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Outcome of varicocele repair in men with nonobstructive azoospermia： systematic review and meta-analysis

Asian Journal of Andrology 2016年第2期18卷 246-253,J0005,J0006页

作者： Sandro C Esteves ricardo Miyaoka Matheus Roque Ashok Agarwal ANDROFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 Campinas SP 13075-460 Brazil ORLGEN Center for Reproductive MedicineRio de Janeiro Aw Rodolfo de Amoedo 140 Rio de Janeiro RJ 22620-330 Brazil American Center for Reproductive Medicine 10681. Carnegie Avenue X-11Cleveland OH 44195 USA.

The objective of this systemic review was to evaluate the benefit of repairing clinical varicocele in infertile men with nonobstructive azoospermia （NOA）. The surgically obtained sperm retrieval rate （SRR） and pregnancy rates following assisted reproductive technology （ART） with the use of retrieved testicular sperm were the primary outcomes. The secondary outcomes included the presence of viable sperm in postoperative ejaculate to avoid the testicular sperm retrieval and pregnancy rates （both assisted and unassisted） using postoperative ejaculated sperm. An electronic search to collect the data was performed using the MEDLINE and EMBASE databases until April 2015. Eighteen studies were included in this systematic review and accounted for 468 patients who were diagnosed with NOA and varicocele. These patients were subjected to either surgical varicocele repair or percutaneous embolization. Three controlled studies evaluating sperm retrieval outcomes indicated that in patients who underwent varicocelectomy, SRR increased compared to those without varicocele repair （OR： 2,65; 95% Cl. 1.69-4.14; P 〈 0.001）. Although pregnancy rates with the use of testicular sperm favored the varicocelectomy group, results were not statistically significant （clinical pregnancy rate OR： 2.07; 95% CI： 0.92-4.65; P = 0.08; live birth rate OR： 2.19; 95% CI： 0.99-4.83; P = 0.05）. The remaining fifteen studies reported postoperative semen analysis results. In 43.9% of the patients （range： 20.8%-55.0%）, sperm were found in postoperative ejaculates. Pregnancy rates for unassisted and assisted （after IVF/ICSI） were 13.6% and 18.9% in the group of men with sperm in postoperative ejaculates, respectively. Our findings indicate that varicocelectomy in patients with NOA and clinical varicocele is associated with improved SRR. In addition, approximately 44% of the treated men will have enough sperm in the ejaculate to avoid sperm retrieval. Limited data on pregnancy outcomes with both postoperative

关键词： azoospermia male infertility meta-analysis sperm retrieval systematic review varicocele varicocelectomy

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Distributed representations of atoms and materials for machine learning

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npj Computational Materials 2022年第1期8卷 415-423页

作者： Luis M.Antunes ricardo Grau-Crespo Keith T.Butler Department of Chemistry University of ReadingWhiteknightsReadingRG66DXUK SciML Scientific Computing DepartmentRutherford Appleton LaboratoryHarwellOX110QXUK

The use of machine learning is becoming increasingly common in computational materials *** build effective models of the chemistry of materials,useful machine-based representations of atoms and their compounds are *** derive distributed representations of compounds from their chemical formulas only,via pooling operations of distributed representations of *** compound representations are evaluated on ten different tasks,such as the prediction of formation energy and band gap,and are found to be competitive with existing benchmarks that make use of structure,and even superior in cases where only composition is ***,we introduce an approach for learning distributed representations of atoms,named SkipAtom,which makes use of the growing information in materials structure databases.

关键词： representations operations competitive

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Novel kinetic model for the simulation analysis of the butanol productivity of Clostridium acetobutylicum ATCC 824 under different reactor configurations

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Chinese Journal of Chemical Engineering 2018年第4期26卷 812-821页

作者： Hugo I.Velázquez-Sánchez ricardo Aguilar-López Center of Research and Advances Studies of the National Polytechnic Institute (CINVESTAV) Biotechnology and Bioengineering DepartmentAv. National Polytechnic Institute 2508 Col. San Pedro Zacatenco

Acetone–butanol–ethanol(ABE)fermentation process can be exploited for the generation of butanol as biofuel,however it does need to overcome its low volumetric solvent productivity before it can commercially compete with fossil fuel *** this regard,mathematical modelling and simulation analysis are tools that can serve as the base for process engineering development of biological *** this work,a novel phenomenological kinetic model of Clostridium acetobutylicum ATCC 824 was considered as a benchmark system to evaluate the behaviour of an ABE fermentation under different process configurations using both free and immobilized cells:single stage batch operation,fed-batch,single stage Continuous Stirred Tank Reactor(CSTR)and multistage CSTRs with and without biomass *** proposed model achieved a linear correlation index r^2=0.9952 and r^2=0.9710 over experimental data for free and immobilized cells *** predicted maximum butanol concentration and productivity obtained were 13.08 g·L^(-1)and 1.9620 g·L^(-1)·h^(-1)respectively,which represents an increase of 1.01%and 990%versus the currently developed industrial scale process reported currently into the *** results provide a reliable platform for the design and optimization of the ABE fermentation system and showcase the adequate predictive nature of the proposed model.

关键词： Biofuels Butanol Clostridium acetobutylicum Mathematical modelling Process configurations

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Entrepreneurship and Unemployment Cycles： A Delay Differential Equation Approach

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2013年第2期8卷 288-292页

作者： Joao ricardo Faria MPA Program University of Texas at E1 Paso E1 Paso TX 79968-0703 USA

This paper is an application of delay differential equations to entrepreneurship and unemployment. It shows that the results of empirical studies can be replicated through a simple DDE. The paper also carries out a comparative study between a solution of a DDE and the observation of cyclic behaviors. The calculated delay （and growth rate） of the entrepreneurship DDE for the US and Spain is 1.25 years （1.25）, for Ireland is 1.75 years （0.89）, and for the UK is 2 years （0.78）. The delay （and growth rate） of the unemployment DDE for the US and Ireland is 1.5 years （1.04）, for Spain is 2 years （0.78）, and for the UK is 2.5 years （0.62）.

关键词： new firms employment creation cycles delay differential equations

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Infrared Spectroscopy of CO Isolated in Solid Nitrogen Matrix

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Chinese Journal of Chemical Physics 2014年第1期27卷 5-8,I0003页

作者：吴磊 ricardo Lambo 谈艳刘安雯胡水明中国科学技术大学合肥微尺度物质科学国家实验室(筹) 合肥230026

The infrared absorption spectra of the CO monomer isolated in solid N2 have been recorded at various temperatures between 4.5 and 30 K. The absorption features of the fundamen- tal stretching mode show its linewidth and matrix-induced frequency shift to be weakly temperature-dependent. As the temperature of the matrix was raised, an increase in the linewidth together with a redshift in the central frequency was observed. These observations were explained in terms of the quenching of the CO rotational states by the N2 matrix into closely-lying librational states. A quantitative model was then used to calculate the energy difference between these librational states. Results show that they can be thermally populated through the absorption of matrix phonons.

关键词： Phonon coupling Vibrational relaxation Energy gap law

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Heme as an inducer of cerebral damage in hemorrhagic stroke:potential therapeutic implications

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Neural Regeneration Research 2022年第9期17卷 1961-1962页

作者： Luiz ricardo da Costa Vasconcellos Pedro Moreno Pimentel-Coelho Cellular Signalling and Cytoskeletal Function Laboratory The Francis Crick InstituteLondonUK Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroInstituto Nacional de Ciência e Tecnologia em Medicina RegenerativaRio de JaneiroRJBrazil

Intracerebral hemorrhage(ICH)consists of the rupture of a cerebral artery leading to bleeding into the surrounding *** event has a primary phase of brain injury consisting of mechanical tissue damage due to the mass effect,followed by a secondary phase of brain injury triggered by the presence of blood components released at the site of bleeding(Bulters et al.,2018).Despite the high rates of mortality and morbidity from ICH,no effective treatment is available so far.

关键词： cerebral damage rupture

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ON THE ORDER OF SUMMABILITY OF THE FOURIER INVERSION FORMULA

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Analysis in Theory and Applications 2010年第1期26卷 13-42页

作者： Jasson Vindas ricardo Estrada Chent University Belgium Louisiana State University USA

In this article we show that the order of the point value, in the sense of Lojasiewicz, of a tempered distribution and the order of summability of the pointwise Fourier inversion formula are closely related. Assuming that the order of the point values and certain order of growth at infinity are given for a tempered distribution, we estimate the order of summability of the Fourier inversion formula. For Fourier series, and in other cases, it is shown that if the distribution has a distributional point value of order k, then its Fourier series is e.v. Cesaro summable to the distributional point value of order k＋1. Conversely, we also show that if the pointwise Fourier inversion formula is e.v. Cesaro summable of order k, then the distribution is the （k ＋ 1）-th derivative of a locally integrable function, and the distribution has a distributional point value of order k ＋ 2. We also establish connections between orders of summability and local behavior for other Fourier inversion problems.

关键词： Fourier inversion formula tempered distribution distributional point value Cesaro summability of Fourier series and integrals summability of distributional evaluations

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The effects of low-volume combined training on health-related physical fitness outcomes in active young adults: A controlled clinical trial

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运动医学与健康科学(英文) 2023年第1期5卷 74-80页

作者： ricardo Martins Nuno Loureiro Department of Arts Humanities and SportsSchool of EducationPolytechnic Institute of BejaLaboratory of Physical Activity and HealthBejaPortugal

The effects of combined training(CT)on improving general health are well known,however,few studies have investigated the effects of low-volume ***,the aim of this study is to investigate the effects of 6 weeks of lowvolume CT on body composition,handgrip strength(HGS),cardiorespiratory fitness(CRF)and affective response(AR)to *** healthy,active young adult man(meanSD,[20.061.66]years;[22.232.76]kg/m2)performed either a low-volume CT(EG,n?9),or maintained a normal life(CG,n?9).The CT was composed of three resistance exercises followed by a high intensity-interval training(HIIT)on cycle ergometer performed twice a *** measures of the body composition,HGS,maximal oxygen consumption(V_O2max)and AR to exercise were taken at baseline and after training for ***,an ANOVA test of repeated measures and t-test paired samples were used with a p*** results showed that EG improved HGS(pre:[45.6711.84]kg ***:[52.4411.90]kg,p0.05),nevertheless the feeling scale was positive in all weeks and without significant differences between them(p>0.05).Lastly,for active young adults,the low-volume CT improved HGS,CRF and had a positive outcome in AR,with less volume and time spent than traditional exercise recommendations.

关键词： Exercise Concurrent training Handgrip strength Cardiorespiratory fitness Affective response Untrained

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Tides and Wind-Driven Circulation in the Tropical and Southern Atlantic Ocean:The BRAZCOAST System

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Atmospheric and Oceanic Science Letters 2014年第5期7卷 476-480页

作者： ricardo de CAMARGO Joseph HARARI Department of Atmospheric Sciences University of Sao Paulo Sao Paulo Brazil Department of Physical Chemical and Geological Oceanography University of Sao Paulo Sao Paulo Brazil

The Brazilian coast is characterized by different tidal regimes and distinct meteorological influences. The northern part has larger tidal amplitudes and is permanently affected by trade winds and tropical disturbances; the southern portion has smaller tidal amplitudes and is frequently influenced by extratropical cyclone activity. Besides these aspects, many features regarding current structure and behavior are also present, such as the equatorial system of currents, the subtropical gyre and the corresponding western boundary currents, and the Brazil-Malvinas confluence region. Within this context, efforts were made to develop the BRAZCOAST system, capable of describing the processes that determine the oceanic circulation from large to coastal scales. A customized version of the Princeton Ocean Model(POM) was implemented in a basin-scale domain covering the whole of the tropical and southern Atlantic Ocean, with 0.5° spatial resolution, as well as three nested grids with(1/12)° resolution covering the different parts of the Brazilian shelf, in a one-way procedure. POM was modified to include tidal potential generator terms and a partially-clamped boundary condition for tidal elevations. The coarse grid captured large-scale features, while the nested grids detailed local circulations affected by bathymetry and coastal restrictions. An interesting aspect at the coarse grid level was the relevance of the Weddell Sea to the location of the tidal amphidromic systems.

关键词： tides wind-driven circulation tropical Atlan-tic South Atlantic Princeton Ocean Model

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Hepatoprotective effects of antioxidants in chronic hepatitis C

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World Journal of Gastroenterology 2010年第15期16卷 1937-1938页

作者： ricardo Moreno-Otero María Trapero-Marugán Digestive Diseases Service and CIBEREHD (Instituto de Salud Carlos Ⅲ) University Hospital La Princesa Autonomous University of Ma-drid

We have read with interest the paper published in issue 2, volume 16 of World Journal of Gastroenterology 2010 by Nakamura et al, demonstrating that the antioxidant resveratrol (RVT) enhances hepatitis C virus (HCV) replication, consequently, they conclude that RVT is not a suitable antioxidant therapy for HCV chronic infection. The data raise some concern regarding the use of complementary and alternative medicine since the most frequent supplements taken by these patients are antioxidants or agents that may be beneficial for different chronic liver diseases. A recent study by Vidali et al on oxidative stress and steatosis in the progression of chronic hepatitis C concludes that oxidative stress and insulin resistance contribute to steatosis, thus accelerating the progression of fibrosis. We are particularly interested in investigating how the oxidative and nitrosative stress mechanisms are involved in the pathogenesis of different chronic liver diseases.

关键词： Antioxidant Chronic hepatitis C Resveratrol Sadenosylmethionine Nitric oxide Nacetylcysteine

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