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Rifaximin,but not growth factor 1,reduces brain edema in cirrhotic rats

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World Journal of Gastroenterology 2012年第17期18卷 2084-2091页

作者： Gemmaòdena Mireia Miquel Anna Serafín Amparo Galan Rosa Morillas ramon Planas ramon bartolí Hepatology Unit Department of GastroenterologyGermans Trias i Pujol Health Science Research Institute08916 BadalonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) 08036 BarcelonaSpain Department of Gastroenterology CorporacióSanitària Parc Taulí08208 SabadellSpain Platform of Laboratory Animal Applied Research Parc Científic de Barcelona08028 BarcelonaSpain Department of Biochemistry Hospital Universitari Germans Trias i Pujol08916 BadalonaSpain Liver Unit Department of GastroenterologyHospital Universitari Germans Trias i Pujol08916 BadalonaSpain

AIM:To compare rifaximin and insulin-like growth factor(IGF)-1 treatment of hyperammonemia and brain edema in cirrhotic rats with portal ***:Rats with CCl4-induced cirrhosis with ascites plus portal vein occlusion and controls were randomized into six groups:Cirrhosis;Cirrhosis + IGF-1;Cirrhosis + rifaximin;Controls;Controls + IGF-1;and Controls + *** oral glutamine-challenge test was performed,and plasma and cerebral ammonia,glucose,bilirubin,transaminases,endotoxemia,brain water content and ileocecal cultures were measured and liver histology was ***:Rifaximin treatment significantly reduced bacterial overgrowth and endotoxemia compared with cirrhosis groups,and improved some liver function parameters(bilirubin,alanine aminotransferase and aspartate aminotransferase).These effects were associated with a significant reduction in cerebral water *** and cerebral ammonia levels,and area-underthe-curve values for oral glutamine-challenge tests were similar in rifaximin-treated cirrhotic rats and control group *** contrast,IGF-1 administration failed to improve most alterations observed in ***:By reducing gut bacterial overgrowth,only rifaximin was capable of normalizing plasma and brain ammonia and thereby abolishing low-grade brain edema,alterations associated with hepatic encephalopathy.

关键词： Hyperammonemia Low-grade brain edema Hepatic encephalopathy Rifaximin Insulin-like growth factor 1 Cirrhosis

Colonoscopy in rats:An endoscopic,histological and tomographic study

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World Journal of Gastrointestinal Endoscopy 2013年第5期5卷 226-230页

作者： ramon bartolí Jaume Boix Gemma ódena Napoleón D De la Ossa Vicente Moreno de Vega Vicente Lorenzo-Zúiga Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD) 08916 BadalonaSpain Endoscopy Unit Department of GastroenterologyHospital Universitari Germans Trias i Pujol08916 BadalonaSpain Department of Pathology Hospital Universitari Germans Trias i Pujol08916 BadalonaSpain Endoscopy Unit Department of GastroenterologyHospital Universitari Germans Trias i PujolCarretera del Canyet s/n08916 BadalonaSpain

AIM:To describe colon anatomy with colonoscopy and computed tomography(CT) to develop a rat model for future studies of therapeutic ***:Eighteen male Sprague-Dawley rats,on average 400-420 g,underwent total colonoscopy,CT and histological *** was performed after bowel preparation with a baby upper gastrointestinal endoscopy with an outer diameter of 6.7 *** obtained a 3D image of total colon after a rectal enema with radiological *** and microscopic examinations were examined with a conventional technique(hematoxylin and eosin).Colonic wall thickness,length and diameter measurements were taken from the anus,3,7,14 and 20 cm from the anal ***:The median colonoscope depth was 24 cm(range 20-28 cm).Endoscopic and tomographic study of colon morphology showed an easy access with tubular morphology in the entire left colon(proximal left colon and rectum).Transverse colon was unapparent on *** colon,proximal to the splenic flexure,was the largest part of the colon and assumed saccular morphology with tangential *** measurements of the colonic length and diameter substantiate a subdivision of the right colon into two parts,the cecum and distal right *** addition,histological measurement of the colonic wall thickness confirmed a progressive decrease from rectum to *** muscular layer was thinner in the proximal left ***:The combination of colonoscopy,tomography and histology leads to a better characterization of the entire *** data are important for deciding when to perform endoscopic resections or when to induce perforations to apply endoscopic treatments.

关键词： Rat Colonoscopy Tomography Colon anatomy Histological measurements

Occult hepatitis B virus infection:A complex entity with relevant clinical implications

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World Journal of Gastroenterology 2011年第12期17卷 1529-1530页

作者： Juan-ramon Larrubia Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Occult hepatitis B virus(HBV) infection is a world-wide entity,following the geographical distribution of detectable hepatitis *** entity is defined as the persistence of viral genomes in the liver tissue and in some instances also in the serum,associated to negative HBV surface antigen *** molecular basis of the occult infection is related to the life cycle of HBV,which produces a covalently closed circular DNA that persists in the cell nuclei as an episome,and serves as a template for gene *** mechanism responsible for the HBsAg negative status in occult HBV carriers is a strong suppression of viral replication,probably due to the host’s immune response,co-infection with other infectious agents and epigenetic *** is emerging evidence of the potential clinical relevance of occult HBV infection,since this could be involved in occult HBV transmission through orthotopic liver transplant and blood transfusion,reactivation of HBV infection during immunosuppression,impairing chronic liver disease outcome and acting as a risk factor for hepatocellular *** it is important to bear in mind this entity in cryptogenetic liver diseases,hepatitis C virus/ HIV infected patients and immunosupressed *** is also necessary to increase our knowledge in this fascinating field to define better strategies to diagnose and treat this infection.

关键词： Hepatitis B virus Occult infection Persistent infection

A Sufficient Degree Condition for a Graph to Contain All Trees of Size k

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Acta Mathematica Sinica,English Series 2011年第1期27卷 135-140页

作者： Camino BALBUENA Alberto MARQUEZ Jose ramon PORTILLO Departament de Matemhtica Aplicada III Universitat Politecnica de Catalunya C/ Jordi Girona 1-3 (Edifici C2 Despatx 302) 08034 Barcelona Spain Departamento de Matemdtica Aplicada I Universidad de SeviUaE.T.S. de Informdtica Avda. Reina Mercedes s//n 41012 SeviUa Spain

The Erdos-Sos conjecture says that a graph G on n vertices and number of edges e（G）〉 n（k - 1）/2 contains all trees of size k. In this paper we prove a sufficient condition for a graph to contain every tree of size k formulated in terms of the minimum edge degree ξ（G） of a graph G defined as {（G） = min{d（u）＋ d（v） - 2 ： uv ∈ E（G）}. More precisely, we show that a connected graph G with maximum degree △（G） ≥ k and minimum edge degree {（G）〉 2k - 4 contains every tree of k edges if dG（x）＋ dG（y） ≥ 2k - 4 for all pairs x, y of nonadjacent neighbors of a vertex u of dG（u） ≥ k.

关键词： Erdos-Sos conjecture

Some Comments on Zonal Polynomials and Their Expected Values with respect to ***

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Acta Mathematicae Applicatae Sinica 2017年第3期33卷 567-574页

作者： Jose A.Diaz-Garcia ramon Gutierrez-Jaimez Department of Statistics and Computation Universidad Autonoma Agraria Antonio Narro25350 BuenavistaSaltilloCoahuilaMexico Department of Statistics and O.R University of GranadaGranada 18071Spain

In this paper, we give alternative proofs of some results in [15] （Li R.,1997） about the expected value of zonal polynomials.

关键词： elliptical matrix distributions random matrices zonal polynomials generalised Wishart distribution

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Tumor organoids to study gastroesophageal cancer: a primer

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Journal of Molecular Cell Biology 2020年第8期12卷 593-606页

作者： ramon U.Jin Jason C.Mills Division of Oncology Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63130USA Division of Gastroenterology Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63130USA Department of Developmental Biology Washington University School of MedicineSt.LouisMO 63130USA Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63130USA

Gastroesophageal cancers are leading causes of cancer *** attempts at adopting molecularly based treatment approaches have been slow and ineffective even though we begin to identify specific targetable gene mutations and *** is dear that we should no longer treat all gastroesophageal cancers as a homogeneous disease,which is what we do when we use nonspecific ***,we currently cannot monitor successful gene/pathway targeting,nor understand how/when tumors develop resistance,nor predict which patients will derive maximal *** improve outcomes,we must precisely detail the heterogeneity of these tumors to then individualize cancer therapy as well as develop novel avenues to study and predict treatment effects in individual *** this end,patient-derived organoids,in which tumor cells from individual patients are grown in a Petri dish,are a new versatile system that allows for timely expandability,detailed molecular characterization,and genetic manipulation with the promise of enabling predictive assessment of treatment *** this review,we will explore the development and basic techniques for organoid generation,and discuss the current and potential future applications of this exciting technology to study the basic science of carcinogenesis and to predict/guide cancer patient care in the clinics.

关键词： targeted therapy precision oncology cancer model tumor heterogeneity cancer evolution personalized medicine

Regular Global Attractors of Type Ⅲ Thermoelastic Extensible Beams

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Chinese Annals of Mathematics,Series B 2010年第5期31卷 619-630页

作者： Michele COTI ZELATI Vittorino PATA ramon QUINTANILLA Mathematics Department Indiana UniversityRawles Hall Dipartimento di Matematica "F. Brioschi" Politecnico di Milano Matemtica Aplicada 2 ETSEIAT-UPC Terrassa

For β∈ R,the authors consider the evolution system in the unknown variables u and ααttu+αxxxxu+αxxtα-(β+αxu L22)αxxu=f,αttα-αxxα-αxxtα-αxxtu=0 describing the dynamics of type III thermoelastic extensible beams,where the dissipation is entirely contributed by the second equation ruling the evolution of the thermal displacement α.Under natural boundary conditions,the existence of the global attractor of optimal regularity for the related dynamical system acting on the phase space of weak energy solutions is established.

关键词： Type III thermoelastic extensible beam Lyapunov functional Global attractor

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Machine Learning-Based Radio Access Technology Selection in the Internet of Moving Things

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China Communications 2021年第7期18卷 13-24页

作者： ramon Sanchez-Iborra Luis Bernal-Escobedo Jose Santa Dept.Engineering and Applied Techniques University Centre of Defence at the Spanish Air Force Academy30729 San JavierSpain Dept.Information and Communication Engineering University of Murcia30100 MurciaSpain Dept.of Electronics Computing Technology and ProjectsTechnical University of Cartagena30202 CartagenaSpain

The Internet of Moving Things(IoMT)takes a step further with respect to traditional static IoT *** this line,the integration of new eco-friendly mobility devices such as scooters or bicycles within the Cooperative-Intelligent Transportation Systems(C-ITS)and smart city ecosystems is crucial to provide novel *** this end,a range of communication technologies is available,such as cellular,vehicular WiFi or Low-Power Wide-Area Network(LPWAN);however,none of them can fully cover energy consumption and Quality of Service(QoS)***,we propose a Decision Support System(DSS),based on supervised Machine Learning(ML)classification,for selecting the most adequate transmission interface to send a certain message in a multi-Radio Access Technology(RAT)set *** ML algorithms have been explored taking into account computing and energy constraints of IoMT enddevices and traffic ***,a real implementation of a decision tree-based DSS for micro-controller units is presented and *** attained results demonstrate the validity of the proposal,saving energy in communication tasks as well as satisfying QoS requirements of certain urgent *** footprint of the real implementation on an Arduino Uno is 444 bytes and it can be executed in around 50µs.

关键词： internet of moving things multi-RAT CITS classification personal mobility

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Gene editing in plants:progress and challenges

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National Science Review 2019年第3期6卷 421-437页

作者： Yanfei Mao Jose ramon Botella Yaoguang Liu Jian-Kang Zhu Shanghai Center for Plant Stress Biology CAS Center of Excellence in Molecular Plant Sciences Chinese Academy of Sciences School of Agriculture and Food Sciences University of Queensland State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Life Sciences South China Agricultural University Department of Horticulture and Landscape Architecture Purdue University

The clustered regularly interspaced short palindromic repeat(CRISPR)-associated protein 9(Cas9)genome editing system is a powerful tool for targeted gene modifications in a wide range of species,including plants. Over the last few years, this system has revolutionized the way scientists perform genetic studies and crop breeding, due to its simplicity, flexibility, consistency and high efficiency. Considerable progress has been made in optimizing CRISPR/Cas9 systems in plants, particularly for targeted gene mutagenesis. However, there are still a number of important challenges ahead, including methods for the efficient delivery of CRISPR and other editing tools to most plants, and more effective strategies for sequence knock-ins and replacements. We provide our viewpoint on the goals, potential concerns and future challenges for the development and application of plant genome editing tools.

关键词： CRISPR Cas9 genome editing base editing gene targeting crop breeding