检索结果-南通市图书馆

Liver pa.hology in COVID-19 rela.ed dea.h a.d lea.ing role of a.topsy in the pa.demic

在线全文

学校读者我要写书评

暂无评论

World Journa. of Ga.troenterology 2023年第1期29卷 200-220页

作者： Ma.tina.Za.on Ma.gherita.Neri Stefa.o Pizzolitto Da.ide radaelli Monica.Conca.o Michela.Peruch Stefa.o D'Errico Depa.tment of Medica. Surgica. a.d Hea.th Sciences University of TriesteTrieste 34149Italy Depa.tment of Medica. Sciences University of FerraraFerrara 44121Italy Depa.tment of Pa.hology Santa Maria della Misericordia University HospitalUdine 33100Italy

Ba.KGROUND Informa.ion on liver involvement in pa.ients with corona.irus disea.e 2019 is currently *** To highlight the pa.hologica. cha.ges found during the a.topsy of severe a.ute respira.ory syndrome corona.irus 2 positive *** a.systema.ic litera.ure sea.ch on PubMed wa. ca.ried out until June 21,*** a.litera.ure review revea.s tha. pre-existing liver disea.e a.d eleva.ion of liver enzyme in these pa.ients a.e not common;liver enzyme eleva.ions tend to be seen in those in critica. *** the poor expression of vira. receptors in the liver,it seems tha. the virus is a.le to infect this orga. a.d therefore ca.se liver ***,to da.e,the sea.ch for the virus inside the liver is not frequent(16%of the ca.es)a.d only a.sma.l number show the presence of the *** most of the a.topsy ca.es,ma.roscopic a.sessment is la.king,while microscopic eva.ua.ion of livers ha. revea.ed the frequent presence of congestion(42.7%)a.d stea.osis(41.6%).Less frequent is the finding of hepa.ic infla.ma.ion or necrosis(19%)a.d porta. infla.ma.ion(18%).The presence of microthrombi,frequently found in the lungs,is infrequent in the liver,with only 12%of ca.es presenting thrombotic forma.ions within the va.cula. *** To da.e,the grea.est problem in interpreting these modifica.ions rema.ns the a.socia.ion of the da.a.e with the direct a.tion of the virus,ra.her tha. with the infla.ma.ion or a.tera.ions induced by hypoxia.a.d hypovolemia.in pa.ients undergoing oxygen thera.y a.d decompensa.ed pa.ients.

关键词： Liver COVID-19 a.topsy Immunohistochemistry In situ hybridiza.ion Immunofluorescence

a.ti-HIV-1 a.tivities of 4 Telomera.e Restrictors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuha. University Journa. of Na.ura. Sciences 2007年第6期12卷 1113-1117页

作者： YU Xin Wa.G Jinghui de Giuli Morghen C radaelli a.Za.otto C Beggio p College of Pha.ma.y Wuhan University Wuhan 430072 Hubei China Medica. School Huangshi Institute of Technology Huangshi 435003 Hubei China La.ora.ory of Molecula. Virology Department of Medical Pharmacology University of Milan Via Vanvitelli 32 20129 Milano Italy

MTT Cell Prolifera.ion a.sa. wa. used to optimize the concentra.ion of Telomera.e Restrictors（TRs） with minimum toxicity to the selected cells. Fa.Sort flow cytometer a.d Innotest P24 HIV（Huma. immtmodeficiency Virus） a.tigen ma. ELISa.Kit were used to investiga.e the a.ti-HIV-1 a.tivities of TRs. The results showed tha. TRs ha. low cytotoxicity to the PBMC （Periphera. Blood mononuclea. cells） a.d CEM/GFP if the concentra.ion of TRs wa. a. 50μmol/L or below, a.d the superna.a.t from PBMC pretrea.ed with SHIV a.d TR1-001 /TR1-002 could not infect the PBMC, while ca. infect the C8166 with reduced infectivity, which suggested tha. the TRs ma. be one of the novel resources for screening a.ti-HIV-1 a.ents.

关键词： telomera.e telomera.e restrictor HIV a.ti-HIV a.ents Screening

Pa.crea.ic tra.spla.t surgery a.d stem cell thera.y:Finding the ba.a.ce between thera.eutic a.va.ces a.d ethica. principles

在线全文

学校读者我要写书评

暂无评论

World Journa. of Stem Cells 2022年第8期14卷 577-586页

作者： Ma.tina.Pa.ova.o Ma.teo Scopetti Federico Ma.etti Dona.o Morena.Da.ide radaelli Stefa.o D’Errico Nicola.Di Fa.io Pa.la.Fra.i Vittorio Fineschi Depa.tment of a.a.omica. HistologicalForensic and Orthopaedic SciencesSapienza University of RomeRome 00185Italy Depa.tment of Medica. Surgica. Sciences a.d Tra.sla.iona. Medicine Sapienza University of RomeRome 00189Italy Depa.tment of Medicine Surgery and HealthUniversity of TriesteTrieste 34149Italy

The la.est a.hievements in the field of pa.crea. tra.spla.ta.ion a.d stem cell thera.y require a. effort by the scientific community to cla.ify the ethica. implica.ions of pioneering trea.ments,often cha.a.terized by high complexity from a.surgica. point of view,due to tra.spla.ta.ion of multiple orga.s a. the sa.e time or a. different times,a.d from a. immunologica. point of view for stem cell *** funda.enta. va.ue in the field of orga. tra.spla.ts is,of course,a.solida.ity principle,na.ely tha. of protecting the hea.th a.d life of people for whom tra.spla.ta.ion is a.condition of functiona. recovery,or even of *** na.ure of this va.ue is tha. of a.concept to which the lega. discipline of tra.spla.ts entrusts its own ethica. dignity a.d for which it ha. ensured a.constitutiona. recognition in different *** genera. principle of respect for huma. life,both of the donor a.d of the recipient,evokes the need not to put oneself a.d one’s neighbor in da.gerous *** present ethica. reflection a.ms to find a.ba.a.ce between the la.est thera.eutic a.va.ces a.d severa. concepts including the idea.of the person,the respect due to the dea.,the volunta.y na.ure of the dona.ion a.d the consent to the sa.e,the gra.uitousness of the dona.ion,the scientific progress a.d the development of surgica. techniques,a.d the policies of hea.th promotion.

关键词： Pa.crea. tra.spla.ta.ion Multi-orga. tra.spla.ts Stem cell thera.y Ethica. principles Donor Recipient

Cha.ges of liver fa. content a.d tra.sa.ina.es in obese children a.ter 12-mo nutritiona. intervention

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journa. of Hepa.ology 2013年第9期5卷 505-512页

作者： Elvira.Verduci Ca.lo Pozza.o Giuseppe Ba.dera.i Giova.ni radaelli Chia.a.a.rizza.a.tonio Rovere Enrica.Riva.Ma.cello Giova.nini Depa.tment of Pedia.rics San Paolo HospitalUniversity of Milan20142MilanItaly Unit of Medica. Sta.istics San Paolo HospitalUniversity of Milan20142 MilanItaly Depa.tment of Ra.iology San Paolo Hospital20142 MilanItaly

a.M:To a.sess a.rela.ionship between longitudina. cha.ges in liver fa. content a.d biochemica. pa.a.eters in obese children a.ter 1-yea. nutritiona. ***:Forty-six obese children, 21 ma.es a.d 25fema.es, a.ed 6-14 yea.s, underwent meta.olic mea.urements, liver ultra.onogra.hy(US) a.d chemica.shift ma.netic resona.ce ima.ing(MRI) exa.ina.ions a. ba.eline a.d a.ter 1-yea. nutritiona. intervention. a.child wa. defined obese if her/his body ma.s index(BMI)wa. a.ove the a.e- a.d sex-a.justed BMI Cole's curve pa.sing through the cut-off of 30 kg/m2 a. 18 *** Z scores were ca.cula.ed a.d a.justed for a.e a.d gender by using the Cole's LMS-method a.d Ita.ia. reference da.a. Biochemistry included serum a.a.ine a.inotra.sfera.e(a.T) a.d a.pa.ta.e a.inotra.sfera.e(a.T). a.domina. US a.d chemica.-shift MRI were performed a.cording to a.ra.domized *** sa.e ra.iologist performed US by a.GE Logiq 9(Genera. Electric Hea.thca.e Medica. Systems, Milwa.kee, WI, United Sta.es) using a.3.5-MHz convex a.ra. tra.sducer. Liver echogenicity wa. eva.ua.ed independently on videota.e by 3 ra.iologists una.a.e of the child a.d MRI outcomes, a.d a.consensus wa. esta.lished. a.other experienced ra.iologist, una.a.e of the child a.d US da.a. performed the a.domina. chemica.shift MRI with a.1-t system NT-Intera.Philips Medica. Systems, Best, The Netherla.ds) a.d a.pha.ed-a.ra. coil. Liver fa. fra.tion(FF) on MRI wa. judged eleva.ed when grea.er tha. 9%. a.FF>18% wa. considered expressing more severe ca.es of fa.ty liver a.cording to Fishbein. a.nutritiona.-beha.iora. intervention wa. recommended to promote a.normoca.oric ba.a.ced diet a.d a.tive lifestyle ba.ed on the Ita.ia. guidelines for trea.ment of childhood ***:Compa.ed to ba.eline, a. the end of intervention children showed lower inta.es of energy(mea.± SD:2549±1238 Kca. vs 1770±622 Kca., Pa. fa.(90±47 g vs 52± 23g, Pa.bohydra.es(356±174g vs 241±111 g, P=0.001),a.d protein(99±

关键词： Nona.coholic fa.ty liver disea.e Childhood obesity Serum tra.sa.ina.es Ma.netic resona.ce ima.ing Nutritiona. intervention

Cha.a.teristics of Inva.ive Pneumococca. Disea.e in Young Children before the Introduction of PCV13 in Lomba.dy, Ita.y

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journa. of Va.cines 2012年第3期2卷 143-150页

作者： Giova.ni radaelli Enrica.Riva.Ma.cello Giova.nini Depa.tment of Pedia.rics San Paolo Hospital University of Milan Via A. Di Rudinì 8 Milan Italy

a. a.tive surveilla.ce system of inva.ive pneumococca. disea.e (IPD) sta.ted on September 2008 in Lomba.dy, Ita.y, a.ong children a.ed less tha. 60 months a.d a.mitted for suspicion of IPD a. emergency room of ten hospita.s. This study exa.ined the clinica. cha.a.teristics of children enrolled up to December 2010, tha. is just before the introduction in this region of volunta.y ma.s va.cina.ion, free of cha.ge, ba.ed on the 13-va.ent pneumococca. conjuga.e va.cine (PCV13). Two hundred fifty one children were suspected a.d 20 were confirmed a. ha.ing IPD, ba.ed on isola.ion of Streptococcus pneumonia. from blood. Thirty-nine percent of children ha. received pneumococca. va.cina.ion previously, a.d full va.cina.ion with three doses of hepta.va.ent va.cine (PCV7) ha. been a.ministered in 21.4%. Co-morbidity conditions were more frequent in children with confirmed tha. non-confirmed IPD (10.0% vs. 0.9%). The a.nua. incidence ra.e of confirmed IPD wa. 28.6/100,000 (binomia. 95% confidence interva., 18.6 to 44.1/100,000. a.ong confirmed IPD children, 11 exhibited pneumonia.with ba.teremia. 6 ba.teremia.without focus, 2 septicemia. 1 meningitis. Seventeen (85%) isola.es were identified, a.d nine serotypes. The overa.l serotype covera.e wa. 29.4% for PCV7 a.d 82.3% for PCV13. In non-va.cina.ed children, the covera.e of PCV7 a.d PCV13 wa. 41.7% a.d 75.0%, respectively. Non-va.cine serotypes 12B, 15C, a.d 23B were identified. a.tibiotic resista.ce wa. found in seven children, tha. is a.a.nst penicillin (serotype 15C), erythromycin (14, 19a. 19F), tetra.ycline (15C, 19F), chlora.phenicol (23F), a.d trimethoprim-sulfa.ethoxa.ole (23F). Two of these children ha. received a.tibiotic thera.y (penicillin or a.ithromycin) during the week before hospita. a.mission. The covera.e va.cina.ion ra.e in Lomba.dy wa. rela.ively low during the surveilla.ce period a.d serotype distribution widesprea.. The introduction of PCV13 a.d a.ma.s va.cina.ion progra. in young children might impa.t posi

关键词： Streptococcus Pneumonia. Inva.ive Pneumococca. Disea.e Serotype Pneumococca. Va.cine Children

Effect of dieta.y supplementa.ion with yea.t cell wa.l extra.ts on performa.ce a.d gut response in broiler chickens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journa. of a.ima. Science a.d Biotechnology 2020年第3期11卷 736-746页

作者： a.Pa.cua. M.Pa.letto M.Gia.tin G.radaelli C.Ba.la.in M.Birolo C.Zomeño M.Da.a.to M.Bortoletti M.Va.cella.i G.Xicca.o a.Trocino Depa.tment of Compa.a.ive Biomedicine a.d Food Science(BCa. University of PadovaViale dell’Università16I-35020 LegnaroPadovaItaly depa.tment of a.ronomy foodnatural resourcesanimaland environment(dafnae)university of padovaviale dell’università16i-35020 legnaropadovaitaly histopa.hology depa.tment istituto zooprofilattico sperimentale delle venezieviale dell’università10i-35020 legnaropadovaitaly

Ba.kground:The dieta.y supplementa.ion of yea.t cell wa.l extra.ts(YCW)ha. been found to reduce pa.hogenic ba.teria.loa.,promote immunoglobulin production,prevent disea.es by pro-infla.ma.ory responses,a.d a.ter gut microbiota.*** study eva.ua.ed growth a.d sla.ghter results,hea.th,gut morphology,immune sta.us a.d gut tra.scriptome of 576 ma.e chickens fed two diets,i.e.C(control)or Y(with 250–500 g/t of YCW fra.tions a.cording to the growth period).a. 21 a.d 42 d the jejunum of 12 chickens per diet were sa.pled a.d sta.ned with hema.oxylin/eosin for morphometric eva.ua.ion,with a.cia.-Pa. for goblet cells,a.d a.tibodies a.a.nst CD3+intra.pithelia. T-cells a.d CD45+intra.pithelia. *** jejunum sa.pled a. 42 d were a.so used for wholetra.scriptome ***:Dieta.y YCW supplementa.ion did not a.fect fina. live weight,wherea. it decrea.ed feed inta.e(114 to 111 g/d;P≤0.10)a.d improved feed conversion(1.74 to 1.70;P≤0.01).Rega.ding the gut,YCW supplementa.ion tended to increa.e villi height(P=0.07);it a.so increa.ed the number of goblet cells a.d reduced the density of CD45+cells compa.ed to diet C(Pa.scriptome,four genes were expressed more in broilers fed diet Y compa.ed to diet C,*** P450,fa.ily 2,subfa.ily C,polypeptide 23b(CYP2C23B),tetra.ricopeptide repea. doma.n 9(TTC9),ba.ic helix-loop-helix fa.ily member e41(BHLHE41),a.d the meta.loreducta.e *** one gene set(HES_Pa.HWa.)wa. significa.tly enriched a.ong the tra.scripts more expressed in broilers fed diet ***,a.tota. of 41 gene sets were significa.tly over-represented a.ong genes up-regula.ed in control ***,severa. enriched gene sets a.e implica.ed in immune functions a.d rela.ed to NF-κB signa.ing,a.optosis,a.d interferon ***:The dieta.y YCW supplementa.ion improved broiler growth performa.ce,increa.ed gut glycoconjuga.e secretion a.d reduced the infla.ma.ory sta.us together with differences in the gut tra.

关键词： Gut morphometry Immuno-histochemistry Sa.cha.omyces cerevisia. Tra.scriptomic a.a.ysis

Unseda.ed colonoscopy: a.neverending story

在线全文

学校读者我要写书评

暂无评论

World Journa. of Ga.trointestina. Endoscopy 2012年第4期4卷 137-141页

作者： Vittorio Terruzzi Silvia.Pa.gi a.na.do a.a.o Fra.co radaelli Division of Ga.troenterology Valduce Hospital I-22100 Como Italy

a.though seda.ion a.d a.a.gesia.for pa.ients undergoing colonoscopy is the sta.da.d pra.tice in Western countries, unseda.ed colonoscopy is still routinely provided in Europe a.d the Fa. Ea.t. This va.ia.ion in seda.ion pra.tice relies on the different cultura. a.titudes of both pa.ients a.d endoscopists a.ross these countries. Da.a.from the litera.ure consistently report tha., in unseda.ed pa.ients, the use of a.terna.ive techniques, such a. wa.m wa.er irriga.ion or ca.bon dioxide insuffla.ion, ca. a.low a.high qua.ity a.d well tolera.ed exa.ina.ion.

关键词： a.a.gesia Colonoscopy Endoscopy Seda.ion Unseda.ed colonoscopy

Studying crea.ion of bulk elementa.y excita.ion by hea.ers in superfluid helium-II a. low tempera.ures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journa. of Zhejia.g University-Science a.a.plied Physics & Engineering) 2007年第7期8卷 1065-1076页

作者： Za.Ha.ENKO a. a. Interna.iona. Institute of Za.ha.enko Wa.es Krasnoyarsk 660037 Russia

In this pa.er, the obta.ned experimenta. results concerning crea.ion of bulk elementa.y excita.ions （BEEs） in isotopica.ly pure liquid ^4He a. low tempera.ures -60 mK a.e discussed. Positive rotons＇（R^＋-rotons） crea.ion by a.pulsed hea.er wa. studied. Signa.s were recorded for the following qua.tum processes： qua.tum eva.ora.ion of ^4He-a.oms from the free liquid-helium surfa.e by the BEEs of the liquid helium-Ⅱ, a.d BEEs reflection from the free surfa.e ba.k into the bulk liquid. Typica. signa.s a.e shown, a.d ra.ios of signa. a.plitudes a.e eva.ua.ed. For long hea.er pulses from 5 to 10 μs, a.pea.a.ce of the second a.omic cloud consisting of eva.ora.ed ^4He-a.oms wa. observed in a.dition to the first a.omic cloud. It is thought tha. the first a.omic cloud of the eva.ora.ed helium a.oms consists of very fa.t ^4He-a.oms with energies ～35 K eva.ora.ed by positive rotons with the specia. energies ～17 K （～2ER～2×8.6 K with ER representing the roton minimum energy） corresponding to the third non-dispersive Za.ha.enko wa.e. The second cloud of slower ^4He-a.oms wa. crea.ed by surfa.e elementa.y excita.ions （SEEs or ripplons） possessing the specia. energies ～7.15 K representing the binding energy. It wa. a.sumed tha. such SEEs ca. be crea.ed by phonons incoming to the liquid surfa.e with specia. energies ～6.2 K corresponding to the first non-dispersive Za.ha.enko wa.e which ca. intera.t a. the liquid surfa.e with the sa.e phonons a.rea.y reflected from the surfa.e for long hea.er pulses. a.so, some pulsed-hea.er cha.a.teristics were studied in order to better understa.d the fea.ures of such hea.ers in low tempera.ure experiments.

关键词： Superfluid helium-II Bulk elementa.y excita.ions (BEEs) Low tempera.ures Cooper pa.ring phenomenon Non-dispersive Za.ha.enko wa.es

在线全文

学校读者我要写书评

暂无评论

设计师大卫

中国建筑装饰装修 2010年第2期 272-273页

作者： Da.ide radaelli

大卫1977年出生于意大利米兰。2002年毕业于米兰理工大学工业设计专业。从2003年开始自由设计创作．并与一些设计工作室合作。2008年，大卫于米兰开设了自己的工作室，为设计的各个领域提供国际顾问服务。

关键词：设计师设计工作室工业设计专业设计创作顾问服务米兰意大利