D-ribose can induce protein glycation and AGEs generation in vivo
作者单位：State Key Lab of Brain and Cognitive Sciencesinstitute of BiophysicsChinese Academy of Sciences
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议》
会议日期：2010年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Advanced glycation end products(AGEs) have been implicated in the chronic complications of diabetes mellitus and have been reported to play an important role in the pathogenesis of Alzheimer’s disease and other neurodegenerative *** is a kind of important reducing sugar in biological body,which can rapidly glycate proteins in *** investigate the role of ribosylation in neurodegenerative diseases,five groups of C57/BL6J mice were injected daily and severally with 0.2%D-ribose,2% D-ribose,0.2%Dglucose,2%D-glucose and saline as