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Enhancement of Urinary Elimination of 3-Bromobenzanthrone Metabolites by Oral Supplementation of Ascorbic Acid in Guinea Pigs

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Biomedical and Environmental Sciences 2004年第4期17卷 390-396页

作者： RAVINDRA P. SINGH raj khanna SUBHASH K. khanna MUKUL DAS Department of Biochemistry Lucknow University Lucknow-226001Department of Biochemistry Lucknow University Lucknow-226001Food Toxicology Laboratory Industrial Toxicology Research Centre Postal Box No. 80 M. G. Marg Lucknow-226 001 IndiaFood Toxicology Laboratory Industrial Toxicology Research Centre Postal Box No. 80 M. G. Marg Lucknow-226 001 India

Objective 3-Bromobenzanthrone (3-BBA), an anthraquinone intermediate dye, is extensively used in textile industry. Since, our prior studies have shown that 3-BBA caused significant depletion of ascorbic acid (AsA) levels, the effect of exogenous supplementation of AsA on the urinary elimination of 3-BBA metabolites was investigated. Method Guinea pigs were treated with single oral dose of 3-BBA (50 mg/kg b. wt.) in groundnut oil while another group was treated with single oral dose of 3-BBA (50 mg/kg b. wt.) along with 3 day prior and post oral supplementation of AsA. Control groups were either treated with groundnut oil or AsA alone. Urine from individual animals was collected, extracted and analysed on HPTLC. Results The highest elimination of 3-BBA (75 mg) was found to be in 0-24 h urine fraction which decreased to 18 mg and 5 mg in the two subsequent 24 hourly fractions of urine. Exogenous supplementation of AsA increased the total urinary elimination of 3-BBA by almost 77%. A total of 10 fluorescent metabolites excluding the parent compound were eliminated in the urine of guinea pigs treated with 3-BBA. Densitometric scanning of chromatogram showed different peaks at Rf 0.18, 0.22, 0.27, 0.34, 0.40, 0.48, 0.56, 0.66, 0.72, 0.80, and 0.95 which were eliminated and marked as urinary metabolite 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 respectively. AsA not only significantly enhanced the elimination of 3-BBA metabolites but also modified the pattern of metabolites drastically in 0-6 h, 6-24 h and 24-48 h urine fractions. Conclusion These results indicate that AsA may be useful in protecting the toxicity of 3-BBA by fascilitating the urinary metabolite(s) excretion of 3-BBA.

关键词： Ascorbic acid 3-Bromobenzanthrone Metabolites High performance thin layer chromatography

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Machine learning classification approach for formation delineation at the basin-scale

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Petroleum Research 2022年第2期7卷 165-176页

作者： Derek Vikara Vikas khanna Department of Civil and Environmental Engineering University of PittsburghPittsburghPA15261United States KeyLogic Systems LLCMorgantownWV26505United States Department of Chemical and Petroleum Engineering University of PittsburghPittsburghPA15261United States

Machine learning and artificial intelligence approaches have rapidly gained popularity for use in many subsurface energy *** are seen as novel methods that may enhance existing capabilities,providing for improved efficiency in exploration and production ***,their inte-gration into reservoir management workflows may shape the future landscape of the energy *** study implements a framework that generates predictive models using multiple machine learning classification-based algorithms which can identify specific stratigraphic units(i.e.,formations)as a function of total vertical depth and spatial *** framework is applied in a case study to 13 specific formations of interest(Upper Spraberry through Atoka/Morrow reservoirs)in the Midland Basin,West Texas,United States;a prominent hydrocarbon producing sub-basin of the larger Permian *** study dataset consists of over 275,000 records and includes data fields like formation iden-tifier,true vertical depth(in feet)of formations observed,and latitude and longitude coordinates(in decimal degrees).A subset of 134,374 data records were relevant to the 13 distinct formations of interest and were extracted and used for machine learning model training,validation,and *** super-vised learning approaches including random forest(RF),gradient boosting(GB),support vector machine(SVM),and multilayer perceptron neural network(MLP)were evaluated and their prediction accuracy *** best performing model was ultimately built on the RF algorithm and is capable of an overall prediction accuracy of 93 percent on holdout *** RF-based model demonstrated high prediction accuracy for major oil and gas producing zones including the San Andres,Upper Spraberry,Lower Spraberry,Clearfork,and Wolfcamp at 98,94,89,94,and 94 percent ***,the resulting data-driven model provides a robust,cost-effective approach which can complement contemporary reservoir manag

关键词： Permian basin Midland basin K-means clustering Random forest Classification machine learning

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Synthesis,Characterization and Biocompatibility of Potassium Ferrite Nanoparticles

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Journal of Materials Science & Technology 2014年第1期30卷 30-36页

作者： Lavanya khanna N.K.Verma Nano Research Lab School of Physics and Materials ScienceThapar University

In the present study, morphology, size distribution, structure, biocompatibility and magnetic properties of potassium ferrite nanoparticles （KFeO2 NPs）, synthesized by conventional sol-gel method have been reported. The formation of spherical nanoparticles with orthorhombic structure has been confirmed by scanning electron microscopy and X-ray diffraction. The particle size, as obtained by transmission electron microscopy has been found to be in the range of 4-7 nm. Further, the size distribution has been scrutinized using Analyse-it software, where a platykurtic feature in the size distribution was observed. Fourier transform-infrared spectroscopy and thermogravimetric analysis showed the formation of metal （Fe, K） bonds at Neel temperature of 337℃. Vibrating sample magnetometer analysis revealed the superparamagnetic behaviour of the synthesized KFeO2 NPs, with saturation magnetization of 25.72 emu/g. In vitro cytotoxicity test, using MTTassay, on T cell lines （Jurkat cells） showed that KFeO2 NPs are biocompatible at a particle concentration of 100μg/ml.

关键词： Potassium ferrite nanoparticles Magnetic nanoparticles Superparamagnetic behaviour Biocompatibility Cytotoxicity

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Building a resilient future:collaborative sustainability regulation

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Clean Energy 2024年第3期8卷 223-237页

作者： Jovita Shanta Job Shivi khanna Christ University BangaloreIndia School of Business and Management Christ University BangaloreIndia

The challenge of sustainability lies in achieving a balance between satisfying present needs and protecting resources for future generations with an emphasis on its three pillars-environmental,social and *** study explored sustainable development encompassing environmental,social and governance aspects along with sustainability reporting through various sustainability frameworks.A systematic review of literature for the period 2010-23 on major worldwide sustainability frameworks was conducted,by offering insights into enhancing reporting mechanisms for a sustainable *** data related to sustainability reports were obtained from the Sustainability Accounting Standards Board and International Integrated Reporting Council,which helped in examining sector and year variations across *** results reflected that mandatory sustainability disclosures help to meet the United Nations Sustainable Development Goals and global sustainability frameworks help to set standards,disseminate information and promote *** of investment,company action and sustainability organizations can lead to a sustainable global *** adoption of sustainability reporting can help organizations by fostering a proper understanding of sustainability practices,improving transparency and identifying potential business opportunities in sectors with lower *** paper provided insights into sustainability reporting published across various countries in both advanced as well as emerging and developing *** analysis showed which sectors and time periods have had the most sustainability reports and which areas needed to be targeted for action to advance sustainable development.

关键词： Environmental,Social and Governance(ESG) Sustainable Development Goals Sustainability Reporting Developing economies Advanced economies

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Circum-Indian Holocene sea-level database:A repository of distinct relative sea-level plots across the Indian Peninsula

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Journal of Palaeogeography 2024年第1期13卷 1-17页

作者： Shradha Menon Pankaj khanna Santanu Banerjee REEFS Lab Department of Earth SciencesIIT GandhinagarPalajGandhinagarGujarat382355India Department of Earth Sciences IIT BombayPowaiMumbai400076India

The Indian Peninsula is one of the most well-studied regions for Holocene sea-level fluctuations in the world, however, standardized relative sea-level datasets are missing. This study provides an archive of sealevel indicators(n = 162, 20 locations) along the western and the eastern sides of the peninsula, that have been used to develop Relative Sea Level(RSL) plots. Each dated sea-level indicator is recalibrated for its elevation based on tidal and tectonic correction, as well as age with reservoir correction, and have been separated into six zones based on coastal geomorphology and number of datasets. The database spans throughout the Holocene and covers sea-level depth/elevations from-45 m to +5 m from mean sea-level(MSL). Approximately 90 % of the dataset range from 8 ka to the present day. The first transgression is highly variable and identified between 8.5-8 ka BP in Gujarat(Zone 1), ~ 5.5 ka BP in Maharashtra(Zone 2), between 8 and 7 ka BP in Tamil Nadu(Zone 4) and between 8 and 7.5 ka BP in the Bengal coasts(Zone 6). No transgression above present sea-level is observed along Andhra Pradesh(Zone 5)(no data for Kerala-Zone 3).Further, Zones 1, 2, 4 and 6 show a strong uplift component(tectonic), whereas Zone 5 exhibits subsidence during the Holocene(Zone 3-insufficient data). Based on these findings, and given the region's coastal topography and tidal components, Zones 6 and 1 will likely undergo the largest coastal inundation, followed by Zones 5, 4, 2, and 3. These insights are critical in planning future coastal inundation measures across the Indian Peninsula.

关键词： Indian ocean Terraces Relative sea level curve Holocene Arabian sea Bay of Bengal

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Modeling and optimization of a wide-band piezoelectric energy harvester for smart building structures

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第2期11卷 31-38页

作者： Prateek Asthana Gargi khanna Electronics and Communication Engineering Department National Institute of Technology Hamirpur Himachal PradeshIndia

Piezoelectric energy harvesting refers to conversion of mechanical energy into usable electrical *** the modern connected world,wireless sensor nodes are scattered around the *** nodes are powered by *** require regular replacement,hence energy harvesters providing continuous autonomous power are used to power these sensor *** work provides two different fixation modes for the resonant frequency for the two *** in geometric parameter and their effect on resonant frequency and output power have been *** harvesters capture a wide-band of ambient vibrations and convert them into usable electrical *** capture random ambient vibrations,the harvester used is a wide-band energy harvester based on conventional seesaw *** proposed structure operates on first two resonant frequencies in comparison to the conventional cantilever system working on first resonant *** frequency,as well as response to a varying input vibration frequency,is carried out,showing better performance of seesaw cantilever *** this work,modeling of wide-band energy harvester with proof mass is being *** of proof mass plays a key role in determining the resonant frequency of the *** the proof mass near or away from fixed end results in increase and decrease in stress on the piezoelectric ***,to avoid the breaking of cantilever,the position of proof mass has been analyzed.

关键词： Finite element modeling optimization seesaw energy harvester wide-band energy harvester piezoelectric

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Simultaneous breast and ovarian metastasis from gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 553-554页

作者： Sanjay Singh Puneet Gupta Rahul khanna Ajay K khanna Department of General Surgery Institute of Medical SciencesBanaras Hindu University

BACKGROUND:Gallbladder carcinoma is a common malignancy in the Indian *** commonly metastasizes through lymphatics,direct invasion,and hematogenous spread.A common extra-abdominal site of metastasis is the *** metastasis to breast and ovary is extremely ***:This report describes an unusual case of carcinoma gallbladder metastasizing to the breast and ovary at the same ***:A 45-year-old woman came to us with complaints of flatulent dyspepsia associated with weight loss and *** of the abdomen revealed hepatomegaly with thick-walled gallbladder with multiple stones and a mass at the fundus,but normal uterus and ***-enhanced computer tomography of the abdomen showed a gallbladder mass infiltrating the liver *** patient underwent radical *** examination revealed a poorly-differentiated adenocarcinoma with margins free from tumor *** month after surgery she developed a breast *** of the abdomen for metastatic workup revealed an ovary *** mastectomy and salphingo-opherectomy were performed,and histopathological examination revealed a metastatic *** patient is now on chemotherapy with ***:This is an unusual case of carcinoma of the gallbladder with metastasis to the breast and ovary,which has not been documented before.

关键词： gallbladder carcinoma breast metastasis ovary metastasis

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Variation of granule mass fraction with coordination number in wet granulation process

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Particuology 2009年第5期7卷 408-413页

作者： Papiya Roy Manish Vashishtha rajesh khanna Duvvuri Subbarao Department of Chemical Engineering Indian Institute of Technology

In granulation, fine particles combine to form a coarse granule in the form of a particle matrix partially or fully saturated with a binder liquid. The final product of granulation possesses a wide variety of granule size distributions with surface mean diameters which differ with operating conditions. The final granule size depends on the operating conditions, e.g. operating gas velocity, inlet air temperature, initial feed particle size, and viscosity of the binder. The objective of this paper is to find out the uniformity in the relation between the granule mass fraction in the final granule size distribution and the number of feed particles present in the granules. The total number of granules obtained depends on the experimental conditions but the granule mass fraction and the number of feed particles forming a single granule are independent of operating variables, feed material and method of granulation. The paper purports further to compare the uniform nature of mass fraction of the granules in final granule size distribution and the primary particles required to form that particular granule size irrespective of experimental conditions of granulation.

关键词： Granules Primary particle Coordination number

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Size-dependent coalescence kernel in fertilizer granulation——A comparative study

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Particuology 2009年第6期7卷 445-450页

作者： Papiya Roy Manish Vashishtha rajesh khanna Duvvuri Subbarao Department of Chemical Engineering Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India Universiti Teknologi PETRONAS 31750TronohPerakMalaysia

Granulation is a key process in several industries like pharmaceutical, food, fertilizer, agrochemicals, etc. Population balance modeling has been used extensively for modeling agglomeration in many systems such as crystallization, aerosols, pelletisation, etc. The key parameter is the coalescence kernel, β（ij） which dictates the overall rate of coalescence as well as the effect of granule size on coalescence rate. Adetayo, Litster, Pratsinis, and Ennis （1995） studied fertilizer granulation with a broad size distribution and modeled it with a two-stage kernel. A constant kernel can be applied to those granules which coalesce successfully. The coalescence model gives conditions for two types of coalescence, Type I and II. A twostage kernel, which is necessary to model granule size distribution over a wide size distribution, is applied in the present fluidized bed spray granulation process. The first stage is size-independent and non-inertial regime, and is followed by a size-dependent stage in which collisions between particles are non-random, i.e. inertial regime. The present work is focused on the second stage kernel where the feed particles of volume i and j collide and form final granule ij instead of i ＋j （Adetayo et al., 1995） which gives a wider particle size distribution of granules than proposed earlier.

关键词： Granulation Coalescence kernel Population balance

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Pediatric hepatocellular carcinoma

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World Journal of Gastroenterology 2018年第35期24卷 3980-3999页

作者： rajeev khanna Sanjeev Kumar Verma Department of Pediatric Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070 India Department of Pediatrics King George Medical University

Pediatric hepatocellular carcinoma (HCC) is the second common malignant liver tumor in children after hepato-blastoma. It differs from the adult HCC in the etiological predisposition, biological behavior and lower frequency of cirrhosis. Perinatally acquired hepatitis-B virus, hepa-torenal tyrosinemia, progressive familial intrahepatic cho-lestasis, glycogen storage disease, Alagille's syndrome and congenital portosystemic shunts are important predis-posing factors. Majority of children (87%) are older than 5 years of age. Following mass immunization against hepatitis-B, there has been a drastic fall in the incidence of new cases of pediatric HCC in the Asia-Pacific region. Management is targeted on complete surgical removal either by resection or liver transplantation. There is a trend towards improving survival of children transplanted for HCC beyond Milan criteria. Chemotherapeutic regi-mens do not offer good results but may be helpful for down-staging of advanced HCC. Surveillance of children with chronic liver diseases with ultrasound and alpha-fetoprotein may be helpful in timely detection, intervention and overall improvement in outcome of HCC.

关键词： Hepatocellular carcinoma Children Riskfactors Outcome Liver transplantation

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