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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromatography coupled with a diode array detector

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Acta Pharmacologica Sinica 2004年第12期25卷 18-23页

作者： Neng-ming LIN2,3, Su ZENG2,4, Sheng-lin MA3, Yun FAN3, Hai-jun ZHONG3, Luo FANG3 2Collegeof Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031 3Zhejiang Cancer Hospital, Hangzhou 310022, China College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 Zhejiang Cancer Hospital Hangzhou 310022

AIM: To establish a high pressure liquid chromatography (HPLC) method for determination of the concentration of gemcitabine (dFdC) and its metabolite(dFdU) in human plasma. METHODS: Plasma 1.0 mL spikedwith floxuridine as an internal standard was extracted with 3.0 mL of methanol-acetonitrile (v/v, 1:9). The supernatant was evapo- rated at 60 oC and the residue was reconstituted with 0.5 mL of the solution used as the mobile phase. After centrifugation, 50 μL of the supernatant was injected into the HPLC system. Separation was achieved on a C18 (4.6 mm×250 mm, 5 μm) column at 25 oC with the flow rate of the mobile phase set to 0.8 mL/min. The compounds were detected at 268 nm. The mobile phase consisted of 40.0 mmol/L acetate ammonium buffer solution (pH 5.5) and acetonitrile (v/v, 97.5:2.5). rESULTS: The linear range was 0.20-10.0 mg/L(r=0.9999) for dFdC and 0.50-50.0 mg/L(r=0.9999) for dFdU. The limit of detection (LOD) was 0.10 mg/L for dFdC and 0.25 mg/L for dFdU, while the limit of quantification (LOQ) was 0.20 mg/L (rSDr dFdC and 0.50 mg/L(rSD 3 %) for dFdU. The average recovery of dFdC and dFdU by this method were 103.3 % and 98.7 %, respectively. For intra-day and inter-day, the corresponding standard deviations of the measurements of dFdC and dFdU were both less than 5.5 %. CONCLUSION: An analytical method was established to measure the concentrations of dFdC and dFdU in human plasma and was effectively applied to the dFdC and dFdU pharmacokinetic studies of 8 Chinese patients with malignant tumors.

关键词： high pressure liquid chromatography gemcitabine deoxycytidine floxuridine

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Formation and decay of neutron-deficient nuclei Po and Pb

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Nuclear Science and Techniques 1998年第1期9卷 11-13页

作者： Chen Xue Shi 1,2 , Ahmad I 3, Andreyev A N 4,Batchelder J C 7, Bijnens N 4, Bingham C r 2,5 , Blumenthal D 3, Busse B C 3,8 , Conticchico L F 3,6 , Davids C N 3 , Huyse M 4, Janssens r V F 3, Mantica P 2, Penttila

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关键词：中子欠缺核钋核铅核衰变

PCr-based site-specific mutagenesis of peptide antibiotics FALL-39 and its biologic activities

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Acta Pharmacologica Sinica 2004年第2期25卷 113-119页

作者： Yun-xia YANG2,3, Yun FENG3, Bo-yao WANG3,Qi WU3 2Department of Pharmacology,3research Unit of Infection & Immunity, West-China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China Department of Pharmacology West-China School of Preclinical and Forensic Medicine Sichuan University Chengdu 610041 research Unit of Infection & Immunity West-China School of Preclinical and Forensic Medicine Sichuan University Chengdu 610041

AIM: To construct PGEX-1λT-FALL-39 expression vector and its mutant vector, and study the relationship of function and structure. METHODS: A cDNA encoding mature FALL-39 was cloned from SPCA-1 cell mrNA and the prokaryotic expression vector PGEX-1λT-FALL-39 was constructed. Two kinds of polymerase chain reaction (PCr) for the site-direction mutagenesis were used to construct FALL-39 mutant expression vector, FALL-39-Lys- 32 and FALL-39-Lys-24. Minimal effective concentration, minimal inhibitory concentration, and minimal bacteri- cidal concentration were used to assay the antibacterial activities of these peptides. Effects of different solution on the antibacterial activity of FALL-39 and FALL-39-Lys-32 were observed by CFU determination. The hemolytic effects of these peptides were also examined on human red blood cells. rESULTS: Two site-specific mutants FALL-39-Lys-32 and FALL-39-Lys24 were obtained by PCr-induced mutagenesis. In comparison with two-step PCr which required two pairs of primers, one step PCr which required one pair of primers is a simple and efficient method for the PCr based site-specific mutagenesis. Using the prokaryotic expression system, the E coli-based products of recombinant FALL39 and its mutant peptides were also obtained. The antibacterial assay showed that FALL-39-Lys-32 and FALL-39-Lys24 were more potential in the antibacterial activity against E coli ML35p and Pseudomonas aeruginosa ATCC27853 than that of FALL-39, and no increase in hemolysis was observed at the antibacterial concentrations. The antibacterial activity of FALL-39-Lys-32 against E coli was more potent than that of FALL-39 in NaCl-containing LB medium, while its activity was almost the same as FALL-39 in SO4 containing 2- Medium E. CONCLUSION: PCr-based mutagensis is a useful model system for studying the structure and function relationship of antimicrobial peptides. Keeping α-helical conformation of FALL-39 and increasing net positive charge can increase the antibacter

关键词： FALL 39 peptide antibiotics polymerase chain reaction mutation hemolysis

Studies on the electronic structures of three-dimensional topological insulators by angle resolved photoemission spectroscopy

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Frontiers of physics 2012年第2期7卷 175-192页

作者： Yulin Chen (1) (2) (3) 1. Department of Physics University of Oxford Clarendon Laboratory Parks Road Oxford OX1 3PU UK2. Stanford Institute for Materials and Energy Sciences SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA3. Geballe Laboratory for Advanced Materials Departments of Physics and Applied Physics Stanford University Stanford CA 94305 USA

Three-dimensional （3D） topological insulators represent a new state of quantum matter with a bulk gap and odd number of relativistic Dirac fermions on the surface. The unusual surface states of topological insulators rise from the nontrivial topology of their electronic structures as a result of strong spin-orbital coupling. In this review, we will briefly introduce the concept of topological insu- lators and the experimental method that can directly probe their unique electronic structure： angle resolved photoemission spectroscopy （ArPES）. A few examples are then presented to demonstrate the unique band structures of different families of topological insulators and the unusual properties of the topological surface states. Finally, we will briefly discuss the future development of topological quantum materials.

关键词： topological insulator (TI) photoemission ArPES

Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia

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Acta Pharmacologica Sinica 2007年第8期28卷 1097-1104页

作者： Xi-hui XU~(2,3) Yi-nan HUA~(2,3) Hui-ling ZHANG~(2,3) Jun-chao WU~(2,3) You-zhu MIAO~(2,3) rong HAN~(2,3) Zhen-lun GU~(2,3) Zheng-hong QIN~(2,3,4) ~2Laboratory of Aging and Nervous Disease and ~3Department of Pharmacology,Soochow University School of Medicine Suzhou 215123,China Laboratory of Aging and Nervous Disease Soochow University School of Medicine Suzhou China Department of Pharmacology Soochow University School of Medicine Suzhou China

Aim:To investigate the effects of lithium(Li)and prostaglandin A1(PGA1)on theexpression of heat shock factor 1(HSF- 1),heat shock proteins(HSP),and apoptosisprotease activating factor-1(Apaf-1)induced by permanent focal ischernia in ***:The rats were pretreated with a subcutaneous(sc)injection of Li for 2 dor a single intracerebral ventricle(icv)administration of PGA1for 15 min beforeischemic insult,or a combination ofLi(sc,1 mEq/kg,2 d)and PGA1(icv,15 minprior to ischemic insult).Brain ischemia was induced by the permanent middlecerebral artery occlusion(pMCAO).Twenty-four hours after the occlusion,theexpression of HSF-1,HSE and Apaf-1 in the ischemic striatum were examined withWestern blot ***:The expression of HSF-1,heme oxygenase-1(HO-1),HSP90α,and Apaf-1 were significantly increased,but the expression ofHSP90β was significantly decreased 24 h after the ***1and Li and theircombination significantly enhanced the ischemia-induced elevation in the levelsof HSF-1,HO-1,and HSP90α,and recovered HSP90β expression,but decreasedApaf-1 levels in the ischemic ***:The present study demon-strates that PGA1and Li have synergistic effects on the enhancement of theexpression of HSP,suggesting that the synergistic effects of PGA1and Li in therat model of permanent focal cerebral ischemia may be mediated by the enhance-ment expression of HSP expression and the downregulation of *** studiessuggest that combined PGA1and Li may have potential clinical value for thetreatment of stroke.

关键词： prostaglandin A1 lithium oxidative stress heat shock factor 1 cerebral ischemia Apaf-IHO-1 HSP90α HSP90β