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Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors

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Bioactive Materials 2022年第5期7卷 107-117页

作者： A.Khodaei F.Jahanmard H.r.Madaah Hosseini r.bagheri A.Dabbagh H.Weinans Amin Yavari Institute for nanoscience and nanotechnology sharif university of technologytehraniran department of orthopedics university medical center utrechtutrechtthe netherlands department of materials science and engineering sharif university of technologytehraniran school of medicine faculty of health and medical sciencestaylor’s universitysubang jayamalaysia regenerative medicine utrecht utrecht universityutrechtthe netherlands

Systemic chemotherapy has lost its position to treat cancer over the past years mainly due to drug resistance,side effects,and limited survival *** a plethora of local drug delivery systems to solve this issue,the combinatorial strategy of chemo-hyperthermia has recently received *** we developed a magneto-thermal nanocarrier consisted of superparamagnetic iron oxide nanoparticles(SPIONs)coated by a blend formulation of a three-block copolymer Pluronic F127 and F68 on the oleic acid(OA)in which Curcumin as a natural and chemical anti-cancer agent was *** subsequent nanocarrier SPION@OA-F127/F68-Cur was designed with a controlled gelation temperature of the shell,which could consequently control the release of *** release was systematically studied as a function of temperature and pH,via response surface methodology(rSM).The bone tumor killing efficacy of the released curcumin from the carrier in combination with the hyperthermia was studied on MG-63 osteosarcoma cells through Alamar blue assay,live-dead staining and apoptosis caspase 3/7 activation *** was found that the shrinkage of the F127/F68 layer stimulated by elevated temperature in an alternative magnetic field caused the curcumin *** the maximum release concentration and cell death took place at 45℃,treatment at 41℃ was chosen as the optimum condition due to considerable cell apoptosis and lower side effects of mild *** cell metabolic activity results confirmed the synergistic effects of curcumin and hyperthermia in killing MG-63 osteosarcoma cells.

关键词： Osteosarcoma Magnetic hyperthermia Curcumin MrI contrast agent

Cryptanalysis of DBST, a lightweight block cipher

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Frontiers of Computer Science 2024年第4期18卷 219-221页

作者： Sadegh SADEGHI Nasour.bagheri Department of Mathematics Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran research Center for Basic Sciences and Modern Technologies(rBST) Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Electrical Engineering Department Shahid Rajaee Teacher Training UniversityTehran 16788-15811Iran School of Computer Science(SCS) Institute for Research in Fundamental Sciences(IPM)Tehran 19395-5531Iran

1 Introduction Conventional cryptographic primitives are not suitable for resource-constrained ***,numerous lightweight primitives have been proposed over the past decade,specifically tailored for such ***,such ciphers would not be used in a real-world application unless they were thoroughly tested for security against existing *** this direction,DBST[1]cipher has been recently proposed by Yan et *** balance security,cost,and efficiency,DBST has implemented a novel 4-branch generalized Feistel variant *** this structure,a 2-branch XOr operation has been incorporated in the middle section,establishing interconnections between all *** the other hand,by leveraging the bit-slice technique and subkeys,the algorithm introduces an innovative approach to constructing a dynamic S-box *** designers of DBST cipher have extensively investigated its resistance to known attacks such as linear and differential cryptanalysis,as well as impossible differential cryptanalysis,among *** them,the objective of differential cryptanalysis[2]is to identify high-probability characteristics in the plaintext that are transmitted to the ciphertext,known as distinguishers.

关键词： structure. primitive branch

Numerical study of flow and thermal characteristics of pulsed impinging jet on a dimpled surface

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 106-117页

作者： Amin bagheri Kazem Esmailpour Morteza Heydari renewable Energy research Center Damavand BranchIslamic Azad UniversityDamavandIran

This research comprehensively investigates the flow and thermal characteristics of a pulsating impinging jet over a dimpled *** analyzes the impact of key parameters(e.g.,inlet velocity pulsation functions,pulsation frequency,amplitude,dimple pitch,dimple depth,reynolds number)on flow patterns and heat *** computational fluid dynamics and the re-normalization group turbulence model are employed to accurately simulate complex turbulent flow *** and average heat transfer coefficients are calculated and compared to steady impingement cases,revealing the potential benefits of pulsation for heat transfer *** study also examines how pulsation-induced flow modulation and thermal mixing affect heat transfer *** indicate that combining fluctuating flow with a dimpled surface can improve heat transfer *** summary,increasing pulsation amplitude consistently enhances heat transfer,while the effect of frequency varies between impinging and wall jet zones.

关键词： Pulsating impinging jet Dimpled surface Heat transfer enhancement Pulsation frequency and amplitude Coherent structures

The nature and movement of thrusts in the eastern Iranian orogen:Sechengi Area on the northern border of Lut and Sistan

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Journal of Mountain Science 2024年第9期21卷 3157-3171页

作者： Shahriar KESHTGAr Mahmoud reza HEYHAT Sasan bagheri Ebrahim GHOLAMI Seyed Naser rAISOSSADAT Department of Geology Faculty of ScienceUniversity of BirjandBirjand ***Iran Department of Geology Faculty of ScienceUniversity of Sistan and BaluchestanZahedan 98167-45845Iran

The eastern Iranian range,known as the Sistan suture zone in the past,has recently been identified as the Sistan *** Paleogene orogeny is located between the Lut and Afghan *** structural analysis shows that most of the thrusts dip towards the NW so that the Permo-Triassic sediments and Jurassic micro-diorites of the Lut Block overthrusted over the younger *** studies show that the tectonic vergence was from the NW to the SE of the Sechengi area in the NW part of Sistan *** recognized three deformation phases in eastern *** first N-S deformation event(D1)resulted in the formation of tight E-W folds(F1)and associated cleavages(S1).The second E-W deformation event(D2),which occurred in the late Paleogene led to the bending of older structures,including the axial plane of the first-generation folds giving them a new northwest direction(F2).Additionally,the ramp of the first-phase thrusts(striking E-W)was reactivated,acquiring a new NNW orientation and exhibiting SSE tectonic *** third deformation event(D3)resulted in the formation of NNE and WNW conjugate faults in eastern *** consecutive deformation events perpendicular to each other are inconsistent with the models of simple linear orogen presented for eastern Iran(*** of eastern Iran continental crust and subsequence linear collision)and seem more consistent with the buckling orogeny(Orocline).

关键词： Thrust Tectonic vergence Orocline Buckling Sechengi Eastern Iranian ranges.

孔隙度对具有不均匀横截面的功能分级多孔梁的自由振动和屈曲行为的影响

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Journal of Central South University 2024年第3期31卷 841-857页

作者： Zeinab bagheri Alireza FIOUZ Mahmood SErAJI Department of Civil Engineering Bushehr BranchIslamic Azad UniversityBushehr ***Iran

本文旨在研究孔隙度对具有不均匀横截面的功能分级多孔梁的自由振动和屈曲行为的影响。一般认为材料的性能沿厚度方向变化,而梁的横截面沿其长度方向分布不均匀。三种不同的孔隙度分布包括对称分布、非对称分布和均匀分布。利用经典的... 详细信息

本文旨在研究孔隙度对具有不均匀横截面的功能分级多孔梁的自由振动和屈曲行为的影响。一般认为材料的性能沿厚度方向变化,而梁的横截面沿其长度方向分布不均匀。三种不同的孔隙度分布包括对称分布、非对称分布和均匀分布。利用经典的梁理论和Hamilton原理推导出了问题的控制方程,并用微分求积法推导出公式。通过已知方法和分析解法对所得结果进行了验证。通过网格独立性研究,确定了最优离散化设置。利用详细的参数化分析研究了不同力学参数,包括孔隙率系数、长径比和变化截面对基频和临界屈曲载荷的影响。结果表明,材料孔隙率的增加会导致梁的屈曲能力显著降低。然而,梁的自由振动行为完全取决于其孔隙度模式。此外,孔隙呈对称分布的梁其屈曲能力和基频性能最好。

关键词：孔隙度功能分级多孔梁自由振动屈曲不均匀截面微分求积法

PCL/HA静电纺丝纤维涂层对可降解Mg/HA复合材料的表面改性:力学性能、腐蚀和生物相容性

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Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1470-1486页

作者： M.SHAMSI M.SEDIGHI A.bagheri School of Mechanical Engineering Iran University of Science and TechnologyTehranIran

采用搅拌铸造和挤压法制备Mg/HA复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/HA)纤维(2.5%和5%HA,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73MPa(纯镁)提高到151MPa,提高了107%... 详细信息

采用搅拌铸造和挤压法制备Mg/HA复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/HA)纤维(2.5%和5%HA,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73MPa(纯镁)提高到151MPa,提高了107%。SEM、EDS和XrD分析表明,HA颗粒分布在多孔涂层中。极化曲线结果表明,涂层试样的耐腐蚀性能均优于未涂覆试样。PCL涂层使样品的腐蚀电流密度降低了两个数量级。通过极化和体外腐蚀试验证明了HA在涂层中的有效性。涂层和随后形成的Ca-P层阻碍了模拟体液与基体的接触和渗透,从而起到保护表面的作用。PCL/2.5%HA涂层样品的腐蚀速率最低,其平均值为0.98mm/a,与未涂层样品相比,在14天内减少了81%。根据3天MTT结果,使用PCL/2.5%HA涂层可使细胞活性从43%提高到121%。综上,涂覆PCL/2.5%HA纤维的Mg/HA复合材料在生物可吸收植入物方面具有广阔的应用前景。

关键词：镁基复合材料复合涂层生物可降解羟基磷灰石聚己内酯纤维

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Mechanism of PArP inhibitor resistance and potential overcoming strategies

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Genes & Diseases 2024年第1期11卷 306-320页

作者： Xiaoyu Fu Ping Li Qi Zhou ruyuan He Guannan Wang Shiya Zhu Amir.bagheri Gary Kupfer Huadong Pei Juanjuan Li Department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA Department of Breast and Thyroid Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Thoracic Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China

PArP inhibitors(PArPi)are a kind of cancer therapy that targets poly(ADP-ribose)*** is the first clinically approved drug to exert synthetic lethality by obstruct-ing the DNA single-strand break repair *** the significant therapeutic effect in pa-tients with homologous recombination(Hr)repair deficiency,innate and acquired resistance to PArPi is a main challenge in the *** this review,we mainly discussed the underlying mechanisms of PArPi resistance and summarized the promising solutions to overcome PArPi resistance,aiming at extending PArPi application and improving patient outcomes.

关键词： Drug resistance Homologous recombination PArP PArP inhibitor Poly(ADP-ribose)polymerase

Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar.bagheri Mohsen rashidi Morteza Oladnabi Stem Cell research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(rPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after rNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

Long-term follow-up of intravesical abobotulinumtoxinA (Dysport®) injections in women with idiopathic detrusor overactivity

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Asian Journal of Urology 2024年第1期11卷 93-98页

作者： Mohammad Sajjad rahnama'i Amin bagheri Elham Jahantabi Hanieh Salehi-Pourmehr Hadi Mostafaei Brigitte Schurch Aida Javan Balegh Marand Sakineh Hajebrahimi Department of Urology St.Elisabeth-Tweesteden Hospital Tilburgthe Netherlands research Center for Evidence-based Medicine Iranian EBM Centre:A Joanna Briggs Institute(JBI)Center of ExcellenceTabriz University of Medical SciencesTabrizIran Urology Department Faculty of MedicineTabriz University of Medical SciencesTabrizIran Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Service de Neuroréhabilitation CHUVLausanneSwitzerland Society of Urological research and Education(SUrE) Heerlenthe Netherlands

Objective:Only a few numbers of studies have been published on the use of abobotulinumtoxinA(Dysport®)in idiopathic detrusor overactivity(IDO).This study reported the long-term follow-up of women with IDO who were treated with intravesical Dysport®***:Two hundred and thirty-six patients with IDO who had failed first-line conservative and antimuscarinic therapy received 500-900 units of Dysport®between April 2014 and July *** patients were followed up for 5 years after their initial injection and interviewed on the ***:A total of 236 women with IDO aged from 18 years to 84 years(mean±standard deviation:49.6±15.9 years)were included in our *** median follow-up time for patients was 36.5(range:10-70)months,and the median recovery time after injection was 18.5(range:0-70)months.A total of 83(35.2%)patients stated that they had subjective improvement of their symptoms whereas 84(35.6%)patients did not report any improvement in *** initial International Consultation on Incontinence Questionnaire Overactive Bladder mean score was 6.9(standard deviation 3.4).There was a positive association between the median recovery time and the components of the International Consultation on Incontinence Questionnaire Overactive Bladder ***:In a sub-population of overactive bladder patients with IDO who have failed first-line therapy,a single intravesical Dysport®injection can resolve patient symptoms completely or reduce the symptoms to an acceptable level that can be controlled with antimuscarinics or re-injection on demands.

关键词： AbobotulinumtoxinA Dysport Intravesical ldiopathic Detrusor overactivity