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Evolutionary history and phylogeography of Scots pine (Pinus sylvestris L.) in Europe based on molecular markers

Journal of Forestry Research 2017年第4期28卷 637-651页

作者： Endre Gy. To′th Zolta′n A. Kobolkuti Andrzej Pedryc Ma′ria Hohn Department of Botany Szent Istva′n University Me′nesi u′t 44Budapest 1118 Hungary Department of Genetics and Plant Breeding Szent Istva′n UniversityMe′nesi u′t 44Budapest 1118Hungary

In this review we summarized recent historical records and molecular studies on evolutionary history and phylogeography of Scots pine with focus on the European highly fragmented distribution area of the species. Fossilized pollen, plant micro- and macrofossil records provided evidences on the large-scale species’ range shifts and demographic changes during the Quaternary. Populations of Scots pine were documented both in the glacial (incl. full glaciation) and interglacial periods. Recolonization of Europe after the glaciation originated from the (Sub) Mediterranean areas like the Balkan Peninsula but also from around the Eastern Alps and the surroundings of the Danube plain. Fennoscandia and northern European Baltic regions were most probably colonized from two main directions, from Western Europe and from the Russian Plain. Modern history of Scots pine was hardly affected by anthropogenic activities that started to strengthen in the Bronze and Iron Age. Along with the fossil records, molecular genetic tools were used to infer the origin and putative history including migration, differentiation and demography of the species. In this paper we compiled the major publications (30) of molecular genetic studies of the past 20 years derived from distinctly inherited organelle genomes (mitochondrial, chloroplast, nuclear) revealed by different marker systems (mtDNA-cox1, -nad1, -nad3, -nad7, ISSR, cpSSR, nSSR, B-SAP, SNP). It is important to consider that different phylogeographic patterns can be drawn by the analysis of different DNA marker types. Accordingly the use of more than one marker simultaneously outlines the most sophisticated phylogeographical pattern on the genetic lineages and can reveal high differentiation of the European distribution. Combined marker systems and markers derived from coding sequences have also been used to detect species’ phylogeographic patterns, but these were rarely applied to Scots pine. Although new molecular techniques can provide h

关键词： Molecular genetic markers Phylogeography Pinus sylvestris Quaternary history Refugia

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Functional and Structural Arterial Vessel Features of Female Patients with Stable Dermatomyositis and Antisynthetase Syndrome

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Open Journal of Rheumatology and Autoimmune Diseases 2019年第3期9卷 101-110页

作者： Rafael Giovani Misse Isabela Bruna Pires Borges Valéria Aparecida Costa Hong Luiz Aparecido Bortolotto Samuel Katsuyuki Shinjo Division of Rheumatology Faculdade de Medicina FMUSP Universidade de Sao Paulo Sao Paulo SP Brazil (BR) Hypertension Unit Instituto do Cora&#231 o Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo SP Brazil (BR)

Introduction: Dermatomyositis (DM) and antisynthetase syndrome (ASS) show a high frequency of metabolic syndrome, which can be preceded by endothelial dysfunction and arterial stiffness. To date, only one study has evaluated these vessel parameters in DM, and no study of ASS exists. Therefore, the aim of the study was to assess the structural and functional arterial of arterial vessels in DM and ASS. Methods: This cross-sectional study enrolled 21 adult female patients (14 DM and 7 ASS) who were age-, gender- and ethnicity-matched to 12 healthy individuals. Patients using lipid lowering agents or prednisone at doses ≥ 0.25 mg/kg/day, and patients with uncontrolled systemic arterial hypertension, diabetes mellitus, cardiac insufficiency, and disease activity were excluded. Arterial stiffness was evaluated using carotid-femoral pulse wave velocity (PWV), and endothelial function was evaluated using dependent flow-mediated dilatation (FMD) of the brachial artery. Results: The mean age of patients with DM or ASS were 45.4 ± 8.6 and 44.0 ± 6.1 years, respectively (P = 1.000), and patients were predominantly of white ethnicity. Six DM patients and three ASS patients had systemic arterial hypertension, whereas 9 DM patients and six ASS patients had dyslipidemia. Endothelial baseline diameter, hyperemia diameter and FMD values were similar among the three groups (P > 0.05). Moreover, the median FMD values were also similar between the patients with DM and patients with ASS [8.3% (4.5% - 10.9%) vs. 6.0% (−1.8% - 8.2%);P = 0.585]. The PWV values were comparable among the three groups (P = 0.253). In addition, no difference was observed between patients with DM and patients with ASS (7.4 ± 0.8 m/s vs. 7.4 ± 0.9 m/s;P = 1.000). Conclusions: Despite the high prevalence of dyslipidemia and systemic arterial hypertension, our female patients with stable DM and ASS had FMD and PWV values comparable to those of the control group.

关键词： Arterial Stiffness Atherosclerosis Endothelial Dysfunction Systemic Autoimmune Myopathies

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Evaluation of granulability and absorbtivity of biomass in agglomeration mixture

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Journal of Central South University 2017年第10期24卷 2260-2265页

作者： Hudák Jozef Lesko Jaroslav Semanová Zuzana Frohlichová Mária Findorák Róbert Legemza Jaroslav Institute of Metallurgy Faculty of MetallurgyTechnical University of KosiceKosice04200Slovakia

The granulability and absorbtivity of sawdust and coke breeze were *** properties are important within the preparation of agglomeration *** have a significant impact on plynodynamic batch *** of materials to wet is a fundamental condition of granulability of *** and water absorption of wood with liquids is generally significantly affected by their chemical *** important factors affecting the wetting process are undoubtedly the wood moisture content,the value of the surface tension of liquid media and their chemical *** increasing moisture content of wood,the time to equilibrium *** of water absorption and granulability of sawdust was conducted to seek their possible use as a partial replacement of coke dust in the production of the *** have been realized with alder,oak and pine sawdust and reference material-coke *** materials were divided to four classes of granularity:supplied material,1-2 mm,0.5-1 mm and less than 0.5 *** different liquid media were used:water 16°C,water 60°C,soapy water,lime milk and surfactant.

关键词： agglomeration biomass coke breeze granulability absorbtivity

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Detection of functional diversity gradients and their geoclimatic filters is sensitive to data types(occurrence ***)and spatial scales(sites ***)

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Plant Diversity 2024年第6期46卷 732-743页

作者： JoséLuiz Alves Silva Alexandre Souza Angela Pierre Vitória Laboratório de Ciências Ambientais Universidade Estadual do Norte Fluminense Darcy RibeiroCampos dos GoytacazesRio de JaneiroBrazil Departamento de Ecologia Universidade Federal do Rio Grande do NorteRio Grande do NorteBrazil

Functional diversity(FD)reflects within-and between-site variation of species traits(α-and β-FD,respectively).Understanding how much data types(occurrence-based ***-weighted)and spatial scales(sites ***)change FD and ultimately interfere with the detection of underlying geoclimatic filters is still *** contribute to this debate,we explored the occurrence of 1690 species in 690 sites,abundances of 1198 species in 343 sites,and seven functional traits of the Atlantic Forest woody flora in South *** FD indices were sensitive and dependent on the data type at both scales,with occurrence particularly increasing a richness and dispersion(occurrence>abundance in 80%of the sites)while abundance increased β total,β replacement,and α evenness(abundance>occurrence in 60%of the sites).Furthermore,detecting the effect of geoclimatic filters depended on the data type and was *** the site scale,precipitation seasonality and soil depth had weak effects on α-and β-FD(max.R^(2)=0.11).However,regional-scale patterns of a richness,dispersion,and evenness strongly mirrored the variation in precipitation seasonality,soil depth,forest stability over the last 120 kyr,and cation exchange capacity(correlations>0.80),suggesting that geoclimatic filters manifest stronger effects at the regional ***,the role of edaphic gradients expands the idea of biogeographical filters beyond *** findings caution functional biogeographic studies to consider the effect of data type and spatial scale before designing and reaching ecological conclusions about the complex nature of FD.

关键词： Environmental filtering Historical events Human pressure n-dimensional hypervolume Biodiversity hotspot Tropical forest

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The bone marrow niche landscape:a journey through aging,extrinsic and intrinsic stressors in the haemopoietic milieu

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 526-537页

作者： Antonio Giovanni Solimando Assunta Melaccio Angelo Vacca Roberto ria Department of Biomedical Sciences and Human Oncology Section of Internal Medicine and Clinical OncologyUniversity of Bari Medical SchoolBari 70124 Italy

Inflammation and its effects in the bone marrow microenvironment represent a paradigmatic condition in which the hematopoietic niche and the immune systems,thought to properly sustain blood cell production and distinguish between friend and foe,can actively sustain a corrupted neighborhood within a chronic aberrant inflamed *** bone marrow niche hijacks the physiologic *** interactions between the hematopoietic stem cells and the niche in the bone marrow are critical determinants of *** examined several approaches to confront the available evidence;three key points emerged,pointing to the chronic inflammation process,especially the chronic infection and systemic inflammatory states,as leading causes of hematopoietic stem cell *** hematopoiesis,defined as a relative expansion of individual clones,is caused by somatic alterations in essential hematopoietic genes,which increase stem cell ***,terminal differentiation plays a significant role in progenitor loss and inflammatory signaling,promoting clonal selection and clonal hematopoiesis *** myeloid malignancies as paradigmatic examples are discussed as a condition associated with inflammation,including the 5q-syndrome,Philadelphia negative myeloproliferative neoplasms,and chronic myeloid *** with increased fitness and hematopoietic stem cell attrition,extrinsic stress,enhanced stressor-specific fitness,and intrinsic defect across the hematopoietic process represent the route for novel insights in defective *** discussion in this review also points out that the hematopoietic niches’inflammatory stimulation may affect differentiation patterns and the function of downstream cells.

关键词： Hematopoietic niche immune system inflammation tumor microenvironment

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Characterization of the High-Strength Mg–3Nd–0.5Zn Alloy Prepared by Thermomechanical Processing

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Acta Metallurgica Sinica(English Letters) 2019年第3期32卷 321-331页

作者： Ji■í Kub■sek Drahomír Dvorsk■ Jozef Vesel■ Peter Min■rik M■ria Zemkov■ Dalibor Vojtěch Department of Metals and Corrosion Engineering Faculty of Chemical Technology University of Chemistry and Technology Prague Department of Physics of Materials Charles University

Magnesium alloys based on Nd and Zn are promising materials for both aviation industry and medical *** mechanical properties of these materials can be achieved by thermomechanical processing such as extrusion or rolling and by aging treatment, which can significantly strengthen the alloy. The question remains especially about the connection of texture strength created in the alloys based on the specific conditions of preparation. This work focuses on the Mg–3 Nd–0.5 Zn magnesium alloy prepared by hot extrusion of the as-cast state at two different temperatures combined with heat pre-treatment. Extrusion ratio of 16 and rate of 0.2 mm/s at 350 and 400 °C were selected for material preparation. The structures of prepared materials were studied by scanning electron microscopy and transmission electron microscopy. The effect of microstructure on mechanical properties was evaluated. Obtained results revealed the strong effect of thermal pre-treatment on final microstructure and mechanical properties of extruded materials. The Hall–Petch relation between grain size and tensile yield strength has been suggested in this paper based on the literature review and presented data. The observed behavior strongly supports the fact that the Hall–Petch of extruded Mg–3Nd–0.5 Zn alloys with different texture intensities cannot be clearly estimated and predicted. In addition, Hall–Petch relations presented in literature can be sufficiently obtained only for fraction of the Mg–3Nd–0.5 Zn alloys.

关键词： Mg–Nd–Zn alloys Extrusion Thermal treatment Microstructure Mechanical properties

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Identify multiple myeloma stem cells: Utopia?

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World Journal of Stem Cells 2015年第1期7卷 84-95页

作者： Ilaria Saltarella Aurelia Lamanuzzi Antonia Reale Angelo Vacca Roberto ria Department of Biomedical Sciences and Human Oncology Section of Internal Medicine "G. Baccelli" University of Bari "Aldo Moro" Medical School Policlinico I-70124 Bari Italy

Multiple myeloma(MM) is a hematologic malignancy of monoclonal plasma cells which remains incurable despite recent advances in therapies. The presence of cancer stem cells(CSCs) has been demonstrated in many solid and hematologic tumors, so the idea of CSCs has been proposed for MM, even if MM CSCs have not been define yet. The existence of myeloma CSCs with clonotypic B and clonotypic non B cells was postulated by many groups. This review aims to focus on these distinct clonotypic subpopulations and on their ability to develop and sustain MM. The bone marrow microenvironment provides to MM CSCs self-renewal, survival and drug resistance thanks to the presence of normal and cancer stem cell niches. The niches and CSCs interact each other through adhesion molecules and the interplay between ligands and receptors activate stemness signaling(Hedgehog, Wnt and Notch pathways). MM CSCs are also supposed to be responsible for drug resistance that happens in three steps from the initial cancer cell homing microenvironment-mediated to development of microenvironment-independent drug resistance. In this review, we will underline all these aspects of MM CSCs.

关键词： Bone marrow microenvironment Cancerstem cells Multiple myeloma Stem cells niche Stemness

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No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples

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World Journal of Gastroenterology 2007年第15期13卷 2205-2208页

作者： Lili Magyari Bernadett Faragó Judit Bene Katalin Horvatovich Lilla Lakner Márta Varga Mária Figler Beáta Gasztonyi Gyula Mózsik Béla Melegh Department of Medical Genetics and Child Development University of Pécs PécsHungary MTA PTE Clinical Genetics Research Group of the Hungarian Academy of Sciences at the University of Pécs Pécs Hungary Markusovszky Hospital Department of Medicine and Gastroenterology SzombathelyHungary Réthy Pál Hospital 3rd Department of Medicine and Gastroenterology BékéscsabaHungary Department of Medicine School of Medicine University of PécsPécsHungary Department of Gastroenterology Zala County Hospital ZalaegerszegHungary

AIM： The goal of the current work was to analyse the prevalence of the ＋49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene （CTLA4） in Hungarian patients with Crohn＇s disease （CD） and ulcerative colitis （UC）. METHODS： A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism （SNP）. The genotypes were determined by using PCR/RFLP test. RESULTS： The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. CONCLUSION： The results of the current study show that carriage of the ＋49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.

关键词： Cytotoxic T-lymphocyte antigen 4 Crohn's disease Ulcerative colitis Inflammatory bowel disease

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How does the brown mussel Perna perna respond to environmental pollution?A review on pollution biomarkers

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Journal of Environmental Sciences 2022年第1期34卷 412-428页

作者： Fernanda Silva dos Santos Raquel A.F.Neves Mirian Araújo Carlos Crapez Valéria Laneuville Teixeira Natascha Krepsky Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Science and BiotechnologyMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Neotropical Biodiversity(PPGBIO)Pasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Marine Biology and Coastal EnvironmentsMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Ecotourism and ConservationPasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil

The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal *** presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to accumulate several classes of pollutants(e.g.,metals,hydrocarbons,among others).Mussels’biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of environmental contamination and its effects on *** full review compiles two decades(2000–2020)of literature concerning biological effects on *** mussel caused by environmental pollutants(i.e.,metals,hydrocarbons,and emerging pollutants),considering environmental and farm-based *** markers related to mussels’oxidative status were efficient for the biomonitoring of metals(i.e.,antioxidant enzymes associated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators(i.e.,comet,micronucleus,and neutral red assays)provided a depiction of hydrocarbon *** neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants(e.g.,pharmaceuticals and biocides)and *** perna hemocyte parameters provided a useful approach for biocide *** paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal *** integrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted ***,it is necessary to investigate biomarker variations according to natural factors(e.g.,season and gonad maturation stage)to standardize them for trustworthy biomonitoring.

关键词： Biological indexes Biomonitoring Emerging pollutants Hydrocarbons Metals Sentinel species

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Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application

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Bioactive Materials 2018年第2期3卷 201-211页

作者： Hilal Ahmad Rather ria Thakore Ragini Singh Dhwani Jhala Sanjay Singh Rajesh Vasita Biomaterials&Biomimetics Laboratory School of Life SciencesCentral University of GujaratGandhinagar382030GujaratIndia Division of Biological and Life Sciences School of Arts and ScienceAhmedabad UniversityNavrangpuraAhmedabad380009GujaratIndia

Skin wound healing involves a coordinated cellular response to achieve complete *** levels of reactive oxygen species(ROS)in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing *** oxide nanoparticles(CeNPs)have the ability to protect the cells from oxidative damage by actively scavenging the ***,matrices like nanofibers have also been explored for enhancing wound *** the current study CeNP functionalised polycaprolactone(PCL)-gelatin nanofiber(PGNPNF)mesh was fabricated by electrospinning and evaluated for its antioxidative *** angle XRD analysis of randomly oriented nanofibers revealed^2.6 times reduced crystallinity than pristine PCL which aided in rapid degradation of nanofibers and release of ***,bioactive composite made between nanoparticles and PCLgelatin maintained the fibrous morphology of PGNPNF upto 14 *** PGNPNF mesh exhibited a superoxide dismutase(SOD)mimetic activity due to the incorporated *** PGNPNF mesh enhanced proliferation of 3T3-L1 cells by^48%as confirmed by alamar blue assay and SEM micrographs of cells grown on the nanofibrous ***,the PGNPNF mesh scavenged ROS,which was measured by relative DCF intensity and fluorescence microscopy;and subsequently increased the viability and proliferation of cells by three folds as it alleviated the oxidative ***,the results of this study suggest the potential of CeNP functionalised PCL-gelatin nanofibrous mesh for wound healing applications.

关键词： Electrospinning Ce nanoparticles Antioxidative Nanofiber

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