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Cannabinoids:Challenges,opportunities and current techniques towards its extraction and purification for edibles

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Food Bioscience 2022年第5期49卷 1-12页

作者： Sharon Lustenberger Grzegorz Boczkaj roberto Castro-Mu˜noz Tecnologico de Monterrey Campus GuadalajaraAv.General Ram´on Corona 2514Zapopan45138JaliscoMexico Gdansk University of Technology Department of Sanitary EngineeringFaculty of Civil and Environmental Engineering11/12 Narutowicza St80-233GdanskPoland Tecnologico de Monterrey Campus TolucaAv.Eduardo Monroy C´ardenas 2000 San Antonio Buenavista50110Toluca de LerdoMexico

Due to the multiple health benefits associated with the consumption of cannabinoids,there is a current trend on continuing to explore their biological ***(CBD)is likely to be the most investigated endocannabinoid from the cannabis ***,the purification of CBD from its natural source and psychotropic analogue(tetrahydrocannabinol,THC)is timely challenging for the research community based on the similar physiochemical properties of both *** latter fact becomes relevant for the final application of CBD in edibles as a bioactive ***,this paper comprehensively reviews the latest development works(over the last 2-3 years)aiming at the extraction of cannabinoids and purification of CBD using traditional,emerging,and synergistic extraction techniques and *** emphasis and discussion have been focused on the innovative extraction techniques and the relevant outcomes with detailed strategies to meet such high extraction *** properties(at lab-scale and clinical case studies),current practices,progress in legislation and commercialization of CBD are also ***,according to the findings of this review,the future trends and research gaps are also given.

关键词： Cannabinoids Cannabidiol(CBD) Extraction Natural drugs Purification Legislation&commercialization

Domain wall-localized phonons in BiFeO_(3):spectrum and selection rules

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npj Computational Materials 2020年第1期6卷 1255-1260页

作者： Peng Chen Louis Ponet Keji Lai roberto Cingolani Sergey Artyukhin Quantum Materials Theory Istituto Italiano di Tecnologia16163 GenovaItaly Scuola Normale Superiore di Pisa 56126 PisaItaly Department of Physics University of Texas at AustinAustinTX 78712USA

Ferroelectric domain walls(DWs)are nanoscale topological defects that can be easily tailored to create nanoscale *** excitations,recently discovered to be responsible for GHz DW conductivity,hold promise for faster signal transmission and processing compared to the existing *** we find that DW phonons have unprecedented dispersion going from GHz all the way to THz frequencies,and resulting in a surprisingly broad GHz signature in DW *** activation of nominally forbidden DW sliding modes in BiFeO_(3) is traced back to DW tilting and resulting asymmetry in wall-localized *** obtained phonon spectra and selection rules are used to simulate scanning impedance microscopy,emerging as a powerful probe in *** results will guide the experimental discovery of the predicted phonon branches and design of DWbased nanodevices operating in the technologically important frequency range.

关键词： phonon walls faster

Combined use of lactoferrin and vitamin D as a preventive and therapeutic supplement for SARS-CoV-2 infection: Current evidence

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World Journal of Clinical Cases 2022年第32期10卷 11665-11670页

作者： Massimiliano Cipriano Enzo Ruberti Marcos roberto Tovani-Palone Department of Laparoscopic Surgery Umberto I General HospitalMedical School Sapienza UniversityRome 161Italy Department of Human Neuroscience Sapienza University of RomeRome 00185Italy Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India

Lactoferrin is a multifunctional protein that exhibits anti-inflammatory,immune regulating and anti-infective *** of its receptor sites is located on severe acute respiratory syndrome coronavirus *** binding of lactoferrin with heparin sulfate proteoglycans may prevent the first contact between the virus and host cells,thus preventing subsequent *** that lactoferrin may act as a natural mucosal barrier,an intranasal treatment together with its oral intake can be hypothesized to prevent the spread,infection and inflammation caused by coronavirus disease 2019(COVID-19).Moreover,the literature reports that vitamin D plays an essential role in promoting immune *** its antiinflammatory and immunoregulatory properties,vitamin D is critical for activating the immune system’s defenses,improving immune cell *** studies also demonstrate that lactoferrin is a potential activator of the vitamin D *** this sense,the combined use of lactoferrin(through an association of oral intake and a nasal spray formulation)and vitamin D could represent a valuable therapy for COVID-19 treatment and ***,further randomized clinical trials are needed before recommending/prescribing them.

关键词： Lactoferrin Vitamin D SARS-CoV-2 COVID-19 Pandemics

Response of Reynolds stresses and scaling behavior of high-order structure functions to a water-worked gravel-bed surface and its implication on sediment transport

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International Journal of Sediment Research 2022年第1期37卷 1-13页

作者： Nadia Penna Ellora Padhi Subhasish Dey roberto Gaudio Dipartimento di Ingegneria Civile Università Della Calabria Department of Civil Engineering Shiv Nadar University Department of Civil Engineering Indian Institute of Technology Kharagpur

The aim of this experimental study is to investigate the interaction between turbulent flow and a gravelbed that mimics the actual roughness structures of a natural bed and its implication on sediment *** particular,the response of the Reynolds stresses and the role of intermittency to the bed roughness is the primary focus of the current *** this end,the flow field,measured with an Acoustice Doppler Velocimeter (ADV),is thoroughly examined,considering the conditional Reynolds shear stresses and the high-order structure functions of *** study results show that the features and the roughness structure of the water-worked gravel-bed (WWGB) have a strong impact on bursting *** reason for this is attributed to the flow layer above the crest in the WWGBs being primarily affected by sweep events rather than ejection events,although the latter events are prevalent in this flow layer in an immobile,man-made,*** coherent structures,which are primarily responsible for sediment transport,also are the key cause of the presence of an intermittency excess that breaks the Kolmogorov self-similarity hypothesis,leading to multi-fractal behavior of the velocity structure functions.

关键词： Water-worked bed Turbulent flow Sweeps Ejections High-order structure functions

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核子形状因子的阈值效应（英文）

中国科学技术大学学报 2016年第4期46卷 308-315页

作者： BALDINIFERROLI rinaldo PACETTI Simone TOMASI-GUSTAFSSON Egle INFN弗拉斯卡蒂国家实验室意大利弗拉斯卡蒂00044 INFN物理系意大利佩鲁贾06123 法国原子能委员会萨克莱核研究中心法国吉夫伊维特91191

在微扰量子色动力学不再适用的低能区,核子形状因子可以作为一个重要参数来研究其强相互作用.诸如根据第一性原理和某个物理基本量的各种模型来描述数据的唯象物理学可以作为一个有效的工具来研究该领域.

关键词：核子形状因子解析方法阈值效应渐进性

Postoperative complications in gastrointestinal surgery: A “hidden” basic quality indicator

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World Journal of Gastroenterology 2019年第23期25卷 2833-2838页

作者： roberto De la Plaza Llamas JoséM Ramia Department of General and Digestive Surgery Hospital Universitario de GuadalajaraGuadalajara 19002Spain

Postoperative complications represent a basic quality indicator for measuring outcomes at surgical units. At present, however, they are not systematically measured in all surgical procedures. A more accurate assessment of their impact could help to evaluate the real morbidity associated with different surgical interventions, establish measures for improvement, increase efficiency and identify benchmarking services. The Clavien-Dindo Classification is the most widely used system worldwide for assessing postoperative ***, the postoperative period is summarized by the most serious complication without taking into account others of lesser magnitude. Recently,two new scoring systems have emerged, the Comprehensive Complication Index and the Complication Severity Score, which include all postoperative complications and quantify them from 0(no complications) to 100(patient’s death), These allow the comparison of results. It is important to train surgical staff to report and classify complications and to record 90-d morbidity rates in all patients. Comparisons with other services must take into account patient comorbidities and the complexity of the particular surgical procedure. To avoid subjectivity and bias, external audits are necessary. In addition, ensuring transparency in the reporting of the results is an urgent obligation.

关键词： Morbidity Postoperative complications Health policy Comprehensive Complication Index Clavien-Dindo Classification Complication Severity Score

Abscisic Acid, High-Light, and Oxidative Stress Down-Regulate a Photosynthetic Gene via a Promoter Motif Not Involved in Phytochrome- Mediated Transcriptional Regulation

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Molecular Plant 2008年第1期1卷 75-83页

作者： roberto J. Staneloni Maria Jose Rodriguez-Batiller Jorge J. Casal Fundacion Instituto Leloir and IIBBA-CONICET C1405BWE-Buenos Aires Argentina IFEVA Facultad de Agronomia Universidad de Buenos Aires and CONICET 1417 Buenos Aires Argentina

In etiolated seedlings, light perceived by phytochrome promotes the expression of light-harvesting chlorophyll a/b protein of photosystem Ⅱ （Lhcb） genes. However, excess of photosynthetically active radiation can reduce Lhcb expression. Here, we investigate the convergence and divergence of phytochrome, high-light stress and abscisic acid （ABA） signaling, which could connect these processes. Etiolated Arabidopsis thaliana seedlings bearing an Lhcb promoter fused to a reporter were exposed to continuous far-red light to activate phytochrome and not photosynthesis, and treated with ABA. We identified a cis-acting region of the promoter required for down-regulation by ABA. This region contains a CCAC sequence recently found to be necessary for ABI4-binding to an Lhcb promoter. However, we did not find a G-box-binding core motif often associated with the ABI4-binding site in genes promoted by light and repressed by ABI4. Mutations involving this motif also impaired the responses to reduced water potential, the response to high photosynthetic light and the response to methyl viologen but not the response to low temperature or to Norflurazon. We propose a model based on current and previous findings, in which hydrogen peroxide produced in the chloroplasts under high light conditions inter- acts with the ABA signaling network to regulate Lhcb expression. Since the mutation that affects high-light and methyl viologen responses does not affect phytochrome-mediated responses, the regulation by retrograde and phytochrome signaling can finally be separated at the target promoter level.

关键词： .cis-Acting Abscisic ABA signaling High-Light and Oxidative Lhcb expression high-light stress Lhcb promoter

360° fusion for realignment of high grade cervical kyphosis by one step surgery: Case report

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World Journal of Clinical Cases 2014年第7期2卷 289-292页

作者： Alessandro Landi Nicola Marotta Cristina Mancarella Demo Eugenio Dugoni roberto Tarantino roberto Delfini Department of Neurology and Psychiatry Division of NeurosurgeryUniversity of RomeSapienza00100 RomeItaly

Surgical treatment for cervical kyphotic deformity is still controversial. Circumferential approach has been well described in the literature but long terms outcomes are not well reported. Important to decide the correct treatment option is the preoperative radiological exams to value the type of deformity(flexible or fixed). We report the case of a 67-year-old woman affected by a severe cervical kyphotic deformity who underwent combined anterior/posterior surgical approach, getting a good reduction of the deformity and an optimal stability in a long term follow up.

关键词： Cervical deformity High grade kyphosis Circumferential fusion Surgical technique Degenerative cervical spine

Inflammatory bowel disease:Efficient remission maintenance is crucial for cost containment

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 114-119页

作者： Giovanni C Actis rinaldo Pellicano the Medical Center Practice Office Hepatogastroenterology Division Ospedale Gradenigo Unit of Gastroenterology Ospedale Molinette

The inflammatory bowel diseases(IBD) are chronicincurable inflammatory disorders of the gut. Some 10% run a downhill course, requiring emergency medical support and often surgery; another small subset are monogenic, and, threatening pediatric patients, are the challenge of these days. The majority of the IBDs, however, are polygenic low-penetrance diseases, running a lifetime waxing-and-waning course. The prevalent trend is towards a slow worsening and steady cost increase. Each and all drugs of the available arsenal exhibit strengths and weaknesses: Mesalamines are chiefly effectively for mildmoderate colitis, and do not work in Crohn's; steroids do not control some 40% of the ulcerative colitis cases, and are not indicated for Crohn's; thiopurines are effective in the maintenance of the IBDs but do not prevent relapses on withdrawal; biologics are still being used empirically(not monitored) causing further increase of their cost over that of hospitalization. Against all these caveats, two simple rules still hold true: Strict adherence maintenance and avoidance of colitogenic drugs. This matter is expanded in this minireview.

关键词： Inflammatory bowel disease Therapy Cost containment Budget Treatment adherence Inflammatory bowel disease managed care