Aristolochia gehrtii inhibits liver toxicity and apoptosis in Schistosoma malayensis infection

作     者：Khaled M.M.Koriem Razmy E.Shahabudin Rafiq Z.Jamaludin 

作者机构：Advanced Medical and Dental Institute(AMDI)Universiti Sains Malaysia(USM)13200 Kepala BatasPulau PinangMalaysia Department of Medical PhysiologyNational Research Centre12622 DokkiGizaEgypt 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第9期

页      面：685-692页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Schistosoma malayensis Aristolochia gehrtii Aristolochiaceae Liver Apoptosis Mice 

摘      要：Objective:To evaluate a protective effect of Aristolochia gehrtii(***)leaves to inhibit liver toxicity and apoptosis in Schistosoma malayensis(***)***:Forty male albino mice were divided into four equal groups:group 1 control including noninfected healthy mice and groups 2,3&4 subcutaneously infected with *** cercariae where groups 3&4 pretreated with *** leaves(200 mg/kg,bwt)&cinnamoylamide(250mg/kg,bwt),***:*** caused a significant increase in serum AST,ALT,ALP,MDA,NO,bilirubin,urea,creatinine,total cholesterol,LDL,triglycerides,and HDL *** pretreatment of A,gehrtii leaves and cinnamoylamide significantly inhibited that *** the other hand,*** induced a significant decrease in serum total protein,albumin,globulin,albumin/globulin ratio,blood SOD and GPx,while *** leaves and cinnamoylamide pretreatment increased the above *** with *** leaves and cinnamoylamide to *** infected mice increased p53 expression but decreased *** results were supported by hislopalholqgical ***:*** inhibits liver toxicity and apoptosis in *** infection and this effect is associated with the major cinnamoylamide ingredient of *** leaves.