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Unbound^(28)O,the heaviest oxygen isotope observed:a cutting-edge probe for testing nuclear models

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Nuclear Science and Techniques 2024年第2期35卷 1-2页

作者： Jian-Guo Li Bai-Shan Hu Shuang Zhang Fu-rong xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting *** unbound feature of the heaviest oxygen isotope,^(28)O,provides an excellent test for stateof-the-art nuclear *** atomic nucleus is a self-organized quantum manybody system comprising specific numbers of protons Z and neutrons N.

关键词： testing quantum system

Programmed nanoparticle-loaded microparticles for effective antigen/adjuvant delivery

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Particuology 2022年第1期20卷 77-89页

作者： rong xu Ying Dong Yajing Zhang Xiaoli Wang Chuangnian Zhang Yanjun Jiang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences&1 Peking Union Medical CollegeTianjin 300192China School of Chemical Engineering and Technology.Hebei University of Technology.Tianjin.300130 China NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic DiseasesChu Hsien-I Memorial Hospital&Tianjin Institute of EndocrinologyTianjin Medical UniversityTianjin 300134China

A microscale vaccine containing SiO_(2)nanoparticles loaded in CaC〇3 microparticles was constructed using the co-precipitation *** antigen ovalbumin(OVA)was covalently conjugated with SiO_(2)nanoparticles,and these nanoparticles and CpG were co-encapsulated into CaCO_(3)microparticles,generating a vaccine with a size of approximately 5.2μ*** electron microscopy(SEM),energy-dispersive X-ray(EDX),elemental mapping,and Fourier transform infrared(FTIR)analyses confirmed the successful preparation of the microscale vaccine;the vaccine had good storage stability without sustained antigen release,and negligible cytotoxicity to dendritic cells(DCs)and *** to SiO_(2)nanoparticles,the microscale vaccine can significantly improve antigen/adjuvant *** internalized the entire microscale vaccine into lysosomes via macropinocytosis,and an increase in antigen endo/lysosomal escape was observed by confocal User scanning microscopy(CLSM).Specifically,DCs pulsed with the vaccine were fully mature,expressing high levels of costimulatory molecules(CD40,CD80,and CD86),MHCⅡ,and MHCⅠand secreting high levels of proinflammatory cytokines(IL-12,TNF-α,IL-1β,and IL-6).In addition,the vaccine had good in vivo biocompatibility,could protect the antigen from rapid degradation,and increased the retention time in lymph ***_(2)nanoparticles-in-CaCO_(3)microparticles were an excellent carrier for antigen and adjuvant ***,this study can provide some information on the design of microscale carriers for vaccine delivery systems.

关键词： Antigen delivery Cross-presentation Microparticle Silica nanoparticle Bone marrow dendritic cell

Analysis of cracking phenomena in continuous casting of 1Cr13 stainless steel billets with final electromagnetic stirring

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International Journal of Minerals,Metallurgy and Materials 2016年第5期23卷 534-541页

作者： Yu xu rong-jun xu Zheng-jie Fan Cheng-bin Li An-yuan Deng En-gang Wang Key Laboratory of Electromagnetic Processing of Materials (Ministry of Education) Northeastern University Research Institute Baoshan Iron & Steel Co. Ltd.

Solidification cracking that occurs during continuous casting of 1Cr13 stainless steel was investigated with and without final elec- tromagnetic stirring （F-EMS）. The results show that cracks initiates and propagates along the grain boundaries where the elements of carbon and sulfur are enriched. The final stirrer should be appropriately placed at a location that is 7.5 m away from the meniscus, and the appropri- ate thickness of the liquid core in the stirring zone is 50 ram. As a stirring current of 250 A is imposed, it can promote colurnnar-equiaxed transition, decrease the secondary dendrite arm spacing, and reduce the segregation of both carbon and sulfur. F-EMS can effectively de- crease the amount of cracks in 1Cr13 stainless steel.

关键词： stainless steel cracking solidification continuous casting electromagnetic stirring

Two New Piperazine Templated Lanthanide Sulfates with 2D Corrugated Layered Crystal Structures

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Chemical Research in Chinese Universities 2013年第1期29卷 10-14页

作者： ZHANG Deng FAN Xin-rong LU Yun xu Yan State Key Laboratory of Materials-oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing 210009 P. R. China

Two new piperazine templated lanthanide sulfates （C4N2HI2）1.5[Ln（SO4）3（H20）]H20[Ln=Gd（1）, Tb（2）] have been synthesized solvothermally and structurally characterized by single crystal X-ray diffraction（XRD）, infrared（IR） spectroscopy, thermal analysis, fluorescent spectra and inductively coupled plasma（ICP）. Single crystal X-ray diffraction reveals that both compounds 1 and 2 crystallized in the monoclinic crystal system, with space group P2t/c and cell dimensions： a=0.64468（19） nm, b=2.9979（9） nm, c=0.9818（3） nm, fl=101.271（4）, V=l.8608（10） nm3, Z=4 for compound 1; a=0.64259（19） nm, b=3.0010（9） rim, c=0.9812（3） nm, fl=101.229（4）, V=1.8560（10） nm3, Z=4 for compound 2. Compounds 1 and 2 are isomorphous and have similar 2D corrugated inorganic frameworks fabricated via the connection of single chains and $204 groups, while fully protonated piperazine cations and water molecules are located between the inorganic layers. The solid state luminescent properties of compound 2 were investigated and it displayed a typical luminescent property of Tb3＋ with excitation wavelength at 371 nm.

关键词： Solvothermal synthesis Lanthanide sulfate Layered structure Luminescence

Berbamine inhibits proliferation and induces apoptosis of KU812 cells by increasing Smad3 activity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 568-574页

作者： Yun LIANG Xi QIU rong-zhen xu Xiao-ying ZHAO Department of Hematology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 3 10009 China Cancer Institute School of Medicine Zhejiang University Hangzhou 310009 China

Objective: The cytotoxic effect of berbamine on chronic myeloid leukemia (CML) cell line KU812 was evaluated,and the mechanisms of its action were ***: The effect of berbamine on the KU812 cell growth was determined by methyl thiazolyl tetrazolium (MTT) *** cytometry was used to profile cell cycle alteration upon berbamine *** transcription polymerase chain reaction (RT-PCR) was carried out to determine the transcripts of transforming growth factor-β (TGF-β) receptors (TβRs),Smad3,c-Myc,cyclin D1,p21Cip1(p21),and p27Kip1(p27).Changes in the protein levels of total Smad3,phosphorylated Smad3,the downstream targets of Smad3,and specific apoptosis-related factors were evaluated by Western ***: Berbamine inhibited KU812 cell proliferation in a doseand time-dependent manner,and the half maximal inhibitory concentration (IC50) values for treatments of 24,48,and 72 h were 5.83,3.43,and 0.75 μg/ml,*** induced G1 arrest as well as apoptosis in KU812 *** of Smad3 and p21 were up-regulated,while those of TβRI,TβRII,c-Myc,cyclin D1 and p27 were not changed *** protein levels of both total Smad3 and phosphorylated Smad3 were both up-regulated after berbamine treatment,together with decreased c-Myc and cyclin D1 and increased ***,the levels of the anti-apoptotic proteins,such as Bcl-2 and Bcl-xL,were decreased,whereas pro-apoptotic Bax was ***: Berbamine suppresses KU812 cell proliferation through induction of cell cycle arrest in G1 and *** activates Smad3 without additional stimulation of TGF-β,and alters the levels of the Smad3 downstream targets,including c-Myc,cyclin D1 and *** findings suggest that berbamine is a promising drug in the treatment of advanced stage patients with CML.

关键词： Berbamine Apoptosis Smad3 KU812 cells

Updating magnetic resonance imaging of small bowel:Imaging protocols and clinical indications

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World Journal of Gastroenterology 2008年第21期14卷 3403-3409页

作者： Jiong Zhu Jian-rong xu Hong-Xia Gong Yan Zhou Department of Radiology Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

High soft tissue contrast resolution,acquisition of multi-planar images and the possibility to obtain functional information make magnetic resonance an interesting imaging technique to evaluate the small bowel *** absence of ionizing radiation is an important feature of magnetic resonance imaging(MRI) examinations because inflammatory diseases such as Crohn's disease(CD) are studied most frequently,which are prevalent among children and young ***,using modern equipment and a rigorous technical approach,can offer detailed morphologic information and functional data on the small *** article discusses the MRI protocols for small bowel and the MR imaging findings of small bowel diseases,such as CD and small bowel neoplasms.

关键词： Magnetic resonance imaging Small bowel Crohn's Neoplasm

Multi-stage penetration characteristics of thick ultra-high molecular weight polyethylene laminates

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Defence Technology（防务技术） 2023年第9期27卷 101-110页

作者： Ming-jin Cao Li Chen rong-zheng xu Si-jia Liu Qin Fang Engineering Research Center of Safety and Protection of Explosion&Impact of Ministry of Education Southeast UniversityNanjing211189China Institute of Architectural Engineering Huanghuai UniversityZhumadian463000China State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China

To further reveal the failure mechanisms of thick ultra-high molecular weight polyethylene(UHMWPE)laminates,field firing tests were conducted for 10-,20-,and 30-mm thick laminates against 12.7-mm calibre wedge-shaped fragment simulated projectiles at high velocities between 450 and 1200 m/*** ballistic performance,deformation process,and staged failure characteristics of the laminates with different thicknesses were compared and *** results demonstrate that the ballistic limits of the UHMWPE laminates increase almost linearly with laminate *** 10-mm thick laminate generally experiences two-stage failure characteristics,whereas three-staged failure occurs in the 20-and 30-mm thick laminates and the progressive delamination is *** energy limit concept representing the maximum energy absorption efficiency and the idea of reuse of the thick UHMWPE laminates are proposed in this *** findings of this research will be useful in the design of flexible and effective UHMWPE-based protective equipment.

关键词： UHMWPE laminates Ballistic limit Thickness Mechanism Energy limit

Monte Carlo simulation of incident electrons passing through thin metal layer

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Nuclear Science and Techniques 2018年第7期29卷 182-190页

作者： Tian-Long He Hong-Liang xu Kai-Ting Huang Zhi-Liang Ren De-rong xu National Synchrotron Radiation Laboratory University of Science and Technology of China

A Monte Carlo simulation using two schemes,the discrete energy loss approach and the continuous slowing down approximation,was implemented in C++ to calculate the energy transmission coefficient and average energy loss for low-energy(1–10 keV) incident electrons passing through a thin metal *** simulation model uses the Ashley model for electron inelastic scattering,the electron elastic scattering cross section taken from the NIST database,and the stopping power derived from the full Penn *** results of the two schemes agree well with each other and can be used to quantitatively evaluate the shielding effect of a thin coated metal layer on incident electrons for a diamond amplified photocathode.

关键词：蒙特卡罗模拟金属层电子事件模拟模型 NIST 防护效果精力

PROTECTION OF CARBON MONOXIDE INHALATION ON LIPOPOLY-SACCHARIDE-INDUCED MULTIPLE ORGAN INJURY IN RATS

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Chinese Medical Sciences Journal 2007年第3期22卷 169-176页

作者： Shao-hua Liu Xin-rong xu Ke Ma Bing xu Intensive Care Unit the First Affiliated Hospital of Nanjing Medicial University Nanjing 210029

Objective To observe the protection of carbon monoxide （CO） inhalation on lipopolysaccharide （LPS）-induced rat multiple organ injury. Methods Sprague-Dawley rats with multiple organ injury induced by 5 mg/kg LPS intravenous injection were exposed to room air or 2.5 × 10 ^-4 （V/V） CO for 3 hours. The lung and intestine tissues of rats were harvested to measure the expression of heme oxygenase-1 （ HO-1 ） with reverse transcription-polymerase chain reaction, the levels of pulmonary tumor necrosis factor-or （ TNF-α）, interleukin-6 （ IL-6）, and intestinal platelet activator factor （ PAF）, intercellular adhesion molecule-1 （ICAM-1） with enzyme-linked immunosorbent assay, the content of maleic dialdehyde （MDA） and the activity of myeloperoxidase （MPO） with chemical method, the cell apoptosis rate with flow cytometry, and the pathological changes with light microscope. Results CO inhalation obviously up-regulated the expression of HO-1 in lung （5.43 ± 0. 92） and intestine （6. 29 ± 1.56） in LPS ＋ CO group compared with （ 3.08 ± 0. 82） and （ 3.97 ± 1.16 ） in LPS group （ both P 〈 0. 05 ）. The levels of TNF-ot, IL-6 in lung and PAF, ICAM-1 in intestine ofLPS ＋ CO group were 0. 91 ±0. 25,0. 64 ±0.05, 1. 19 ± 0. 52, and 1.83 ±0. 35 pg/mg, respectively, significantly lower than the corresponding values in LPS group （ 1.48 ± 0. 23, 1.16 ± 0. 26, 1.84 ± 0. 73, and 3.48 ± 0. 36 pg/mg, all P 〈 0. 05 ）. The levels of MDA, MPO, and cell apoptosis rate in lung and intestine of LPS ＋ CO group were 1.02 ± 0. 23 nmol/mg, 1.74 ± 0. 17 nmol/mg, 7.18 ± 1.62 U/mg, 6. 30 ±0. 97 U/mg, 1.60% ±0. 34%, and 30. 56% ±6. 33%, respectively, significantly lower than the corresponding values in LPS group （ 1.27 ± 0. 33 nmol/mg, 2. 75 ± 0. 39 nmol/mg, 8. 16 ± 1.49 U/mg, 7. 72 ± 1.07 U/mg, 3.18% ±0. 51%, and 41.52% -＋3.36%, all P 〈0.05）. In addition, injury of lung and intestine induced by LPS was attenuated at presence of CO inhalation. Conclusion CO inhalation protects rat lung and intestine from LP

关键词： carbon monoxide lung intestine multiple organ injury