In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds:An Update

作     者：Ursula Catalan Laura Barrubes Rosa Maria Vails Rosa Soila Laura Rubio 

作者机构：Functional NutritionOxidation and Cardiovascular Diseases Group(NFOC-Salut)Technological Center of Nutrition and Health(CTNS)lnstitut d'lnvestigacio Sanitaria Pere Virgili(IISPV)Faculty of Medicine and ttealth SciencesUniversitat Rovira i VirgiliReus 43201Spain Food Technology DepartmentUniversitat de Lleida-AGROTECNIO CenterLleida 25198Spain 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2017年第15卷第4期

页      面：236-245页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 08[工学] 09[农学] 0815[工学-水利工程] 

基　　金：supported by grants(Grant Nos.AGL2009-13517-C03-03 and AGL2012-40144-C03-02)from the Spanish Ministry of Education Science(Ministerio de Educacion y Ciencia,Spain),a Sara Borrell post-doctoral grant(CD14/00275 Spain) a Pla estrategic de recerca i innovacio en salut(PERIS)post-doctoral grant(SLT002/16/00239 Catalunya,Spain) support of Institut d’InvestigacioSanitaria Pere Virgili(IISPV)and Centre Tecnologic de Nutricio i Salut(CTNS),Reus,Spain 

主　　题：Cell-based Metabolomics Phenolic compounds Mechanism of action Disease prevention 

摘      要：Dietary phenolic compounds （PCs） have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro metabolomic approaches are suitable for the investigation o1 the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been cxalnined for PCs from rosemary （Rosmarinus officinalis）, olive oil, and reSVCl-atrol using cell-based mctabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vi[ro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro-and micro-nutrient meta- bolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerativc diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are nccdcd and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.