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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Chanshuai Han rongqiao he State Key Lab of Brain and Cognitive Sciences institute of BiophysicsChinese Academy of Sciences

Advanced glycation end products(AGEs) have been implicated in the chronic complications of diabetes mellitus and have been reported to play an important role in the pathogenesis of Alzheimer’s disease and other neurodegenerative *** is a kind of important reducing sugar in biological body,which can rapidly glycate proteins in *** investigate the role of ribosylation in neurodegenerative diseases,five groups of C57/BL6J mice were injected daily and severally with 0.2%D-ribose,2% D-ribose,0.2%Dglucose,2%D-glucose and saline as

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Ribosylation induces cognitive impairment and neural cell death

Ribosylation induces cognitive impairment and neural cell de...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yan WEI rongqiao he State Key laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of Sciences

D-ribose in cells and human serum participates in the glycation of proteins resulting in advanced glycation end products(AGEs) that affect cell metabolism and induce cell *** have been shown to be implicated in the senile plaques and neurofibrillary tangles in the brain of Alzheimer’s *** high levels of ribose,along with glucose were found in the urine of patients with type 2 diabetic ***,the effects of D-ribose and ribosylation on protein,cell and animal were investigated by biochemical,cellular and animal *** with D-ribose induced protein to misfold rapidly and form globular amyloid-like aggregations which play an important role in cytotoxicity to neural cells.D-ribose also decreased cell viability and induced more AGE accumulation in *** injection,oral administration and tail intravenous injection of D-ribose caused impairment of spatial learning and memory ability in animals,along with A deposition,tau hyperphosphorylation and glia activation,which were the key pathological features in Alzheimer’s *** may be some mechanistic link between ribosylation and cognitive *** ribosylation could be a promising therapeutic strategy to prevent Alzheimer’s disease and diabetic encephalopathies.

关键词： ribosylation Alzheimer’s disease tau hyperphosphorylation cognitive impairment

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D-ribose,an overlooked player in type 2 diabetes mellitus?

D-ribose,an overlooked player in type 2 diabetes mellitus?

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Tao Tao Su rongqiao he Institute of Biophysics Chinese Academy of Sciences

Type 2 diabetes mellitus is a metabolic disorder that is characterized by high blood glucose due to either insulin resistance or insulin deficiency. A direct correlation between Dglucose and diabetic complications has long been established, and is the focus of most research in this field. In contrast, D-Ribose has been overlooked so far as a potential risk player in the development of *** published reports found abnormally high levels of D-ribose in the urine of diabetic patients. Elsewhere, intravenous administration of D-ribose resulted in a decrease in blood D-glucose, concomitantly with an increase in the level of glycated serum proteins. It is known that administration of high dose of D-ribose rapidly glycates proteins in vivo and in vitro, which results in the production of high levels of advanced glycation end products.D-glucose, in contrast, cannot be used to the same effect, even under identical ***, as we hypothesized, dysfunction of the metabolism of D-ribose may play a roleinvolving the development of complications of type 2 diabetes mellitus, and it is feasible that D-ribose could be used as a biomarker for type 2 diabetes mellitus. That is, diabetics suffer from dysfunction of energy metabolism, involving not only D-glucose, but also *** viewpoint for D-ribose in diabetes is based on these observations:(i) Diabetics display abnormal increases in the level of uric D-ribose;(ii) Raised levels of D-ribose result in increased ribosylation activity, in the result of which more advanced glycation end products accumulate in cells;and(iii) D-ribose could be used as a new biomarker for type2 diabetes mellitus, as it is easily measured in the urine of diabetic *** suggest that this novel view of type 2 diabetes mellitus deserves further and detailed in vestigation, both at the level of basic and clinical research, to clarify whether and how Dribose and its metabolism are related with diabetic complications.

关键词： ribosylation type 2 diabetes mellitus

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Formaldehyde induces Tau hyperphosphorylation in vivo

Formaldehyde induces Tau hyperphosphorylation in vivo

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生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会

作者： Junye Miao Jing Lu rongqiao he 中国科学院生物物理研究所

Formaldehyde(FA) is the simplest aldehye,which is widely distributed in environment as well as in *** lab have demonstrated that formaldehyde could promote BSA and protein Tau to aggregation in *** aggregates had cytotoxicity that could in-duce cell apoptosis and *** more,urine formaldehyde concentration of pa-tients with dementia were much higher than control.

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Identification and functional analysis of noval non coding RNAs in Xenopus

Identification and functional analysis of noval non coding R...

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生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会

作者： Xiumei Wang Shunmin he Ying Liu rongqiao he 中国科学院生物物理研究所中国科学院动物研究所

Noncoding RNAs(ncRNAs) are one of the major components of the brain ***,the roles of many ncRNAs are unclear,and the regulation of ncRNA expression is even much less *** analyzing more than 50 thousands of non-coding transcripts identified from the human fetal brain,high sequence conservation was found in the flank-ing 5’ or 3’ of the genomic loci of the *** applied the genome of Xenopus tropicalis to search for ncRNA candidates adjacent with the conserved genomic ***-fold ananlysis showed the similar second structure of ncRNAs in the brain of human fetus and xenopus and Xenc034 had a conserved sequence of tRNA and a stem-loop structure like *** the RT-PCR verification of four predicted ncRNAs

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Endogenous formaldehyde as one of important risk factors involving sporadic alzheimer's disease

Endogenous formaldehyde as one of important risk factors inv...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： rongqiao he Jing Lu Junye Miao State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences Department of psychology and psychiatry Beijing Senile Hospital

Formaldehyde is one of the most toxic organic compounds, which is also produced and degraded by human cells at each *** shown in our results,the level of human endogenous formaldehyde is kept at low concentration (0.01-0.1 mM) in urine under physiological condition, but the concentration is getting higher during ***

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Substrate-induced changes in protease active site conformation impact subsequent reactions with substrates

Substrate-induced changes in protease active site conformati...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Rong Pan Zijian Zhang rongqiao he University of New Mexico Institute of Biophysics Chinese Academy of Sciences

Enzymatic catalysis of biochemical reactions is essential to all living *** "lock and key" and "induced fit" models were early contributions to our understanding of the mechanisms involved in the reaction between an enzyme and its ***,whether a given substrateinduced conformation is rigid or remains flexible has not yet been *** measuring the enzyme activity and intrinsic fluorescence of a nonspecific Eisenia fetida protease-I with different chromogenic substrates,we show that in subsequent reactions of protease with substrates,both

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Earthworm proteases multiply function in protein fibrils degradation involving several diseases including hepatitis B

Earthworm proteases multiply function in protein fibrils deg...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Xiumei Wang Shichao Fan rongqiao he Institute of Biophysics Chinese Academy of Sciences

Eisenia fetida proteases(Ef Ps) and Lumbricus rubellus proteases(LrPs) have been used to treat human important diseases including cardiovascular diseases,ischemic encephalopathy,diabetic encephalopathy diabetic kidney disease,as well as hepatitis *** the treatment of all those diseases,the general mechanisms of Ef Ps and LrPs are linked with degradation and decrement of protein fibrils on specific *** described by our previous work,Ef Ps as a complex drug markedly cleave fibrinogen and decrease fibrogenesis to prevent clotting formation and clotting *** Ps showed high activity on fibrinogen-chain,moderate activity on-chain and low activity *** other words,the activity of Ef Ps prefers decrease fibrinogen to proteolysis of *** found that fibronectin an important molecule participates in hepatitis B infection and liver *** purified the component of Ef Ps,which had highest proteolytic activity on fibronectin,and verified to use in HBV infection treatment in hepG2.2.15 *** observed that Ef Ps contained eight isozymes including ***,we demonstrated that Ef Ps had a definite effect on HBV infection in animal model not only through proteolysis of fibronectin,but also degradation of *** data provide valuable information to understand the therapeutic role and potential therapeutic mechanism of Ef Ps as effective antiviral medicine in treating chronic hepatitis B.

关键词： Earthworm protease Fibronectin HBeAgase Isozyme Ischemic Encephalopathy Chronic hepatitis B

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Decomposition of ribose producing reactive carbonyl species including formaldehyde

Decomposition of ribose producing reactive carbonyl species ...

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中国生物化学与分子生物学会2016年全国学术会议

作者： Yujing Wang Tao Su Yan Wei rongqiao he State Key Laboratory of Brain and Cognitive Sciences Institute of Biophysics Chinese Academy of Sciences University of Chinese Academy of Sciences Sichuan Medical Univeristy Key Laboratory of Mental health Institute of PsychologyChinese Academy of Sciences Alzheimer's Disease Center Beijing Institute for Brain DisordersCapital Medical University

Formaldehyde is implicated in epigenetics and in the pathologies of various chronic diseases such as neurodegenerative diseases,cancers and *** several pathways in production of formaldehyde have been studied,no labor... 详细信息

关键词： ribose formaldehyde reactive carbonyl species

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Excess endogenous formaldehyde leads to cognitive decline during aging

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中国药理通讯 2013年第2期30卷 29-30页

作者： Tao Su Jiawan Wang Ying Liu Yun Yue rongqiao he State Key Laboratory of Brainand Cognitive Science Institute of Biophysics Chinese Academy of Sciences Depaztment of Anesthesiology Chaoyang Hospital Capital Medical University Key Laboratory of Mental health Institute of Psychology Chinese Academy of Sciences Graduate University Chinese Academy of Sciences

Post-operative cognitive dysfunction (POCD), especially for elderly patients, is reported in many studies. In our study, Ninety-five patients, ages 65 - 80 years, scheduled for major orthopedic or abdominal surgery were enrolled. Twenty-two patients aged between 20-40 years undergoing the same procedure served as controls. Subjects received neuropsychological tests one- day prior and one week post procedure. Morning urine samples were obtained one day before surgery and on day 1, day 2 and day 7post surgery. Urine formaldehyde was determined with high-performance liquid chromatography (HPLC). After statistical analysis,

关键词：路易体病治疗精神病疗效

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