C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice

作     者：Hritik Rathod Ritu M.Soni Jigna S.Shah Hritik Rathod;Ritu M.Soni;Jigna S.Shah

作者机构：Department of PharmacologyInstitute of Pharmacy Nirma UniversityAhmedabadGujaratIndia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2024年第14卷第7期

页      面：279-287页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Nirma University  NU 

主　　题：Parkinson’s disease C-phycocyanin Alphasynuclein BDNF Oxidative stress Rotenone 

摘      要：Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s ***:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 *** studies(Y-maze,rotarod,round beam walk,and wire-hang tests)were carried out to assess neurobehavioral *** and malondialdehyde were determined in both serum and striatal *** proteins(AKT,AMPK,NF-κB,BDNF,and alpha-synuclein)in the striatum were estimated using *** analyses(hematoxylin and eosin stainning as well as Nissl staining)were carried out to assess structural abnormalities in the ***:C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein *** also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone ***,rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by ***:C-phycocyanin might have potential neuroprotective effects against Parkinson’s *** studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.