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Journal of Bioresources and Bioproducts 2023年第2期8卷 108-124页

作者： Akansha Shrivastava Mamta Pal Rakesh kumar sharma Department of Biosciences Manipal University JaipurJaipur 303007India Sardar Swaran Singh National Institute of Bio-Energy Jalandhar 144601India

Yeast has been used as a cell factory for thousands of years to produce a wide variety of com-plex biofuels,bioproducts,biochemicals,food ingredients,and *** a variety of biotechnological production hosts,a few specific genera of yeast have proven *** developments in metabolic engineering and synthetic biology provide a workable long-term supply solution for these *** this review,we have covered recent advances in the design of yeast cell factories for the synthesis of terpenoids,alkaloids,phenylpropanoids,and other natural chemicals,primarily focusing on Pichia ***-edge solutions involving genetic and process engineering have also been ***,the review summarized recent advancements and challenges in synthetic and systems biology,as well as initiatives in metabolic engineering aimed at commercializing non-conventional yeasts like *** processes used in non-traditional yeasts to produce enzymes,therapeutic proteins,lipids,and metabolic products for industrial applications were thoroughly elaborated.

关键词： Natural product Pichia Non-conventional yeast Biosynthesis System biology Synthetic biology

Climate change detection and attribution in the Ganga-Brahmaputra-Meghna river basins

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Geoscience Frontiers 2021年第5期12卷 192-201页

作者： Chetan sharma Anoop kumar Shukla Yongqiang Zhang Civil Engineering Department JIETJodhpurRajasthanIndia Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Ganga-Brahmaputra-Meghna(GBM)river basin is the third-largest and one of the most populated river basins in the *** climate change is affecting most of the hydrometeorological variables across the globe,this study investigated the existence of climate change signal in all four climatological seasons in the GBM river basin and assessed the contribution of anthropogenic activities,i.e.,Greenhouse Gases(GHGs)emission in the *** decreasing trends in the monsoon and a small increase in pre-monsoon precipitation were *** change was detected in post-monsoon and winter season ***5 GCMs were used for climate change detection,change point estimation,and attribution *** Vector Machine(SVM)regression method was adopted to downscale GCM variables at the local ***-Carlo simulation approach was used to detect changes in different *** climate change‘signals’were detectable after the year 1980 using Signal to Noise ratio(SNR)method in the majority of central and north-western *** change point was detectable only in annual monsoon precipitation at the basin *** analysis indicated>50%contribution of anthropogenic activities(GHGs)to annual monsoon precipitation ***,there is high confidence that monsoon precipitation in GBM has significantly changed due to anthropogenic *** mitigation and adaption measures are also suggested,which may be adopted to manage the growing demand and water availability in the basin.

关键词： Ganga-Brahmaputra-Meghna(GBM) Climate change Support vector machine Signal to noise ratio Anthropogenic activities

PDE solution to UAV/UGV trajectory planning problem by spatio-temporal estimation during wildfires

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Chinese Journal of Aeronautics 2021年第5期34卷 601-616页

作者： Mohammadreza RADM ANESH Balaji sharma Manish kumar Donald FRENCH Aerial Mobility Group NASA Jet Propulsion Lcib(JPL)Pasadena 91016USA Mathworks BuffaloNew YorkUSA Department of Mechanical and Material Engineering.University of Cincinnati Cincinnati 45221USA Department of Mathematical Sciences University of CincinnatiCincinnati 45221USA

Unmanned Aerial Vehicles(UAVs)and Unmanned Ground Vehicles(UGVs)have been used in research and development community due to their strong potential in high-risk *** of the most important civilian implementations of UAV/UGV cooperative path planning is delivering medical or emergency supplies during disasters such as wildfires,the focus of this ***,wildfires themselves pose risk to the UAVs/UGVs and their paths should be planned to avert the risk as well as complete the *** this paper,wildfire growth is simulated using a coupled Partial Differential Equation(PDE)model,widely used in literature for modeling wildfires,in a grid environment with added process and measurement *** principles of Proper Orthogonal Decomposition(POD),and with an appropriate choice of decomposition modes,a low-dimensional equivalent fire growth model is obtained for the deployment of the space-time Kalman Filtering(KF)paradigm for estimation of wildfires using simulated *** KF paradigm is then used to estimate and predict the propagation of wildfire based on local data obtained from a camera mounted on the *** information is then used to obtain a safe path for the UGV that needs to travel from an initial location to the final position while the UAV’s path is planned to gather information on *** planning of both UAV and UGV is carried out using a PDE based method that allows incorporation of threats due to wildfire and other obstacles in the form of risk *** results from numerical simulation are presented to validate the proposed estimation and path planning methods.

关键词： State-estimation Trajectory planning UAV UGV Wild-fire

Synthesis and characterization of copper foams through a powder metallurgy route using a compressible and lubricant space-holder material

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International Journal of Minerals,Metallurgy and Materials 2018年第8期25卷 902-912页

作者： Mohit sharma O.P.Modi Punit kumar Department of Mechanical Engineering National Institute of TechnologyKurukshetraHaryana 136119India CSIR-Advanced Materials&Processes Research Institute Bhopal 462026India Department of Material Science&Metallurgical Engineering Maulana Azad National Institute of TechnologyBhopal 462003India

In the present work,a compressible and lubricating space-holder material commonly known as "acrawax" was used to process Cu foams with various pore sizes and various *** foams were processed without using binders to avoid contamination of their metal *** lubricant space-holder material was found to facilitate more uniform flow and distribution of metal powder around the surface of the space *** addition,the use of acrawax as a space-holder material yielded considerably dense cell walls,which are an essential prerequisite for better material *** foams processed with a smaller-sized space holder were found to exhibit better electrical and mechanical properties than those processed with a coarser-sized space *** isotropic pore shape,uniform pore distribution throughout the metal matrix,and uniform cell wall thickness were found to enhance the properties pertaining to fine-pore foam *** processed foams exhibit properties similar to those of the foams processed through the lost-carbonate sintering process.

关键词： copper foam powder metallurgy space holder acrawax flexural strength sintering electrical resistivity

Spatio-temporal variation of trace elements distributed over surface water of Upper Ganga River Basin in Western Himalayan Region

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Journal of Mountain Science 2023年第1期20卷 145-162页

作者： Deepika DIMRI Ambika kumar Deepakkumar MISHRA Archana sharma Doon University Dehradun248012India Bhagalpur National College Bhagalpur812007India

The rivers draining from the Himalayan range distribute enormous amount of fresh water to the people living in downstream *** metals flowed with river water can lead to serious impact on ecological system and human ***,the documentation on trace elements of Himalayan rivers is inadequately *** current study deals with the spatial and temporal variability of the major and trace elements of Ganga river water in epirhithron,metarhithron and hyporhithron zone belonging to Himalayan *** samples from nineteen monitoring locations were collected in pre-monsoon(May-June),monsoon(AugustSeptember)and post-monsoon(December)seasons and subjected to be assessed for 20 elements(Ag,Al,Ba,Cd,Ca,Cr,Cu,Fe,Ga,K,Mn,Mg,Na,Ni,Pb,Sr,Th,U,Zn,and Zr)using ICP-OES(Inductively Coupled Plasma-Optical Emission Spectrometer).Different water pollution indexes such as HPI(Heavy Metal Pollution Index),MI(Metal Index)and PI(Pollution Index)were used to describe current water quality status at each monitoring station under particular classified ecological *** studied stations in hyporhithron zone had the value of Metal Index(MI>1),indicating threshold of ***,the highest values of HPI in hyporhithron zone correspond to poor water quality *** with poor water quality were also found to be contaminated as per the Pollution Index(PI),exhibiting high concentrations for element(Fe).However,the epirhithron and metarhithron zone in Himalayan segment showed excellent water quality mainly contributed from natural *** Analysis(CA)and Principal Component Analysis(PCA)were applied to identify the main influential sources for Ganga river water *** Kriging interpolation method was also applied to prepare spatial distribution map of computed indexes(HPI,MI,and PI).With the help of index of local Moran’s I(LMI),identified spatial clusters and spatial outliers revealed the elevated concentration of most elements in hyporhithr

关键词： Trace elements Spatial variation Temporal variation Surface water Ganga River Basin ICP-OES

Tribological characteristics of friction stir processed graphite and tin/LM24 surface composites

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Friction 2021年第3期9卷 569-582页

作者： Vipin sharma Ujjwal PRAKASH B.Venkata MANOJ kumar Department of Metallurgical and Materials Engineering Indian Institute of Technology RoorkeeRoorkee 247667India

Friction stir processing(FSP)is an emerging solid-state technique for preparing surface composites using various *** and metallic particles are easily reinforced in a matrix by this *** composites made from an LM24 alloy reinforced with graphite and tin,with good wettability and material flow owing to the low melting point of tin,were fabricated by FSP at two rotational speeds of 1,400 and 1,000 *** its low hardness,the graphite/LM24 surface composite fabricated at a higher rotational speed of 1,400 rpm exhibited better wear ***,its frictional behavior was not significantly affected by the *** fabricated surface composites with graphite and tin reinforcement as well as graphite-only reinforcement exhibited contradicting behaviors under sliding wear *** post wear analysis indicated that abrasion,adhesion,layer formation,and delamination occurred on the composite surfaces.

关键词： composites friction stir processing graphite tin Al-Si alloy wear

Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 27-32页

作者： Praveen sharma Barjesh Chander sharma Shiv kumar Sarin Department of Gastroenterology G.B.Pant Hospital

BACKGROUND:Minimal hepatic encephalopathy (MHE) impairs quality of life and predicts overt hepatic encephalopathy (HE) in cirrhotic *** of MHE requires cumbersome *** is effective in the treatment of *** study aimed to evaluate the use of critical flicker frequency (CFF) for the diagnosis of MHE in cirrhotic patients after ***:One hundred and ten patients were evaluated by psychometry (number connection tests A,B or figure connection tests A,B),P300 auditory event related potential (P300ERP),venous ammonia,and CFF for *** was diagnosed by abnormal psychometry (>2SD age matched controls) and *** patients were treated with lactulose for one *** was defined by normalization (<2SD of matched controls) of both psychometry and ***:Of the 110 patients [Child Turcott Pugh score A:B:C 39:42:29,(age 41.6±11.6 years,M:F 82:28)],75 (68%) had abnormal results of psychometric tests,and 74 (67%) had prolonged *** (20%) patients with abnormal results of psychometric tests had normal *** sixty (54.5%) patients were diagnosed as having *** treatment for one month,34 (57%) recovered while 26 (43%) continued to have abnormal resents of psychometric or P300ERP *** was <39 Hz in 72 (65.4%) patients before treatment and in 20 (33.3%) after *** sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy for the assessment of recovery of MHE were 65%,91%,85%,77% and 80%,***:CFF is a simple,relatively reliable,and accurate test without any dependence on age or literacy in the diagnosis and assessment of recovery of patients with MHE.

关键词： minimal hepatic encephalopathy critical flicker frequency lactulose

Recent Developments in Integrated Solar Combined Cycle Power Plants

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Journal of Thermal Science 2020年第2期29卷 298-322页

作者： KHANDELWAL Neelam sharma Meeta SINGH Onkar SHUKLA Anoop kumar Mechanical Engineering Department Amity University Uttar PradeshNoida(U.P.)201313India Mechanical Engineering Department Harcourt Butler Technical UniversityKanpur(U.P.)208002India

Global concern for depleting fossil fuel reserves have been compelling for evolving power generation options using renewable energy sources. The solar energy happens to be a potential source for running the power plants among renewable energy sources. Integrated Solar Combined Cycle(ISCC) power plants have gained popularity among the thermal power plants. Traditional ISCC power plants use Direct Steam Generation(DSG) approach. However, with the DSG method, the ISCC plant’s overall thermal efficiency does not increase significantly due to variations in the availability of solar energy. Thermal Energy Storage(TES) systems when integrated into the solar cycle can address such issues related to energy efficiency, process flexibility, reducing intermittency during non-solar hours. This review work focuses and discusses the developments in various components of the ISCC system including its major cycles and related parameters. The main focus is on CSP technologies, Heat Transfer Fluid(HTF), and Phase Change Material(PCM) used for thermal energy storage. Further, study includes heat enhancement methods with HTF and latent heat storage system. This study will be beneficial to the power plant professionals intending to modify the solar-based Combined Cycle Power Plant(CCPP) and to retrofit the existing Natural Gas Combined Cycle(NGCC) plant with the advanced solar cycle.

关键词： CSP(Concentrated Solar Power) HTF(Heat Transfer Fluid) ISCC(Integrated Solar Combined Cycle) TES(Thermal Energy Storage) PCM(Phase Change Material)

Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury

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World Journal of Stem Cells 2024年第7期16卷 742-759页

作者： Prashasti sharma Dharmendra kumar Maurya Life Sciences Homi Bhabha National InstituteMumbai 400094MaharashtraIndia Radiation Biology&Health Sciences Division Bhabha Atomic Research CentreMumbai 400085MaharashtraIndia

Wharton’s jelly mesenchymal stem cells(WJ-MSCs)are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation ***-MSCs are more naïve and have a better safety profile,making them suitable for both autologous and allogeneic *** review highlights the regenerative potential of WJ-MSCs and their clinical applications in mitigating various types of radiation *** this review,we will also describe why WJ-MSCs will become one of the most probable stem cells for future regenerative medicine along with a balanced view on their strengths and ***,the most updated literature related to both preclinical and clinical usage of WJ-MSCs for their potential application in the regeneration of tissues and organs will also be compiled.

关键词： Stem cells Wharton’s jelly mesenchymal stem cells Radiotherapy Xerostomia Lung fibrosis

Selective Mapping Scheme for Universal Filtered Multicarrier

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Intelligent Automation & Soft Computing 2023年第5期36卷 1273-1282页

作者： Akku Madhusudhan Sudhir kumar sharma Jaipur National University JagatpuraJaipur302017RajasthanIndia

The next step in mobile communication technology,known as 5G,is set to go live in a number of countries in the near *** wireless applica-tions have high data rates and mobility requirements,which have posed a chal-lenge to mobile communication technology researchers and designers.5G systems could beneﬁt from the Universal Filtered Multicarrier(UFMC).UFMC is an alternate waveform to orthogonal frequency-division multiplexing(OFDM),inﬁltering process is performed for a sub-band of subcarriers rather than the entire band of subcarriers Inter Carrier Interference(ICI)between neighbouring users is reduced via the sub-bandﬁltering process,which reduces out-of-band ***,the UFMC system has a high Peak-to-Average Power Ratio(PAPR),which limits its *** optimization based Selective mapping(SLM)is used in this paper to optimise the *** on the cognitive behaviour of crows,the research study suggests an innovative metaheuristic opti-mization known as Crow Search Algorithm(CSA)for SLM ***-pared to the standard UFMC,SLM-UFMC system,and SLM-UFMC with conventional metaheuristic optimization techniques,the suggested technique sig-niﬁcantly reduces *** the UFMC system,the suggested approach has a very low Bit Error Rate(BER).

关键词： -Universalﬁltered multicarrier(UFMC) selective mapping(SLM) metaheuristic optimization crow search algorithm(CSA) bit error rate(BER)