Notch signalling pathway in development of cholangiocarcinoma
作者机构：Institute of Molecular Biology and BiotechnologyUniversity of LahoreLahore 54000Pakistan Institute of Biomedical and Allied Health SciencesUniversity of Health SciencesLahore 54000Pakistan Department of BiologyFaculty of ScienceKing Abdulaziz University Jeddah Kingdom of Saudi Arabia Department of Gastrointestinal medicineCroydon University HospitalCroydon CR77YEUnited Kingdom
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2020年第12卷第9期
页 面：957-974页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cholangicarcinoma Notch receptors Therapeutic targets Notch signalling pathway Gamma secretase inhibitor Cholangiocytes
摘 要：Cholangiocarcinoma(CCA)comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile *** incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian *** risk factors involve chronic damage and inflammation of bile duct epithelium from primary sclerosing cholangitis,chronic hepatitis virus infection,gallstones and liver fluke *** genetic variants have also been identified and as CCA develops on the background of biliary inflammation,diverse range of molecular mechanisms are involved in its *** these,the Notch signalling pathway acts as a major driver of cholangiocarcinogenesis and its components(receptors,ligands and downstream signalling molecules)represent a promising therapeutic ***-Secretase Inhibitors have been recognized in inhibiting the Notch pathway efficiently.A comprehensive knowledge of the molecular pathways activated by the Notch signalling cascade as well as its functional crosstalk with other signalling pathways provide better approach in developing innovative therapies against CCA.
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