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Asian Pacific Journal of Tropical Biomedicine 2012年第3期2卷 189-194页

作者： Abdul Viqar Khan qamar uddin ahmed Indu Shukla Athar Ali Khan Department of Botany Faculty of Life SciencesAligarh Muslim University Department of Pharmaceutical Chemistry Faculty of PharmacyInternational Islamic University Malaysia Department of Microbiology Jawaharlal Nehru Medical CollegeAligarh Muslim University

Objective:To investigate antibacterial potential of Trifolium alexandrinum(***) Linn,against seven gram positive and eleven gram negative hospital isolated human pathogenic bacterial strains responsible for many tropical ***:Non-polar and polar extracts of the leaves of *** i.e.,hexane,dichloromethane(DCM),ethyl acetate(EtOAc), methanol(MeOH) and aqueous(AQ) extracts at five different concentrations(1,2,5,10 and 15 mg/ mL) were prepared to evaluate their antibacterial *** standards were strictly followed to perform antimicrobial disc susceptibility test using disc diffusion ***:Polar extracts demonstrated significant antibacterial activity against tested *** and MeOH extracts showed maximum antibacterial activity with higher inhibition zone and were found effective against seventeen of the tested *** AQ plant extract inhibited the growth of sixteen of the test *** and MeOH plant extracts inhibited the growth of all seven gram positive and ten of the gram negative bacterial ***:The present study strongly confirms the effectiveness of crude leaves extracts against tested human pathogenic bacterial strains causing several tropical *** Egyptian clover is used as a fodder plant,it could be helpful in controlling various infectious diseases associated with cattle as well.

关键词： Trifolium alexandrinum L. Fabaceae Antibacterial activity Pathogenic bacteria Gram-positive bacteria Gram-negative bacteria Tropical disease Infectious disease

Potential bioactive coating system for high-performance absorbable magnesium bone implants

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Bioactive Materials 2022年第6期7卷 42-63页

作者： Murni Nazira Sarian Nida Iqbal Pedram Sotoudehbagha Mehdi Razavi qamar uddin ahmed Cortino Sukotjo Hendra Hermawan Institute of Systems Biology(INBIOSIS) Universiti Kebangsaan Malaysia43600Bandar Baru BangiSelangorMalaysia Bio-Medical Engineering Centre University of Engineering&Technology LahoreNew CampusPakistan BiionixTM(Bionic Materials Implants&Interfaces)ClusterDepartment of Internal MedicineCollege of MedicineUniversity of Central Florida Health Sciences Campus at Lake Nona6900 Lake Nona BlvdOrlandoFL 32827USA Department of Pharmaceutical Chemistry Kulliyyah of PharmacyInternational Islamic University Malaysia25200Kuantan DMPahangMalaysia Department of Restorative Dentistry College of DentistryUniversity of Illinois at ChicagoUSA Department of Mining Metallurgical and Materials EngineeringLaval UniversityQuebec CityG1V 0A6Canada

Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation *** main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be *** coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone *** this review,a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing *** main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate ***,collagen type I,recombinant human bone morphogenetic proteins 2,simvastatin,zoledronate,and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone *** addition to coating,the substrate itself can be made bioactive by alloying magnesium with calcium,zinc,copper,and manganese that were found to promote bone regeneration.

关键词： Absorbable metals Bioactive agent Bone fracture Coating Magnesium alloys

Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking

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Journal of Pharmaceutical Analysis 2019年第2期9卷 91-99页

作者： Suganya Murugesu Zalikha Ibrahim qamar uddin ahmed Bisha Fathamah Uzir Nik Idris Nik Yusoff Vikneswari Perumal Faridah Abas Khozirah Shaari Alfi Khatib Department of Pharmaceutical Chemistry Kulliyyah of PharmacyInternational Islamic University Malaysia Department of Pharmaceutical Technology Faculty Pharmacy & Health SciencesUniversiti Kuala LumpurRoyal College of Medicine Perak Laboratory of Natural Products Institute of BioscienceUniversiti Putra Malaysia

The present study used in vitro and in silico techniques, as well as the metabolomics approach to characterise α-glucosidase inhibitors from different fractions of Clinacanthus nutans. C. nutans is a medicinal plant belonging to the Acanthaceae family, and is traditionally used to treat diabetes in Malaysia. nHexane, n-hexane: ethyl acetate(1:1, v/v), ethyl acetate, ethyl acetate: methanol(1:1, v/v), and methanol fractions were obtained via partitioning of the 80% methanolic crude extract. The in vitro α-glucosidase inhibitory activity was analyzed using all the fractions collected, followed by profiling of the metabolites using liquid chromatography combined with mass spectrometry. The partial least square(PLS) statistical model was developed using the SIMCA P^+14.0 software and the following four inhibitors were obtained:(1) 4,6,8-Megastigmatrien-3-one;(2) N-Isobutyl-2-nonen-6,8-diynamide;(3) 1′,2′-bis(acetyloxy)-3′,4′-didehydro-2′-hydro-β, ψ-carotene; and(4) 22-acetate-3-hydroxy-21-(6-methyl-2,4-octadienoate)-olean-12-en-28-oic acid. The in silico study performed via molecular docking with the crystal structure of yeast isomaltase(PDB code: 3 A4 A) involved a hydrogen bond and some hydrophobic interactions between the inhibitors and protein. The residues that interacted include ASN259, HID295, LYS156, ARG335,and GLY209 with a hydrogen bond, while TRP15, TYR158, VAL232, HIE280, ALA292, PRO312, LEU313,VAL313, PHE314, ARG315, TYR316, VAL319, and TRP343 with other forms of bonding.

关键词： Clinacanthus nutans LC-MS-QTOF Metabolomics α-Glucosidase inhibitors Diabetes Molecular docking

Salacca zalacca:A short review of the palm botany, pharmacological uses and phytochemistry

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 645-652页

作者： Mohammed S.M.Saleh Mohammad Jamshed Siddiqui ahmed Median Nor Hadiani Ismail qamar uddin ahmed Siti Zaiton Mat So'ad Salima Saidi-Besbes Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy International Islamic University Malaysia Atta-ur-Rahman Institute for Natural Product Discovery Universiti Teknologi MARA Faculty of Applied Science Universiti Teknologi MARA Université Oran1 ahmed Ben Bella Laboratoire de Synthèse Organique Appliquée Département de chimie Facultédes sciences exactes et appliquées

Salacca zalacca(Gaertn.) Voss(family Arecaceae) is the snake fruit commonly known in Malay language as salak in Malaysia. This exotic fruit has diverse and potential pharmacological properties due to its high antioxidant content. It is often consumed due to its sweet taste. The abundant natural sugar and fibre along with minerals and vitamin makes it a nutritious fruit. Phytochemical investigation on this fruit has revealed the presence of flavonoids, phenolics, glycosides as well as some volatile and aromatic compounds, including gallic acid, quercetin, chlorogenic acid, epicatechin, proanthocyanidins, lycopene and β-carotene. Pharmacological studies on the fruit flesh and peel have shown some tremendous antioxidant, anti-inflammatory, anticancer and antidiabetic potential. This review provides the botanical information of Salacca zalacca as well as its scientific investigations involving the distinct pharmacological and phytochemical benefits. This could help in highlighting the lacking data and research gaps on this plant.

关键词： Snake fruit Salacca zalacca Arecaceae Antioxidant Antidiabetic Anticancer

Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains

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Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 452-455页

作者： Abdul Viqar Khan qamar uddin ahmed M Ramzan Mir Indu Shukla Athar Ali Khan Department of Botany Faculty of Life SciencesAligarh Muslim University Department of Pharmaceutical Chemistry Facully of PharmacyInternational Islamic University Malaysia Department of Microbiology Faculty of Life SciencesAligarh Muslim University

Objective:To investigate the antibacterial potential of the polar and non-polar extracts of the seeds of Melia azedarach(***) L.(Meliaceae) against eighteen hospital isolated human pathogenic bacterial ***:Petrol,benzene,ethyl acetate,methanol,and aqueous extracts at five different concentrations(1,2,5,10 and 15 mg/mL) were *** diffusion method was followed to evaluate the antibacterial ***:All extracts of the seeds demonstrated significant antibacterial activity against tested *** all extracts,ethyl acetate extract revealed the highest inhibition *** present study also favored the traditional uses reported ***:Results of this study strongly confirm that the seed extracts of *** could be effective antibiotics,both in controlling gram-positive and gram-negative human pathogenic infections.

关键词： Melia azedarach Antibacterial efficacy Pathogenic bacteria

Antibacterial potential of some plants of traditional use in India against pathogenic strains of ***

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Journal of Coastal Life Medicine 2015年第3期 204-210页

作者： Abdul Viqar Khan qamar uddin ahmed Athar Ali Khan Department of Botany Faculty of Life SciencesAligarh Muslim UniversityAligarh-202002State of Uttar PradeshIndia Department of Pharmaceutical Chemistry Faculty of PharmacyInternationalIslamic University Malaysia25200-KuantanPahang Darul MakmurMalaysia

Objective:To evaluate antibacterial sensitivity of 43 ethnomedicinally important plants belonging to 25 different families from Western Uttar Pradesh,a northern province in India,against hospital isolated pathogenic strains of Staphylococcus aureus(***).Methods:Methanol(MeOH)and aqueous extracts of plants were subjected to sensitivity test against *** ATCC 25953 and two hospital isolated virulent strains of *** SA1 and SA2 following disc diffusion assay to determine sensitivity and agar dilution method to test minimum inhibition concentration using Mueller-Hinton ***:Potential antibacterial activity was recorded for MeOH extracts against test pathogens,while moderate antibacterial activity was observed in case of aqueous *** of 43 plant species,39 species were found sensitive to tested *** inhibition concentration values of MeOH extracts were demonstrated at low concentration ranging from 15.5 mg/mL up to 45.5 mg/mL compared to aqueous extracts which were observed ranging from 30.0 mg/mL up to 95.0 mg/***:The present findings strongly support traditional uses of these plants in the treatment of infectious maladies and further urge of phytochemical and pharmacological research to develop safer and cheaper drugs for the benefit of ailing humanity.

关键词： Antibacterial sensitivity Crude extracts Ethnobotanical plants Traditional uses S.aureus Disc diffusion MIC

Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms

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Journal of Coastal Life Medicine 2014年第1期 70-75页

作者： Nurul Huda Syed Ibrahim Muhammad Taher Deny Susanti Mohamed ZaffarAli Mohamed Amiroudine qamar uddin ahmed Department of Biomedical Science Faculty of ScienceInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Chemistry Faculty of ScienceInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Pharmaceutical Chemistry Faculty of PharmacyInternational Islamic University Malaysia25200 KuantanPahangMalaysia

Objective:To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and ***:Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration(FIC).Results:The experiment was carried out using broth microdilution and checkerboards *** showed no interaction with the combination withα-mangostin where the FIC indexes were between the range of 0.5*** of doxycycline on Pseudomonas aeruginosa fell into other set of range,FIC_(index)≥4 which is an *** activity of all four bacteria towards ampicillin,penicillin G,streptomycin and Conclusions:The FIC index is far away in the *** coupled antibiotic andα-mangostin is considered synergy in action if it lies in FIC_(index)≤0.5 and it was found that the isolated compound,α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics.

关键词： α-mangostin Direct Indirect Antimicrobial FIC index

Studies on bactericidal efficacy of pumpkin(Cucurbita moschata Duchesne)peel

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Journal of Coastal Life Medicine 2014年第2期 146-153页

作者： El Zawane Kamarudin qamar uddin ahmed Abul Bashar Mohammed Helaluddin Zuvairea Nazren Mohd Sirajudin Ahmad Jalal Khan Chowdhury Department of Biotechnology Faculty of ScienceInternational Islamic University Malaysia(IIUM)25200 KuantanPahang Darul MakmurMalaysia Department of Pharmaceutical Chemistry Faculty of PharmacyInternational Islamic University Malaysia(IIUM)25200 KuantanPahang Darul MakmurMalaysia

Objective:To explore the in vitro antibacterial potential of the peel of Cucurbita moschata Duchesne(tropical pumpkin)(***)against human pathogenic ***:In the present study,dichloromethane(DCM),methanol(MEOH)and aqueous extracts of *** peel were examined for in vitro antibacterial potency against eight bacterial strains *** cereus,Burkholderia cepacia,Escherichia coli,Enterococcus faecalis,Staphyloccocus aureus,Pseudomonas aerugenosa,Vibrio alginolyticus,Vibrio parahaemolyticus using Kirby-Bauer disk diffusion susceptibility and broth micro-dilution ***:DCM extract of pumpkin peel exhibited the maximum zone of inhibition against Staphyloccocus aureus(21 mm)whereas aqueous extract of pumpkin peel revealed the least zone of inhibition against Escherichia coli(8 mm).MEOH extract gave maximum zone of inhibition against Pseudomonas aerugenosa(19 mm).Broth micro-dilution method showed minimum inhibitory concentration for the DCM extract against Burkholderia cepacia at 6.25 mg/*** minimum bactericidal concentrations were also determined to know the nature of all *** and MEOH extracts exhibited bactericidal nature to all bacterial strains except for the Vibrio *** minimum bactericidal concentrations values exhibited bactericidal nature ranging from 3.12 mg/mL to 100.00 mg/*** screening of antimicrobial properties of different extracts of *** peel revealed that the DCM extract possessed good antimicrobial efficacy compared to MEOH and aqueous ***:Peel of *** possesses antibacterial compounds and could be potential source for a new class of antibiotics.

关键词： Cucurbita moschata Pumpkin peel Antibacterial activity Pathogenic bacteria Foodborne diseases

The Space-Time CE/SE Method for Solving Reduced Two-Fluid Flow Model

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Communications in Computational Physics 2012年第9期12卷 1070-1095页

作者： Shamsul qamar Munshoor ahmed Ishtiaq Ali Department of Mathematics COMSATS Institute of Information TechnologyPark RoadChak Shahzad IslamabadPakistan Max Planck Institute for Dynamics of Complex Technical Systems Sandtorstr.139106 MagdeburgGermany

The space-time conservation element and solution element(CE/SE)method is proposed for solving a conservative interface-capturing reducedmodel of compressible two-fluid *** flow equations are the bulk equations,combined with mass and energy equations for one of the two *** latter equation contains a source term for accounting the energy *** one and two-dimensional flow models are numerically investigated in this *** CE/SE method is capable to accurately capture the sharp propagating wavefronts of the fluids without excessive numerical diffusion or spurious *** contrast to the existing upwind finite volume schemes,the Riemann solver and reconstruction procedure are not the building block of the suggested *** method differs from the previous techniques because of global and local flux conservation in a space-time domain without resorting to interpolation or *** order to reveal the efficiency and performance of the approach,several numerical test cases are *** validation,the results of the current method are compared with other finite volume schemes.

关键词： Reduced model space-time CE/SE method central schemes conservation laws hyperbolic systems shock solutions

IPv6 Cryptographically Generated Address:Analysis,Optimization and Protection

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Computers, Materials & Continua 2021年第7期68卷 247-265页

作者： Amjed Sid ahmed Rosilah Hassan Faizan qamar Mazhar Malik Department of Computing and Information Technology Global College of Engineering and TechnologyRuwi112Sultanate of Oman Faculty of Information Science and Technology Center for Cyber SecurityUniversiti Kebangsaan MalaysiaBangi43600Malaysia Faculty of Information Science and Technology Universiti Kebangsaan Malaysia43600BangiMalaysia

In networking,one major difficulty that nodes suffer from is the need for their addresses to be generated and verified without relying on a third party or public authorized *** resolve this issue,the use of selfcertifying addresses have become a highly popular and standardized method,of which Cryptographically Generated Addresses(CGA)is a prime *** was primarily designed to deter the theft of IPv6 addresses by binding the generated address to a public key to prove address *** though the CGA technique is highly effective,this method is still subject to several vulnerabilities with respect to security,in addition to certain limitations in its *** this study,the authors present an intensive systematic review of the literature to explore the technical specifications of CGA,its challenges,and existing proposals to enhance the *** that CGA generation is a time-consuming process,this limitation has hampered the application of CGA in mobile environments where nodes have limited energy and *** Hash2 conditions in CGA is the heaviest and most timeconsuming part of *** improve the performance of CGA,we replaced the Secure Hash Algorithm(SHA1)with the Message Digest(MD5)hash ***,this study also analyzes the possible methods through which a CGA could be *** conducting this analysis,Denial-of-Service(DoS)attacks were identified as the main method of attack toward the CGA verification process,which compromise and threaten the privacy of ***,we propose some modifications to the CGA standard verification algorithm to mitigate DoS attacks and to make CGA more security conscious.

关键词： IPv6 GCA SEND DoS attacks RSA SHA-1