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The Preliminary Study of Glucocorticoid receptor Gene in Chinese Patients with Glucocorticoid-induced Glaucoma

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眼科学报 1999年第1期15卷 46-50页

作者： Yehong Zhuo, Jian Ge, Yan Guo, Mingkai LinZhongshan Ophthalmic center, sun {2.-sen university of Medical Sciences , guangzhou 510060 , china Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Background: To study the glucocorticoid receptor (Gr) and the associated gene regulation in the pathogenesis of glucocorticoid- induced glaucoma (GIG) in Chinese ***: The trabecular cells of normal individuals and patients with GIG were cultured in vitro. By using polymerase chain reaction (PCr),gene fragments on Gr DNA binding sites of trabecular cells were amplified. The product was detected by gel ***: The trabecular cells were cultured successfully in normal individuals and patients with GIG in vitro. A single PCr product was obtained in both two groups with the same size of 545 base ***: There is not any difference in gene on the Gr DNA binding sites between normal individuals and patients with GIG. The results suggest the difference in mrNA or other functional genes. Eye Science 1999 ; 15 ; 46 - 50.

关键词：糖皮质激素受体基因青光眼

Management of Post-traumatic Aniridia with retinal Detachment

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Eye Science 2001年第1期17卷 35-38页

作者： Shibo Tang, Guanting Qiu, Pei Wang, Xiaoling LiangZhongshan Ophthalmic center, sun {2.-sen university of Medical Sciences, guangzhou 510060, china Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To reconstruct the anatomic and functional impairment in patients with post-traumatic aniridia, aphakia, and retinal detachment.Methods: Four patients with unilateral aniridia and aphakia as well as retinal detachment as results of severe eye injuries underwent scleral buckling, vitrectomy, membrane peeling, endolaser photocoagulation, silicone oil or gas temponade, combined with iris diaphragm-IOL implantation.results: All four patients achieved successfully anatomic and functional reconstruction after surgery. During five to 2. months postoperative follow-up, all retinas remained attached. The final visual acuity increased from finger counting to 0.1 ～ 0.3.Conclusions: The combination of vitreoretinal surgery and iris diaphrgm-IOL implantation is an effective method for post-traumatic aniridia, aphakia and traumatic retinal detachment. It could ameliorate photophobia and improve the biocular ***, artificial iris diaphragm implantation could prevent silicone oil-endothelia contact and salvage silicone keratopathy. Eye Science 2.01; 17:35 ～ 38.

关键词：视网膜分离对甲氧基苯甲醛解剖学无晶状体眼眼损伤

The Clinical Analysis of Secondary Glaucoma Following Posterior Chamber Intraocular Lens Implantation

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眼科学报 1994年第1期10卷 57-59,64页

作者： Zhende Lin, Wenbing Zhou, Shaozhen Li, Zhenping ZhangZhonshan Ophthalmic center, sun {2.-sen university of Medical Sciences guangzhou 510060, china Zhonshan Ophthalmic center Sun Yat-Sen University of Medical Sciences Guangzhou China.

We present 14 patients with secondary gluacoma following the implantation of a posterior chamber intraocular lens (lOLs). All patients were u-nilateral gluacoma , which developed within 1 month following the IOL implantation in 10 cases, and from 1 to 3 years in 4 cases. The angle of anterior chamber was open in 8 patients, and close in 6 ones. Seven patients required treatment of antiglaucomatous medicine; 4 patients underwent laser indecto-my and 3 patients required antiglaucoma surgery. The results s...

关键词： intraocular lens complication secondary glaucoma

A Study on the Compliance of the Patients with Ocular Fundus Diseases

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眼科学报 1999年第1期15卷 61-64页

作者： hongshan Chen, Chenjin Jin, Yuanping LiThe First Affiliated hospital, sun yat-{2. university of Medical Science, guangzhou 510089 , china Zhongshan Ophthalmic center, sun yat-{2. university of Medical Science, guangzhou {12., china First Affiliated hospital Sun Yat-sen University of Medical Science Guangzhou 510089 China

Purpose: To investigate the compliance of the patients with ocular fundus diseases with recommendation for follow-up examination after laser treatment, and the underlying reasons for ***: 53 patients with ocular fundus disease were asked to fill in a questionnaire which includes the socio-demographic characteristics, fear of the fundus disease, conception of the laser treatment and the motivation for staying healthy. Variables were compared for the compliers group and the non-compliers group by chi-square test. result; Of the 53 subjects, 35 were classified as non-compliers and 18 were classified as compliers. There was no statistically significant difference between the two groups on all selected socio-demographic factors, conception of the laser treatment and the motivation for staying healthy. Significant difference was found between the two groups on two of those items concerning the fear of the diseases (Phalf of the participants showed the lack of knowledge

关键词：弹性变形眼底疾病病人

Indocyanine Green Angiographic and Multifocal Electroretinographic Features in the Diffuse and regional From of Bietti's Cystalline retinopathy

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Eye Science 2002年第1X期18卷 9-13页

作者： Libin Jiang, Feng Wen, Lezheng Wu, hong Yan, Shixing huZhongshan Ophthalmic center, sun {2.-sen university, guangzhou 510060, china Zhongshan Ophthalmic center Sun Yat-sen University Guangzhou 510060 China

Prpose: To observe different features of indocyanine green angiography(ICGA) andtifocal electroretinography (ErG) in the diffuse and regional type of Bieti′sc stalline retinopathy (BCr). Thods: ICGA and the multifocal ErG were performed in two cases of the diffuse andregional type of BCr respectively. These data were compared with fluoresceinangiography (FA), standard Ganzfeld ErG, and visual field testing. results: In the regional case, ICGA revealed reduced perfusion of the choroidalcirculation in the early phase and multiple hypofluorescent spots in the posterior pole in the late phase, due to choriocapillaris filling defect; the extent of choroiocapillaris losswas shown in early phase of ICGA and there were multifocal hyperfluorescent dotssurrounding hypofluorescent spots in late phase in the diffuse case. The multifocal ErGshowed that the central responses were markedly depressed, corresponding to the visualfield defects, while the findings of Ganzfeld ErG were normal in the regional BCr;however, both the multifocal ErG and Ganzfeld ErG were severely subnormal in thediffuse ***: The features of ICGA and multifocal ErG are different between the diffuseand regional BCr. In the meantime, the two tools are also useful to differentiate the typeand assess the extentof evolution in BCr.

关键词：盘状红斑狼疮晶状视网膜病靛蓝花青血管造影多灶视网膜电流图

The Etiology of Vision Impairment in Target Population

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Eye Science 1996年第3期16卷 118-120页

作者： Siping Zhu, Jingjing Xu, Qiang Yu, Qing LiuZhongshan Ophthalmic center, sun {2.-sen university of Medical Sciensces, guangzhou 510060, china Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciensces Guangzhou China.

Purpose: r.sear.h the etiology of vision impairment in target persons over 45 years old in Doumen county , Guangdong ***: Depending on the prevalences of the blindness among the person aged over 50 years, the theoretic sample rate is 1 000/4 8733×100%=2. 05%. The 8 districts were divided into 3 parts according to the local economic situation and the proportion of the population in the areas. In fact, the sampling rate is 932. 10055 = 88.34%.results:W’e found that impairment r 10. 94%. The prevalence of bilateral blindness and low vision was 1. 61% and 3. 2.%, respectively. Both prevalences of blindness and low vision were increased with age. The leading cuase of blindness was cataract (45. 2.). The second was corneal opacity (16. 7% ). Prevalentces of the low vision and the blindness were higher in females than in males (Prable and preventable diseases were the leading cause for the blindness (70%). Prevalences of blindness and the low vision

关键词： blindness low vision epidemiology

Unilateral Acute Idiopathic Maculopathy

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眼科学报 1998年第3期14卷 182-186页

作者： Guanting Qiu, Zhaoke hu, Mei li, Shunying LiuZhongshan Ophthalmic center, sun {2.-sen university of Medical Sciences , guangzhou 510060, china Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To discuss the fluorescein angiographic features and diagnosis as well as differential *** : In our hospital, we have found three cases of UAIM, one of them has eccentric maculopathy, another has papillitis, and the third associates with pregnancy. Each has characteristic clinical findings. We have made the diagnosis base on ophthalmoscopy and fluorescein angiography (FA).results: Three patients with UAIM have been experienced sudden unilateral decreased visual acuity. The significant changes on fundus are retinal pigment epithelium (rPE) thickening with neurosensory retinal detachment with in the macular area. FA showed early patchy hypofluorescence and hyperfluorescence at the level of the rPE.' Bull' s eye appearance may occur in the macular area after the acute stage of the disease. The clinical findings are similar to what the foreign report described. But there were no previous reports in china. Conclusion : We can establish the diagnosis on the base of clinical and fundus

关键词：斑点眼色素上皮细胞荧光素血管造影术 uAIM

The Preliminary report of Pathological Changes of Epiretinal Membranes and Internal Limiting Membrane removed during Idiopathic Macular hole Surgery

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眼科学报 2002年第3期18卷 143-146页

作者： Jiaqing Li, Shibo Tang, Yan Luo, Jie Zhang, Shaofen LinZhongshan Ophthalmic center, sun {2.-sen university, guangzhou 510060, china Zhongshan Ophthalmic center Sun Yat-sen University Guangzhou 510060 China

Purpose:To investigate the pathological changes of epiretinal membranes(ErM)and internal limiting membrane (ILM) removed during idiopathic macular hole ***:Ten consecutive patients with a unilateral idiopathic macular hole underwent pars plana vitrectomy(PPV) with the surgical removal of the ErMs overlying the hole and ILM surrounding the hole. The pathological features of the excised tissues were examined under the microscope. results:According to the morphological changes, four ErMs showed cellular elements which looked like glia cells, macrophages, plasma cells, lymphocytes and fibroblast cells. Two of the ILM appeared as transparent membranes without cellular elements. The other eight ILM showed cellular elements on the transparent ***: Our study supports the hypothesis that the tangential traction of vitreous and proliferative cellular elements on the inner surface of ILM causes idiopathic macular holes. removal of the posterior cortical vitreous, ILM and proliferative cellular tissue is a valid treatment for IMh.

关键词：特发性视网膜黄斑裂洞手术视网膜外层膜视网膜内介膜病理变化

A Study of Spectral Electroretinogram of Color Vision Defects Due to Macular Diseases

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眼科学报 1994年第3期10卷 163-167页

作者： Nong Tian , De-Zheng Wu, Jiongji LiangZhongshan Ophthalmic center,sun {2.-sen university of Medical Sciences guangzhou 510060, china. Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou China.

Studies of spectral electroretinograms in central serous retinopa-thy (CSr) and hereditary macular degeneration (hMD) showed that the b-wave amplitudes of most wavelengths of CSr were significantly decreased as compared with normal controls, and those of hMD were obviously lower than the normal values. Patients of hMD with type-A color vision defects (CVD) had primarily a reduction of b-wave amplitudes in the full spectrum of 480-62. nm, and patients with type- I CVD a reduction of b-wave amplitudes wav...

关键词： macular color vision ErG