoholic fatty liver disease(NAFLD)affects about a quarter of the world’s population and poses a major health and economic burden ***,there have been hasty attempts to rename NAFLD to metabolic-associated fatty liver disease(MAFLD)despite the fact that there is no scientific rationale for *** for a“positive criterion”to diagnose the disease and destigmatizing the disease have been the main reasons put forth for the name change.A close scrutiny of the pathogenesis of NAFLD would make it clear that NAFLD is a heterogeneous disorder,involving different pathogenic mechanisms of which metabolic dysfunction-driven hepatic steatosis is only *** NAFLD with MAFLD would neither enhance the legitimacy of clinical practice and clinical trials,nor improve clinical care or move NAFLD research *** than changing the nomenclature without a strong scientific backing to support such a change,efforts should be directed at understanding NAFLD pathogenesis across diverse populations and ethnicities which could potentially help develop newer therapeutic options.

关键词： Heterogeneity MAFLD Metabolic NAFLD NASH Nomenclature Steatohepatitis

Non-alcoholic Fatty Liver Disease: A Review of Anti-diabetic Pharmacologic Therapies

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Journal of Clinical and Translational Hepatology 2018年第2期6卷 168-174页

作者： Heather S.Snyder Sami A.Sakaan katherine L.March Osama Siddique Rosann Cholankeril Carolyn D.Cummings Chiran Gadiparthi sanjaya k.satapathy Aijaz Ahmed George Cholankeril Department of Pharmacy Methodist University HospitalMemphisTNUSA College of Pharmacy University of Tennessee Health Science CenterMemphisTNUSA Department of Medicine Memorial Hospital of Rhode IslandProvidenceRIUSA Roger Williams Medical Center ProvidenceRIUSA Methodist University Hospital Transplant Institute University of Tennessee Health Sciences CenterMemphisTNUSA Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA

Non-alcoholic fatty liver disease(NAFLD),the most common cause of liver disease,affects approximately 75 to 100 million *** with concurrent NAFLD and type 2 dia-betes mellitus have a higher risk of progressing to advanced fibrosis and non-alcoholic steatohepatitis compared to *** modifications,including weight loss,remain the mainstay of treatment for NAFLD,as there are no med-ications currently indicated for this disease ***-diabetic pharmacologic therapies aimed at improving insulin sensitivity and decreasing insulin production have been studied to determine their potential role in slowing the progression of *** this review,we focus on the evidence surrounding anti-diabetic medications and their ability to improve disease progression in patients with NAFLD.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Diabetes mellitus

Performance and combustion study of a low heat rejection engine running with biogas–diethyl ether–diesel

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Waste Disposal and Sustainable Energy 2024年第1期6卷 151-162页

作者： sanjaya k.Mishra Premananda Pradhan Shakti P.Jena Department of Mechanical Engineering S‘O’A Deemed to be UniversityBhubaneswar751030India

The present research focuses on addressing the faster depletion of fossil fuels and environmental pollution in addition to the energy crisis that hinders the progress of a *** the current research,waste banana leaves were considered as substrates for biogas *** is taken as the primary fuel in dual fuel(DF)operations to maximize possible diesel *** performance and combustion assessment were executed in a low heat rejection(LHR)engine using 5%diethyl ether by volume blended with diesel(5DEE)as pilot *** combustion attributes of the engine reveal that the apex of net heat release rate(NHRR)curve retarded a bit as compared to apex of base *** peak cylinder pressure was noted to be 6.19 MPa in the LHR engine running with 5DEE+biogas at 11.7°crank angle(CA)after top dead center(aTDC)compared to 5.23 MPa for the diesel alone operation at the same *** apex point for NHRR was observed to be 54.51 J(°)^(−1)for 5DEE+biogas in LHR engine positioned at 3.2°*** brake thermal efficiency at full engine load operation decreased by 12.7%and 5.2%for biogas substitutions of 0.8 kg h^(−1)with diesel and 5DEE,respectively,compared to the base *** smoke opacity and nitric oxide emissions were reduced during the DF run accompanied by diethyl ether as a fuel additive.

关键词： Biogas Banana leaves Coating Diesel engine Diethyl ether Exhaust emissions

Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality

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World Journal of Transplantation 2024年第2期14卷 62-75页

作者： Faisal Inayat Pratik Patel Hassam Ali Arslan Afzal Hamza Tahir Ahtshamullah Chaudhry Rizwan Ishtiaq Attiq Ur Rehman kishan Darji Muhammad Sohaib Afzal Gul Nawaz Alexa Giammarino sanjaya k.satapathy Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Internal Medicine Saint Francis Hospital and Medical CenterHartfordCT 06105United States Division of Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine Campbell University and Cape Fear Valley Medical CenterFayettevilleNC 28301United States Department of Internal Medicine North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States Division of Hepatology North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States

BACkGROUND The coronavirus disease 2019(COVID-19)pandemic has posed a major public health concern *** with comorbid conditions are at risk of adverse outcomes following *** organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 *** could lead to higher rates of inpatient complications and mortality in this patient ***,studies on COVID-19 outcomes in liver transplant(LT)recipients have yielded inconsistent *** To evaluate the impact of the COVID-19 pandemic on hospital-related outcomes among LT recipients in the United *** We conducted a retrospective cohort study using the 2019–2020 National Inpatient Sample *** with primary LT hospitalizations and a secondary COVID-19 diagnosis were identified using the International Classi-fication of Diseases,Tenth Revision coding *** primary outcomes included trends in LT hospitalizations before and during the COVID-19 *** outcomes included comparative trends in inpatient mortality and transplant rejection in LT *** A total of 15720 hospitalized LT recipients were *** 0.8% of patients had a secondary diagnosis of COVID-19 *** both cohorts,the median admission age was 57 *** linear trends for LT hospitalizations did not differ significantly before and during the pandemic(P=0.84).The frequency of in-hospital mortality for LT recipients increased from 1.7% to 4.4% between January 2019 and December *** to the pre-pandemic period,a higher association was noted between LT recipients and in-hospital mortality during the pandemic,with an odds ratio(OR)of 1.69[95% confidence interval(CI):1.55-1.84),P<0.001].The frequency of transplant rejections among hospitalized LT recipients increased from 0.2%to 3.6% between January 2019 and December *** hospitalizations during the COVID-19 pandemic had a higher associ

关键词： Liver transplant recipients Solid organ transplantation COVID-19 Hospitalization Transplant rejection Mortality

Structural,optical and dielectric investigations on RECr_(0.85)Mn_(0.15)O_(3)(RE=Ho,Gd and Pr) nanoparticles

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Journal of Rare Earths 2024年第2期42卷 399-408,I0006页

作者： komal kanwar Sonali Pradhan S.satapathy Yugandhar Bitla Neeraj Panwar Department of Physics Central University of Rajasthan BandarsindrAjmer305817RajasthanIndia Laser Material Section HBNIRaja Ramanna Centre for Advanced TechnologyIndore452013India

We hereby report the room-temperature structural and optical characterization of RECr_(0.85)Mn_(0.15)O_(3)(RECMO,RE=Ho,Gd and Pr) compounds synthesized by the auto-combustion sol-gel *** low temperature dielectric properties are also *** RECMO compounds crystallize in an orthorhombic Pbnm symmetry with an average grain size range of 51-80 *** analysis reveals an increase in the structural distortion compared to that of the undoped bulk *** measurements exhibit a significant reduction in bandgap values for RECMO nanoparticles when compared with their undoped bulk ***,from the absorbance measurements various optical parameters such as skin depth,extinction coefficient,refractive index and optical conductivity were also *** dielectric analysis confirms the lower values of the dielectric permittivity and dielectric loss than those of their corresponding bulk *** conductivity versus frequency and temperature data are fitted according to the Jonscher's power law and Arrhenius law,*** small polaron hopping is responsible for the electric conduction in these *** tunability of the optical and dielectric properties as a result of substitution and particle size reduction makes these materials useful for various potential applications in photocatalysis,optoelectronics and low permittivity dielectrics.

关键词： Rare-earth orthochromites Nanoparticles Optical properties Dispersion parameters Dielectric properties Small polaron hopping

Impact of metabolic dysfunction-associated steatotic liver disease on COVID-19 hospitalizations:A propensity-matched analysis of the United States

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World Journal of Virology 2024年第1期13卷 51-60页

作者： Abdullah Sohail Hassam Ali Pratik Patel Subanandhini Subramanium Dushyant Singh Dahiya Amir H Sohail Manesh kumar Gangwani sanjaya k.satapathy Department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY11777United States Department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Section on Gastroenterology and Hepatology North Shore University Hospital and Long Island Jewish Medical CenterManhassetNY 11030United States

BACkGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),formally known as nonalcoholic fatty liver disease,is the most common chronic liver disease in the United *** with MASLD have been reported to be at a higher risk of developing severe coronavirus disease 2019(COVID-19)and ***,most studies are single-center studies,and nationwide data in the AIM To study the influence of MASLD on COVID-19 hospitalizations during the initial phase of the *** We retrospectively analyzed the 2020 National Inpatient Sample(NIS)database to identify primary COVID-19 hospitalizations based on an underlying diagnosis of MASLD.A matched comparison cohort of COVID-19 hospit-alizations without MASLD was identified from NIS after 1:N propensity score matching based on gender,race,and comorbidities,including hypertension,heart failure,diabetes,and *** primary outcomes included inpatient mortality,length of stay,and hospitalization *** outcomes included the prevalence of systemic *** A total of 2210 hospitalizations with MASLD were matched to 2210 hospitalizations without MASLD,with a good comorbidity ***,there was a higher prevalence of severe disease with more intensive care unit admissions(9.5%vs 7.2%,P=0.007),mechanical ventilation(7.2%vs 5.7%,P=0.03),and septic shock(5.2%vs 2.7%,P<0.001)in the MASLD cohort than in the non-MASLD ***,there was no difference in mortality(8.6%vs 10%,P=0.49),length of stay(5 d vs 5 d,P=0.25),and hospitalization costs(42081.5$vs 38614$,P=0.15)between the MASLD and non-MASLD *** The presence of MAFLD with or without liver cirrhosis was not associated with increased mortality in COVID-19 hospitalizations;however,there was an increased incidence of severe COVID-19 *** data(2020)predates the availability of COVID-19 vaccines,and many MASLD patients have since been *** will be interesting to see if these trends are

关键词： COVID-19 Metabolic dysfunction-associated steatotic liver disease Prevalence Hospital charges Inpatient resource utilization

Global trends in hepatitis C-related hepatocellular carcinoma mortality:A public database analysis(1999-2019)

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World Journal of Virology 2024年第1期13卷 69-83页

作者： Hassam Ali Fnu Vikash Vishali Moond Fatima khalid Abdur Rehman Jamil Dushyant Singh Dahiya Amir Humza Sohail Manesh kumar Gangwani Pratik Patel sanjaya k.satapathy Department of Internal Medicine/Gastroenterology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Internal Medicine Saint Peter's University Hospital/Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Department of Internal Medicine Quaid-e-Azam Medical CollegeBahawalpur 63100PunjabPakistan Department of Internal Medicine Samaritan Medical CentreWatertownMA 13601United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery New York University Winthrop HospitalNew YorkMineloaNY 11501United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY 11777United States Division of Hepatology Department of MedicineNorth Shore University HospitalManhassetNY 11030United States

BACkGROUND Hepatitis C is the leading cause of chronic liver disease worldwide and it significantly contributes to the burden of hepatocellular carcinoma(HCC).However,there are marked variations in the incidence and mortality rates of HCC across different geographical *** the advent of new widely available treatment modalities,such as direct-acting antivirals,it is becoming increasingly imperative to understand the temporal and geographical trends in HCC mortality associated with Hepatitis ***,gender disparities in HCC mortality related to Hepatitis C are a crucial,yet underexplored aspect that adds to the disease's global *** some studies shed light on gender-specific trends,there is a lack of comprehensive data on global and regional mortality rates,particularly those highlighting gender *** gap in knowledge hinders the development of targeted interventions and resource allocation *** The results of our study show an overall decline in the mortality rates of patients with hepatitis C-related HCC over the last two ***,females exhibited a remarkable decrease in mortality compared to ***,East Asia and the Pacific displayed a significant decline in mortality,while Europe and Central Asia witnessed an upward *** America and the Caribbean also experienced an increase in mortality ***,no significant difference was observed in the Middle East and North *** America exhibited a notable upward *** Asia and Sub-Saharan Africa significantly declined throughout the study *** raises the hope of identifying areas for implementing more targeted *** some progress,multiple challenges remain in meeting the WHO 2030 goal of eliminating viral hepatitis[24].

关键词： Carcinoma Hepatocellular Antiviral agents Global Burden of Disease Quality indicators Health care Liver neoplasms Hepatitis C Chronic hepatitis C

Emerging bedaquiline resistance:A threat to the global fight against drug-resistant tuberculosis

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Journal of Biosafety and Biosecurity 2024年第1期6卷 13-15页

作者： Prakasini satapathy Ramaiah Itumall Ahmad Neyazi Abdul Mobin Nabizai Taraki Mahalaqua Nazli khatib Shilpa Gaidhane Quazi Syed Zahiruddin Sarvesh Rustagi Mehrab Neyazi Center for Global Health Research Saveetha Medical College and HospitalSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Medical Laboratories Techniques Department AL-Mustaqbal University51001 HillahBabilIraq School of Management The Apollo UniversityChittoorAndhra Pradesh 517127India Afghanistan Center for Epidemiological Studies Afghanistan Division of Evidence Synthesis Global Consortium of Public Health and ResearchDatta Meghe Institute of Higher EducationWardhaIndia One Health Centre(COHERD) Jawaharlal Nehru Medical CollegeDatta Meghe Institute of Higher EducationWardhaIndia South Asia Infant Feeding Research Network(SAIFRN) Division of Evidence SynthesisGlobal Consortium of Public Health and ResearchDatta Meghe Institute of Higher EducationWardhaIndia School of Applied and Life Sciences Uttaranchal UniversityDehradunUttarakhandIndia

Bedaquiline resistance is increasingly observed in the treatment of rifampicin-resistant tuberculosis(TB),yet standardized regimens for managing bedaquiline-resistant TB are *** indicate a high proportion of bedaquiline-resistant cases have previously been treated for TB,and often involve strains resistant to *** monitoring of the culture status in patients receiving bedaquiline resistance treatment is *** such as experimental evolution,protein modeling,genome sequencing,and phenotypic analysis have been instrumental in identifying the mechanisms of bedaquiline ***,variants in the Rv0678 transcriptional repressor of the MmpS5-MmpL5 efflux system are linked to this type of *** probability estimates show promise in determining the genotypic–phenotypic association for bedaquiline resistance,suggesting potential utility in clinical *** research should explore the practical application of Bayesian probabilities in managing bedaquiline ***-based technologies are anticipated to play a vital role in the early detection and management of drug-resistant TB strains.

关键词： Bedaquiline Resistance Drug-Resistant Tuberculosis Quinolone Resistance

Aqueous-phase reforming of hydroxyacetone solution to bio-based H_(2)over supported Pt catalysts

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Green Energy & Environment 2024年第4期9卷 777-788页

作者： A.k.k.Vikla k.koichumanova Songbo He k.Seshan Joint International Research Laboratory of Circular Carbon Nanjing Tech UniversityNanjing211816China Faculty of Science and Technology University of Twente7500 AE EnschedeThe Netherlands CoRe Pro 9723 BL GroningenThe Netherlands

Aqueous-phase reforming(APR)is an attractive process to produce bio-based hydrogen from waste biomass streams,during which the catalyst stability is often challenged due to the harsh reaction *** this work,three Pt-based catalysts supported on C,AlO(OH),and ZrO_(2)were investigated for the APR of hydroxyacetone solution in afixed bed reactor at 225℃and 35 *** them,the Pt/C catalyst showed the highest turnover frequency for H_(2)production(TOF of 8.9 molH_(2)molPt^(-1)min^(-1))and the longest catalyst *** the AlO(OH)and ZrO_(2)supported Pt catalysts,the side reactions consuming H_(2),formation of coke,and Pt sintering result in a low H_(2)production and the fast catalyst *** proposed reaction pathways suggest that a promising APR catalyst should reform all oxygenates in the aqueous phase,minimize the hydrogenation of the oxygenates,maximize the WGS reaction,and inhibit the condensation and coking reactions for maximizing the hydrogen yield and a stable catalytic performance.

关键词： APR Hydroxyacetone TOF Bio-based H_(2) Support effect