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Computers, Materials & Continua 2020年第3期62卷 1125-1142页

作者： Kamaleldin Abodayeh Ali Raza Muhammad Shoaib Arif Muhammad rafiq Mairaj Bibi Muhammad Mohsin Department of Mathematics and General Sciences Prince Sultan UniversityRiyadhSaudi Arabia Stochatic Analysis&Optimization Research Group Department of MathematicsAir UniversityPAF Complex E-9Islamabad44000Pakistan Faculty of Engineering University of Central Punjab LahorePakistan Department of Mathematics Comsats UniversityChak Shahzad Campus park roadIslamabadPakistan Department of Mathematics Uppsala UniversityUppsalaSweden

This paper aims to perform a comparison of deterministic and stochastic *** stochastic modelling is a more realistic way to study the dynamics of gonorrhoea infection as compared to its corresponding deterministic ***,the deterministic solution is itself mean of the stochastic solution of the *** numerical analysis,first,we developed some explicit stochastic methods,but unfortunately,they do not remain consistent in certain *** we proposed an implicitly driven explicit method for stochastic heavy alcohol epidemic *** proposed method is independent of the choice of parameters and behaves well in all ***,some theorems and simulations are presented in support of the article.

关键词： Heavy alcohol model stochastic techniques stability analysis

Structure-Preserving Dynamics of Stochastic Epidemic Model with the Saturated Incidence Rate

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Computers, Materials & Continua 2020年第8期64卷 797-811页

作者： Wasfi Shatanawi Muhammad Shoaib Arif Ali Raza Muhammad rafiq Mairaj Bibi Javeria Nawaz Abbasi Department of Mathematics and General Sciences Prince Sultan UniversityRiyadhSaudi Arabia Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan Department of M-Commerce and Multimedia Applications Asia UniversityTaichung41354Taiwan Stochastic Analysis&Optimization Research Group Department of MathematicsAir UniversityPAF Complex E-9Islamabad44000Pakistan Faculty of Engineering University of Central PunjabLahorePakistan Department of Mathematics Comsats UniversityIslamabadPakistan

The structure-preserving features of the nonlinear stochastic models are positivity,dynamical consistency and *** features have a significant role in different fields of computational biology and many ***,the existing stochastic approaches in literature do not restore aforesaid structure-preserving features,particularly for the stochastic ***,these gaps should be occupied up in literature,by constructing the structure-preserving features preserving numerical *** writing aims to describe the structure-preserving dynamics of the stochastic *** have analysed the effect of reproduction number in stochastic modelling the same as described in the literature for deterministic *** usual explicit stochastic numerical approaches are *** have developed the implicitly driven explicit approach for the stochastic epidemic *** have proved that the newly developed approach is preserving the structural,dynamical properties as positivity,boundedness and dynamical ***,convergence analysis of a newly developed approach and graphically illustration is also presented.

关键词： Epidemic model stochastic numerical approaches convergence analysis

On Computer Implementation for Comparison of Inverse Numerical Schemes for Non-Linear Equations

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Computer Systems Science & Engineering 2021年第3期36卷 493-507页

作者： Mudassir Shams Naila rafiq Nazir Ahmad Mir Babar Ahmad Saqib Abbasi Mutee-Ur-Rehman Kayani Department of Mathematics and Statistics Riphah International UniversityI-14Islamabad44000Pakistan Department of Mathematics NUMLIslamabadPakistan Department of Mathematics Comsats UniversityIslamabad44000Pakistan

In this research article,we interrogate two new modifications in inverse Weierstrass iterative method for estimating all roots of non-linear equation *** modifications enables us to accelerate the convergence order of inverse Weierstrass method from 2 to *** analysis proves that the orders of convergence of the two newly constructed inverse methods are *** computer algebra system Mathematica,we find the lower bound of the convergence order and verify it *** planes of the inverse simultaneous methods and classical iterative methods are generated using MATLAB(R2011b),to present the global convergence properties of inverse simultaneous iterative methods as compared to classical *** non-linear models are taken from Physics,Chemistry and engineering to demonstrate the performance and efficiency of the newly constructed *** CPU time,and residual graphs of the methods are provided to present the dominance behavior of our newly constructed methods as compared to existing inverse and classical simultaneous iterative methods in the literature.

关键词： Non-linear equation inverse iterative method simultaneous method basins of attraction lower bound of convergence

The World Health Organization road map for neglected tropical diseases 2021-2030:implications for onchocerciasis elimination programs

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Infectious Diseases of Poverty 2021年第3期10卷 58-61页

作者： Melissa Krizia Vieri Makoy Yibi Logora Kamran rafiq Robert Colebunders Global Health Institute University of AntwerpKinsbergen CentrumDoornstraat 3312610 AntwerpBelgium Neglected Tropical Diseases Unit Ministry of HealthJubaRepublic of South Sudan The International Society for Neglected Tropical Diseases LondonUK.

In its new roadmap for neglected tropical diseases,the World Health Organization proposes three important strategic shifts:(i)Stronger accountability which shifting from process to impact indicators;(ii)Intensified cross-cutting approaches;and(iii)Stronger country *** this paper we discuss the implementation of these three strategies in the setting of a high onchocerciasis disease burden in South Sudan.

关键词： WHO road map Onchocerciasis Elimination Epilepsy Nodding syndrome Community based program Ivermectin

A Reliable Stochastic Numerical Analysis for Typhoid Fever Incorporating With Protection Against Infection

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Computers, Materials & Continua 2019年第6期59卷 787-804页

作者： Muhammad Shoaib Arif Ali Raza Muhammad rafiq Mairaj Bibi Rabia Fayyaz Mehvish Naz Umer Javed Department of Mathematics Air UniversityPAF Complex E-9Islamabad44000Pakistan Faculty of Engineering University of Central PunjabLahore54500Pakistan Department of Mathematics Comsats UniversityChak Shahzad CampusIslamabad44000Pakistan Department of Electrical and Computer Engineering Comsats UniversityWah Campus47040IslambadPakistan

In this paper,a reliable stochastic numerical analysis for typhoid fever incorporating with protection against infection has been *** have compared the solutions of stochastic and deterministic typhoid fever *** has been shown that the stochastic typhoid fever model is more realistic as compared to the deterministic typhoid fever *** effect of threshold number T*hold in stochastic typhoid fever *** proposed framework of the stochastic non-standard finite difference scheme(SNSFD)preserves all dynamical properties like positivity,bounded-ness and dynamical consistency defined by Mickens,*** stochastic numerical simulation of the model showed that increase in protection leads to low disease prevalence in a population.

关键词： Typhoid fever stochastic differential equations euler maruyama scheme stochastic euler scheme stochastic runge-kutta scheme stochastic NSFD scheme

Numerical Control Measures of Stochastic Malaria Epidemic Model

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Computers, Materials & Continua 2020年第10期65卷 33-51页

作者： Muhammad rafiq Ali Ahmadian Ali Raza Dumitru Baleanu Muhammad Sarwar Ahsan Mohammad Hasan Abdul Sathar Faculty of Engineering University of Central PunjabLahorePakistan Institute of Visual Informatics National University of MalaysiaBangi43600 UKMMalaysia Faculty of Computing National College of Business Administration and EconomicsLahorePakistan Department of Mathematics Cankaya UniversityAnkara06530Turkey Centre of Foundation Studies for Agricultural Science Universiti Putra MalaysiaSerdang43400Malaysia

Nonlinear stochastic modeling has significant role in the all discipline of *** essential control measuring features of modeling are positivity,boundedness and dynamical ***,the existing stochastic methods in literature do not restore aforesaid control measuring features,particularly for the stochastic ***,these gaps should be occupied up in literature,by constructing the control measuring features numerical *** shall present a numerical control measures for stochastic malaria model in this *** results of the stochastic model are discussed in contrast of its equivalent deterministic *** the basic reproduction number is less than one,then the disease will be in control while its value greater than one shows the perseverance of disease in the *** standard numerical procedures are conditionally *** propose method is competitive and preserve all the control measuring features *** has also been concluded that the prevalence of malaria in the human population may be controlled by reducing the contact rate between mosquitoes and *** awareness programs run by world health organization in developing countries may overcome the spread of malaria disease.

关键词： Malaria disease model stochastic modelling stochastic methods convergence

Difficulty in differentiating two cases of sigmoid stenosis by diverticulitis from cancer

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World Journal of Gastroenterology 2012年第27期18卷 3623-3626页

作者： Noriko Nishiyama Hirohito Mori Hideki Kobara Kazi rafiq Shintarou Fujihara Mitsuyoshi Kobayashi Tsutomu Masaki Department of Gastroenterology and Neurology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Pharmacology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

The incidence of colonic diverticulosis with or without diverticulitis has increased in the Japanese population due to the modernization of food and *** rate of diverticulitis in colon diverticulosis ranges from 8.1% to 9.6%.However,few cases of stenosis due to diverticulitis have been *** reports suggest that the differentiation between sigmoid diverticulitis and colon cancer is *** report describes two cases of colon stenosis due to diverticulitis that were difficult to differentiate from colon *** 1 was a 70-year-old woman with narrowed stools for 1 month who underwent colonofiberscopy (CFS).CFS revealed a diverticulum and circumferential stenosis in the sigmoid *** enema revealed a marked,hourglassshaped,2-cm circumferential stenosis in the sigmoid *** (FDG)-positron emission tomography computed tomography (CT) revealed an increased FDG uptake at the affected portion of the sigmoid *** colon cancer was suspected,and laparoscopic sigmoidectomy was *** examination demonstrated active inflammation with no evidence of *** 2 was a 50-yearold man who presented to a nearby clinic with reduced stool output despite the urge to *** detected severe stenosis in the sigmoid colon approximately 25 cm from the dentate ***-enhanced abdominal CT revealed multiple diverticula,wall thickening,and swelling of the lymph nodes around the peritoneal aorta and the inferior mesenteric artery.A partial sigmoidectomy was *** examination of the resected specimen revealed no changes in the mucosal epithelial surface,but a marked infiltration of inflammatory cells was observed.

关键词：结肠癌狭窄正电子发射断层扫描计算机断层扫描癌症食物安全病理检查脱氧葡萄糖

Numerical Study of Computer Virus Reaction Diffusion Epidemic Model

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Computers, Materials & Continua 2021年第3期66卷 3183-3194页

作者： Umbreen Fatima Dumitru Baleanu Nauman Ahmed Shumaila Azam Ali Raza Muhammad rafiq Muhammad Aziz-ur Rehman Department of Computer Science The University of LahoreLahorePakistan Department of Mathematics Cankaya UniversityAnkaraTurkey Institute of Space Sciences Magurele-BucharestRomania Department of Medical Research China Medical University HospitalChina Medical UniversityTaichungTaiwan Department of Mathematics and Statistics The University of LahoreLahorePakistan Department of Mathematics National College of Business Administration and Economics LahoreLahorePakistan Faculty of Engineering University of Central PunjabLahorePakistan Department of Mathematics University of Management and TechnologyLahorePakistan

Reaction–diffusion systems are mathematical models which link to several physical *** most common is the change in space and time of the meditation of one or more ***–diffusion modeling is a substantial role in the modeling of computer propagation like infectious *** investigated the transmission dynamics of the computer virus in which connected to each other through network *** current study devoted to the structure-preserving analysis of the computer propagation *** manuscript is devoted to finding the numerical investigation of the reaction–diffusion computer virus epidemic model with the help of a reliable *** designed technique is finite difference scheme which sustains the important physical behavior of continuous model like the positivity of the dependent variables,the stability of the *** theoretical analysis of the proposed method like the positivity of the approximation,stability,and consistency is discussed in detail.A numerical example of simulations yields the authentication of the theoretical results of the designed technique.

关键词： Computer virus dynamics reaction-diffusion system positive solution simulations

Notch signalling pathway in development of cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 957-974页

作者： Bisma Rauff Arif Malik Yasir Ali Bhatti Shafiq Ahmad Chudhary Ishtiaq Qadri Shafquat rafiq Institute of Molecular Biology and Biotechnology University of LahoreLahore 54000Pakistan Institute of Biomedical and Allied Health Sciences University of Health SciencesLahore 54000Pakistan Department of Biology Faculty of ScienceKing Abdulaziz University Jeddah Kingdom of Saudi Arabia Department of Gastrointestinal medicine Croydon University HospitalCroydon CR77YEUnited Kingdom

Cholangiocarcinoma(CCA)comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile *** incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian *** risk factors involve chronic damage and inflammation of bile duct epithelium from primary sclerosing cholangitis,chronic hepatitis virus infection,gallstones and liver fluke *** genetic variants have also been identified and as CCA develops on the background of biliary inflammation,diverse range of molecular mechanisms are involved in its *** these,the Notch signalling pathway acts as a major driver of cholangiocarcinogenesis and its components(receptors,ligands and downstream signalling molecules)represent a promising therapeutic ***-Secretase Inhibitors have been recognized in inhibiting the Notch pathway efficiently.A comprehensive knowledge of the molecular pathways activated by the Notch signalling cascade as well as its functional crosstalk with other signalling pathways provide better approach in developing innovative therapies against CCA.

关键词： Cholangicarcinoma Notch receptors Therapeutic targets Notch signalling pathway Gamma secretase inhibitor Cholangiocytes

Aristolochia gehrtii inhibits liver toxicity and apoptosis in Schistosoma malayensis infection

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 685-692页

作者： Khaled M.M.Koriem Razmy E.Shahabudin rafiq Z.Jamaludin Advanced Medical and Dental Institute(AMDI) Universiti Sains Malaysia(USM)13200 Kepala BatasPulau PinangMalaysia Department of Medical Physiology National Research Centre12622 DokkiGizaEgypt

Objective:To evaluate a protective effect of Aristolochia gehrtii(***)leaves to inhibit liver toxicity and apoptosis in Schistosoma malayensis(***)***:Forty male albino mice were divided into four equal groups:group 1 control including noninfected healthy mice and groups 2,3&4 subcutaneously infected with *** cercariae where groups 3&4 pretreated with *** leaves(200 mg/kg,bwt)&cinnamoylamide(250mg/kg,bwt),***:*** caused a significant increase in serum AST,ALT,ALP,MDA,NO,bilirubin,urea,creatinine,total cholesterol,LDL,triglycerides,and HDL *** pretreatment of A,gehrtii leaves and cinnamoylamide significantly inhibited that *** the other hand,*** induced a significant decrease in serum total protein,albumin,globulin,albumin/globulin ratio,blood SOD and GPx,while *** leaves and cinnamoylamide pretreatment increased the above *** with *** leaves and cinnamoylamide to *** infected mice increased p53 expression but decreased *** results were supported by hislopalholqgical ***:*** inhibits liver toxicity and apoptosis in *** infection and this effect is associated with the major cinnamoylamide ingredient of *** leaves.

关键词： Schistosoma malayensis Aristolochia gehrtii Aristolochiaceae Liver Apoptosis Mice