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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma shu-ping yang Ying Li Tian-tian Xu Ya-lin yang Hui-yong yang Heng-bing Li Le-jin Zhou Yong Diao su-yun Li school of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the exis.ing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the exis.ing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).inclusion criteria:Meta-analyses that inves.igated and quantitatively es.imated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers.independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PiCO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect es.imates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea surement Tool to Assess systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations.indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice safety Adverse health outcomes Umbrella review Meta-analysis systematic review

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Wood anatomy chronologies of scots pine in the foothills of the Western sayan(siberia)

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Journal of Forestry Research 2024年第3期35卷 13-27页

作者： Elena A.Babushkina Dmitry R.Dergunov Mikhail s.Zharkov Liliana V.Belokopytova Dina F.Zhirnova Bao yang Jingjing Liu Xiaomei Peng Eugene A.Vaganov khakass Technical ins.itute Siberian Federal UniversityAbakan 655017Russia ins.itute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660036Russia Mathematical Methods and iT Department Siberian Federal UniversityKrasnoyarsk 660036Russia key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000People's Republic of China school of Geographic and Oceanographic s.iences Nanjing UniversityNanjing 210093People's Republic of China Department of Dendroecology V.N.Sukachev Institute of ForestSiberian Branch of the Russian Academy of ScienceKrasnoyarsk 660036Russia

Recent methodological advances.in quantitative wood anatomy have provided new insights.into the climatic responses of radial growth at the scale of cell structure of tree rings. This study considered long-term chronologies of tracheid measurements, indexed by a novel approach to separate their specific climatic responses from signal recorded in cell production(closely reflected in tree-ring width). To fill gaps.in understanding the impact of climate on conifer xylem structure, scots pine(Pinus sylvestris L.)trees > 200 years old were selected within the forest-steppe zone in southern siberia. such habitats undergo mild moisture deficits and the resulting climatic regulation of growth processes. Mean and maximum values of cell radial diameter and cell wall thickness were recorded for each tree *** a low level of climatogenic stress, components of cell chronologies.independent of cambial activity were separated to obtain significant climatic signals revealing the timing of the specific stages of tracheid differentiation. Cell expansion lasted from mid-April to July and was.impacted similarly to tree-ring width(s.imulated by precipitation and stressed by heat), maximum cell size formed late June. A s.itch in the climatic responses of mean anatomical traits.indicated transition to latewood in mid-July. secondary wall deposition lasted until mid-september, suppressed by end of season temperatures. Generally, anatomical climatic responses were modulated by a less dry May and september compared with summer months.

关键词： Quantitative wood anatomy Cell radial size Cell wall thickness Pinus sylvestris Climatic response

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Reporting quality evaluation of clinical practice guidelines for pulmonary nodules with the RiGHT checklist

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Chinese Medical Journal 2024年第5期137卷 625-627页

作者： Xuan Wu Wenqiang Wang Quncheng Zhang Ya sun Nan Wei Li yang Yuanjian yang Huizhen yang Haiyang Liu Xiaoju Zhang Department of Res.iratory and Critical Care Medicine Zhengzhou University People’s HospitalHenan Provincial People’s HospitalZhengzhouHenan 450003China Department of internal Medicine Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450001China Department of internal Medicine Xinxiang Medical UniversityXinxiangHenan 453003China

To the Editor:Pulmonary nodules are defined as localized opacities of up to 30 mm in diameter,surrounded by pulmonary parenchyma or located adjacent to the pleura.^([1])The ideal management for pulmonary nodules.is to diagnose and treat malignant nodules as early as pos.ible and minimize radiation exposures,based on the general *** practice guidelines(CPGs)always provide efficient recommendations based on systematic reviews of high-quality evidence and reporting to optimize patient care.^([2])Accumulating evidence shows that adherence to the guidelines.improves patient outcomes.^([3])However,the reporting quality of CPGs seems poor.^([4])several instruments have been generated to evaluate the quality of CPGs.

关键词： pulmonary Clinical clinical

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Application of DsAPsO Algorithm in Distribution Network Reconfiguration with Distributed Generation

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Energy Engineering 2024年第1期121卷 187-201页

作者： Caixia Tao s.ize yang Taiguo Li school of Automation and Electrical Engineering Lanzhou Jiaotong UniversityLanzhou730070China

With the current integration of distributed energy resources.into the grid,the structure of distribution networks.is becoming more *** complexity significantly expands the solution space in the optimization process for network reconstruction using intelligent ***,traditional intelligent algorithms frequently encounter insufficient search accuracy and become trapped in local *** tackle this.issue,a more advanced particle swarm optimization algorithm is *** address the varying emphases at different stages of the optimization process,a dynamic strategy is.implemented to regulate the social and self-learning *** Metropolis criterion is.introduced into the simulated annealing algorithm to occasionally accept suboptimal solutions,thereby mitigating premature convergence in the population optimization *** inertia weight is adjusted using the logis.ic mapping technique to maintain a balance between the algorithm’s global and local search *** incorporation of the Pareto principle involves the consideration of network losses and voltage deviations as objective functions.A fuzzy members.ip function is employed for selecting the *** analysis.is carried out on the restructuring of the distribution network,using the iEEE-33 node system and the iEEE-69 node system as examples.in conjunction with the integration of distributed energy *** findings demonstrate that,in comparison to other intelligent optimization algorithms,the proposed enhanced algorithm demonstrates a shorter convergence time and effectively reduces active power losses within the ***,it enhances the amplitude of node voltages,thereby improving the stability of distribution network operations and power supply ***,the algorithm exhibits a high level of generality and applicability.

关键词： Reconfiguration of distribution network distributed generation particle swarm optimization algorithm simulated annealing algorithm active network loss

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A mutation in TBXT causes congenital vertebral malformations.in humans and mice

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Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： shuxia Chen Yunping Lei Yajun yang Chennan Liu Lele kuang Li Jin Richard HFinnell Xueyan yang Hongyan Wang Obstetrics and Gynecology Hos.ital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China shanghai key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE key Laboratory of Contemporary Anthropology School of Life SciencesFudan UniversityShanghai 200438China Department of As.isted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Children’s Hos.ital Fudan University399 Wanyuan RoadShanghai 201102China

T-box transcription factor T(TBXT;T)is required for mesodermal formation and axial skeletal *** it has been extensively studied in various model organisms,human congenital vertebral malformations(CVMs.involving T are not well ***,we report a family with 15 CVM patients distributed across 4 *** affected individuals carry a heterozygous mutation,T c.596A>G(p.Q199R),which is not found in unaffected family members.indicating co-segregation of the genotype and *** vitro assays show that T p.Q199R increases the nucleocytoplas.ic ratio and enhances.its DNA-binding affinity,but reduces.its transcriptional activity compared to the *** determine the pathogenicity of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human CVM *** heterozygous Q199R mice show subtle kinked or shortened tails,while homozygous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in T causes CVM in humans and mice,providing previously unreported evidence supporting the function of T in the genetic etiology of human CVM.

关键词： Congenital vertebral malformation TBXT T gene Loss-of-function mutation

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Eat at the right time: Regulation of ER-phagy receptors.in plant response to environmental stresses

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Molecular Plant 2024年第2期17卷 236-239页

作者： yang shao Jiaqi sun Huanquan Zheng The key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China Department of Biology McGill UniversityMontrealQC H3A 1B1Canada

The endoplas.ic reticulum(ER)is a cellular factory for biosynthesis of proteins and *** accommodate a wide array of biosynthetic demands.in responses to environmental stresses,the plant ER remodels to maintain a structural and functional homeostasis.A key process facilitating this balance is selective autophagy of the ER(ER-phagy),where malfunctioned ER is recognized,engulfed by autophagosomes,and then delivered to the vacuole for degradation.

关键词： maintain accommodate function

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Design,synthesis,and biological evaluation of novel chrysin derivatives as poly(ADP-ribose)polymerase 1(PARP1)inhibitors for the treatment of breast cancer

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Chinese Journal of Natural Medicines 2024年第5期22卷 455-465页

作者： yang Yao TONG Jing XiE Xianshun CAO Hong FU Yong LUO Yong LiU shan CHEN Wen yang Ning Hengyang Medical school University of South ChinaHengyang 421200China Emergency Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hengyang Medical school The Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hemato-oncology Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Department of Breast and Thyroid surgery Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China

in this study,we reported the discovery and structure-activity relations.ip analysis of chrysin derivatives as a new class of inhibitors targeting poly(ADP-ribose)polymerase 1(PARP1).Among these derivatives,compound 5d emerged as the most effective chrysin-based inhibitor of PARP1,with an iC50 value of 108 nmol·L^(-1).This compound significantly inhibited the proliferation and migration of breast cancer cell lines HCC-1937 and MDA-MB-436 by inducing DNA ***,5d induced apoptosis and caused an extended G1/s-phase in these cell *** docking studies revealed that 5d possesses a strong binding affinity toward *** vivo,in a xenograft model,5d effectively reduced tumor growth by downregulating PARP1 ***,compound 5d shows promise as a potential therapeutic agent for the treatment of BRCA wild-type breast cancer.

关键词： Chrysin derivatives PARP1 Antitumor DNA damage small molecules

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LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway

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Genes & Diseases 2024年第5期11卷 183-197页

作者： Jiamei Li Feng Xiao siqi Wang Xiaolan Fan Zhi He Taiming Yan Jia Zhang Mingyao yang Deying yang College of Animal s.ience and Technology Sichuan Agricultural UniversityChengduSichuan 611130China Farm Animal Genetic Resources Exploration and innovation key Laboratory of sichuan Province Sichuan Agricultural UniversityChengduSichuan 611130China Chengdu Women’s and Children’s Central Hos.ital School of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610017China

A long noncoding RNA(lncRNA)is longer than 200 *** regulates various biological processes mainly by interacting with DNA,RNA,or protein in multiple kinds of biological *** monophosphate-activated protein kinase(AMPk)is activated during nutrient starvation,especially glucose starvation and oxygen deficiency(hypoxia),and exposure to toxins that inhibit mitochondrial res.iratory chain complex *** is an energy s.itch in organisms that controls cell growth and multiple cellular processes.including lipid and glucose metabolism,thereby maintaining intracellular energy homeostasis by activating catabolism and inhibiting *** AMPk signalling pathway consists of AMPk and its upstream and downstream *** upstream targets.include proteins such as the transforming growth factor b-activated kinase 1(TAk1),liver kinase B1(LkB1),and calcium/calmodulindependent protein kinase b(CaMkkb),and its downstream targets.include proteins such as the mechanis.ic/mammalian target of rapamycin(mTOR)complex 1(mTORC1),hepatocyte nuclear factor 4a(HNF4a),and silencing information regulatory 1(siRT1).in general,proteins function relatively independently and *** this article,a review of the currently known lncRNAs.involved in the AMPk signalling pathway is presented and insights.into the regulatory mechanisms.involved in human ageing and age-related diseases are provided.

关键词： Age-related diseases Ageing AMPk signalling pathway Long noncoding RNA microRNA

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Coupling Effect of Cryogenic Freeze-Thaw Cycles and Chloride ion Erosion Effect in Pre-Cracked Reinforced Concrete

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structural Durability & Health Monitoring 2024年第3期18卷 255-276页

作者： yang Li sibo Jiang Ruixin Lan school of Civil Engineering and Architecture Hubei University of TechnologyWuhan430068China

Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study inves.igates the impact of different low-temperaturecycles (20°C, –80°C, and −160°C) and concrete specimen crack widths (0, 0.3, and 0.6 mm) on the Cl−ion diffusion performance through rapid erosion tests conducted on pre-cracked concrete. The results show thatthe minimum temperature and crack width of freeze-thaw cycles enhance the erosive effect of chloride ions. TheCl− ion concentration and growth rate increased with the increasing crack width. Based on the experimental modeland in accordance with Fick’s second law of diffusion, the Cl− ion diffusion equation was modified by introducingcorrection factors.in consideration of the freeze-thaw temperature, crack width, and their coupling *** experimental and fitting results obtained from this model can provide excellent reference for practical engineeringapplications.

关键词： Chloride ions freeze-thaw cycles cracks

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Mice with type i interferon signaling deficiency are prone to epilepsy upon HsV-1 infection

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Virologica sinica 2024年第2期39卷 251-263页

作者： Wei yang Chong-yang Tang Dong-Ying Fan Yi-song Wang Pei-Gang Wang Jing An Guo-Ming Luan Beijing key Laboratory of Epilepsy Sanbo Brain HospitalCapital Medical UniversityBeijing100093China Beijing ins.itute for Brain Disorders Capital Medical UniversityBeijing100093China Department of Neurosurgery Epilepsy CenterSanbo Brain HospitalCapital Medical UniversityBeijing100093China Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Chinese ins.itute for Brain Research Beijing102206China

Viral encephalitis continues to be a significant public health *** our previous study,we discovered a lower expres.ion of antiviral factors,such as.iFN-β,s.iNG and iFi16,in the brain tissues of patients with Rasmussen's encephalitis(RE),a rare chronic neurological disorder often occurred in children,characterized by unihemispheric brain ***,a higher cumulative viral score of human herpes viruses(HHVs)was also found to have a significant positive correlation with the unihemispheric atrophy in *** i iFNs.iFN-i)signaling is essential for innate anti-infection response by binding to iFN-α/βreceptor(iFNAR).in this study,we infected WT mice and iFNAR-deficient A6 mice with herpes simplex virus 1(HsV-1)via periocular injection to inves.igate the relations.ip between iFN-i signaling and HHVs.induced brain *** all mice exhibited typical viral encephalitis lesions.in their brains,HsV-induced epilepsy was only observed in A6 *** gene expres.ion matrix,functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HsV-induced ***,ten key genes with the highest scores were *** together,these findings.indicate that intact iFN-i signaling can effectively limit HHVs.induced neural symptoms and brain lesions,thereby confirming the positive correlation between iFN-i signaling repres.ion and brain atrophy in RE and other HHVs encephalitis.

关键词： iFN-i signaling Human herpes viruses(HHVs) Rasmussen's encephalitis(RE)

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