Identification and functional analysis of noval non coding RNAs in Xenopus
作者单位：中国科学院生物物理研究所 中国科学院动物研究所
会议名称：《生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会》
会议日期：2012年
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
摘 要：Noncoding RNAs(ncRNAs) are one of the major components of the brain ***,the roles of many ncRNAs are unclear,and the regulation of ncRNA expression is even much less *** analyzing more than 50 thousands of non-coding transcripts identified from the human fetal brain,high sequence conservation was found in the flank-ing 5’ or 3’ of the genomic loci of the *** applied the genome of Xenopus tropicalis to search for ncRNA candidates adjacent with the conserved genomic ***-fold ananlysis showed the similar second structure of ncRNAs in the brain of human fetus and xenopus and Xenc034 had a conserved sequence of tRNA and a stem-loop structure like *** the RT-PCR verification of four predicted ncRNAs