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Heavy Metals in Native Potato and Health Risk Assessment in Highland Andean zones of Junín, Peru

Journal of Environmental Protection 2020年第11期11卷 921-937页

作者： Edith Orellana María Carolina Bastos Walter Cuadrado rosa zárate Vicky Sarapura Luz Yallico Fiorella Tabra Diana Bao Universidad Nacional del Centro del Perú Huancayo Perú Centro Internacional de la Papa (CIP) Huancayo Perú

Heavy metals are transferred from the abiotic environment to living organisms, accumulate in food, contaminate the food chain, and are an important route of human exposure involving a potential health risk. In this study, the concentrations of heavy metals (Cd, Fe, Pb, zn and As) in agricultural soils and tubers of Solanum tuberosum spp. andigena (native potato) were evaluated. Also, an assessment of the health risk associated with the daily intake by the local population was performed in the four districts of the department of Junín, between altitudes of 3800 m to 4200 m. The heavy metals concentrations in soils with native potato cultivation followed the following decreasing order of Fe > zn > Pb > As > Cd, with values below national standards. The heavy metals content in native potatoes was below the limits recommended by international standards with the exception of Pb. The bioconcentration factor (BCF) for the two native potato varieties in decreasing order was zn > Cd > Pb > As > Fe, all less than 0.5. The estimated daily intake of metals (EDIM) in adults and children through the consumption of native potatoes was higher for Fe and zn. The threshold carcinogenic risk values (TCR) for As exceeded the safety limits 1 × 10-4. It is concluded that the residents in the four high Andean localities would be exposed to carcinogenic adverse health effects associated with the intake of native potatoes. It is important to monitor the concentration of As and other heavy metals in the Andean soils and crops in order to implement a soil and crop management program to ensure food quality.

关键词： Bioconcentration Factor Daily Intake Non-Carcinogenic Risk Carcinogenic Risk Native Potato

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Environmental degradation through mining for energy resources:The case of the shrinking Laguna Santa rosa wetland in the Atacama Region of Chile

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Energy Geoscience 2022年第2期3卷 182-190页

作者： Mohammad Ayaz Alam rosa Sepúlveda Departamento de Geología Facultad de IngenieríaUniversidad de AtacamaAvenida Copayapu 485CopiapoRegion de AtacamaChile

As the world strives to replace fossil fuels with clean energy e reflected by global surge in the number of electric vehicles e the environmental impact of mining all the lithium(Li)needed to enable such a transformation has become a problem in its own *** South America,the biggest problem is the excessive use of water in Li extraction process in one of the driest areas in the *** from causing severe friction over water rights between local communities and mining companies,it puts enormous pressure on the region's fragile and poorly understood wetland *** are one of the most threatened ecosystems on the Earth,despite their great importance as habitats for a vast number of species and corresponding to one of the most productive *** work is the outcome of an investigation on Laguna Santa rosa's(LSR)vulnerability resulting from ongoing metal mining operations in its surroundings that require a large volume of water extracted from local aquifers,in addition to a high evaporation rate in the *** groundwater-dependent wetland will soon be further vulnerable with the commencement of water-intensive Li mining at Salar de Maricunga,with the extraction project already having an environmental impact study *** of this wetland protected under the Ramsar Convention and home to numerous wildlife species habiting this highland sector of the Andean Cordillera is vital for the associated *** variation in the water surface area of LSR has been deciphered through the application of a Landsat-5 Thematic Mapper(TM)satellite image *** has been done both for the hydrological year 2016e2017 and 1993-2014 period.A decreasing trend in the water surface area of LSR,a hypersaline lake at the southern extreme of Salar de Maricunga,a salt flat in the Atacama Region of Chile,was observed through the study of satellite images between 1993 and 2014,showing shrinking of this ***,this shrinking t

关键词： Laguna Santa rosa Salar de Maricunga Lithium Water Wetland Ecosystem

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A Numerical Study on Piezoelectric Energy Harvesting by Combining Transverse Galloping and Parametric Instability Phenomena

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Journal of Marine Science and Application 2017年第4期16卷 465-472页

作者： Guilherme rosa Franzini Rebeca Caramêz Saraiva Santos Celso Pupo Pesce Escola PolitEnica University of SAO Paulo SAO Paulo SP 05508-030 Brazil

This paper aims to numerically investigate the effects of parametric instability on piezoelectric energy harvesting from the transverse galloping of a square prism. A two degrees-of-freedom reduced-order model for this problem is proposed and numerically integrated. A usual quasi-steady galloping model is applied, where the transverse force coefficient is adopted as a cubic polynomial function with respect to the angle of attack. Time-histories of nondimensional prism displacement, electric voltage and power dissipated at both the dashpot and the electrical resistance are obtained as functions of the reduced velocity. Both, oscillation amplitude and electric voltage, increased with the reduced velocity for all parametric excitation conditions tested. For low values of reduced velocity, 2:1 parametric excitation enhances the electric voltage. On the other hand, for higher reduced velocities, a 1:1 parametric excitation(i.e., the same as the natural frequency) enhances both oscillation amplitude and electric voltage. It has been also found that, depending on the parametric excitation frequency, the harvested electrical power can be amplified in 70% when compared to the case under no parametric excitation.

关键词： transverse galloping energy harvesting piezoelectricity parametric instability numerical simulations

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In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds:An Update

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Genomics, Proteomics & Bioinformatics 2017年第4期15卷 236-245页

作者： Ursula Catalan Laura Barrubes rosa Maria Vails rosa Soila Laura Rubio Functional Nutrition Oxidation and Cardiovascular Diseases Group(NFOC-Salut)Technological Center of Nutrition and Health(CTNS)lnstitut d'lnvestigacio Sanitaria Pere Virgili(IISPV)Faculty of Medicine and ttealth SciencesUniversitat Rovira i VirgiliReus 43201Spain Food Technology Department Universitat de Lleida-AGROTECNIO CenterLleida 25198Spain

Dietary phenolic compounds （PCs） have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro metabolomic approaches are suitable for the investigation o1 the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been cxalnined for PCs from rosemary （Rosmarinus officinalis）, olive oil, and reSVCl-atrol using cell-based mctabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vi[ro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro-and micro-nutrient meta- bolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerativc diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are nccdcd and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.

关键词： Cell-based Metabolomics Phenolic compounds Mechanism of action Disease prevention

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Irritable bowel syndrome:A clinical review

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World Journal of Gastroenterology 2014年第34期20卷 12144-12160页

作者： rosa LS Soares Internal Medicine Department Faculty of MedicineFederal Fluminense UniversityRio de Janeiro 24030-210Brazil

Irritable bowel syndrome (IBS) remains a clinical challenge in the 21st century. It’s the most commonly diagnosed gastrointestinal condition and also the most common reason for referral to gastroenterology clinics. Its can affect up to one in five people at some point in their lives, and has a significantly impact of life quality and health care utilization. The prevalence varies according to country and criteria used to define IBS. Various mechanisms and theories have been proposed about its etiology, but the biopsychosocial model is the most currently accepted for IBS. The complex of symptoms would be the result of the interaction between psychological, behavioral, psychosocial and environmental factors. The diagnosis of IBS is not confirmed by a specific test or structural abnormality. It is made using criteria based on clinical symptoms such as Rome criteria, unless the symptoms are thought to be atypical. Today the Rome Criteria III is the current gold-standard for the diagnoses of IBS. Secure positive evidence of IBS by means of specific disease marker is currently not possible and cannot be currently recommended for routine diagnosis. There is still no clinical evidence to recommend the use of biomarkers in blood to diagnose IBS. However, a number of different changes in IBS patients were demonstrated in recent years, some of which can be used in the future as a diagnostic support. IBS has no definitive treatment but could be controlled by non-pharmacologic management eliminating of some exacerbating factors such certain drugs, stressor conditions and changes in dietary *** traditional pharmacologic management of IBS has been symptom based and several drugs have been used. However, the cornerstone of its therapy is a solid patient physician relationship. This review will provide a summary of pathophysiology, diagnostic criteria and current and emerging therapies for IBS.

关键词： Irritable bowel syndrome Clinical review Pathogenesis Diagnostic Treatment Biopsychosocial model

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Analysis of hydrodynamic effects on biofilm thickness in fluidized-bed tapered bioreactors

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Particuology 2021年第5期19卷 48-57页

作者： Daniela Maria Koerich Leonardo Machado da rosa Chemical Engineering Department University of Blumenau(FURB)3250 Sao Paulo Street89030-000 BlumenauSanta CatarinaBrazil

Fluidized beds in tapered geometries provide advantages such as a broad range of optimum operating ***,the dynamics of the flow inside these bioreactors is significantly more complex,as they promote non-uniform bioparticles *** this end,the CFD technique can give a detailed description of the flow in the ***,the aim of this work is to assess the influence of the hydrodynamic on the steady-state biofilm thickness through numerical simulations of liquid–solid fluidized *** geometries of tapered bioreactors in the operating conditions used to develop *** were run to solve the two-phase RANS equations using the open-source software OpenFOAM in *** SST k−ω model was used to estimate the turbulent features of the *** and bioparticles distribution inside the reactor were analyzed for different inlet velocities,while bioparticles collision frequency and shear stresses were evaluated for various operating *** comparison between the turbulent kinetic energy and the granular temperature indicated that the fluid flow is more turbulent than the bioparticles *** hydrodynamics influence on the steady-state biofilm thickness was assessed,and results led to the conclusion that biofilm is more sensitive to hydrodynamic shear stress than bioparticles collisions.

关键词： Liquid-solid fluidization Shear stress Particles collisions Computational fluid dynamics Biofilm Tapered bioreactors

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Searching for alternatives to brain regeneration

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Neural Regeneration Research 2021年第11期16卷 2198-2200页

作者： Chiara La rosa Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi(NICO) OrbassanoItaly Department of Veterinary Sciences University of TurinGrugliascoItaly

Brain regeneration from an evolutionary perspective:Brain regeneration(the full restoration of tissue after loss from injury or disease)is the most sought after goal for researchers working in developmental *** also appears to be the most challenging to achieve when considering the mammalian *** remarkable regenerative capacities can be present in the central nervous systems of many non-mammalian vertebrates(e.g.,fish,amphibians),these kinds of processes appear to be dramatically reduced in mammals(Bonfanti,2011).

关键词： regeneration sought injury

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Capsule endoscopy and panendoscopy:A journey to the future of gastrointestinal endoscopy

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World Journal of Gastroenterology 2024年第10期30卷 1270-1279页

作者： Bruno rosa JoséCotter Department of Gastroenterology Hospital da Senhora da OliveiraGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal ICVS/3B's PT Government Associate LaboratoryBraga 4710-057Portugal

In 2000,the small bowel capsule revolutionized the management of patients with small bowel ***,the technological development achieved by the new models of double-headed endoscopic capsules,as miniaturized devices to evaluate the small bowel and colon[pan-intestinal capsule endoscopy(PCE)],makes this non-invasive procedure a disruptive concept for the management of patients with digestive *** technology is expected to identify which patients will require conventional invasive endoscopic procedures(colonoscopy or balloon-assisted enteroscopy),based on the lesions detected by the capsule,i.e.,those with an indication for biopsies or endoscopic *** use of PCE in patients with inflammatory bowel diseases,namely Crohn’s disease,as well as in patients with iron deficiency anaemia and/or overt gastrointestinal(GI)bleeding,after a non-diagnostic upper endoscopy(esophagogastroduodenoscopy),enables an effective,safe and comfortable way to identify patients with relevant lesions,who should undergo subsequent invasive endoscopic *** recent development of magnetically controlled capsule endoscopy to evaluate the upper GI tract,is a further step towards the possibility of an entirely non-invasive assessment of all the segments of the digestive tract,from mouth-to-anus,meeting the expectations of the early developers of capsule endoscopy.

关键词： Non-invasive endoscopy Panendoscopy Magnetically controlled capsule endoscopy Crohn’s disease Digestive bleeding

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In vitro germination and shoot proliferation of the threatened species Cinchona officinalis L(Rubiaceae).

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Journal of Forestry Research 2016年第6期27卷 1229-1236页

作者： rosa Armijos-Gonzalez Cesar Perez-Ruiz Departamento de Ciencias Naturales Universidad Tecnica Particular de LojaCP 1101 608 LojaEcuador Departamento de Biotecnologia y Biologia Vegetal E.T.S.Ingenieros AgronomosUniversidad Politecnica de MadridCP 728040 MadridSpain

Cinchona officinalis （Rubiaceae） is an endemic species of the Loja Valley in southern Ecuador with medicinal uses. Because of over-exploitation in the nine- teenth century and more recent disturbances to its ecosystem, C. officinalis populations are threatened. Currently, natural regeneration of the populations is low, despite its high plant regeneration and seed formation capacity. In the present study, an efficient protocol for germination, shoot proliferation and plantlets regeneration was developed for this species. Phenolic content and germination rate of C. officinalis seeds were compared with a control species, C. pubescens. Nodal segments from seedlings of C. officinalis were cultured on Gamborg medium supplemented with different combinations of plant growth regulators. Because the phenol content is high in C. officinalis, the phenolic should be removed with hydrogen peroxide or water washes to stimulate germination. Shoots and callus developed from nodal segments within 45 days using most of the tested combinations of plant growth regulators. The best rates of shoot proliferation, callus formation and adventitious buds were obtained in medium supplemented with 5.0 mg L^-1 6-benzyl-aminopurine and 3.0 mg L^-1 indole- 3-butyfic acid.

关键词： Callus Cinchona officinalis Germination Phenols Rubiaceae Shoot

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Landslide risk perception and communication for disaster risk management in mountain areas of developing countries：a Mexican foretaste

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Journal of Mountain Science 2016年第12期13卷 2079-2093页

作者： Irasema ALCáNTARA-AYALA Ana rosa MORENO Institute of Geography National Autonomous University of Mexico(UNAM)Ciudad UniversitariaCoyoaedn04510Mexico CityMexico Faculty of Medicine Department of Public HealthNational Autonormous University of Mexico(UNAM)Ciudad UniversitariaCoyoacan04510Mexico CityMexico

The increasing impact of disasters at local,national,regional and global scales in recent decades has provided enough evidence to urgently direct attention towards the necessity of disaster risk reduction and management,and this requires *** without communication is barren,and to communicate the risk of disaster it is necessary to understand the perception of the people at *** particular,this paper deals with the necessity to delineate strategies of risk communication in pursuance of risk knowledge as a core of disaster risk reduction and management,especially in mountain areas of developing *** portray this issue,an analysis of landslide risk perception in terms of experience,landslide risk awareness,exposure,preparedness,and risk communication and trust was undertaken in the municipality of Teziutlán,Puebla,Mexico,an area that has been affected for several decades by episodes of mass *** of the responses to a risk perception questionnaire has offered valuable insights in terms of the information and knowledge most required by the people living in the area of interest,in order to devise a realistic and functional strategy to communicate the risk of a landslide *** includes better understanding of controlling factorsand drivers of this risk,and the establishment of potential trusted sources of risk *** considering practical matters of risk assessment and management,risk perception and communication can increase the resilience of vulnerable people,and can enhance capacity building for present and future generations.

关键词： Risk perception Risk communication Landslides Disaster risk Mountain areas

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