Potential bioactive coating system for high-performance absorbable magnesium bone implants
作者机构：Institute of Systems Biology(INBIOSIS)Universiti Kebangsaan Malaysia43600Bandar Baru BangiSelangorMalaysia Bio-Medical Engineering CentreUniversity of Engineering&Technology LahoreNew CampusPakistan BiionixTM(Bionic MaterialsImplants&Interfaces)ClusterDepartment of Internal MedicineCollege of MedicineUniversity of Central Florida Health Sciences Campus at Lake Nona6900 Lake Nona BlvdOrlandoFL 32827USA Department of Pharmaceutical ChemistryKulliyyah of PharmacyInternational Islamic University Malaysia25200Kuantan DMPahangMalaysia Department of Restorative DentistryCollege of DentistryUniversity of Illinois at ChicagoUSA Department of MiningMetallurgical and Materials EngineeringLaval UniversityQuebec CityG1V 0A6Canada
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第6期
页 面：42-63页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：supported by the Universiti Kebangsaan Malaysia Research University Grant(GGPM-2020-037,MNS) the Natural Sciences and Engineering Research Council of Canada(RGPIN-2017-04274,HH)
主 题：Absorbable metals Bioactive agent Bone fracture Coating Magnesium alloys
摘 要：Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation *** main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be *** coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone *** this review,a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing *** main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate ***,collagen type I,recombinant human bone morphogenetic proteins 2,simvastatin,zoledronate,and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone *** addition to coating,the substrate itself can be made bioactive by alloying magnesium with calcium,zinc,copper,and manganese that were found to promote bone regeneration.
维普期刊数据库