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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 319-330页

作者： Priya Bhardwaj Swarnabha Sarkar ritu Mishra Department of Pharmacology All India Institute of Medical SciencesNew Delhi-110029India Department of Physiology All India Institute of Medical SciencesNew Delhi-110029India Department of Zoology University of AllahabadPrayagrajUttar Pradesh-211002India

The recently re-emerged mpox(monkeypox)virus that causes mpox disease is a member of genus Orthopoxvirus and has unprecedentedly spread *** studies have contributed to our understanding of its evolution,pathophysiology,and clinical *** current outbreak of the mpox virus depicts its novel route of transmission as a new ***,the exact reason for its transition from an epidemic to a pandemic remains ***,other poxviruses such as vaccinia virus,variola virus,and cowpox virus,also belong to the same genus,*** the present review,our objective was to summarize the evidence on evolution,pathophysiology,and clinical manifestations of mpox virus and its related *** present review would aid in a better understanding of the current circulating mpox virus and its differences from other *** addition,the shared genetic factors contributing to virulence in these Orthopoxvirus highlight their evolutionary connections and genetic *** they exhibit differences in virulence,studying these genetic relationships is crucial for understanding their biology,pathogenicity,and the development of effective vaccines and antiviral therapeutics to curb mpox disease.

关键词： Evolution Mpox Orthopoxviruses Pathophysiology Poxviruses Transmission

C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 279-287页

作者： Hritik Rathod ritu M.Soni Jigna S.Shah Department of Pharmacology Institute of Pharmacy Nirma UniversityAhmedabadGujaratIndia

Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s ***:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 *** studies(Y-maze,rotarod,round beam walk,and wire-hang tests)were carried out to assess neurobehavioral *** and malondialdehyde were determined in both serum and striatal *** proteins(AKT,AMPK,NF-κB,BDNF,and alpha-synuclein)in the striatum were estimated using *** analyses(hematoxylin and eosin stainning as well as Nissl staining)were carried out to assess structural abnormalities in the ***:C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein *** also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone ***,rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by ***:C-phycocyanin might have potential neuroprotective effects against Parkinson’s *** studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.

关键词： Parkinson’s disease C-phycocyanin Alphasynuclein BDNF Oxidative stress Rotenone

Preparation, characterization and luminescence behavior of some samarium complexes

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Rare Metals 2021年第9期40卷 2618-2626页

作者： Archana Chauhan ritu Langyan Department of Chemistry Kurukshetra UniversityKurukshetra 136119India

The synthesis of luminescent complexes of Sm(III) with the general formula [Sm(L)_(3)·(X)] was done in powder form. In the formula, L is 6-methyl-4-oxo-4 H-1-benzopyran-3-carboxaldehyde and X represents 2H_(2)O(C1), 1,10-phenanthroline(C2), 2,20-bipyridine(C3);bathophenanthroline(C4) and neocuproine(C5). The complexes were characterized by using various analytical and spectroscopic tools like elemental analysis, electrospray ionization mass spectrometry(ESI–MS+), Fourier transform infrared spectroscopy(FTIR), ultraviolet–visible(UV–Vis) spectroscopy, thermo-gravimetric analysis/differential thermal gravimetric analysis(TGA/DTG), field emission scanning electron microscopy(FESEM), powder X-ray diffraction(XRD), and photoluminescence(PL)studies. TGA/DTG showed high thermal stability of synthesized complexes. Powder XRD depicts that the average particle size lies in the nano-range. On monitoring at the excitation wavelength of 370 nm, the complexes display characteristic luminescence peaks of Sm(III) at ~564,~600 and ~647 nm assigned to^(4)G_(5/2)→^(6)H_(5/2),^(4)G_(5/2)→^(6)H_(7/2), and ^(4)G_(5/2)→6H9/2 transitions, respectively, with the most intense transition at ~600(orange emission) and~647 nm(bright red emission) in liquid and powder state, respectively. The investigations demonstrate that the synthesized novel complexes might be practically useful in electroluminescent devices, bio-assays, and liquid lasers due to their attractive photoluminescent properties.

关键词： Samarium complexes Luminescence Thermal analysis Quantum yield

Hybrid Image Compression-Encryption Scheme Based on Multilayer Stacked Autoencoder and Logistic Map

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China Communications 2022年第1期19卷 238-252页

作者： Neetu Gupta ritu Vijay Computer Science&Engineering Department Banasthali VidyapithBanasthaliIndia Department of Electronics Engineering Banasthali VidyapithBanasthaliIndia.

Secure transmission of images over a communication channel, with limited data transfer capacity, possesses compression and encryption schemes. A deep learning based hybrid image compression-encryption scheme is proposed by combining stacked auto-encoder with the logistic map. The proposed structure of stacked autoencoder has seven multiple layers, and back propagation algorithm is intended to extend vector portrayal of information into lower vector space. The randomly generated key is used to set initial conditions and control parameters of logistic map. Subsequently, compressed image is encrypted by substituting and scrambling of pixel sequences using key stream sequences generated from logistic *** proposed algorithms are experimentally tested over five standard grayscale images. Compression and encryption efficiency of proposed algorithms are evaluated and analyzed based on peak signal to noise ratio(PSNR), mean square error(MSE), structural similarity index metrics(SSIM) and statistical,differential, entropy analysis respectively. Simulation results show that proposed algorithms provide high quality reconstructed images with excellent levels of security during transmission..

关键词： compression-encryption stacked autoencoder chaotic system back propagation algorithm logistic map

Remediation of polycyclic aromatic hydrocarbon-contaminated soils using microbes and nanoparticles: A review

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Pedosphere 2023年第1期33卷 93-104页

作者： ritu PANWAR Jyoti MATHUR Department of Bioscience and Biotechnology Banasthali VidyapithRajasthan 304022India

Polycyclic aromatic hydrocarbon(PAH)pollution is a global concern because of their toxicity to environment and ecosystem,which induces adverse effects on plants,animals,and *** are mainly released from natural and anthropogenic activities,such as incomplete fuel combustion,leakages in oil pipelines,and the extensive use of pesticides;PAH contaminants include petroleum hydrocarbons(PHCs),halogenated hydrocarbons,chlorophenols,and *** using microorganisms such as bacteria and fungi is developing as an effective and promising technique to remediate PAHs from the *** to their remediation efficiency,this method is environmentally friendly and represents a novel approach for reducing the risk of PAHs to human health and the *** may be applied in bioremediation,and will not only induce fewer toxic effects but also reduce the effective overall time and costs *** article provides a summary of the application of nanomaterials,bacteria,and fungi to PAH remediation;we review and briefly discuss the structure,properties,sources,fate,toxicity,and remediation approaches involved in the remediation of PAH-polluted sites.

关键词： bioremediation microorganisms pesticides persistent organic pollutants petroleum hydrocarbons

Antimicrobial ability and growth promoting effects of feed supplemented with probiotic bacterium isolated from gut microflora of Cirrhinus mrigala

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Journal of Integrative Agriculture 2015年第3期14卷 583-592页

作者： Anita Bhatnagar ritu Lamba Department of Zoology Kurukshetra University

The present studies were conducted to isolate, select, identify and characterize gut bacteria as antimicrobial and growth promoting agent for the feed of economically important fish Cirrhinus mrigala. Intestinal microflora were isolated, counted, and identified, and their in vitro antibacterial properties were determined. The results have revealed that occurrence of Gram-negative rods was around 75% and of Gram-positive rods was 25%. Among the isolates Gram-positive were maintained in nutrient agar slants at 4℃. Of these, eight strains were replica-plated on agar seeded with Aeromonas hydrophila and only one strain CM2（C. mrigala 2） exhibited antibacterial properties in vitro showing inhibition against fish pathogen by well diffusion assay. This isolated strain was identified as Bacillus cereus. This bacterium was mass cultured and incorporated in the pelleted diet（40% protein and 18 k J g^–1 gross energy） of C. mrigala to investigate its effect on growth performance, digestibility, nutrient retention and activities of digestive enzymes. The results of feeding trial revealed significantly（P〈0.05） high growth performance in terms of specific growth rate, growth percent gain in body weight（BD）（272.4±1.5）%, high apparent protein digestibility（（79.9±0.30）%） and low food conversion ratio in the group of fishes fed on diet containing B. cereus in comparison to the fishes fed on diet without probiotics. The carcass composition also revealed high accumulation of proteins（（15.28±0.15） g 100 g^–1） in fishes fed on diet containing probiotics. Intestinal enzyme activities of protease, amylase and cellulase were also significantly（P〈0.05） high in the group of fishes fed on diet supplemented with probiotics indicating the extracellular enzyme production by B. cereus. These results indicate that probiotics stimulate the digestion through the supply of digestive enzyme and certain essential nutrients to animals. Also significantly（P〈0.05） low excretion of metabolites, i.e., ammonia

关键词： Aeromonas Bacillus cereus digestive enzymes growth performance Cirrhinus mrigala probiotics

Nuclear magnetic resonance based structure of the protoberberine alkaloid coralyne and its self-association by spectroscopy techniques

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Journal of Pharmaceutical Analysis 2019年第6期9卷 437-448页

作者： Kumar Padmapriya ritu Barthwal Department of Biotechnology Indian Institute of Technology Roorkee

Coralyne is an important alkaloid due to its anti-cancer and other medicinal *** targets DNA in cells and acts as human topoisomerase-I poison,telomerase inhibitor and nucleic acid *** has high tendency to undergo self-association,which is a matter of concern for therapeutic *** understanding of its interaction with DNA requires precise knowledge of chemical shifts in Nuclear Magnetic Resonance(NMR)spectra besides *** present study is the first report of a complete assignment of all 1H/13C resonances in NMR spectra of coralyne in DMSO-d6 using one dimensional 1H/13C and two dimensional NMR *** chemical shift of all proton and several 13C resonances have also been obtained in D2O and *** same has been calculated using Density Functional Theory(DFT).NMR spectra of coralyne show upfield shift of 0.6e1.2 ppm in aromatic ring protons suggesting stacking *** from 11 intra molecular NOE cross peaks in 2D 1H e1H ROESY spectra,3 short distance NOE correlations,H6e10OCH3,H5e10OCH3 and H12e16CH3,give direct independent evidence of the formation of a stacked *** absorbance,fluorescence,circular dichroism and fluorescence lifetime experiments conducted in the present investigations corroborate results obtained by NMR.

关键词： Coralyne alkaloid NMR spectra Chemical shift calculations Restrained molecular dynamics

Synthesis,characterization and photoluminescent properties of Eu(Ⅲ)complexes with 5-hydroxy-2-hydroxymethyl-4H-4-pyranone and N,N’-donor heterocyclic coligands

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Rare Metals 2021年第5期40卷 1118-1125页

作者： Shammy Laj Dhania Archana Chauhan ritu Langyan Department of Chemistry Kurukshetra UniversityKurukshetra 136119India

In present work,five novel europium complexes[Eu(L)3·Phen(2),Eu(L)3·Bipy(3),Eu(L)3·Neo(4),Eu(L)3·Biq(5)and Eu(L)3·Batho(6)]were synthesized,derived from[Eu(L)3·2 H_(2)O](1)complex by using ligand(HL)5-hydroxy-2-(hydroxymethyl)-4 H-pyran-4-one and coligands 1,10-phenanthroline,bipyridine,neocuproine,2,2’-biquinoline and *** order to seek excellent photoluminescent properties,coligands were introduced in the complexes to form a rigid conjugated system,thus enhancing luminescence properties of *** synthesized complexes reveal four narrow characteristic emission lines of Eu(III)consistent with ^(5)D0→^(7)FJ transitions,where J=0,1,2 and 3 at about 580,595,614 and 650 nm,*** ^(5)D0→^(7)F_(2) transition is responsible for strong red *** coordinate diagram also indicates that x,y coordinates lie in deep red *** data are in favour of high thermal stability of synthesized *** to their high thermal stability and strong red luminescence,these complexes might be used in fabrication of optoelectronic devices.

关键词： Photoluminescence Europium complexes Color coordinates Optoelectronic devices Thermal stability

Potential of biocontrol agents against Ganoderma lucidum causing basal stem rot in mesquite(Prosopis cineraria)in arid regions of India

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Journal of Forestry Research 2021年第3期32卷 1269-1279页

作者： ritu Mawar Deepesh Sharma Ladhu Ram ICAR-Central Arid Zone Research Institute Jodhpur 342003India College of Horticulture and Forestry JhalarapatanJhalawar 326001India

This study investigates the potential of native biocontrol agents(BCAs)as controls against Ganoderma lucidum causing root rot mortality in Indian *** disease is prevalent in sandy soils where trees grow under rainfed *** addition,a beetle namely A canthophorus serraticornis damages the roots,resulting in increasing vulnerability of the host thereby allowing easy of the *** dual culture tests,Ganoderma infected cowpea root bit experiment and compatibility with insecticides revealed that the three BCAs(Trichoderma longibrachiatum,***,and Aspergillus nidulans)significantly inhibited *** mycelial *** highest mycelial growth inhibition(47.6%)was recorded after 96 h followed by 39.8%and 29.3%at 72 and 48 h,respectively,by *** free filtrates of ***,***,and *** were superior in inhibiting mycelium growth.A low concentration(3 ml)of *** was more effective in inhibiting mycelium growth compared to other *** P rosopis julifl ora compost and onion residue compost amendments as food substrates favored the growth of these BCAs,which ultimately reduced the viability of Ganoderma-colonized root bits of *** on compatibility between insecticides and BCAs suggests that ***,harzianum and *** can be combined with phorate or chloropyriphos(both organophosphates)at variable concentrations if amended together for partially infected trees,or as a prophylactic measure in healthy *** studies demonstrate that there is considerable opportunity for using native BCAs against *** in managing root rot disease.

关键词： Trichoderma longibrachiatum Trichoderma harzianum Aspergillus nidulans Prosopis cineraria Onion residues Prosopis juliflora compost