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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp(Ctenopharyngodon idella):in vitro and in vivo studies

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1638-1656页

作者： piao zhao Lin Feng Weidan Jiang Pei Wu Yang Liu Hongmei Ren Xiaowan Jin Lu Zhang Haifeng Mi Xiaoqiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory of Animal Disease‑Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130SichuanChina Tongwei Co. Ltd.Healthy Aquaculture Key Laboratory of Sichuan ProvinceChengdu 610041SichuanChina

Background Ochratoxin A(OTA),a globally abundant and extremely hazardous pollutant,is a significant source of contamination in aquafeeds and is responsible for severe food *** developmental toxicity of OTA and the potential relieving strategy of natural products remain *** study screened the substance curcumin(Cur),which had the best effect in alleviating OTA inhibition of myoblast proliferation,from 96 natural products and investigated its effect and mechanism in reducing OTA myotoxicity in vivo and in *** A total of 720 healthy juvenile grass carp,with an initial average body weight of 11.06±0.05 g,were randomly assigned into 4 groups:the control group(without OTA and Cur),1.2 mg/kg OTA group,400 mg/kg Cur group,and 1.2 mg/kg OTA+400 mg/kg Cur *** treatment consisted of 3 replicates(180 fish)for 60 *** Firstly,we cultured,purified,and identified myoblasts using the tissue block culture *** preliminary screening and re-screening of 96 substances,we examined cell proliferation-related indicators such as cell viability and ultimately found that Cur had the best ***,Cur could alleviate OTA-inhibited myoblast differentiation and myofibrillar development-related proteins(Myo G and MYHC)in vivo and in vitro and improve the growth performance of grass ***,Cur could also promote the expression of OTA-inhibited protein synthesis-related proteins(S6K1 and TOR),which was related to the activation of the AKT/TOR signaling ***,Cur could downregulate the expression of OTA-enhanced protein degradation-related genes(murf1,foxo3a,and ub),which was related to the inhibition of the Fox O3a signaling *** In summary,our data demonstrated the effectiveness of Cur in alleviating OTA myotoxicity in vivo and in *** study confirms the rapidity,feasibility,and effectiveness of establishing a natural product screening method targeting myoblasts to alleviate fungal toxin toxicity.

关键词： Curcumin Grass carp Myotoxic Ochratoxin A Protein deposition

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Dietary curcumin alleviates intestinal damage induced by ochratoxin A in juvenile grass carp(Ctenopharyngodon idella):Necroptosis and inflammatory responses

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Animal Nutrition 2024年第3期18卷 119-132页

作者： piao zhao Wei Dan Jiang Pei Wu Yang Liu Hong Mei Ren Xiao Wan Jin Lin Feng Xiao Qiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceSichuan611130China

Ochratoxin A(OTA)is one of the most common pollutants in aquatic *** a first line of defense,intestinal barriers could be utilized against OTA in order to prevent *** product supplementation is one of the most popular strategies to alleviate toxicity induced by mycotoxins,but there is a lack of knowledge about how it functions in the teleost *** this study,720 juvenile grass carp of about 11 g were selected and four treatment groups(control group,OTA group,curcumin[Cur]group,and OTA+Cur group)were set up to conduct a 60-day growth *** the test,the growth performance and intestinal health related indexes of grass carp were *** addition of dietary Cur could have the following main results:(1)inhibit absorption and promote efflux transporters mRNA expression,reducing the residuals of OTA,(2)decrease oxidative stress by reducing oxidative damage and enhancing the expression of antioxidant enzymes,(3)promote mitochondrial fusion proteins to inhibit the expression of mitotic proteins and mitochondrial autophagy proteins and enhance mitochondrial function,(4)reduce necroptosis-related gene expression through inhibiting the tumor necrotic factor receptor-interacting protein kinase/mixed lineage kinase domain-like pathway,(5)reduce the expression of pro-inflammatory factors by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway to alleviate the intestinal inflammatory *** summary,the results suggested that Cur could alleviate OTA-induced intestinal damage by enhancing antioxidant capacity and mitochondrial function as well as reducing necroptosis and inflammation in the grass carp *** study provided a theoretical basis and production implications for dietary Cur that could improve growth performance and alleviate the intestinal damage induced by OTA in fish.

关键词： Curcumin Ochratoxin A Grass carp growth performance Mid-intestine mitochondria function Necroptosis

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The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi zhao piao zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.Luu Sherwin Ho Michael J.Lee Jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang piao zhao Guozhi zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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母亲孕期风险暴露对儿童焦虑症及其亚型脑结构和功能影响的关联分析

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中国临床心理学杂志 2024年第1期32卷 57-64页

作者：赵飘飘顾薪睿刘宇於葛畅范华鑫廉正旭胡叶辰杨森友吴欣然张捷复旦大学类脑智能科学与技术研究院上海200433 复旦大学计算神经科学与类脑智能教育部重点实验室上海200433 上海大学中欧工程技术学院上海200072 香港中文大学医学院中国香港999077

目的:探究母亲孕期风险暴露对儿童焦虑症及其亚型脑结构和功能的影响。方法:基于ABCD(Adolescent Brain Cognitive Development)数据库5686名儿童(平均年龄9.95岁,其中焦虑症儿童2743名)数据,采用线性混合效应模型,比较焦虑组和焦虑症... 详细信息

目的:探究母亲孕期风险暴露对儿童焦虑症及其亚型脑结构和功能的影响。方法:基于ABCD(Adolescent Brain Cognitive Development)数据库5686名儿童(平均年龄9.95岁,其中焦虑症儿童2743名)数据,采用线性混合效应模型,比较焦虑组和焦虑症亚型组与健康组儿童孕期风险暴露、大脑结构以及静息态功能连接的差异,并且探究母亲孕期风险因素与儿童脑结构以及静息态功能连接的关联。结果:(1)与健康组对比,焦虑组儿童表现出母亲孕期风险暴露(如接受医疗护理次数)增加和颞上回等皮层厚度增加、脑岛等表面积降低以及扣带顶叶网络-尾状核等的功能连接增强。(2)母亲孕期医疗护理与焦虑组儿童左侧颞上回厚度增加有关。(3)母亲孕期风险暴露(如严重贫血、孕期医疗护理次数)是儿童焦虑症及其亚型的共同风险,同时焦虑症亚型儿童大脑结构和功能连接也表现出异常。结论:母亲孕期风险暴露是儿童焦虑症的重要风险因素,其长期影响可能与脑结构和功能的异常有关。

关键词：儿童焦虑症脑结构静息态功能连接母亲孕期风险暴露

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泡沫金属经典本构模型表征三轴拉伸和拉压组合条件下宏观力学性能的研究

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南华大学学报（自然科学版） 2024年第2期38卷 66-72页

作者：张晓阳刘泽宇赵飘南华大学数理学院湖南衡阳421001 南华大学土木工程学院湖南衡阳421001

泡沫金属在实际工程应用中往往承受多轴拉伸、拉压组合和压缩等复杂应力状态,且拉伸和压缩性能差异显著,而现有的本构关系理论模型基于多轴压缩实验构建,能否描述多轴拉伸和拉压组合条件下泡沫金属宏观弹塑性力学性能存疑。本文采用数... 详细信息

泡沫金属在实际工程应用中往往承受多轴拉伸、拉压组合和压缩等复杂应力状态,且拉伸和压缩性能差异显著,而现有的本构关系理论模型基于多轴压缩实验构建,能否描述多轴拉伸和拉压组合条件下泡沫金属宏观弹塑性力学性能存疑。本文采用数值模拟的方法开展多轴加载数值仿真实验,基于数值模拟结果检验泡沫金属两个经典模型:D-F模型与汤立群等提出的理论模型(以下简称Tang模型),在三轴拉伸和拉压组合工况下的合理性。结果表明,D-F模型的椭圆度参数显著影响模型的预测精度,基于三轴拉伸、压缩和拉压组合屈服面拟合计算的椭圆度预测效果最优,结合单轴拉伸应力应变曲线,D-F模型能较好地表征泡沫金属三轴拉压组合条件下力学性能,但存在无法描述塑性耗散功大于单轴拉伸破坏时对应的塑性耗散功的力学行为的缺陷;该模型不能准确描述三轴拉伸力学性能。Tang模型分别描述三轴拉伸和拉压组合破坏前的力学行为,等效应力和应变曲线均具有良好的一致性,但确定等效应力和应变的四个参数均不同且不同于三轴压缩对应的参数;综合考虑三轴拉压组合和三轴压缩工况时,等效应力和应变曲线的一致性很差。

关键词：泡沫金属本构关系理论模型三轴拉伸三轴拉压组合弹塑性力学性能

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平衡火罐联合耳穴贴压干预在非器质性失眠患者中的应用效果

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临床医学研究与实践 2024年第28期9卷 115-118页

作者：龚俭霞赵飘刘晓荣旬阳市中医医院内科陕西安康725700 西安市中医医院针灸推拿康复科陕西西安710021

目的探讨平衡火罐联合耳穴贴压在非器质性失眠患者中的应用效果。方法选择2020年1月至2022年12月收治的100例非器质性失眠患者为研究对象,以随机数字表法将其分为对照组和中医组,各50例。对照组予以常规西药治疗和常规护理,中医组在... 详细信息

目的探讨平衡火罐联合耳穴贴压在非器质性失眠患者中的应用效果。方法选择2020年1月至2022年12月收治的100例非器质性失眠患者为研究对象,以随机数字表法将其分为对照组和中医组,各50例。对照组予以常规西药治疗和常规护理,中医组在对照组基础上采用平衡火罐联合耳穴贴压干预。比较两组的睡眠质量、失眠情况、疲劳程度、临床疗效及不良反应发生情况。结果干预后,两组的匹兹堡睡眠质量指数(PSQI)、阿森斯失眠量表(AIS)评分均低于干预前,且中医组低于对照组(P0.05)。结论平衡火罐联合耳穴贴压干预用于非器质性失眠中的效果显著,能够有效改善患者的睡眠质量,减轻失眠及疲劳程度,且安全性高。

关键词：平衡火罐耳穴贴压非器质性失眠

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恒定高应变率拉伸条件下泡沫金属力学性能

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爆炸与冲击 2024年第1期44卷 106-114页

作者：张晓阳谭仕锋刘泽宇赵飘南华大学数理学院湖南衡阳421001 南华大学土木工程学院湖南衡阳421001

为了探究泡沫金属恒定应变率动态拉伸力学行为,基于3D Voronoi模型,采用双向拉伸加载方式和1.55倍等效胞孔直径高度的试件,实现了5000 s^(-1)恒定高应变率动态拉伸条件下泡沫金属力学性能测试数值模拟实验,模拟结果显示:动态拉伸过程满... 详细信息

为了探究泡沫金属恒定应变率动态拉伸力学行为,基于3D Voronoi模型,采用双向拉伸加载方式和1.55倍等效胞孔直径高度的试件,实现了5000 s^(-1)恒定高应变率动态拉伸条件下泡沫金属力学性能测试数值模拟实验,模拟结果显示:动态拉伸过程满足应力均匀性和变形均匀性要求,且试件破坏位置合理;在恒定应变率(0.5~5000 s^(-1))动态拉伸时,泡沫金属的破坏应变基本不受应变率的影响;当应变率不超过500 s^(-1)时,破坏应力受应变率影响很小,当应变率在500~5000 s^(-1)时,破坏应力随着加载速率的增大而线性增大。

关键词：恒定高应变率动态拉伸泡沫金属破坏行为

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正畸牙齿移动过程中自噬的作用

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中国组织工程研究 2024年第34期28卷 5558-5564页

作者：王天琦廖成成刘建国陈鹿鹿赵飘肖琳琳管晓燕遵义医科大学附属口腔医院贵州省遵义市563000 贵州省普通高等学校口腔疾病研究特色重点实验室贵州省遵义市563000 四川大学华西口腔医学院四川省成都市610000

背景:正畸力通过多种信号通路激活牙周组织自噬,进一步增强或减弱相关细胞(牙周膜细胞、骨细胞、破骨细胞和成骨细胞等)的活性来促进牙周重塑。目的:综述目前正畸力介导牙周组织自噬的研究进展和其对正畸牙齿移动的影响。方法:在PubMed... 详细信息

背景:正畸力通过多种信号通路激活牙周组织自噬,进一步增强或减弱相关细胞(牙周膜细胞、骨细胞、破骨细胞和成骨细胞等)的活性来促进牙周重塑。目的:综述目前正畸力介导牙周组织自噬的研究进展和其对正畸牙齿移动的影响。方法:在PubMed、Web of Science、中国生物医学文献数据库和中国知网数据库进行文献检索,设置检索时限为2010-2023年,总结了2010年以来正畸与自噬相关研究进展,最终纳入76篇文献进行分析讨论。结果与结论:(1)正畸力可通过牙周机械感受器和其造成的无菌性炎症引发一系列生物化学信号的转变,进而引起牙周组织自噬。(2)自噬通过级联放大的信号通路如磷脂酰肌醇-3-激酶/蛋白激酶B通路、河马通路及丝裂原活化蛋白激酶通路等,产生相应反馈从而促进牙周组织改建,最终实现牙齿的移动与稳定。正畸力诱导的自噬可差异性调节牙齿压力侧骨吸收和张力侧骨形成,相关靶点在正畸临床治疗的应用中具有良好前景。(3)然而,正畸力与自噬的机制较为复杂,现有研究仅停留在探究自噬对正畸牙齿移动的作用,自噬与正畸牙齿移动过程中的相互调节作用、涉及相关通路上游机械受体及信号通路间的交互作用均需要进一步的探究。

关键词：正畸牙齿移动自噬信号通路牙周组织骨重塑骨吸收骨形成力学生物学综述

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Green Leaves, Gold Mines

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Beijing Review 2020年第40期63卷 34-35页

作者： zhao piao 不详

Tea industry becomes a pillar for poverty alleviation in a prefecture in central ChinaIf you ask the locals to name one thing that has played a key role in shaking off poverty in Enshi Tujia and Miao Autonomous Prefec... 详细信息

关键词： shaking poverty Mines

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