Combined use of lactoferrin and vitamin D as a preventive and therapeutic supplement for SARS-CoV-2 infection: Current evidence

作     者：Massimiliano Cipriano Enzo Ruberti Marcos Roberto Tovani-Palone 

作者机构：Department of Laparoscopic SurgeryUmberto I General HospitalMedical School Sapienza UniversityRome 161Italy Department of Human NeuroscienceSapienza University of RomeRome 00185Italy Department of Research AnalyticsSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第32期

页      面：11665-11670页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：Lactoferrin Vitamin D SARS-CoV-2 COVID-19 Pandemics 

摘      要：Lactoferrin is a multifunctional protein that exhibits anti-inflammatory,immune regulating and anti-infective *** of its receptor sites is located on severe acute respiratory syndrome coronavirus *** binding of lactoferrin with heparin sulfate proteoglycans may prevent the first contact between the virus and host cells,thus preventing subsequent *** that lactoferrin may act as a natural mucosal barrier,an intranasal treatment together with its oral intake can be hypothesized to prevent the spread,infection and inflammation caused by coronavirus disease 2019(COVID-19).Moreover,the literature reports that vitamin D plays an essential role in promoting immune *** its antiinflammatory and immunoregulatory properties,vitamin D is critical for activating the immune system’s defenses,improving immune cell *** studies also demonstrate that lactoferrin is a potential activator of the vitamin D *** this sense,the combined use of lactoferrin(through an association of oral intake and a nasal spray formulation)and vitamin D could represent a valuable therapy for COVID-19 treatment and ***,further randomized clinical trials are needed before recommending/prescribing them.