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World Journal of Gastroenterology 2007年第8期13卷 1292-1294页

作者： Aspasia s soultati s.yridon p dourakis.alexandra alexopoulou Melanie Deutsch Athanasios J Archimandritis 2nd Department of Internal Medicine University of Athens Medical School Hippokration General Hospital 114 Vas Sofias Avenues Athens 11527 Greece

Classical interferon-alpha has been shown to be correlated with the development of a variety of autoimmune disorders. A 38 year-old female patient developed simultaneously diabetic ketoacidosis and hyperthyroidism 5 mo following initiation of treatment with pegylated interferon-α and ribavirin for chronic hepatitis C. High titers of glutamic acid decarboxylase, antinuclear and thyroid (thyroid peroxidase and thyroglobulin) antibodies were detected. Antiviral treatment was withdrawn and the patient was treated with insulin for insulin-dependent diabetes mellitus and propranolol for hyperthyroidism. Twelve months after cessation of pegylated interferon-α therapy the patient was euthyroid without any medication but remained insulin-dependent.

关键词： Autoimmune thyroiditis Insulin dependent diabetes mellitus pegylated interferon-alpha Chronic hepatitis C

predicting utility of a model for end stage liver disease in alcoholic liver disease

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World Journal of Gastroenterology 2006年第25期12卷 4020-4025页

作者： Aspasia s soultati s.yridon p dourakis.alexandra alexopoulou Melanie Deutsch Larissa Vasilieva Athanasios J Archimandritis 2nd Department of Internal Medicine University of Athens Medical school Hippokration General Hospital114 Vas Sofias AvenuesAthens 11527Greece

AIM： To validate the statistic utility of both the Maddrey Discriminant Function score and the Model for End-stage Liver Disease as predictors of short term （30 d and 90 d） mortality in patients with alcoholic hepatitis and to assess prognostic factors among clinical characteristics and laboratory variables of patients with alcoholic hepatitis. METHODs： Thirty-four patients with the diagnosis of alcoholic hepatitis admitted to Hippokration University Hospital of Athens from 2000 to 2005 were assessed in the current retrospective study and a statistical analysis was conducted. REsULTs： 30- and 90-d mortality rates were reported at 5.9% （2/34） and 14.7% （5/34）, respectively. significant correlation was demonstrated for the Model for End- stage Liver Disease （p30 = 0.094, p90 = 0.046） and the Maddrey Discriminant Function score （p30 = 0.033, p90 = 0.038） with 30- and 90-d mortality whereas a significant association was also established for alanine aminotrans- ferase （p = 0.057）, fibrin degradation products （p = 0.048） and C-reactive protein （p = 0.067） with 90-d mortality. For 30-d mortality the Area Under the Curve was 0.969 （95%CI： 0.902-1.036, p = 0.028） for the Model for End-stage Liver Disease score and 0.984 （95%CI： 0.942-1.027, p = 0.023） for the Maddrey Discriminant Function score with the optimal cut off point of 30.5 （sensitivity 1, specificity 0.937） and 108.68 （sensitivity 1, specificity 0.969）, respectively. Accordingly, for 90-d mortality the Area Under the Curve was 0.762 （95%CI： 0.559-0.965, p = 0.065） for the Model for End-stage Liver Disease score and 0.752 （95%CI： 0.465-1.038, p = 0.076） for the Maddrey Discriminant Function score with the optimal cut off point of 19 （sensitivity 0.6, specificity 0.6） and 92 （sensitivity 0.6, specificity 0.946）, respectively. The observed Kaplan Meier survival rates for different score-categories were compared with logrank tests and higher score values were correlated with a lower survival. CONCLUsION： Equivale

关键词： Alcoholic liver disease Alcoholic hepatitis Maddrey discriminant function score Model for end-stage liver disease score

*** model of riboflavin transporter deficiency(RTD)disorder reveals deficits in synaptic transmission and movement

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Genes & Diseases 2024年第4期11卷 120-123页

作者： Ramesh K.Narayanan Gonzalo perez-siles Kamila A.Marzec alexandra Boyling Brent Neumann Manoj p.Menezes Marina L.Kennerson Northcott Neuroscience Laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia sydney Medical school University of SydneySydneyNSw 2050Australia ANZAC Research Institute-sydney Local Health District SydneyNSW 2139Australia Neuroscience program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY Nelson Department of Neurology and Neurosurgery and Kids Neuroscience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia paediatrics and Child Health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine Laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin transporter deficiency(RTD),previously known as Brown-Vialetto-Van Laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle weakness,optic atrophy,and respiratory *** in sLC52A2 and sLC52A3,solute carrier family members that encode riboflavin(RF)transporters RFVT2 and RFVT3,are known to cause RTD types 2 and 3,respectively.

关键词： RTD degeneration TD

Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia

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World Journal of Gastroenterology 2016年第15期22卷 4049-4056页

作者： alexandra alexopoulou Larisa Vasilieva Danai Agiasotelli Kyriaki siranidi sophia pouriki Athanasia Tsiriga Marina Toutouza s.yridon p dourakis Department of Internal Μedicine Hippokration Hospital Medical School National and Kapodistrian University of Athens 11527 Athens Greece Department of Microbiology Hippokration Hospital 11527 Athens Greece

AIM: To evaluate the epidemiology and outcomes of culture-positive spontaneous bacterial peritonitis (sBp) and spontaneous bacteremia (sB) in decompensated ***: We prospectively collected clinical, laboratory characteristics, type of administered antibiotic, susceptibility and resistance of bacteria to antibiotics in one hundred thirty cases (68.5% males) with positive ascitic fluid and/or blood cultures during the period from January 1, 2012 to May 30, 2014. All patients with sBp had polymorphonuclear cell count in ascitic fluid > 250/mmsup>3sup>. In patients with sB a thorough study did not reveal any other cause of bacteremia. The patients were followed-up for a 30-d period following diagnosis of the infection. The final outcome of the patients was recorded in the end of follow-up and comparison among 3 groups of patients according to the pattern of drug resistance was ***: Gram-positive-cocci (GpC) were found in half of the cases. The most prevalent organisms in a descending order were Escherichia coli (33), Enterococcus spp (30), streptococcus spp (25), Klebsiella pneumonia (16), s. aureus (8), pseudomanas aeruginosa (5), other Gram-negative-bacteria (GNB) (11) and anaerobes (2). Overall, 20.8% of isolates were multidrug-resistant (MDR) and 10% extensively drug-resistant (XDR). Health-care-associated (HCA) and/or nosocomial infections were present in 100% of MDR/XDR and in 65.5% of non-DR cases. Meropenem was the empirically prescribed antibiotic in HCA/nosocomial infections showing a drug-resistance rate of 30.7% while third generation cephalosporins of 43.8%. Meropenem was ineffective on both XDR bacteria and Enterococcus faecium (E. faecium). All but one XDR were susceptible to colistin while all GpC (including E. faecium) and the 86% of GNB to tigecycline. Overall 30-d mortality was 37.7% (69.2% for XDR and 34.2% for the rest of the patients) (log rank, p = 0.015). In multivariate analysis, factors adversely affecting

关键词： spontaneous bacterial peritonitis spontaneous bacteremia Multidrug-resistant bacteria Extensively drug-resistant bacteria susceptibility to antibiotics

Effect of vaccinations and school restrictions on the spread of COVID-19 in different age groups in Germany

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Infectious Disease Modelling 2024年第4期9卷 1250-1264页

作者： Christiane Dings Dominik selzer Nicola Luigi Bragazzi Eva Mohler Markus Wenning Thomas Gehrke Ulf Richter alexandra Nonnenmacher Folke Brinkmann Tobias Rothoeft Michael Zemlin Thomas Lücke Thorsten Lehr Department of Clinical pharmacy Saarland University66123SaarbrückenGermany Department of Child and Adolescent psychiatry Saarland University Hospital66421HomburgGermany Medical Association Westfalen-Lippe48151MünsterGermany school of Education and psychology Siegen University57072SiegenGermany University Children's Hospital Ruhr University44791BochumGermany University Children's Hospital Airway Research Center North(ARCN)German Center for Lung Research(DZL)LübeckGermany Department of General pediatrics and Neonatology Saarland University Hospital66421HomburgGermany

With the emergence of sARs-CoV-2,various non-pharmaceutical interventions were adopted to control virus transmission,including school ***,the introduction of vaccines mitigated not only disease severity but also the spread of *** study leveraged an adapted sIR model and non-linear mixed-effects modeling to quantify the impact of remote learning,school holidays,the emergence of Variants of Concern(VOCs),and the role of vaccinations in controlling sARs-CoV-2 spread across 16 German federal states with an age-stratified *** highlight a significant inverse correlation(spearman's ρ=0.92,ps and peak incidence rates across all age ***-parameter estimation using the observed number of cases stratified by federal state and age allowed to assess the effects of school closure and holidays,considering adjustments for vaccinations and spread of VOCs over ***,modeling revealed significant(ps in the virus's spread among pre-school children(0-4),children(5-11),adolescents(12-17),adults(18-59),and the elderly(60+).The transition to remote learning emerged as a critical measure in significantly reducing infection rates among children and adolescents(ps an increased infection risk was noted among the elderly during these periods,suggesting a shift in infection networks due to altered caregiving ***,during school holiday periods,infection rates among adolescents mirrored those observed when schools were *** exercises based on the model provided evidence that COVID-19 vaccinations might serve a dual purpose:they protect the vaccinated individuals and contribute to the broader community's safety.

关键词： COVID-19 Vaccination Non-pharmaceutical interventions Age Mathematical modeling

Clinical and Demographic profile of Women with Uterine Fibroids Living in puerto Rico

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1347-1362页

作者： Edwin Y. soto-Velázquez Alexander J. Jaramillo-Cañas shania N. Aponte-paris Gabriela V. Martínez-Marrero Irazu s. Guinan Gabrielle A. Rivera-Maldonado alexandra Novas pedro L. Cruz-Rosa Idhaliz Flores-Caldera Maricarmen Colón-Diaz Department of physiology and pathology San Juan Bautista School of Medicine Caguas Puerto Rico United States ponce Research Institute Ponce Health Sciences University Ponce Puerto Rico United States

Introduction: Uterine leiomyomas, or fibroids, are prevalent benign tumors affecting up to 70% of reproductive-age women in the United states, significantly impacting productivity and quality of life. Despite their commonality, the epidemiology and clinical patterns of leiomyomas in puerto Rico remain inadequately researched. Methods: This study conducted a secondary data analysis using clinical, menstrual cycle characteristics, and demographic data from self-administered questionnaires of women undergoing diagnostic laparoscopy for endometriosis in puerto Rico. Chi-square tests and t-tests analyzed categorical and continuous variables, respectively (p Results: Among 1,610 endometriosis cases, 312 included uterine fibroids. prevalence estimates were 10.3% (40 years). primiparous women averaged 22.14 years, with 40.71% having 2 - 3 pregnancies and 26.28% experiencing miscarriages. symptoms included infertility (29.5%), dyspareunia (40.7%), severe pain (50%), and dysmenorrhea (75.6%). Comorbidities included ovarian cysts (52.2%) and abnormal uterine bleeding (37.8%). Conclusions: Advanced age, parity, and comorbidities like diabetes and hypertension were prevalent in our cohort. Understanding the epidemiological profile of women living in puerto Rico with uterine fibroids is crucial for improving diagnostic awareness and enhancing patient care.

关键词： Uterine Fibroids puerto Rico Epidemiology Dysmenorrhea Abnormal Uterine Bleeding

pET-modified red mud as catalysts for oxidative desulfurization reactions

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Journal of Environmental sciences 2017年第7期29卷 312-320页

作者： Nayara T.do prado Ana p.Heitmann Herman s.Mansur alexandra A.Mansur Luiz C.A.Oliveira Cinthia s.de Castro Department of Chemistry Federal University of Minas GeraisAv.Antonio Carlos 6627Campus Pampulha31270-901BH-MGBrazil Department of Metallurgical and Materials Engineering Au.Antonio Carlos 6627Campus Pampulha31270-901BH-MGBrazil

This work describes the synthesis of catalysts based on red mud/polyethylene terephthalate（pET） composites and their subsequent heat treatment under N2 *** materials were characterized by scanning electron microscopy（sEM）,temperature programmed reduction（TpR）,Fourier transform infrared spectroscopy（FT–IR）,X-ray diffraction（XRD）,thermogravimetric（TG） analysis and N2adsorption/*** catalysts were evaluated in the oxidative desulfurization reaction of dibenzothiophene（DBT） in a biphasic *** results indicated that the pET impregnation on red mud increased the affinity of the catalyst with the nonpolar phase（fuel）,in which the contaminant was dissolved,allowing a higher conversion（up to 80%） and selectivity to the corresponding dibenzothiophene *** sulfone compound is more polar than DBT and diffused into the polar solvent as indicated by the data obtained via gas chromatography–mass spectrometry（GC–Ms）.

关键词： Red mud pET Dibenzothiophene Desulfurization Dibenzothiophene sulfone

Biomarkers of hypoxic-ischemic encephalopathy:a systematic review

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World Journal of pediatrics 2023年第6期19卷 505-548页

作者： Ines Caramelo Margarida Coelho Miguel Rosado Carla M.p.Cardoso alexandra Dinis Carlos B.Duarte Mario Graos Bruno Manadas CNC-Center for Neuroscience and Cell Biology University of Coimbra3004‑504 CoimbraPortugal phD programme in Experimental Biology and Biomedicine Institute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry Department Faculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal stemlab sA 3060‑197 CantanhedePortugal pediatric Intensive Care Unit Hospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life sciences University of Coimbra3001‑401 CoimbraPortugal Biocant Technology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)3030‑789 CoimbraPortugal

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement ***,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(pROspERO ID:CRD42021272610).Data sources searches were performed in pubMed,Web of science,and science Direct databases until November *** original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were *** was assessed by the Newcastle–Ottawa *** search and data extraction were verified by two authors *** From 373 papers,30 met the inclusion *** from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and s100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal *** addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic ***,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to *** Neuron-specific enolase and s100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy ***,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.

关键词： Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase s100-calcium-binding protein-B

post-dispersal seed predation of three grassland species in a plant diversity experiment

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Journal of plant Ecology 2013年第6期6卷 468-479页

作者： Gesine pufal alexandra-Maria Klein Institute of Ecology Leuphana UniversityScharnhorststr.121335 LüneburgGermany

Aims post-dispersal seed predation is an important ecosystem process because it can influence the seed’s fate after the initial dispersal from the mother plant and subsequently transform *** at small scales,post-dispersal seed predation can vary greatly depending on seed identity,granivorous taxa or microhabitat ***,little is known about the role of plant species richness and functional group richness in post-dispersal seed *** overall aim of this study was to test whether increasing plant species richness or plant functional group richness affects the rate and variability of post-dispersal seed *** additionally investigated the influence of vegetation structure and seed species identity on the rate and variability of post-dispersal seed predation and whether the influence of different granivorous taxa changed with increasing plant species *** We conducted seed removal experiments along a long-term experimental plant diversity gradient,comprising plots with monocultures to 60 species mixtures of common grassland species in Jena,Germany,in August *** studied seeds of Onobrychis viciifolia,pastinaca sativa and Trifolium pratense in exclusion experiments(seed cafeterias),an experimental setup that allowed access either for arthropods or slugs or for all granivorous ***,seeds removed from seed cafeterias were classified as consumed but we used traceable fluorescent-coloured seeds to obtain more accurate predation rates by subtracting recovered seeds from overall removed *** effect of multiple vegetation variables on mean and variability of seed predation rates was analysed using generalized mixed-effect models and linear regressions,*** Findings Rates of recovered seeds were low but contributed to significant differences between seed predation rates and removal rates of seeds in some *** predation rates were not directly correlated with increasing plant spe

关键词： arthropods cafeteria-style experiments ecosystem functions granivorous taxa slugs

Treating refractory depression in parkinson’s disease:a meta-analysis of transcranial magnetic stimulation

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Translational Neurodegeneration 2018年第1期7卷 75-80页

作者： alexandra M.Lesenskyj Megan p.samples Jill M.Farmer Christina R.Maxwell Rowan University school of Osteopathic Medicine StratfordNJ 08048USA Drexel Neurosciences Institute 245 N 15th Street ms 423PhiladelphiaPA 19102USA

Background:parkinson’s disease(pD)is often accompanied by clinically identified *** effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to *** this reason,alternatives to standard anti-depressant treatments,such as repetitive transcranial magnetic stimulation(rTMs),have been evaluated within the parkinson’s ***:A literature search was conducted on the pubMed database for all studies that evaluated rTMs as a treatment in patients with both depression and pD.A meta-analysis was performed on all studies that reported mean pre-and post-rTMs depression inventory *** used depression inventories included both self-report and clinician-administered *** size for individual study groups and across all studies was ***:six of 7 studies meeting inclusion criteria reported significantly improved depression scores,large effect sizes,and significant *** weighted average effect size was calculated at 1.32 across all study groups that applied ***:Across all but one study,rTMs appears to effectively reduce depression scores among self-reported and clinician administered *** total weight average effect size showed that,when considering study sample sizes and degree of findings,this form of neurostimulation can relieve pD patients of their depressive ***,rTMs is a promising alternative to traditional anti-depressant therapies when treating refractory depression in patients with pD.

关键词： parkinson’s disease Depression Transcranial magnetic stimulation