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Food Bioscience 2022年第3期47卷 271-278页

作者： Leticia Montes Maria Santamaria raquel garzon Cristina M.Rosell Ramón Moreira Department of Chemical Engineering Universidade de Santiago de Compostelarúa Lope Gómez de Marzoas/n15782Santiago de CompostelaSpain Institute of Agrochemistry and Food Technology (IATA-CSIC).C/Agustin Escardino 746980PaternaSpain

Corn starch gels(1:4 w:w)were made with the addition(up to 2%w/w starch basis)of sodium alginates of different average molecular sizes and *** of the starchy gels were characterized to evaluate their *** were subjected to in vitro digestion to estimate the effect of alginates addition on glycemic *** alginates significantly decreased the value of the elastic modulus of *** coordination number obtained from complex modulus indicated that in general,less compact structures were obtained in the presence of *** results were confirmed by scanning electron micrographs,where significant differences in the structure of alginate-corn starch gels were observed,but molecular size of alginates was not *** rate decreased with the presence of alginates in corn starch gels by interactions of alginates with leached *** high alginate content,slower hydrolysis rates were determined when the most hygroscopic alginates were added.

关键词： Biopolymers In vitro digestion Average molecular weight Rheology Scanning electron microscopy(SEM)

Analysis of Bone Remodeling Under Piezoelectricity Effects Using Boundary Elements

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Journal of Bionic Engineering 2017年第4期14卷 659-671页

作者： Miguel Cerrolaza Vannessa Duarte Diego garzon-Alvarado National Institute of Bioengineering Central University of Venezuela Caracas Venezuela International Center for Numerical Methods in Engineering ( CIMNE) Polytechnic University of Catalonia Barcelona Spain Virtual Rooms Program ( CIMNE) Polytechnic University of Catalonia Barcelona Spain Laboratory of Biomimetics Group of Mechanobiology of Organs and Tissues Biotechnology Institute Department of Mechanical Engineering and Mechatronics National University of Colombia Bogota Colombia

Piezoelectric materials exhibit a response to mechanical-electrical coupling, which represents an important contribution to the electrical-mechanical interaction in bone remodeling process. Therefore, the study of the piezoelectric effect on bone re- modeling has high interest in applied biomechanics. The effects of mechano-regulation and electrical stimulation on bone healing are explained. The Boundary Element Method （BEM） is used to simulate piezoelectric effects on bones when shearing forces are applied to collagen fibers to make them slip past each other. The piezoelectric fundamental solutions are obtained by using the Radon transform. The Dual Reciprocity Method （DRM） is used to simulate the particular solutions in time-dependent problems. BEM analysis showed the strong influence of electrical stimulation on bone remodeling. The examples discussed in this work showed that, as expected, the electrically loaded bone surfaces improved the bone deposition. BEM results confirmed previous findings obtained by using the Finite Element Method （FEM）. This work opens very promising doors in biomechanics research, showing that mechanical loads can be replaced, in part, by electrical charges that stimulate strengthening bone density. The obtained results herein are in good agreement with those found in literature from experimental testing and/or other simu- lation approaches.

关键词： bone remodeling numerical methods piezoelectricity boundary element anisotropy

EULER SCHEME FOR FRACTIONAL DELAY STOCHASTIC DIFFERENTIAL EQUATIONS BY ROUGH PATHS TECHNIQUES

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Acta Mathematica Scientia 2019年第3期39卷 747-763页

作者： Johanna garzon Samy TINDEL Soledad TORRES Departamento de Matematicas Universidad Nacional de ColombiaBogota D.C.Colombia Department of Mathematics Purdue University150 N.University StreetW.LafayetteIN 47907USA Facultad de Ingenierza CIMF AV Universidad de ValparaisoCasilla 123-V4059 ValparaisoChile

In this note, we study a discrete time approximation for the solution of a class of delayed stochastic differential equations driven by a fractional Brownian motion with Hurst parameter H ∈(1/2,1). In order to prove convergence, we use rough paths techniques. Theoretical bounds are established and numerical simulations are displayed.

关键词： Fractional Brownian motion stochastic differential equations rough paths,discrete time approximation

Development and mapping of SSR markers linked to resistance-gene homologue clusters in common bean

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The Crop Journal 2014年第4期2卷 183-194页

作者： Luz Nayibe garzon Matthew Wohlgemuth Blair Universidad Nacional de Colombia Dept. de Agronomia Av. El Dorado Bogotá and Dept. de Ciencias Agricolas Km. 12 Via ChapineroPalmira Colombia Universidad de Cundinamarca Facultad de Ciencias agropecuarias Programa Ingeniería Agronómica Facatativá-Cundinamarca Universidad Nacional de Colombia Dept. de Ciencias Agricolas Km. 12 Chapinero Palmira Colombia Tennessee State University Department of Agriculture and Natural Science Lawson Hall 3500 John A. Merritt Blvd. NashvilleTN 37219 USA

Common bean is an important but often a disease-susceptible legume crop of temperate,subtropical and tropical regions worldwide. The crop is affected by bacterial, fungal and viral pathogens. The strategy of resistance-gene homologue(RGH) cloning has proven to be an efficient tool for identifying markers and R(resistance) genes associated with resistances to diseases. Microsatellite or SSR markers can be identified by physical association with RGH clones on large-insert DNA clones such as bacterial artificial chromosomes(BACs). Our objectives in this work were to identify RGH-SSR in a BAC library from the Andean genotype G19833 and to test and map any polymorphic markers to identify associations with known positions of disease resistance genes. We developed a set of specific probes designed for clades of common bean RGH genes and then identified positive BAC clones and developed microsatellites from BACs having SSR loci in their end sequences. A total of 629 new RGH-SSRs were identified and named BMr(bean microsatellite RGH-associated markers). A subset of these markers was screened for detecting polymorphism in the genetic mapping population DOR364 × G19833. A genetic map was constructed with a total of 264 markers,among which were 80 RGH loci anchored to single-copy RFLP and SSR markers. Clusters of RGH-SSRs were observed on most of the linkage groups of common bean and in positions associated with R-genes and QTL. The use of these new markers to select for disease resistance is discussed.

关键词： Bacterial artificial chromosome(BAC) clone end sequences(BES) Simple sequence repeats(SSRs) Plant disease resistance(R) genes Nucleotide binding site targeted sequencing Resistance gene analogs

Immersible ergocycle prescription as a function of relative exercise intensity

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Journal of Sport and Health Science 2017年第2期6卷 219-224页

作者： Mauricio garzon Mathieu Gayda Anil Nigam Alain-Steve Comtois Martin Juneau Cardiovascular Prevention and Rehabilitation Centre (EPIC) Montreal Heart Institute and University of Montreal Montreal Quebec HIT 1N6 Canada Research Center Montreal Heart Institute and University of Montreal Montreal Quebec H1T 1C8 Canada Department of Kinesiology University of Monireal Montreal Quebec H3T 1J4 Canada Department of Medicine University of Montreal Montreal Quebec H3T 1J4 Canada Kinanthropology Department University of Quebec in Montreal (UQAM) Montreal Quebec H2X 1Y4 Canada

Purpose: The purpose of this study was to establish the relationship between various expressions of relative exercise intensity percentage of maximal oxygen uptake(%VO_(2max)), percentage of maximal heart rate(%HR_(max)), %VO_2 reserve(%VO_2R), and %HR reserve(%HRR)) in order to obtain the more appropriate method for exercise intensity prescription when using an immersible ergocycle(IE) and to propose a prediction equation to estimate oxygen consumption(VO_2) based on IE pedaling rate(rpm) for an individualized exercise training ***: Thirty-three healthy participants performed incremental exercise tests on IE and dryland ergocycle(DE) at equal external power output(Pext). Exercise on IE began at 40 rpm and was increased by 10 rpm until exhaustion. Exercise on DE began with an initial load of 25 W and increased by 25 W/min until exhaustion. VO_2 was measured with a portable gas analyzer(COSMED K4b^2) during both incremental tests. On IE and DE, %VO_2R, %HRmax, and %HRR at equal Pext did not differ(p > 0.05).Results: The %HRR vs. %VO_2R regression for both IE and DE did not differ from the identity line %VO_2R IE = 0.99 × HRR IE(%) + 0.01(r^2= 0.91, SEE = 11%); %VO_2R DE = 0.94 × HRR DE(%) + 0.01(r^2= 0.94, SEE = 8%). Similar mean values for %HRmax, %VO_2R, and %HRR at equal Pext were observed on IE and DE. Predicted VO_2 obtained according to rpm on IE is represented by: VO_2(L/min) = 0.000542 × rpm2-0.026 × rpm + 0.739(r = 0.91, SEE = 0.319 L/min).Conclusion: The %HRR–%VO_2R relationship appears to be the most accurate for exercise training prescription on IE. This study offers new tools to better prescribe, control, and individualize exercise intensity on IE.

关键词： Exercise prescription Heart rate Immersed ergocycle Oxygen uptake Pedaling rate

Chemistry-led investigations into the mode of action of NAMPT activators,resulting in the discovery of non-pyridyl class NAMPT activators

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Acta Pharmaceutica Sinica B 2023年第2期13卷 709-721页

作者： Siyuan Tang Miguel garzon Sanz Oliver Smith Andreas Krämer Daniel Egbase Paul W.Caton Stefan Knapp Sam Butterworth Division of Pharmacy and Optometry School of Health SciencesManchester Academic Health Sciences CentreUniversity of ManchesterManchester M139PLUK Structural Genomics Consortium(SGC) 60438 Frankfurt Am MainGermany Buchmann Institute for Life Sciences(BMLS) 60438 Frankfurt Am MainGermany Institut für Pharmazeutische Chemie Goethe University60438 Frankfurt Am MainGermany Frankfurt Cancer Institute(FCI) 60596 Frankfurt Am MainGermany Department of Diabetes School of Cardiovascular and Metabolic Medicine&SciencesFaculty of Life Sciences&MedicineKing's College LondonLondon SE11ULUK

The cofactor nicotinamide adenine dinucleotide(NAD+)plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+levels is an established approach to enhancing healthy ***,several classes of nicotinamide phosphoribosyl transferase(NAMPT)activators have been shown to increase NAD+levels in vitro and in vivo and to demonstrate beneficial effects in animal *** best validated of these compounds are structurally related to known urea-type NAMPT inhibitors,however the basis for the switch from inhibitory activity to activation is not well *** we report an evaluation of the structure activity relationships of NAMPT activators by designing,synthesising and testing compounds from other NAMPT ligand chemotypes and mimetics of putative phosphoribosylated adducts of known *** results of these studies led us to hypothesise that these activators act via a through-water interaction in the NAMPT active site,resulting in the design of the first known urea-class NAMPT activator that does not utilise a pyridine-like warhead,which shows similar or greater activity as a NAMPT activator in biochemical and cellular assays relative to known analogues.

关键词： Nicotinamide phosphoribosyl transferase activator Healthy aging Drug discovery Bioisosteres Medicinal chemistry

Multivariate Statistical Analysis of Phyllite Samples Based on Chemical(XRF)and Mineralogical Data by XRD

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American Journal of Analytical Chemistry 2012年第5期3卷 347-363页

作者： Eduardo garzon garzon Antonio Ruiz-Conde Pedro Jose Sanchez-Soto Department of Rural Engineering University of AlmeriaLa Canada de San UrbanoSpain Instituto de Ciencia de Materiales Centro Mixto C.S.I.C.—US.Avda.Americo VespuccioSevillaSpain

It is presented the results obtained of a multivariate statistical analysis concerning the chemical and phase composition, as a characterization purpose, carried out with 52 rock phyllite samples selected from the provinces of Almería and Granada (SE Spain). Chemical analysis was performed by X-ray fluorescence (XRF). Crystalline phase analysis was performed by X-ray powder diffraction (XRD) and the mineralogical composition was then deduced. Quantification of weight loss (100? and 1000?C) was carried out by thermal analysis. The aims of this investigation were to analyze and compare the chemical and mineralogical composition of all these samples and to find similarities and differences between them to allow a classification. Several correlations between results of the characterization techniques have been also investigated. All the data have been processed using the multivariate statistical analysis method. The XRF macro-elements (10) and microelements (39) data generate one macrogroup with two new subgroups (1 and 2), and an isolated sample. In subgroup 1 of macroelements, a positive correlation was found between XRF results and geographic location characterized by lower MgO content, which is associated to its geological origins. When multivariate statistical analysis is applied to results obtained by XRD, two groups appear: the first one with a sample with zero percentage of iron oxide and the second one with the rest of the samples, which is classified in two groups. A correlation is observed between the alkaline content (XRF) and illite (XRD), CaO and MgO with dolomite and indirectly between the weight loss after heating at 1000?C and the contents of phase minerals that lose structural water (illite + chlorite) or carbon dioxide (dolomite). The present investigation has interest and implications for geochemistry and analytical chemistry concerning earth rocks and silicate raw materials.

关键词： Selection Multivariate Phyllites XRF XRD

Polycaprolactone-carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion

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Bio-Design and Manufacturing 2018年第4期1卷 245-253页

作者： M.E.Aleman-Domfnguez Z.Ortega A.N.Benitez Mario Monzon L.V.garzon Sara Ajami Chaozong Liu Departamento de Ingenier/a de Procesos Universidad de Las Palmas de Gran CanadaEdificio de Fabricacion integrada Parque Cientifico-Tecnologico de la ULPGC35017Las PalmasSpain Departamento de Ingenierfa Mecainica Universidad de Las Palmas de Gran CanadaEdificio de Fabricacion integrada Parque Cientifico-Tecnologico de la ULPGC35017 Las PalmasSpain Institute of Orthopaedic and Musculoskeletal Science Royal National Orthopaedic HospitalUniversity College London StanmoreLondon HA74LPUK

Polycaprolactone-carboxymethyl cellulose composites have been obtained and used to print porous structures by material *** materials used contained 0,2 and 5% w/w of the carboxymethyl cellulose *** structures have been analyzed in terms of their morphology (including the evaluation of their porosity),mechanical properties under compression load and cell *** affinity has been evaluated by culturing sheep mesenchymal stem cells and analyzing their viability by the Alamar Blue(R)assay at days 1,3,6 and *** results show that composites samples have similar values of porosity and apparent density than pure polycaprolactone ***,samples containing 5%w/w of carboxymethyl cellulose have micropores on the filaments due to a hindered deposition *** characteristic affects the mechanical properties of the structures,so these ones have a mean compression modulus significantly lower than pure polycaprolactone ***, the samples containing 2%w/w of carboxymethyl cellulose show no significant difference with the pure polycaprolactone ones in terms of their mechanical ***,the presence of 2%w/w of additive improves cell proliferation on the surface of the porous *** complementary information,the flow properties of the composite materials were studied and the power law equations at 210℃ obtained,as this temperature was the 3D printing *** equations can be useful for simulation and designing purposes of other manufacturing processes.

关键词： Additive manufacturing Tissue engineering Viscosity model Biomaterials 3D printing Bone regeneration

Adaptive immune response during hepatitis C virus infection

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World Journal of Gastroenterology 2014年第13期20卷 3418-3430页

作者： Juan Ramon Larrubia Elia Moreno-Cubero Megha Uttam Lokhande Silvia Garcia-garzon Alicia Lazaro Joaquin Miquel Cristian Perna Eduardo Sanz-de-Villalobos Translational Hepatology Unit Guadalajara University HospitalUniversity of AlcalaE-19002 GuadalajaraSpain Department of Medicine and Medical Specialities School of MedicineUniversity of AlcalaE-28801 Alcala de HenaresSpain

Hepatitis C virus(HCV)infection affects about 170 million people worldwide and it is a major cause of liver cirrhosis and hepatocellular *** is a hepatotropic non-cytopathic virus able to persist in a great percentage of infected hosts due to its ability to escape from the immune *** damage and disease progression during HCV infection are driven by both viral and host ***,adaptive immune response carries out an essential task in controllingnon-cytopathic viruses because of its ability to recognize infected cells and to destroy them by cytopathic mechanisms and to eliminate the virus by non-cytolytic *** is able to impair this response by several means such as developing escape mutations in neutralizing antibodies and in T cell receptor viral epitope recognition sites and inducing HCV-specific cytotoxic T cell anergy and *** impair HCV-specific T cell reactivity,HCV affects effector T cell regulation by modulating T helper and Treg response and by impairing the balance between positive and negative co-stimulatory molecules and between pro-and antiapoptotic *** this review,the role of adaptive immune response in controlling HCV infection and the HCV mechanisms to evade this response are reviewed.

关键词： Hepatitis C, Adaptive immune response, Hepatitis C virus-specific cytotoxic T cells, Hepatitis C virus-specific T helper cells, T regs, Hepatitis C virus escape mutations, Anergy, Apoptosis, Chemotaxis

Toward Liquid Phase Processable Metal Organic Frameworks:Dream or Reality?

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Accounts of Materials Research 2021年第12期2卷 1133-1140页

作者： Daria Poloneeva Shuvo Jit Datta Luis garzon-Tovar Sara Durini Magnus Rueping Mohamed Eddaoudi Anastasiya Bavykina Jorge Gascon KAUST Catalysis Center(KCC) Advanced Catalytic MaterialsKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia Advanced Membranes and Porous Materials Center Functional Materials DesignDiscovery and Development Research GroupKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

CONSPECTUS:Conventionally,the virtue of porosity is only given to porous *** Organic Frameworks(MOFs),carbon materials,or zeolites are some ***,processing these solids is not a straightforward ***,we discuss how to endow porous solids(MOFs)with liquid phase *** specifically,we show that surface modification of MOF crystals can lead to the formation of porous liquids(PLs)that can be further processed in the liquid *** instance,when placed in mesitylene,ZIF-67 predictably *** contrast,with the adequate surface modification,stable dispersion of ZIF-67 can be *** proposed surface modification is facile and rapid.N-Heterocyclic carbenes are chosen as modifying agents as they are similar to imidazole linkers present on ZIFs.A simple stirring of a MOF and carbene mixture results in a modified *** morphology and textural properties of the modified MOF do not change from the ones of its *** the porosity in solution remains unoccupied,the obtained stable colloids behave as porous *** into porous liquids is an emerging field that has already shown great promise in gases *** breakthrough experiments show that these particular PLs have large potential for the separation of CO_(2)/CH_(4)mixtures.

关键词： porous solids porosity