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Str.ctural effects induced by dialysis-based purification of carbon nanomaterials

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Nano materials Science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.m.Ferraria A.m.Botelho do rego A.S.Viana A.J.S.Fernandes A.J.Fielding r.A.Videira m.c.oliveira cQ-Vr and chemistry Department University of Trás-os-Montes e Alto Douro BSIrG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics Department University of AveiroCampus de Santiago Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores University rEQUImTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a cr.cial role in the purification of nanomaterials but its impact on the str.ctural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electr.chemically in potassium phosphate buffer,was char.cterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,str.ctural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking str.ctures of small nanoparticles （m）.In parallel,alcohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （EPr） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis pr.cess,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of str.ctural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon Surface functionalization Nmr XPS Hydrophilic carbon Paramagnetic

Elucidating the Degradation Pathways of Human Insulin in the Solid State

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Journal of Analysis and Testing 2024年第03期8卷 288-299页

作者： Andrew Fagan Lorraine m.Bateman Joseph P.o'Shea Abina m.crean SSPc the SFI Centre for Pharmaceutical Research School of Pharmacy University College Cork School of Pharmacy University College Cork Analytical and Biological chemistry research Facility (ABcrF) University College Cork School of chemistry University College Cork

While there have been significant advances in the development of peptide oral dosage forms in r.cent years, highlighted by the clinical and commercial success of approved peptides such as rybelsus?, there remain several barriers in the way of broad range applicability of this approach to peptide delivery. one such barrier includes the poor physical and chemical stability inherent to their str.ctures, which persists in the solid state although degradation typically occurs at different rates and via different pathways in comparison to the solution state. Using insulin as a model peptide, this work sought to contribute to the development of analytical techniques for investigating common insulin degradation pathways. chemically denatured,deamidated and aggregated samples were prepared and used to benchmark circular dichroism spectroscopy, reverse phase HPLc and size exclusion chromatography methods for the investigation of unfolding, chemical modifications and covalent aggregation of the insulin molecule respectively. Solid state degraded samples were prepared by heating insulin powder at 60 °c and 75% relative humidity for 1, 3, 5 and 7 d, and the degradation profiles of the samples were evaluated and compared with those observed in solution. While no unfolding was observed to occur, significant deamidation and covalent aggregation were detected. reductive disulfide bond cleavage using dithiothreitol allowed for separation of the insulin A-and B-chains,offering a facile yet novel means of assessing the mechanisms of deamidation and covalent aggregation occurring in the solid state.

关键词： Biopharmaceutical analysis covalent aggregation Deamidation Disulfide cleavage Insulin Solid state Stability

Exploring centimeter-sized crystals of bismuth-iodide perovskite toward highly sensitive X-ray detection

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chinese chemical Letters 2024年第6期35卷 185-188页

作者： Xin Dong Jing Liang Zhijin Xu Huajie Wu Lei Wang Shihai You Junhua Luo lina Li college of chemistry Fuzhou UniversityFuzhou 350116China State Key Laboratory of Str.cture chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of chinese Academy of Sciences Beijing 100049China

Lead-halide perovskites exhibit outstanding performance in X-ray detection due to their intrinsic features such as high charge carrier mobility,large atomic number,and long carrier lifetime,but the toxicity of lead is regarded as the major factor hindering their ***,we introduce organic molecule(r)-(-)-2-methylpiperazine(r-mPz)into the bismuth-based str.cture to synthesize lead-free(r)-(H_(2)mPz)BiI_(5)(r-mBI).The high-quality centimeter-sized single crystals have been obtained,which show a low dark current and superior environmental ***,the single-crystal device of r-mBI exhibits a highμτproduct up to 1.88×10^(-4)cm^(2)/V and a low trap density of 1.21×10^(10)cm^(-3).Further,the detector displays excellent detection sensitivity of 263.58μc Gy_(air)^(-1)cm^(-2)and a favorable low detection limit of 4.35μGyair/s,both of which meet the requirement for medical *** findings shed light on the exploration of innovative bismuth-based hybrid perovskites for high-performance X-ray detection.

关键词： Perovskite Lead-free Bismuth-based X-ray detection Sensitivity

Assimilation of GoES-r Geostationary Lightning mapper Flash Extent Density Data in GSI 3DVar, EnKF, and Hybrid En3DVar for the Analysis and Short-Term For.cast of a Supercell Storm case

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Advances in Atmospher.c Sciences 2024年第2期41卷 263-277页

作者： rong KoNG ming XUE Edward r.mANSELL chengsi LIU Alexandre o.FIErro center for Analysis and Prediction of Storms Norman Oklahoma 73072U.S.A University of oklahoma Norman Oklahoma 73072U.S.A NoAA/National Severe Storms Laboratory NormanOklahoma 73072U.S A.4Zentralanstalt für meteorologie und Geodynamik Department of Forecasting Models-ZAMGVienna 1190Austria

capabilities to assimilate Geostationary operational Environmental Satellite “r-series ”(GoES-r) Geostationary Lightning mapper(GLm) flash extent density(FED) data within the operational Gridpoint Statistical Interpolation ensemble Kalman filter(GSI-EnKF) framework were previously developed and tested with a mesoscale convective system(mcS) case. In this study, such capabilities are further developed to assimilate GoES GLm FED data within the GSI ensemble-variational(EnVar) hybrid data assimilation(DA) framework. The results of assimilating the GLm FED data using 3DVar, and pure En3DVar(PEn3DVar, using 100% ensemble covariance and no static covariance) are compared with those of EnKF/DfEnKF for a supercell storm case. The focus of this study is to validate the corr.ctness and evaluate the performance of the new implementation rather than comparing the performance of FED DA among different DA schemes. only the results of 3DVar and pEn3DVar are examined and compared with EnKF/DfEnKF. Assimilation of a single FED observation shows that the magnitude and horizontal extent of the analysis increments from PEn3DVar are generally larger than from EnKF, which is mainly caused by using different localization strategies in EnFK/DfEnKF and PEn3DVar as well as the integration limits of the graupel mass in the observation operator. overall, the for.cast performance of PEn3DVar is comparable to EnKF/DfEnKF, suggesting corr.ct implementation.

关键词： GoES-r lightning data assimilation EnKF EnVar

Ferroptosis mechanism and Alzheimer's disease

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Neural regeneration research 2024年第8期19卷 1741-1750页

作者： lina Feng Jingyi Sun Ling Xia Qiang Shi Yajun Hou Lili Zhang mingquan Li cundong Fan Baoliang Sun Shandong Key Laboratory of Tcm multi-Target Intervention and Disease control the Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Internal medicine Taian Traffic HospitalTaianShandong ProvinceChina Department of Neurology the Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchunJilin ProvinceChina

regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living *** pr.cess plays a cr.cial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living *** is a classic regulatory mode of cell *** studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s *** review summarizes the molecular mechanisms of ferroptosis and r.cent research advances in the role of ferro ptosis in Alzheimer’s *** findings are expected to serve as a theoretical and experimental foundation for.clinical research and targeted therapy for Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E Fe^(2+) ferroptosis glial cell glutathione peroxidase 4 imbalance in iron homeostasis lipid peroxidation regulated cell death system Xc^(-)

molecular engineering towards dual surface local polarization sites on poly(heptazine imide)framework for boosting H_(2)o_(2) photo-production

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chinese chemical Letters 2024年第8期35卷 396-400页

作者： Zhenchun Yang Bixiao Guo Zhenyu Hu Kun Wang Jiahao cui lina Li chun Hu Yubao Zhao Key Laboratory for Water Quality and conservation of the Pearl river Delta Ministry of EducationInstitute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou 510006China Department of Environmental Science and Engineering Guangzhou UniversityGuangzhou 510006China

The selective 2e^(−)orr reaction on polymer.c carbon nitride framework is one of the most promising approaches for solar-driven hydrogen peroxide ***(heptazine imide)(PHI)as a class of K+-incorporated crystalline carbon nitride framework,is highly active for photocatalytic H_(2)o_(2)*** upgrade on the H_(2)o_(2)photoproduction performance of PHI is realized and the mechanistic insights are revealed in this *** photochemical reaction,the electron withdrawing groups of hydroxyl group and cyano group are grafted on the surface of PHI *** dual polarization sites on the sur-face contribute significantly to the enhancement of the exciton *** optimized PHI with dual polarization sites exhibits a remarkable photocatalytic H_(2)o_(2)production performance,which is 2times of the active pristine *** importantly,the photochemical reaction method is generally applicable to improve the exciton dissociation of a wide range of polymer.c carbon nitride frameworks with vari-ous str.cture and compositions;and the thiourea-derived polymer.c carbon nitride framework with dual surface polarization sites exhibits a remarkable photocatalytic performance with a high H_(2)o_(2)production rate of 40.5 mmol h^(−1)g^(−1).

关键词： Photocatalysis Hydrogen peroxide production carbon nitride framework Surface functionalization orr

Energy and blast performance of beryllium in a model thermobar.c composition in comparison with aluminum and magnesium

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Defence Technology（防务技术） 2024年第6期36卷 13-19页

作者： Thomas m.Klapotke Stanisław cudziło Waldemar A.Tr.cinski Jozef Paszula Energetic materials research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany military University of Technology Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A dir.ct comparison is made between the effectiveness of Al,mg,and Be powders as additional fuels in model thermobar.c compositions containing 20%fuel,20%ammonium perchlorate,and 60%rDX(1,3,5-Trinitro-1,3,5-triazacyclohexane)passivated with *** determined calorimetr.c measurements of the heat of detonation,along with the overpressure histories in an explosion chamber filled with nitrogen,were used to determine the quasi-static pressure(QSP)under anaerobic *** measurements were also performed in a semi-closed bunker,and all blast wave parameters generated after the detonation of 500 g charges of the tested explosives were *** calorimetry results,QSP values,and blast wave parameters(pressure amplitude,specific and total impulses)clearly indicate that Be is much more effective as an additional fuel than either Al or mg in both anaerobic post-detonation reactions as well as the subsequent aerobic *** heat of detonation of the rDXwax/AP/Be explosive mixture is over 40%and 50%higher than that of the mixture containing aluminum and magnesium instead of beryllium,***,the TNT equivalent of the Be-containing composition due to the overpressure in the nitrogen-filled explosion chamber is 1.66,while the equivalent calculated using an air shock wave-specific impulse at a distance of 2.5 m is equal to *** high values of these parameters confirm the high reactivity of beryllium in both the anaerobic and aerobic stages of the thermobar.c explosion.

关键词： Thermobar.c explosives Beryllium Heat of detonation Quasi-static overpressure Blast wave parameters

Liquid metal as an efficient protective layer for lithium metal anodes in all-solid-state batteries

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carbon Energy 2024年第7期6卷 219-229页

作者： Shiqiang Zhou mengrui Li Peike Wang Lukuan cheng lina chen Yan Huang Boxuan cao Suzhu Yu Qingju Liu Jun Wei Shenzhen Key Laboratory of Flexible Printed Electronics Technology Harbin Institute of TechnologyShenzhenChina School of materials Science and Engineering Harbin Institute of TechnologyShenzhenChina State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbinChina Yunnan Key Laboratory for micro/Nano materials and Technology School of Materials and EnergyYunnan UniversityKunmingChina

Lithium metal batteries with inorganic solid-state electrolytes have emerged as strong and attr.ctive candidates for electr.chemical energy storage devices because of their high-energy content and ***,inherent challenges of deleterious lithium dendrite growth and poor interfacial stability hinder their.commercial ***,we report a liquid metal-coated lithium metal(Lm@Li)anode strategy to improve the contact between lithium metal and a Li6PS5cl inorganic *** Lm@Li symmetr.c cell shows over 1000 h of stable lithium plating/stripping cycles at 2mA cm^(-2) and a significantly higher.critical current density of 9.8 mAcm^(-2) at 25°*** addition,a full battery assembled with a high-capacity composite LiNbo3@-LiNi_(0.7)co_(0.2)mn_(0.1)o_(2)(LNo@Ncm721)cathode shows stable cycling *** and computational results have demonstrated that dendrite growth tolerance and physical contact in solid-state batteries can be reinforced by using Lm interlayers for interfacial modification.

关键词： all-solid-state batteries interface engineering liquid metals lithium metal anodes

Use of DrEAm to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant

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FroNTIErS oF ENVIroNmENTAL ScIENcE & ENGINEErING 2024年第9期18卷 113-0页

作者： Pampanin, Daniela m. Schlenk, Daniel Vitale, matteo Liboureau, Pierre Sydnes, magne o. Univ Stavanger Dept Chem Biosci & Environm Engn N-4036 Stavanger Norway Univ calif riverside Dept Environm Sci Riverside CA 92521 USA

concerns related to environmental risks associated with pharmaceuticals and personal care products (PPcPs) have led researchers to seek methods for assessing and monitoring these contaminants in the aquatic environment. Identifying and validating risk assessment tools that can evaluate ecological concerns and risks associated with PPcPs is critical. Herein, the suitability of a dose-related risk and effect assessment model, which estimates predicted environmental concentrations and allowed comparisons with predicted no effect concentrations determined, in combination with in vitro analyses of the whole effluent toxicity, was verified for the char.cterization of a PPcP hazard. concentrations of the most utilized PPcPs in Norway were measured in influent and effluent samples and used to parameterize the fate *** than 90% removal was attained for 12 out of 22 detected PPcPs. removal was not dependent on the class or the concentration of the specific substance and varied between 12% and 100%. The PPcPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent, and no risk was identified for the targeted 30 PPcP. The simulations provided valuable information regarding the discharge plume distribution over time, which can aid planning of future environmental monitoring *** (using fish liver.cells, PLHc-1) were used for assessing overall effluent toxicity, through cell viability, production of reactive oxygen species, and ethoxyresorufin-o-deethylase (EroD) *** present study may allow regulators to use risk-based strategies over removal criteria for monitoring studies and confirms the importance to take PPcP contamination into consideration when establishing environmental regulations.

关键词： Pharmaceuticals Wastewater effluent ciprofloxacin metoprolol Amitriptyline carbamazepine modelling risk assessment monitoring mArINE-ENVIroNmENT AQUATIc ENVIroNmENT rEmoVAL cArBAmAZEPINE EXPoSUrE DrUGS ANTIDEPrESSANTS ANTIBIoTIcS SEDImENT cAFFEINE