Colonoscopy in rats:An endoscopic,histological and tomographic study

作     者：Ramon Bartolí Jaume Boix Gemma ódena Napoleón D De la Ossa Vicente Moreno de Vega Vicente Lorenzo-Zúiga 

作者机构：Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD)08916 BadalonaSpain Endoscopy UnitDepartment of GastroenterologyHospital Universitari Germans Trias i Pujol08916 BadalonaSpain Department of PathologyHospital Universitari Germans Trias i Pujol08916 BadalonaSpain Endoscopy UnitDepartment of GastroenterologyHospital Universitari Germans Trias i PujolCarretera del Canyet s/n08916 BadalonaSpain 

出 版 物：《World Journal of Gastrointestinal Endoscopy》 (世界胃肠内镜杂志（英文版）（电子版）)

年 卷 期：2013年第5卷第5期

页      面：226-230页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Spanish Carlos Ⅲ Institute Project Grant No. PI10/00132 

主　　题：Rat Colonoscopy Tomography Colon anatomy Histological measurements 

摘      要：AIM:To describe colon anatomy with colonoscopy and computed tomography(CT) to develop a rat model for future studies of therapeutic ***:Eighteen male Sprague-Dawley rats,on average 400-420 g,underwent total colonoscopy,CT and histological *** was performed after bowel preparation with a baby upper gastrointestinal endoscopy with an outer diameter of 6.7 *** obtained a 3D image of total colon after a rectal enema with radiological *** and microscopic examinations were examined with a conventional technique(hematoxylin and eosin).Colonic wall thickness,length and diameter measurements were taken from the anus,3,7,14 and 20 cm from the anal ***:The median colonoscope depth was 24 cm(range 20-28 cm).Endoscopic and tomographic study of colon morphology showed an easy access with tubular morphology in the entire left colon(proximal left colon and rectum).Transverse colon was unapparent on *** colon,proximal to the splenic flexure,was the largest part of the colon and assumed saccular morphology with tangential *** measurements of the colonic length and diameter substantiate a subdivision of the right colon into two parts,the cecum and distal right *** addition,histological measurement of the colonic wall thickness confirmed a progressive decrease from rectum to *** muscular layer was thinner in the proximal left ***:The combination of colonoscopy,tomography and histology leads to a better characterization of the entire *** data are important for deciding when to perform endoscopic resections or when to induce perforations to apply endoscopic treatments.