检索结果-南通市图书馆

Targeted therapy in gastric cancer:Personalizing cancer treatment based on patient genome

World Journal of Gastroenterology 2014年第8期20卷 2042-2050页

作者： Sun min lim Jae Yun lim Jae Yong Cho Division of Medical Oncology Department of Internal MedicineSeverance HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Medical Oncology Gangnam Severance HospitalYonsei University College of MedicineSeoul 135-720South Korea

Gastric cancer is the second leading cause of cancerrelated deaths *** cytotoxic chemotherapy has limited efficacy for metastatic gastric cancer,with an overall survival of approximately ten *** advances in high-throughput technologies have enabled the implementation of personalized cancer therapy for high-risk *** use of such high-throughput technologies,including microarray and next generation sequencing,have promoted the discovery of novel targets that offer new treatment strategies for patients lacking other therapeutic *** molecular pathways are currently under investigation as therapeutic targets in gastric cancer,including those related to the epidermal growth factor receptor family,the mesenchymal-epithelial transition factor axis,and the phosphatidylinositol 3-kinase-AKTmammalian target of rapamycin *** in molecular diagnostic tools further support the discovery of new molecular *** exist,however;not all patients can be tested for biomarkers,and numerous challenges hamper implementation of targeted therapy in clinical ***,the scale of tumor genomic profiling is rapidly outpacing our ability to appropriately synthesize all the information in order to optimally refine patient ***,clinicians must continue to educate themselves regarding new tools and frameworks,and to utilize multidisciplinary team science,comprised of oncologists,geneticists,pathologists,biologists and bioinformaticians,to successfully implement this genomic approach therapeutically.

关键词： Gastric cancer Targeted therapy Biomarker Microarr

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatic resection vs percutaneous radiofrequency ablation of hepatocellular carcinoma abutting right diaphragm

引用

World Journal of Gastrointestinal Oncology 2019年第3期11卷 227-237页

作者： Kyoung Doo Song Hyo Keun lim Hyunchul Rhim min Woo Lee Tae Wook Kang Yong Han Paik Jong Man Kim Jae-Won Joh Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Department of Health Sciences and Technology SAIHSTSungkyunkwan University Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine

BACKGROUND It is usually difficult to adequately conduct percutaneous ultrasound-guided radiofrequency(RF) ablation for hepatocellular carcinomas(HCCs) abutting the diaphragm. Our hypothesis was that the subphrenic location of HCC could have an effect on the long-term therapeutic outcomes after hepatic resection and RF *** To compare the long-term therapeutic outcomes of hepatic resection and percutaneous RF ablation for HCCs abutting the *** A total of 143 Child-Pugh class A patients who had undergone hepatic resection(n = 80) or percutaneous ultrasound-guided RF ablation(n = 63) for an HCC(≤ 3 cm) abutting the right diaphragm were included. Cumulative local tumor progression(LTP), cumulative intrahepatic distant recurrence(IDR), disease-free survival(DFS), and overall survival(OS) rates were estimated. Prognostic factors for DFS and OS were analyzed. Complications were *** The cumulative IDR rate, DFS rate, and OS rate for the hepatic resection group and RF ablation group at 5 years were "35.9% vs 65.8%", "64.1% vs 18.3%", and"88.4% vs 68.7%", respectively. Hepatic resection was an independent prognostic factor for DFS(P ≤ 0.001; hazard ratio, 0.352; 95%CI: 0.205, 0.605; with RF ablation as the reference category); however, treatment modality was not an independent prognostic factor for OS. The LTP rate was 46.6% at 5 years for the RF ablation group. The major complication rate was not significantly different between the groups(P = 0.630). The rate of occurrence of peritoneal seeding was higher in the RF ablation group(1.3% vs 9.5%, P = 0.044).CONCLUSION Although OS was not significantly different between patients who had gone hepatic resection or percutaneous RF ablation for HCCs abutting the diaphragm,DFS was better in the hepatic resection group.

关键词： Hepatic resection Radiofrequency ablation Hepatocellular carcinoma Diaphragm Treatment outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mpulse Breakdown Strength of Nano-ZnO/XLPE Nanocomposite Material on Temperature Rise

引用

Modeling and Numerical Simulation of Material Science 2013年第1期3卷 28-29页

作者： min-Hae Park Kee-Joe lim Department of Electrical Engineering Chungbuk National University Cheongju Republic of Korea

Development of new materials using composite materials has been much interest. XLPE is a kind of power cable in high voltage insulation. Recently research for cable insulating material has shown that nano-size filler added to XLPE is electrically and physically stable. In this paper, Impulse strength was measured in XLPE that composite by adding na-no-ZnO with different mass proportions. There is positive and negative impulse voltage. However, there is no differ-ence between them on the film specimen. Therefore we tested only positive voltage. In order to understand temperature properties of XLPE nanocomposite sample, experiment of impulse breakdown strength were measured at room temper-ature and maximum allowable temperature (90℃). From this result, it can be considered that the breakdown strength of addition of

关键词： XLPE Nano Composite Nano-ZnO Impulse Breakdown Strength

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In-situ formation of MOF derived mesoporous Co3N/amorphous N-doped carbon nanocubes as an efficient electrocatalytic oxygen evolution reaction

引用

Nano Research 2019年第7期12卷 1605-1611页

作者： Bong Kyun Kang Seo Young Im Jooyoung Lee Sung Hoon Kwag Seok Bin Kwon SintayehuNibret Tiruneh min-Jun Kim Jung Ho Kim Woo Seok Yang Byungkwon lim Dae Ho Yoon Nano Materials and Components Research Center Korea Electronics Technology InstituteSeongnam 463-816Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University Suwon 440-746Republic of Korea Advanced Materials & Processing Center Institute for Advanced Engineering (IAE)Yongin 175-28Republic of Korea Australian Institute for Innovative Materials (AIIM) University of WollongongSquires WayNorth Wollongong NSW 2500Australia Department of Advanced Materials Engineering for Information and Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do17104Republic of Korea

The suitable materials,metal nitrides,are a promising class of electrocatalyst materials for a highly efficient oxygen evolution reaction (OER) because they exhibit superior intrinsic conductivity and have higher sustainability than oxide-based *** our knowledge,for the first time,we report a designable synthesis of three-dimensional (3D) and mesoporous Co3N@ amorphous N-doped carbon (AN-C) nanocubes (NCs) with well-controlled open-framework structures via monodispersed Co3[Co(CN)6]2 Prussian blue analogue (PBA) NC precursors using in situ nitridation and calcination ***3N@AN-C NCs (2 h) demonstrate better OER activity with a remarkably low Tafel plot (69.6 mV-dec-1),low overpotential of 280 mV at a current density of 10 ***,excellent cycling stability in alkaline electrolytes was exhibited without morphological changes and voltage elevations,superior to most reported hierarchical structures of transition-metal nitride *** presented strategy for synergy effects of metal-organic frameworks (MOFs)-derived transition-metal nitrides-carbon hybrid nanostructures provides prospects for developing high-performance and advanced electrocatalyst materials.

关键词： transition-metal nitride metal organic framework mesoporous oxygen evaluation reaction alkaline water electrolysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research Achievements of High Power Laser Technology and Their Applications

Research Achievements of High Power Laser Technology and The...

引用

长三角光子科技创新论坛暨2006年安徽博士科技论坛

作者： Li Hyo min Kim Chol lim sang min Jong Dae Song Hong Song Chong Ryu Myong Su Pak Sung Gwon Ri sang Ryol Kim Jong Hyok China-Korea Friendship laser laboratory Institute of High power Laser Technology University of Science and Technology of China

1 Introduction Since 1984,the scientific and technological exchanges have been made between the scientists of the University of Natural Sciences(UNS),D.P.R.K and University of Science and Technology of China (USTC).Th...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Optimal postoperative surveillance strategies for stage III colorectal cancer

引用

World Journal of Gastrointestinal Surgery 2021年第9期13卷 1012-1024页

作者： min Young Park In Ja Park Hyo Seon Ryu Jay Jung minsung Kim Seok-Byung lim Chang Sik Yu Jin Cheon Kim Colon and Rectal Surgery Asan Medical CenterSeoul 05505South Korea Colon and Rectal Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Optimal surveillance strategies for stage III colorectal cancer(CRC)are lacking,and intensive surveillance has not conferred a significant survival *** To examine the association between surveillance intensity and recurrence and survival rates in patients with stage III *** Data from patients with pathologic stage III CRC who underwent radical surgery between January 2005 and December 2012 at Asan Medical Center,Seoul,Korea were retrospectively *** consisted of abdominopelvic computed tomography(CT)every 6 mo and chest CT annually during the 5 year follow-up period,resulting in an average of three imaging studies per *** who underwent more than the average number of imaging studies annually were categorized as high intensity(HI),and those with less than the average were categorized as low intensity(LI).RESULTS Among 1888 patients,864(45.8%)were in HI ***,sex,and location were not different between *** group had more advanced T and N stage(P=0.002,0.010,each).Perineural invasion(PNI)was more identified in the HI group(21.4%vs 30.3%,P<0.001).The mean overall survival(OS)and recurrence-free interval(RFI)was longer in the LI group(P<0.001,each).Multivariate analysis indicated that surveillance intensity[odds ratio(OR)=1.999;95%confidence interval(CI):1.680–2.377;P<0.001],pathologic T stage(OR=1.596;95%CI:1.197–2.127;P=0.001),PNI(OR=1.431;95%CI:1.192–1.719;P<0.001),and circumferential resection margin(OR=1.565;95%CI:1.083–2.262;P=0.017)in rectal cancer were significantly associated with *** mean post-recurrence survival(PRS)was longer in patients who received curative resection(P<0.001).Curative resection rate of recurrence was not different between HI(29.3%)and LI(23.8%)groups(P=0.160).PRS did not differ according to surveillance intensity(P=0.802).CONCLUSION Frequent surveillance with CT scan do not improve OS in stage III CRC *** need to evaluate role of other surveillance method rather tha

关键词： Colorectal cancer Surveillance intensity Survival Recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

别有洞天——首尔PANAM旗舰店

引用

现代装饰 2022年第6期 24-29页

作者： Sung chul Park Areum Han Soo Jeong lim Sung Young Heo min Ju Lee sang Hee Park Jae Sung LEE(摄影) Tak Hyun Kim(摄影) 范嘉苑(编译) 不详

位于首尔的圣水洞(Seongsu-dong)绝对是韩国近年最火的热门地区之一。从前,圣水洞到处都是制造商店,包括印刷店、手工鞋店及皮革行业。如今,却吸引了很多MZ世代的年轻人前去,因为圣水洞与其他地方不同,它将过去与现在和谐结合,形成了独... 详细信息

位于首尔的圣水洞(Seongsu-dong)绝对是韩国近年最火的热门地区之一。从前,圣水洞到处都是制造商店,包括印刷店、手工鞋店及皮革行业。如今,却吸引了很多MZ世代的年轻人前去,因为圣水洞与其他地方不同,它将过去与现在和谐结合,形成了独树一帜的文化。这里汇集了各种各样的商业空间,既有由旧工厂和仓库改造的商店,又有融合该地区特色的新生空间,使之拥有了与众不同的独特氛围,许多国际知名品牌也在此开设旗舰店,无疑成为拥有众多时尚品牌的热门区域。

关键词：皮革行业商业空间国际知名品牌仓库改造时尚品牌旗舰店首尔过去与现在

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model

引用

Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 653-658页

作者： Sung min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae lim Kim Kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le Interdisciplinary Program of Biomodulation Myongji UniversityYonginGyeonggi 17058Republic of Korea Center for Nutraceutical and Pharmaceutical Materials Myongji UniversityYonginGyeonggi 17058Republic of Korea Teazen Co. B-606 Acrotower230 Sinim-daeroDongan-guAnyang-siGyeonggi-do 14067Republic of Korea Department of Food Science&Biotechnology Shin Ansan UniversityAnsanGyeonggi 15435Republic of Korea' Division of Bioscience and Bioinformatics Myongji UniversityYonginGyeonggi 17058Republic of Korea Department of Biotechnology Chonnam National UniversityYeosuChonnam 59626Republic of Korea

Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer.

关键词： Immune system enhancement Cyclophosphamide Cornus officinalis Sieb Et Zucc Eriobotrya japonica Lindley Olive leaves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

阴道毛滴虫的分泌产物降低小鼠精子的体外受精能力

引用

Asian Journal of Andrology 2015年第2期17卷 319-323,I0012页

作者： Jaesook Roh Young-Su lim min-Young Seo Yuri Choi Jae-Sook Ryu Department of Anatomy and Cell Biology Laboratory of Reproductive Endocrinology College of Medicine Hanyang University Seoul Korea Department of Anesthesiology and Pain Medicine St. Mary's Hospital Catholic University Incheon Korea Department of Environmental Biology and Medical Parasitology College of Medicine Hanyang University Seoul Korea.

Trichomonas vaginalis infection is one of the most prevalent sexually transmitted infections in humans and is now recognized as an important cause of infertility in men. There is little information about the effect of extracellular polymeric substances （EPS） from T. vaginalis on sperm, but previous reports do not provide a conclusive description of the functional integrity of the sperm. To investigate the impact of EPS on the fertilizing capacity of sperm, we assessed sperm motility, acrosomal status, hypo-osmotic swelling, and in vitro fertilization rate after incubating the sperm with EPS in vitro using mice. The incubation of sperm with EPS significantly decreased sperm motility, viability, and functional integrity in a concentration and time-dependent manner. These effects on sperm quality also resulted in a decreased fertilization rate in vitro. This is the first report that demonstrates the direct negative impact of the EPS of T. vaginalis on the fertilization rate of sperm in vitro. However, further study should be performed using human sperm to determine if EPS has similar negative impact on human sperm fertilizing capacity in vitro.

关键词： extracellular polymeric substances fertilization sperm Trichomonas vaginalis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

直肠癌根治术中的盆腔自主神经保护:30年变迁

引用

Gastroenterology Report 2016年第3期4卷 173-185,I0001页

作者： min-Hoe Chew Yu-Ting Yeh Evan lim Francis Seow-Choen Department of Colorectal Surgery Singapore General HospitalSingapore Singhealth Academy Singapore General HospitalSingapore Seow-Choen Colorectal Centre Singapore

全直肠系膜切除(TME)理念及微创技术(如腹腔镜结直肠手术和机器人手术)的出现大大提高直肠癌的外科疗效。然而,术后排尿功能和性功能障碍率仍然较高,从而给患者造成巨大的痛苦,同时也会给手术医生带来困扰。新辅助和辅助放疗应用的增多... 详细信息

全直肠系膜切除(TME)理念及微创技术(如腹腔镜结直肠手术和机器人手术)的出现大大提高直肠癌的外科疗效。然而,术后排尿功能和性功能障碍率仍然较高,从而给患者造成巨大的痛苦,同时也会给手术医生带来困扰。新辅助和辅助放疗应用的增多也带来了更多的功能问题。在本文中,我们对盆腔神经解剖的目前认识进行了评价,将盆腔神经分为肠系膜下动脉根部、侧盆壁及泌尿生殖器官周围等区域,探讨了在这些区域如何进行手术操作。同时,我们也讨论了过去30年不同手术方式(包括开腹、腹腔镜和机器人)的功能状况。

关键词：全直肠系膜切除术盆腔自主神经保护排尿功能障碍性功能障碍

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：