LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway

作     者：Jiamei Li Feng Xiao Siqi Wang Xiaolan Fan Zhi He Taiming Yan Jia Zhang Mingyao Yang Deying Yang 

作者机构：College of Animal Science and TechnologySichuan Agricultural UniversityChengduSichuan 611130China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan ProvinceSichuan Agricultural UniversityChengduSichuan 611130China Chengdu Women’s and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610017China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第5期

页      面：183-197页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

基　　金：the National Natural Science Foundation of China(No.NSFC31972777) the China Scholarship Council(No.202106915017) 

主　　题：Age-related diseases Ageing AMPK signalling pathway Long noncoding RNA microRNA 

摘      要：A long noncoding RNA(lncRNA)is longer than 200 *** regulates various biological processes mainly by interacting with DNA,RNA,or protein in multiple kinds of biological *** monophosphate-activated protein kinase(AMPK)is activated during nutrient starvation,especially glucose starvation and oxygen deficiency(hypoxia),and exposure to toxins that inhibit mitochondrial respiratory chain complex *** is an energy switch in organisms that controls cell growth and multiple cellular processes,including lipid and glucose metabolism,thereby maintaining intracellular energy homeostasis by activating catabolism and inhibiting *** AMPK signalling pathway consists of AMPK and its upstream and downstream *** upstream targets include proteins such as the transforming growth factor b-activated kinase 1(TAK1),liver kinase B1(LKB1),and calcium/calmodulindependent protein kinase b(CaMKKb),and its downstream targets include proteins such as the mechanistic/mammalian target of rapamycin(mTOR)complex 1(mTORC1),hepatocyte nuclear factor 4a(HNF4a),and silencing information regulatory 1(SIRT1).In general,proteins function relatively independently and *** this article,a review of the currently known lncRNAs involved in the AMPK signalling pathway is presented and insights into the regulatory mechanisms involved in human ageing and age-related diseases are provided.