Polycaprolactone-carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion

作     者：M.E.Aleman-Domfnguez Z.Ortega A.N.Benitez Mario Monzon L.V.Garzon Sara Ajami Chaozong Liu 

作者机构：Departamento de Ingenier/a de ProcesosUniversidad de Las Palmas de Gran CanadaEdificio de Fabricacion integrada Parque Cientifico-Tecnologico de la ULPGC35017Las PalmasSpain Departamento de Ingenierfa MecainicaUniversidad de Las Palmas de Gran CanadaEdificio de Fabricacion integrada Parque Cientifico-Tecnologico de la ULPGC35017 Las PalmasSpain Institute of Orthopaedic and Musculoskeletal ScienceRoyal National Orthopaedic HospitalUniversity College London StanmoreLondon HA74LPUK 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2018年第1卷第4期

页      面：245-253页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：Horizon 2020 Framework Programme  H2020  (734156) 

主　　题：Additive manufacturing Tissue engineering Viscosity model Biomaterials 3D printing Bone regeneration 

摘      要：Polycaprolactone-carboxymethyl cellulose composites have been obtained and used to print porous structures by material *** materials used contained 0,2 and 5% w/w of the carboxymethyl cellulose *** structures have been analyzed in terms of their morphology (including the evaluation of their porosity),mechanical properties under compression load and cell *** affinity has been evaluated by culturing sheep mesenchymal stem cells and analyzing their viability by the Alamar Blue(R)assay at days 1,3,6 and *** results show that composites samples have similar values of porosity and apparent density than pure polycaprolactone ***,samples containing 5%w/w of carboxymethyl cellulose have micropores on the filaments due to a hindered deposition *** characteristic affects the mechanical properties of the structures,so these ones have a mean compression modulus significantly lower than pure polycaprolactone ***, the samples containing 2%w/w of carboxymethyl cellulose show no significant difference with the pure polycaprolactone ones in terms of their mechanical ***,the presence of 2%w/w of additive improves cell proliferation on the surface of the porous *** complementary information,the flow properties of the composite materials were studied and the power law equations at 210℃ obtained,as this temperature was the 3D printing *** equations can be useful for simulation and designing purposes of other manufacturing processes.